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Photo of Baojie Wan

Baojie Wan

SR RES SPEC, Institute for Tuberculosis Research

Contact Information

833 S. Wood Street
412
Chicago, IL 60612

Phone: (312) 996-9673

Intellectual Contributions

Journal Article

  • Palmer BD, Sutherland HS, Blaser A, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA, Thompson AM. "Synthesis and Structure-Activity Relationships for Extended Side Chain Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).". Journal of medicinal chemistry. 2015;58(7):3036-59. doi:10.1021/jm501608q.
  • Siricilla S, Mitachi K, Wan B, Franzblau SG, Kurosu M. "Discovery of a capuramycin analog that kills nonreplicating Mycobacterium tuberculosis and its synergistic effects with translocase I inhibitors.". The Journal of antibiotics. 2014;. doi:10.1038/ja.2014.133.
  • Ramos Alvarenga RF, Wan B, Inui T, Franzblau SG, Pauli GF, Jaki BU. "Airborne antituberculosis activity of Eucalyptus citriodora essential oil.". Journal of natural products. 2014;77(3):603-10. doi:10.1021/np400872m.
  • Pieroni M, Wan B, Cho S, Franzblau SG, Costantino G. "Design, synthesis and investigation on the structure-activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents.". European journal of medicinal chemistry. 2014;72:26-34. doi:10.1016/j.ejmech.2013.11.007.
  • Klein L, Petukhova V, Wan B, Wang Y, Santasiero BD, Lankin DC, Pauli GF, Franzblau SG. "A novel indigoid anti-tuberculosis agent.". Bioorganic & medicinal chemistry letters. 2014;24(1):268-70. doi:10.1016/j.bmcl.2013.11.024.
  • Lv W, Banerjee B, Molland KL, Seleem MN, Ghafoor A, Hamed MI, Wan B, Franzblau SG, Mesecar AD, Cushman M. "Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase.". Bioorganic & medicinal chemistry. 2014;22(1):406-18. doi:10.1016/j.bmc.2013.11.011.
  • Ekins S, Reynolds RC, Franzblau SG, Wan B, Freundlich JS, Bunin BA. "Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models.". PloS one. 2013;8(5):e63240. doi:10.1371/journal.pone.0063240.
  • Tukulula M, Little S, Gut J, Rosenthal PJ, Wan B, Franzblau SG, Chibale K. "The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives.". European journal of medicinal chemistry. 2012;57:259-67. doi:10.1016/j.ejmech.2012.08.047.
  • Kunciw DL, Liechty JJ, Mitchell MO, Wan B, Franzblau SG. "Structural requirements for the antitubercular quaternized triflupromazine pharmacophore.". Bioorganic & medicinal chemistry letters. 2012;22(17):5679-80. doi:10.1016/j.bmcl.2012.06.095.
  • Dulla B, Wan B, Franzblau SG, Kapavarapu R, Reiser O, Iqbal J, Pal M. "Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents.". Bioorganic & medicinal chemistry letters. 2012;22(14):4629-35. doi:10.1016/j.bmcl.2012.05.096.
  • Chopra S, Koolpe GA, Tambo-Ong AA, Matsuyama KN, Ryan KJ, Tran TB, Doppalapudi RS, Riccio ES, Iyer LV, Green CE, Wan B, Franzblau SG, Madrid PB. "Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis.". Journal of medicinal chemistry. 2012;55(13):6047-60. doi:10.1021/jm300123s.
  • Debnath J, Siricilla S, Wan B, Crick DC, Lenaerts AJ, Franzblau SG, Kurosu M. "Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis.". Journal of medicinal chemistry. 2012;55(8):3739-55. doi:10.1021/jm201608g.
  • Gill SK, Xu H, Kirchhoff PD, Cierpicki T, Turbiak AJ, Wan B, Zhang N, Peng KW, Franzblau SG, Garcia GA, Showalter HD. "Structure-based design of novel benzoxazinorifamycins with potent binding affinity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerases.". Journal of medicinal chemistry. 2012;55(8):3814-26. doi:10.1021/jm201716n.
  • Lu X, Liu X, Wan B, Franzblau SG, Chen L, Zhou C, You Q. "Synthesis and evaluation of anti-tubercular and antibacterial activities of new 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives. Part 2.". European journal of medicinal chemistry. 2012;49:164-71. doi:10.1016/j.ejmech.2012.01.007.
