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Investigating the Impact of Bisphenols on Germline Function across Generations

3:30 pm - 4:30 pm, October 18, 2017

The Department of Biopharmaceutical Sciences presents:

"Investigating the Impact of Bisphenols on Germline Function across Generations"

Patrick Allard, Ph.D
Assistant Professor
UCLA Institute for Society & Genetics
University of California
Los Angeles, CA

October 18, 2017
3:30 PM – 4:30 PM

Room 134-3 COP / E223 Rockford
833 S. Wood Street
Chicago, IL

Abstract: Germ cells are the bridge between generations and their integrity is paramount to the health and viability of all organisms. As such, the dysregulation of germ cells development and function significantly contributes to infertility and is also the leading cause of birth defects and infant deaths in the United States. We investigated the effect of Bisphenols, Bisphenol A, and its substitute Bisphenol S, on germline homeostasis across generations. We show that BPA and BPS both disrupt normal germline function including the meiotic processes of homologous chromosome recombination and synapsis, although this is achieved through mostly different mechanisms. We also show that BPA alters the germline’s epigenetic control in a transgenerational manner through the disruption of the repressive histone marks H3K9me3 and H3K27me3. Together, these results highlight the need to examine toxicity pathways across a large developmental and generational time-span.

Event Details

Location: College of Pharmacy
Room: 134-3 COP/E223 Rockford
Address:
833 S. Wood Street
Chicago, IL

Sponsor: Department of Biopharmaceutical Sciences

Contact Name: Celina Tejada
Contact Email: Tejada@uic.edu
Contact Phone: 312-996-0888

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Date Posted: Wed, Oct 4
Date Updated: Wed, Oct 4

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