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2018 FAQ's

The monthly frequently asked questions are compiled by DIG faculty, residents, and students.  These summaries provide a concise overview of a current drug therapy topic.

2018 FAQs


Does administration of sodium bicarbonate to patients with severe metabolic acidosis yield a mortality benefit?

What data support use of topical tranexamic acid for epistaxis in adults?

What is the evidence for online vancomycin dose calculators?


What are important considerations for using cannabidiol for the treatment of pediatric seizures?

What are the 2018 SCCM guideline recommendations for pain, agitation/sedation, delirium, immobility, and sleep disruption (PADIS)?

Is intravenous lidocaine effective for renal colic in patients with urolithiasis?


What data are available to support administration of high-dose (>200 mg) iron sucrose in patients with non-dialysis-dependent chronic kidney disease?

What is the appropriate management of acute pain in a patient with opioid use disorder?

Probiotics and Clostridium difficile infections: What do we know now?


What is the emerging pathogen Candida auris and what should pharmacists know about it?

What role does intravenous magnesium play in the management of migraines?

What clinical data are available comparing meropenem 500 mg every 6 hours to meropenem 1000 mg every 8 hours?


What data support the use of andexanet alfa (ANDEXXA) for the reversal of factor Xa inhibitors?

What new data are available linking an increased infection risk with chronic opioid therapy?

Can intraoperative methadone reduce postoperative opioid requirements?


What is the efficacy and safety of IV acetaminophen when compared to oral acetaminophen?

What is the clinical efficacy of fish-oil containing lipid emulsion products compared to soybean oil-based lipid emulsion products for parenteral nutrition?

What is the evidence on the use of valbenazine (Ingrezza) for tardive dyskinesia?


What is the current evidence on using aromatherapy for treating postoperative nausea and/or vomiting?

What data are available to support etelcalcetide in hemodialysis patients with secondary hyperparathyroidism?

What guideline recommendations are available regarding perioperative multimodal analgesia (MMA)?


Update: What are aminophylline alternatives for the reversal of adenosine agonists used in pharmacologic stress testing?

In critically ill patients, do balanced solutions improve renal outcomes and decrease mortality when compared to normal saline?

What evidence is available for enoxaparin dosing for VTE prophylaxis in patients undergoing bariatric surgery?


Is there a potential for misuse and abuse with gabapentin (Neurontin®) and pregabalin (Lyrica®)?

What is the evidence behind the recent approval of the Shingrix vaccine?

What is the appropriate management of tetanus exposure?


Is one type of influenza vaccine more effective than another?

What is the role of Giapreza (angiotensin II) in shock?

What data are available for intravenous immune globulin (IVIG) in Clostridium difficile infection?


Are there data to support an increased risk of heart failure exacerbation/decompensation with pregabalin use?

What does the PRESERVE trial tell us about the prevention of contrast-induced acute kidney injury?

What data supports the efficacy and safety of meropenem-vaborbactam?


What is alpha-gal allergy and how does it impact medication therapy?

What is the evidence for the use of high-dose intravenous vitamin C for the treatment of cancer?

What are considerations for determining whether a drug may be administered via a midline catheter?