  • Chopra S, Matsuyama K, Tran T, Malerich JP, Wan B, Franzblau SG, Lun S, Guo H, Maiga MC, Bishai WR, Madrid PB. "Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.". The Journal of antimicrobial chemotherapy. 2012;67(2):415-21. doi:10.1093/jac/dkr449.
  • Blaser A, Palmer BD, Sutherland HS, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Thompson AM, Denny WA. "Structure-activity relationships for amide-, carbamate-, and urea-linked analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).". Journal of medicinal chemistry. 2012;55(1):312-26. doi:10.1021/jm2012276.
  • Jin Y, Gill SK, Kirchhoff PD, Wan B, Franzblau SG, Garcia GA, Showalter HD. "Synthesis and structure-activity relationships of novel substituted 8-amino, 8-thio, and 1,8-pyrazole congeners of antitubercular rifamycin S and rifampin.". Bioorganic & medicinal chemistry letters. 2011;21(20):6094-9. doi:10.1016/j.bmcl.2011.08.054.
  • Thompson AM, Sutherland HS, Palmer BD, Kmentova I, Blaser A, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA. "Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5h-imidazo[2,1-b][1,3]oxazine (PA-824).". Journal of medicinal chemistry. 2011;54(19):6563-85. doi:10.1021/jm200377r.
  • Lu X, Wan B, Franzblau SG, You Q. "Design, synthesis and anti-tubercular evaluation of new 2-acylated and 2-alkylated amino-5-(4-(benzyloxy)phenyl)thiophene-3-carboxylic acid derivatives. Part 1.". European journal of medicinal chemistry. 2011;46(9):3551-63. doi:10.1016/j.ejmech.2011.05.018.
  • Macabeo AP, Vidar WS, Chen X, Decker M, Heilmann J, Wan B, Franzblau SG, Galvez EV, Aguinaldo MA, Cordell GA. "Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.". European journal of medicinal chemistry. 2011;46(7):3118-23. doi:10.1016/j.ejmech.2011.04.025.
  • Lu JP, Yuan XH, Yuan H, Wang WL, Wan B, Franzblau SG, Ye QZ. "Inhibition of Mycobacterium tuberculosis methionine aminopeptidases by bengamide derivatives.". ChemMedChem. 2011;6(6):1041-8. doi:10.1002/cmdc.201100003.
  • Hans RH, Wiid IJ, van Helden PD, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. "Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents.". Bioorganic & medicinal chemistry letters. 2011;21(7):2055-8. doi:10.1016/j.bmcl.2011.02.008.
  • Kmentova I, Sutherland HS, Palmer BD, Blaser A, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA, Thompson AM. "Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).". Journal of medicinal chemistry. 2010;53(23):8421-39. doi:10.1021/jm101288t.
  • Pieroni M, Lilienkampf A, Wang Y, Wan B, Cho S, Franzblau SG, Kozikowski AP. "NOC chemistry for tuberculosis-further investigations on the structure-activity relationships of antitubercular isoxazole-3-carboxylic acid ester derivatives.". ChemMedChem. 2010;5(10):1667-72. doi:10.1002/cmdc.201000169.
  • Mao J, Yuan H, Wang Y, Wan B, Pak D, He R, Franzblau SG. "Synthesis and antituberculosis activity of novel mefloquine-isoxazole carboxylic esters as prodrugs.". Bioorganic & medicinal chemistry letters. 2010;20(3):1263-8. doi:10.1016/j.bmcl.2009.11.105.
  • Hans RH, Guantai EM, Lategan C, Smith PJ, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. "Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.". Bioorganic & medicinal chemistry letters. 2010;20(3):942-4. doi:10.1016/j.bmcl.2009.12.062.
  • Guo S, Song Y, Huang Q, Yuan H, Wan B, Wang Y, He R, Beconi MG, Franzblau SG, Kozikowski AP. "Identification, synthesis, and pharmacological evaluation of tetrahydroindazole based ligands as novel antituberculosis agents.". Journal of medicinal chemistry. 2010;53(2):649-59. doi:10.1021/jm901235p.
  • Lilienkampf A, Pieroni M, Wan B, Wang Y, Franzblau SG, Kozikowski AP. "Rational design of 5-phenyl-3-isoxazolecarboxylic acid ethyl esters as growth inhibitors of Mycobacterium tuberculosis. a potent and selective series for further drug development.". Journal of medicinal chemistry. 2010;53(2):678-88. doi:10.1021/jm901273n.
