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Exploring and Exploiting the Extracellular Matrix for Diagnosing and Treating Cancers
3:30 pm - 4:30 pm, February 22, 2017
The Department of Biopharmaceutical Sciences Presents:
"Exploring and Exploiting the Extracellular Matrix for Diagnosing and Treating Cancers"
Alexandra Naba, Ph. D
Assistant Professor, Department of Physiology and Biophysics
February 22, 2017
3:30 - 4:30 PM
Room 134-3 COP/Rockford E226
833 S Wood St.
Abstract: The extracellular matrix (ECM) is a complex meshwork of cross-linked proteins that provides biophysical and biochemical cues that are major regulators of cell migration, differentiation, survival, etc. ECM deposition (desmoplasia) is a hallmark of tumor progression and pathologists have used excessive ECM as a marker of tumors with poor prognosis long before the composition and the complexity of the ECM was even uncovered. However, the biochemical properties of ECM proteins (large size, insolubility) have compromised systematic characterization of ECM composition. In this talk I will describe the proteomic-based strategy I developed to characterize with high throughput the composition of the ECM of tissues and tumors. I will then discuss the result of a screen aimed at identifying ECM signatures of metastatic colorectal cancers. In the last part of my talk, I will present our recent attempt at converting proteomic-derived ECM signature into immunohistochemical test kits for use by pathologists and at identifying novel therapeutic targets within the ECM.
Location: College of Pharmacy
Room: 134-3/Rockford E226
833 S Wood St.
Sponsor: Department of Biopharmaceutical Sciences
Contact Name: Celina Tejada
Contact Email: firstname.lastname@example.org
Contact Phone: 312-996-0888
Date Posted: Fri, Jan 13
Date Updated: Fri, Jan 20