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Photo of Chun-Tao Che

Chun-Tao Che

Harry H.S. Fong Professor of Pharmacognosy, Medicinal Chemistry and Pharmacognosy

Contact Information

833 S. Wood St., Rm 323 (781)
Rm 323 College of Pharmacy
Chicago, IL 60612

Phone: (312) 996-5234

Fax: (312) 996-7107

Website: https://sites.google.com/site/whoictm/participants/che

Education

  • PhD, Pharmacognosy, University of Illinois at Chicago, Chicago, 1982

Research Interests

Pharmacognosy; natural products; traditional medicine; plant chemistry; dietary supplements; natural drug discovery and development

Teaching Interests

Pharmacognosy; natural products; traditional medicine; plant chemistry; dietary supplements; natural drug discovery and development

Professional Organizations

  • American Chemical Society
  • American Society of Pharmacognosy

Intellectual Contributions

Journal Article

  • Zhao M, Cheng J, Guo BC, Duan J, Che C. "Momilactone and Related Diterpenoids as Potential Agricultural Chemicals.". Journal of agricultural and food chemistry. 2018;66(30):7859-7872. doi:10.1021/acs.jafc.8b02602.
  • Tabrizizadeh M, Kazemipoor M, Hakimian M, Maleksabet M, Kazemipoor M, Zandi H, Pourrajab F, Che C, Cordell GA. "Effects of a Peganum harmala (Zygophyllaceae) preparation for root canal disinfection.". Phytotherapy research : PTR. 2018;32(4):672-677. doi:10.1002/ptr.6015.
  • Zhao M, Guo BC, Onakpa MM, Wong T, Wakasa K, Che C, Warpeha K. "Activity of Icacinol from Icacina trichantha on Seedling Growth of Oryza sativa and Arabidopsis thaliana.". Journal of natural products. 2017;80(12):3314-3318. doi:10.1021/acs.jnatprod.7b00668.
  • Szymulanska-Ramamurthy KM, Zhao M, Che C. "Phytochemical study of Illicium angustisepalum and its biological activities.". Acta pharmaceutica Sinica. B. 2017;7(4):485-490. doi:10.1016/j.apsb.2017.06.002.
  • Feng R, Tan XS, Wen BY, Shou JW, Fu J, He CY, Zhao ZX, Li XY, Zhu HX, Zhu P, Shi JG, Che C, Yeung JH, Zhang XF, Wang Y. "Interaction effects on cytochrome P450 both in vitro and in vivo studies by two major bioactive xanthones from Halenia elliptica D. Don.". Biomedical chromatography : BMC. 2016;30(12):1953-1962. doi:10.1002/bmc.3771.
  • Lin Z, Wu ZF, Jiang CH, Zhang QW, Ouyang S, Che C, Zhang J, Yin ZQ. "The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats.". Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016;23(12):1475-1483. doi:10.1016/j.phymed.2016.08.003.
  • Guo BC, Onakpa MM, Huang XJ, Santarsiero BD, Chen W, Zhao M, Zhang XQ, Swanson SM, Burdette JE, Che C. "Di-nor- and 17-nor-pimaranes from Icacina trichantha.". Journal of natural products. 2016;79(7):1815-21. doi:10.1021/acs.jnatprod.6b00289.
  • Ghura S, Tai L, Zhao M, Collins N, Che C, Warpeha KM, LaDu MJ. "Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer's disease in vitro.". Scientific reports. 2016;6:29364. doi:10.1038/srep29364.
  • Che C, Wong MS, Lam CW. "Natural Products from Chinese Medicines with Potential Benefits to Bone Health.". Molecules (Basel, Switzerland). 2016;21(3):239. doi:10.3390/molecules21030239.
  • Johnson OO, Zhao M, Gunn JJ, Santarsiero BD, Yin ZQ, Ayoola GA, Coker HA, Che C. "α-Glucosidase Inhibitory Prenylated Anthranols from Harungana madagascariensis.". Journal of natural products. 2016;79(1):224-9. doi:10.1021/acs.jnatprod.5b00924.
  • Deng XM, Yu JY, Ding MJ, Zhao M, Xue XY, Che C, Wang SM, Zhao B, Meng J. "Liquid Chromatography-diode Array Detector-electrospray Mass Spectrometry and Principal Components Analyses of Raw and Processed Moutan Cortex.". Pharmacognosy magazine. 2016;12(45):50-6. doi:10.4103/0973-1296.176046.
  • Yin ZQ, Yu SL, Wei YJ, Ma L, Wu ZF, Wang L, Zhang QW, Zhao M, Ye WC, Che C, Zhang J. "C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells.". Steroids. 2015;. doi:10.1016/j.steroids.2015.12.008.
  • Che C, Wong MS. "Ligustrum lucidum and its Constituents: A Mini-Review on the Anti-Osteoporosis Potential.". Natural product communications. 2015;10(12):2189-94.
