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Photo of Dejan S Nikolic

Dejan S Nikolic

Research Associate Professor, Medicinal Chemistry and Pharmacognosy

Contact Information

833 S. Wood Street (781)
435
Chicago, IL 60612

Phone: (312) 355-2786

Intellectual Contributions

Journal Article

  • Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen S, Nikolic DS, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. "Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.". Chemical research in toxicology. 2015;28(11):2130-41. doi:10.1021/acs.chemrestox.5b00310.
  • Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen S, Nikolic DS, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. "Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.". Chemical research in toxicology. 2015;28(11):2130-41. doi:10.1021/acs.chemrestox.5b00310.
  • Ramos Alvarenga RF, Friesen JB, Nikolic DS, Simmler C, Napolitano JG, van Breemen RB, Lankin DC, McAlpine JB, Pauli GF, Chen S. "K-targeted metabolomic analysis extends chemical subtraction to DESIGNER extracts: selective depletion of extracts of hops (Humulus lupulus).". Journal of natural products. 2014;77(12):2595-604. doi:10.1021/np500376g.
  • van Breemen RB, Yuan Y, Banuvar S, Shulman LP, Qiu X, Alvarenga RF, Chen S, Dietz BM, Bolton JL, Pauli GF, Krause EC, Viana M, Nikolic DS. "Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops.". Molecular nutrition & food research. 2014;58(10):1962-9. doi:10.1002/mnfr.201400245.
  • Simmler C, Nikolic DS, Lankin DC, Yu Y, Friesen JB, van Breemen RB, Lecomte A, Le Quémener C, Audo G, Pauli GF. "Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice.". Journal of natural products. 2014;77(8):1806-16. doi:10.1021/np5001945.
  • Simmler C, Jones T, Anderson JR, Nikolic DS, van Breemen RB, Soejarto DD, Chen S, Pauli GF. "Species-specific Standardisation of Licorice by Metabolomic Profiling of Flavanones and Chalcones.". Phytochemical analysis : PCA. 2014;25(4):378-88.
  • Krause EC, Yuan Y, Hajirahimkhan A, Dong H, Dietz BM, Nikolic DS, Pauli GF, Bolton JL, van Breemen RB. "Biological and chemical standardization of a hop (Humulus lupulus) botanical dietary supplement.". Biomedical chromatography : BMC. 2014;28(6):729-34. doi:10.1002/bmc.3177.
  • Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen S, Nikolic DS, Dietz BM, Pauli GF, van Breemen RB, Bolton JL. "Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms.". PloS one. 2013;8(7):e67947. doi:10.1371/journal.pone.0067947.
  • Dietz BM, Hagos GK, Eskra JN, Wijewickrama GT, Anderson JR, Nikolic DS, Guo J, Wright BJ, Chen S, Pauli GF, van Breemen RB, Bolton JL. "Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo.". Molecular nutrition & food research. 2013;57(6):1055-66. doi:10.1002/mnfr.201200534.
  • Dong SH, Nikolic DS, Simmler C, Qiu F, van Breemen RB, Soejarto DD, Pauli GF, Chen S. "Diarylheptanoids from Dioscorea villosa (Wild Yam).". Journal of natural products. 2012;75(12):2168-77. doi:10.1021/np300603z.
  • Yuan Y, Qiu X, Nikolic DS, Dahl JH, van Breemen RB. "Method development and validation for ultra-high-pressure LC/MS/MS determination of hop prenylflavonoids in human serum.". Journal of AOAC International. 2012;95(6):1744-9.
  • Hu C, Nikolic DS, Eggler AL, Mesecar AD, van Breemen RB. "Screening for natural chemoprevention agents that modify human Keap1.". Analytical biochemistry. 2012;421(1):108-14. doi:10.1016/j.ab.2011.10.028.
  • Chen S, Webster D, Nikolic DS, van Breemen RB, Wang Z, Fong HH, Farnsworth NR, Pauli GF. "Phytoconstituents from Vitex agnus-castus fruits.". Fitoterapia. 2011;82(4):528-33. doi:10.1016/j.fitote.2010.12.003.
  • Cao H, Yu R, Tao Y, Nikolic DS, van Breemen RB. "Measurement of cyclooxygenase inhibition using liquid chromatography-tandem mass spectrometry.". Journal of pharmaceutical and biomedical analysis. 2011;54(1):230-5. doi:10.1016/j.jpba.2010.08.001.
  • Bolca S, Li J, Nikolic DS, Roche N, Blondeel P, Possemiers S, De Keukeleire D, Bracke M, Heyerick A, van Breemen RB, Depypere H. "Disposition of hop prenylflavonoids in human breast tissue.". Molecular nutrition & food research. 2010;54 Suppl 2:S284-94. doi:10.1002/mnfr.200900519.