  • Sutherland HS, Blaser A, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Palmer BD, Denny WA, Thompson AM. "Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains.". Journal of medicinal chemistry. 2010;53(2):855-66. doi:10.1021/jm901378u.
  • Palmer BD, Thompson AM, Sutherland HS, Blaser A, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA. "Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).". Journal of medicinal chemistry. 2010;53(1):282-94. doi:10.1021/jm901207n.
  • Mao J, Yuan H, Wang Y, Wan B, Pieroni M, Huang Q, van Breemen RB, Kozikowski AP, Franzblau SG. "From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters.". Journal of medicinal chemistry. 2009;52(22):6966-78. doi:10.1021/jm900340a.
  • Huang Q, Mao J, Wan B, Wang Y, Brun R, Franzblau SG, Kozikowski AP. "Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles.". Journal of medicinal chemistry. 2009;52(21):6757-67. doi:10.1021/jm901112f.
  • Pieroni M, Lilienkampf A, Wan B, Wang Y, Franzblau SG, Kozikowski AP. "Synthesis, biological evaluation, and structure-activity relationships for 5-[(E)-2-arylethenyl]-3-isoxazolecarboxylic acid alkyl ester derivatives as valuable antitubercular chemotypes.". Journal of medicinal chemistry. 2009;52(20):6287-96. doi:10.1021/jm900513a.
  • Guo S, Tipparaju SK, Pegan SD, Wan B, Mo S, Orjala J, Mesecar AD, Franzblau SG, Kozikowski AP. "Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents.". Bioorganic & medicinal chemistry. 2009;17(20):7126-30. doi:10.1016/j.bmc.2009.08.061.
  • Zhao Y, Bacher A, Illarionov B, Fischer M, Georg G, Ye QZ, Fanwick PE, Franzblau SG, Wan B, Cushman M. "Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis.". The Journal of organic chemistry. 2009;74(15):5297-303. doi:10.1021/jo900768c.
  • Lilienkampf A, Mao J, Wan B, Wang Y, Franzblau SG, Kozikowski AP. "Structure-activity relationships for a series of quinoline-based compounds active against replicating and nonreplicating Mycobacterium tuberculosis.". Journal of medicinal chemistry. 2009;52(7):2109-18. doi:10.1021/jm900003c.
  • Yuan H, He R, Wan B, Wang Y, Pauli GF, Franzblau SG, Kozikowski AP. "Modification of the side chain of micromolide, an anti-tuberculosis natural product.". Bioorganic & medicinal chemistry letters. 2008;18(19):5311-5. doi:10.1016/j.bmcl.2008.08.027.
  • Mao J, Eoh H, He R, Wang Y, Wan B, Franzblau SG, Crick DC, Kozikowski AP. "Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase.". Bioorganic & medicinal chemistry letters. 2008;18(19):5320-3. doi:10.1016/j.bmcl.2008.08.034.
  • Zhu ZJ, Krasnykh O, Pan D, Petukhova V, Yu G, Liu H, Hong S, Wang Y, Wan B, Liang W, Franzblau SG. "Structure-activity relationships of macrolides against Mycobacterium tuberculosis.". Tuberculosis (Edinburgh, Scotland). 2008;88 Suppl 1:S49-63. doi:10.1016/S1472-9792(08)70036-2.
  • Velaparthi S, Brunsteiner M, Uddin R, Wan B, Franzblau SG, Petukhov PA. "5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs.". Journal of medicinal chemistry. 2008;51(7):1999-2002. doi:10.1021/jm701372r.
  • Mao J, Wang Y, Wan B, Kozikowski AP, Franzblau SG. "Design, synthesis, and pharmacological evaluation of mefloquine-based ligands as novel antituberculosis agents.". ChemMedChem. 2007;2(11):1624-30. doi:10.1002/cmdc.200700112.
  • Mao J, Wan B, Wang Y, Franzblau SG, Kozikowski AP. "HTS, chemical hybridization, and drug design identify a chemically unique antituberculosis agent-coupling serendipity and rational approaches to drug discovery.". ChemMedChem. 2007;2(6):811-3. doi:10.1002/cmdc.200700048.
  • Cho S, Warit S, Wan B, Hwang CH, Pauli GF, Franzblau SG. "Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.". Antimicrobial agents and chemotherapy. 2007;51(4):1380-5. doi:10.1128/AAC.00055-06.
  • Jayaprakash S, Iso Y, Wan B, Franzblau SG, Kozikowski AP. "Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents.". ChemMedChem. 2006;1(6):593-7. doi:10.1002/cmdc.200600010.
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