Andrew Riley
Assistant Professor, College of Pharmacy - Pharmaceutical Sciences
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PSCI Ph.D. Thesis Research (PSCI 599), 1/8/2024 – 4/26/2024
Doctoral Restch in Med Chem (MDCH 599), 1/8/2024 – 4/26/2024
Undergrad Res Exp Pharm Sci (PSCI 300), 1/8/2024 – 4/26/2024
PSCI Ph.D. Thesis Research (PSCI 599), 8/21/2023 – 12/1/2023
PhD Thesis Research (BPS 599), 8/21/2023 – 12/1/2023
Doctoral Restch in Med Chem (MDCH 599), 8/21/2023 – 12/1/2023
Research Presentation (PSCI 502), 8/21/2023 – 12/1/2023
Fundamentals of Drug Action (PHAR 422), 8/21/2023 – 12/1/2023
Fundamentals of Drug Action (PHAR 422), 8/21/2023 – 12/1/2023
Selected Grants
Aristotelia Alkaloids as Probes for the Nicotinic Acetylcholine Receptors, National Institutes of Health (National Center for Complementary and Integrative Health)., 5/16/2024 - 5/15/2026, Obligated Amount: $47694; Anticipated Amount: $95388
Selective Targeting of Nicotinic Acetylcholine Receptor Subtypes for Cocaine Use Disorder, National Institutes of Health (National Institute on Drug Abuse)., 3/1/2024 - 12/31/2028, Obligated Amount: $703988; Anticipated Amount: $3373690
Defining ?9?10 nAChR Complex Using the ATLAS Kit, Sigma-Aldrich., 12/16/2022 - 9/15/2023, Obligated Amount: $30000; Anticipated Amount: $30000
Prodrug Development for Pharmaceutical Uses, Innovo Pharmaceuticals., 9/16/2022 - 9/15/2024, Obligated Amount: $44793; Anticipated Amount: $44793
Synthesis and Evaluation of Alkaloids to Probe Membrane Receptors, National Institutes of Health (National Institute of General Medical Sciences)., 8/1/2022 - 6/30/2027, Obligated Amount: $823585; Anticipated Amount: $2073134
Hans W. Vahlteich Research Award, UIC College of Pharmacy., Date Not Set - Present, No Obligated Amount Set; No Anticipated Amount Set
Selected Publications
Riley, Andrew P. (2024). In This Issue, Volume 15, Issue 4. ACS Medicinal Chemistry Letters, 15, (4), 434-435. doi:10.1021/acsmedchemlett.4c00123.
Rusali, Lisa E, Lopez-Hernandez, Ana M, Kremiller, Kyle M, Kulkarni, Gauri C, Gour, Abhishek, Straub, Carolyn J, Argade, Malaika D, Peters, Christian J, Sharma, Abhisheak, Toll, Lawrence, Cippitelli, Andrea, Riley, Andrew P. (2024). Synthesis of α3β4 Nicotinic Acetylcholine Receptor Modulators Derived from Aristoquinoline That Reduce Reinstatement of Cocaine-Seeking Behavior. Journal of Medicinal Chemistry, 67, (1), 529-542. doi:10.1021/acs.jmedchem.3c01758.
Hennessy, Madeline R, Gutridge, Anna M, French, Alexander R, Rhoda, Elizabeth S, Meqbil, Yazan J, Gill, Meghna, Kashyap, Yavnika, Appourchaux, Kevin, Paul, Barnali, Wang, Zaijie Jim, van Rijn, Richard M, Riley, Andrew P. (2023). Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor. Journal of Medicinal Chemistry, 66, (5), 3312-3326. doi:10.1021/acs.jmedchem.2c01707.
Straub, Carolyn J, Rusali, Lisa E, Kremiller, Kyle M, Riley, Andrew P. (2023). What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders. Journal of Medicinal Chemistry, 66, (1), 107-121. doi:10.1021/acs.jmedchem.2c01562.
Shelton, Catherine L, Meneely, Kathleen M, Ronnebaum, Trey A, Chilton, Annemarie S, Riley, Andrew P, Prisinzano, Thomas E, Lamb, Audrey L. (2022). Rational inhibitor design for Pseudomonas aeruginosa salicylate adenylation enzyme PchD. JBIC Journal of Biological Inorganic Chemistry, 27, (6), 541-551. doi:10.1007/s00775-022-01941-8.
Argade, Malaika D, Riley, Andrew P. (2022). Syntheses of Aristotelia Alkaloids: Reflections in the Chiral Pool. Synlett, 33, (13), 1209-1214. doi:10.1055/a-1856-7334.
Argade, Malaika D, Straub, Carolyn J, Rusali, Lisa E, Santarsiero, Bernard D, Riley, Andrew P. (2021). Synthesis of Aristoquinoline Enantiomers and Their Evaluation at the α3β4 Nicotinic Acetylcholine Receptor. Organic Letters, 23, (20), 7693-7697. doi:10.1021/acs.orglett.1c02057.
Creed, Simone M, Gutridge, Anna M, Argade, Malaika D, Hennessy, Madeline R, Friesen, J Brent, Pauli, Guido F, van Rijn, Richard M, Riley, Andrew P. (2021). Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids. Journal of Natural Products, 84, (1), 71-80. doi:10.1021/acs.jnatprod.0c01036.
Crowley, Rachel S, Riley, Andrew P, Alder, Amy F, Anderson, Richard J, Luo, Dan, Kaska, Sophia, Maynez, Pamela, Kivell, Bronwyn M, Prisinzano, Thomas E. (2020). Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G‑protein Activation Bias at the μ‑Opioid Receptor. ACS Chemical Neuroscience, 11, (12), 1781-1790. doi:10.1021/acschemneuro.0c00191.
Professional Leadership
Auditing Committee, American Society of Pharmacognosy, 8/7/2019 - Present
Auditing Committee, 8/7/2019 - Present
Notable Honors
2024, ACS MEDI Young Investigator Symposium, American Chemical Society
2024, UIC Rising Star in Basic Life Sciences, UIC
2023, Thieme Chemistry Journal Award, Thieme Journals
Education
Degrees:
BA, Ohio Wesleyan University, United States, 2010
PhD, The University of Kansas, USA, 2015
Postgraduate Training:
NRSA Postdoctoral Fellowship (NIH-F32), University of Illinois at Urbana-Champaign, United States, 2018