  • Inui T, Wang Y, Nikolic DS, Smith DC, Franzblau SG, Pauli GF. "Sesquiterpenes from Oplopanax horridus.". Journal of natural products. 2010;73(4):563-7. doi:10.1021/np900674d.
  • van Breemen RB, Liang W, Banuvar S, Shulman LP, Pang Y, Tao Y, Nikolic DS, Krock KM, Chen S, Hedayat S, Bolton JL, Pauli GF, Piersen CE, Krause EC, Geller SE, Farnsworth NR. "Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh.". Clinical pharmacology and therapeutics. 2010;87(2):219-25. doi:10.1038/clpt.2009.251.
  • Geller SE, Shulman LP, van Breemen RB, Banuvar S, Zhou Y, Epstein G, Hedayat S, Nikolic DS, Krause EC, Piersen CE, Bolton JL, Pauli GF, Farnsworth NR. "Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial.". Menopause (New York, N.Y.). 2009;16(6):1156-66. doi:10.1097/gme.0b013e3181ace49b.
  • Gödecke T, Lankin DC, Nikolic DS, Chen S, van Breemen RB, Farnsworth NR, Pauli GF. "Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa).". Journal of natural products. 2009;72(3):433-7. doi:10.1021/np8006952.
  • Gödecke T, Nikolic DS, Lankin DC, Chen S, Powell SL, Dietz BM, Bolton JL, van Breemen RB, Farnsworth NR, Pauli GF. "Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.". Phytochemical analysis : PCA. 2009;20(2):120-33. doi:10.1002/pca.1106.
  • Powell SL, Gödecke T, Nikolic DS, Chen S, Ahn S, Dietz BM, Farnsworth NR, van Breemen RB, Lankin DC, Pauli GF, Bolton JL. "In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent.". Journal of agricultural and food chemistry. 2008;56(24):11718-26. doi:10.1021/jf803298z.
  • Chen S, Turner A, Jaki BU, Nikolic DS, van Breemen RB, Pauli GF. "An experimental implementation of chemical subtraction.". Journal of pharmaceutical and biomedical analysis. 2008;46(4):692-8. doi:10.1016/j.jpba.2007.12.014.
  • Guo J, Liu D, Nikolic DS, Zhu D, Pezzuto JM, van Breemen RB. "In vitro metabolism of isoliquiritigenin by human liver microsomes.". Drug metabolism and disposition: the biological fate of chemicals. 2008;36(2):461-8. doi:10.1124/dmd.107.018721.
  • Pang Y, Nikolic DS, Zhu D, Chadwick LR, Pauli GF, Farnsworth NR, van Breemen RB. "Binding of the hop (Humulus lupulus L.) chalcone xanthohumol to cytosolic proteins in Caco-2 intestinal epithelial cells.". Molecular nutrition & food research. 2007;51(7):872-9. doi:10.1002/mnfr.200600252.
  • Chen S, Lankin DC, Nikolic DS, Lu ZZ, Ramirez B, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. "Chlorination diversifies Cimicifuga racemosa triterpene glycosides.". Journal of natural products. 2007;70(6):1016-23. doi:10.1021/np0700319.
  • Wang Z, Yuan H, Nikolic DS, van Breemen RB, Silverman RB. "(+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway.". Biochemistry. 2006;45(48):14513-22. doi:10.1021/bi061592m.
  • Deng S, Chen S, Lu J, Wang Z, Nikolic DS, van Breemen RB, Santarsiero BD, Mesecar A, Fong HH, Farnsworth NR, Pauli GF. "GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels.". Phytochemical analysis : PCA. 2006;17(6):398-405.
  • Deng S, Chen S, Lu J, Wang Z, Nikolic DS, van Breemen RB, Santarsiero BD, Mesecar A, Fong HH, Farnsworth NR, Pauli GF. "GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels.". Phytochemical analysis : PCA. 2006;17(6):398-405.
  • Guo J, Nikolic DS, Chadwick LR, Pauli GF, van Breemen RB. "Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.).". Drug metabolism and disposition: the biological fate of chemicals. 2006;34(7):1152-9. doi:10.1124/dmd.105.008250.
  • Nikolic DS, Li Y, Chadwick LR, van Breemen RB. "In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.).". Pharmaceutical research. 2006;23(5):864-72. doi:10.1007/s11095-006-9902-8.
  • Deng S, Chen S, Yao P, Nikolic DS, van Breemen RB, Bolton JL, Fong HH, Farnsworth NR, Pauli GF. "Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.". Journal of natural products. 2006;69(4):536-41. doi:10.1021/np050301s.