  • Lin ZX, Che C, Lee SS, Chan RC, Ip PS, Yang JM. "Sophora flavescens (Ku-Shen) as a booster for antiretroviral therapy through cytochrome P450 3A4 inhibition.". Hong Kong medical journal = Xianggang yi xue za zhi. 2015;21 Suppl 7:S18-21.
  • Zhao M, Onakpa MM, Santarsiero BD, Chen W, Szymulanska-Ramamurthy KM, Swanson SM, Burdette JE, Che C. "(9βH)-Pimaranes and Derivatives from the Tuber of Icacina trichantha.". Journal of natural products. 2015;. doi:10.1021/acs.jnatprod.5b00688.
  • Deng X, Yu J, Zhao M, Zhao B, Xue X, Che C, Meng J, Wang S. "Quality assessment of crude and processed ginger by high-performance liquid chromatography with diode array detection and mass spectrometry combined with chemometrics.". Journal of separation science. 2015;38(17):2945-52. doi:10.1002/jssc.201500294.
  • Zhao M, Onakpa MM, Santarsiero BD, Huang XJ, Zhang XQ, Chen J, Cheng J, Longnecker R, Che C. "Icacinlactone H and Icacintrichantholide from the Tuber of Icacina trichantha.". Organic letters. 2015;17(15):3834-7. doi:10.1021/acs.orglett.5b01806.
  • Zhou M, Zhou K, Gao XM, Jiang ZY, Lv JJ, Liu ZH, Yang GY, Miao MM, Che C, Hu QF. "Fistulains A and B, New Bischromones from the Bark of Cassia fistula, and Their Activities.". Organic letters. 2015;17(11):2638-41. doi:10.1021/acs.orglett.5b01007.
  • Ma Y, Jiang C, Yao N, Li Y, Wang Q, Fang S, Shang X, Zhao M, Che C, Ni Y, Zhang J, Yin Z. "Antihyperlipidemic effect of Cyclocarya paliurus (Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice.". Journal of ethnopharmacology. 2015;166:286-96. doi:10.1016/j.jep.2015.03.030.
  • Zhao M, Onakpa MM, Chen W, Santarsiero BD, Swanson SM, Burdette JE, Asuzu IU, Che C. "17-Norpimaranes and (9βH)-17-Norpimaranes from the Tuber of Icacina trichantha.". Journal of natural products. 2015;78(4):789-96. doi:10.1021/np5010328.
  • Zhao M, Onakpa MM, Chen W, Santarsiero BD, Swanson SM, Burdette JE, Asuzu IU, Che C. "17-Norpimaranes and (9βH)-17-Norpimaranes from the Tuber of Icacina trichantha.". Journal of natural products. 2015;. doi:10.1021/np5010328.
  • Zhang Y, Diao TY, Wang L, Che C, Wong MS. "Protective effects of water fraction of Fructus Ligustri Lucidi extract against hypercalciuria and trabecular bone deterioration in experimentally type 1 diabetic mice.". Journal of ethnopharmacology. 2014;158 Pt A:239-45. doi:10.1016/j.jep.2014.10.025.
  • Monday Onakpa M, Zhao M, Gödecke T, Chen W, Che C, Santarsiero BD, Swanson SM, Uzoma Asuzu I. "Cytotoxic (9βH)-pimarane and (9βH)-17-norpimarane diterpenes from the tuber of Icacina trichantha.". Chemistry & biodiversity. 2014;11(12):1914-22. doi:10.1002/cbdv.201400151.
  • Zhou M, Miao MM, Du G, Li XN, Shang SZ, Zhao W, Liu ZH, Yang GY, Che C, Hu QF, Gao XM. "Aspergillines A-E, highly oxygenated hexacyclic indole-tetrahydrofuran-tetramic acid derivatives from Aspergillus versicolor.". Organic letters. 2014;16(19):5016-9. doi:10.1021/ol502307u.
  • Cheung FW, Leung AW, Liu WK, Che C. "Tyrosinase inhibitory activity of a glucosylated hydroxystilbene in mouse melan-a melanocytes.". Journal of natural products. 2014;77(6):1270-4. doi:10.1021/np4008798.
  • Witt CM, Aickin M, Cherkin D, Che C, Elder C, Flower A, Hammerschlag R, Liu JP, Lao L, Phurrough S, Ritenbaugh C, Rubin LH, Schnyer R, Wayne PM, Withers SR, Zhao-Xiang B, Young J, Berman BM. "Effectiveness guidance document (EGD) for Chinese medicine trials: a consensus document.". Trials. 2014;15:169. doi:10.1186/1745-6215-15-169.
  • Zhao M, Zhang X, Wang Y, Huang M, Duan JA, Gödecke T, Szymulanska-Ramamurthy KM, Yin Z, Che C. "Germacranes and m-menthane from Illicium lanceolatum.". Molecules (Basel, Switzerland). 2014;19(4):4326-37. doi:10.3390/molecules19044326.
  • Feng R, Zhou X, Tan XS, Or PM, Hu T, Fu J, Ma JY, Huang M, He CY, Shi JG, Che C, Yeung JH, Wang Y. "In vitro identification of cytochrome P450 isoforms responsible for the metabolism of 1-hydroxyl-2,3,5-trimethoxy-xanthone purified from Halenia elliptica D. Don.". Chemico-biological interactions. 2014;210:12-9. doi:10.1016/j.cbi.2013.12.008.
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