  • Booth NL, Overk CR, Yao P, Burdette JE, Nikolic DS, Chen S, Bolton JL, van Breemen RB, Pauli GF, Farnsworth NR. "The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract.". Journal of alternative and complementary medicine (New York, N.Y.). 2006;12(2):133-9. doi:10.1089/acm.2006.12.133.
  • Overk CR, Yao P, Chadwick LR, Nikolic DS, Ajayi OK, Cuendet MA, Deng Y, Hedayat AS, Pauli GF, Farnsworth NR, van Breemen RB, Bolton JL. "Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense).". Journal of agricultural and food chemistry. 2005;53(16):6246-53. doi:10.1021/jf050448p.
  • Nikolic DS, Lankin DC, Chen S, Jaki BU, Krunic A, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. "Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa.". Journal of natural products. 2005;68(8):1266-70. doi:10.1021/np050066d.
  • Nikolic DS, Li Y, Chadwick LR, Pauli GF, van Breemen RB. "Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes.". Journal of mass spectrometry : JMS. 2005;40(3):289-99. doi:10.1002/jms.753.
  • Zhu Y, Nikolic DS, van Breemen RB, Silverman RB. "Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification.". Journal of the American Chemical Society. 2005;127(3):858-68. doi:10.1021/ja0445645.
  • Booth NL, Nikolic DS, van Breemen RB, Geller SE, Banuvar S, Shulman LP, Farnsworth NR. "Confusion regarding anticoagulant coumarins in dietary supplements.". Clinical pharmacology and therapeutics. 2004;76(6):511-6. doi:10.1016/j.clpt.2004.08.023.
  • Chadwick LR, Nikolic DS, Burdette JE, Overk CR, Bolton JL, van Breemen RB, Fröhlich R, Fong HH, Farnsworth NR, Pauli GF. "Estrogens and congeners from spent hops (Humulus lupulus).". Journal of natural products. 2004;67(12):2024-32. doi:10.1021/np049783i.
  • Li Y, Grubjesic S, Nikolic DS, Zhu D, Kosmeder JW, Moriarty RM, Pezzuto JM, van Breemen RB. "In vitro assessment of intestinal permeability and hepatic metabolism of 4'-bromoflavone, a promising cancer chemopreventive agent.". Xenobiotica; the fate of foreign compounds in biological systems. 2004;34(6):535-47. doi:10.1080/00498250410001713159 .
  • Li Y, Yao J, Chang M, Nikolic DS, Yu L, Yager JD, Mesecar AD, van Breemen RB, Bolton JL. "Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase.". Chemical research in toxicology. 2004;17(4):512-20. doi:10.1021/tx0342464.
  • Nikolic DS, van Breemen RB. "New metabolic pathways for flavanones catalyzed by rat liver microsomes.". Drug metabolism and disposition: the biological fate of chemicals. 2004;32(4):387-97. doi:10.1124/dmd.32.4.387.
  • Nikolic DS, Li Y, Chadwick LR, Grubjesic S, Schwab P, Metz P, van Breemen RB. "Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes.". Drug metabolism and disposition: the biological fate of chemicals. 2004;32(2):272-9. doi:10.1124/dmd.32.2.272.
  • Liu J, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic DS, Mahady GB, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR. "Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry).". Phytomedicine : international journal of phytotherapy and phytopharmacology. 2004;11(1):18-23. doi:10.1078/0944-7113-00331.
  • Lu X, Nikolic DS, Mitchell DJ, van Breemen RB, Mersfelder JA, Hille R, Silverman RB. "A mechanism for substrate-Induced formation of 6-hydroxyflavin mononucleotide catalyzed by C30A trimethylamine dehydrogenase.". Bioorganic & medicinal chemistry letters. 2003;13(22):4129-32.
  • Kouloumbos VN, Tsipi DF, Hiskia AE, Nikolic DS, van Breemen RB. "Identification of photocatalytic degradation products of diazinon in TiO2 aqueous suspensions using GC/MS/MS and LC/MS with quadrupole time-of-flight mass spectrometry.". Journal of the American Society for Mass Spectrometry. 2003;14(8):803-17. doi:10.1016/S1044-0305(03)00333-7.
  • Su BN, Park EJ, Nikolic DS, Schunke Vigo J, Graham JG, Cabieses F, van Breemen RB, Fong HH, Farnsworth NR, Pezzuto JM. "Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora.". Journal of natural products. 2003;66(8):1089-93. doi:10.1021/np030081n.
  • Su BN, Park EJ, Nikolic DS, Santarsiero BD, Mesecar AD, Vigo JS, Graham JG, Cabieses F, van Breemen RB, Fong HH, Farnsworth NR, Pezzuto JM. "Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.". The Journal of organic chemistry. 2003;68(6):2350-61. doi:10.1021/jo020542u.
  • Su BN, Park EJ, Nikolic DS, Santarsiero BD, Mesecar AD, Vigo JS, Graham JG, Cabieses F, van Breemen RB, Fong HH, Farnsworth NR, Pezzuto JM, Kinghorn AD. "Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.". The Journal of organic chemistry. 2003;68(6):2350-61. doi:10.1021/jo020542u.
  • Yang Y, Nikolic DS, Swanson SM, van Breemen RB. "Quantitative determination of N7-methyldeoxyguanosine and O6-methyldeoxyguanosine in DNA by LC-UV-MS-MS.". Analytical chemistry. 2002;74(20):5376-82.
  • Johnson BM, Nikolic DS, van Breemen RB. "Applications of pulsed ultrafiltration-mass spectrometry.". Mass spectrometry reviews. 2002;21(2):76-86. doi:10.1002/mas.10020.
  • Mitchell DJ, Nikolic DS, Jang MH, van Breemen RB, Hille R, Silverman RB. "Inactivation of C30A trimethylamine dehydrogenase by N-cyclopropyl-alpha-methylbenzylamine, 1-phenylcyclopropylamine, and phenylhydrazine.". Biochemistry. 2001;40(29):8523-30.
  • Mitchell DJ, Nikolic DS, van Breemen RB, Silverman RB. "Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: mass spectral evidence for the flavin adduct.". Bioorganic & medicinal chemistry letters. 2001;11(13):1757-60.
  • Mitchell DJ, Nikolic DS, Rivera E, Sablin SO, Choi SA, van Breemen RB, Singer TP, Silverman RB. "Spectrometric evidence for the flavin-1-phenylcyclopropylamine inactivator adduct with monoamine oxidase N.". Biochemistry. 2001;40(18):5447-56.
  • Nikolic DS, van Breemen RB. "DNA oxidation induced by cyclooxygenase-2.". Chemical research in toxicology. 2001;14(4):351-4.
  • Nikolic DS, Habibi-Goudarzi S, Corley DG, Gafner S, Pezzuto JM, van Breemen RB. "Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration mass spectrometry.". Analytical chemistry. 2000;72(16):3853-9.
  • Gu C, Nikolic DS, Lai J, Xu X, van Breemen RB. "Assays of ligand-human serum albumin binding using pulsed ultrafiltration and liquid chromatography-mass spectrometry.". Combinatorial chemistry & high throughput screening. 1999;2(6):353-9.
  • Korecka M, Nikolic DS, van Breemen RB, Shaw LM. "The apparent inhibition of inosine monophosphate dehydrogenase by mycophenolic acid glucuronide is attributable to the presence of trace quantities of mycophenolic acid.". Clinical chemistry. 1999;45(7):1047-50.
  • Nikolic DS, Fan PW, Bolton JL, van Breemen RB. "Screening for xenobiotic electrophilic metabolites using pulsed ultrafiltration-mass spectrometry.". Combinatorial chemistry & high throughput screening. 1999;2(3):165-75.
  • Chen Y, Shen L, Zhang F, Lau SS, van Breemen RB, Nikolic DS, Bolton JL. "The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro.". Chemical research in toxicology. 1998;11(9):1105-11. doi:10.1021/tx980083l.
  • Nikolic DS, van Breemen RB. "Screening for inhibitors of dihydrofolate reductase using pulsed ultrafiltration mass spectrometry.". Combinatorial chemistry & high throughput screening. 1998;1(1):47-55.
  • Shen L, Qiu S, Chen Y, Zhang F, van Breemen RB, Nikolic DS, Bolton JL. "Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical.". Chemical research in toxicology. 1998;11(2):94-101. doi:10.1021/tx970181r.
  • van Breemen RB, Nikolic DS, Bolton JL. "Metabolic screening using on-line ultrafiltration mass spectrometry.". Drug metabolism and disposition: the biological fate of chemicals. 1998;26(2):85-90.
  • van Breemen RB, Nikolic DS, Xu X, Xiong Y, van Lieshout M, West CE, Schilling AB. "Development of a method for quantitation of retinol and retinyl palmitate in human serum using high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.". Journal of chromatography. A. 1998;794(1-2):245-51.
  • Zhao YZ, van Breemen RB, Nikolic DS, Huang CR, Woodbury CP, Schilling A. "Screening solution-phase combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry.". Journal of medicinal chemistry. 1997;40(25):4006-12. doi:10.1021/jm960729b.
  • van Breemen RB, Huang CR, Nikolic DS, Woodbury CP, Zhao YZ. "Pulsed ultrafiltration mass spectrometry: a new method for screening combinatorial libraries.". Analytical chemistry. 1997;69(11):2159-64.
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