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Photo of James H. Fischer

James H. Fischer

Professor Emeritus, Pharmacy Practice

Contact Information

833 South Wood Street (886)
112B PHARM
Chicago, IL 60612

Phone: (312) 996-5549

Fax: (312) 996-0379

Education

  • Postdoctoral Fellowship in Neurology and Clinical Pharmacokinetics, University of Minnesota and St. Paul-Ramsey Medical Center, St. Paul, MN, 1981
  • PharmD, University of Minnesota, Minneapolis, MN, 1979
  • BS, Drake University, Des Moines, IA, 1977

Research Interests

Dr. Fischer's areas of interest include pharmacometrics and the clinical pharmacology of the antiepileptic drugs

Intellectual Contributions

Journal Article

  • Fischer JH, Sarto GE, Hardman J, Endres L, Jenkins TM, Kilpatrick SJ, Jeong H, Geller S, Deyo KL, Fischer PA, Rodvold KA. "Influence of gestational age and body weight on the pharmacokinetics of labetalol in pregnancy.". Clinical pharmacokinetics. 2014;53(4):373-83. doi:10.1007/s40262-013-0123-0.
  • Lauten A, Gerhard-Garcia A, Suhr F, Fischer JH, Figulla HR, Bloch W. "Impact of ischemia-reperfusion on extracellular matrix processing and structure of the basement membrane of the heart.". PloS one. 2014;9(3):e92833. doi:10.1371/journal.pone.0092833.
  • Fischer JH, Sarto GE, Habibi M, Kilpatrick SJ, Tuomala RE, Shier JM, Wollett L, Fischer PA, Khorana KS, Rodvold KA. "Influence of body weight, ethnicity, oral contraceptives, and pregnancy on the pharmacokinetics of azithromycin in women of childbearing age.". Antimicrobial agents and chemotherapy. 2012;56(2):715-24. doi:10.1128/AAC.00717-11.
  • Della Torre M, Hibbard JU, Jeong H, Fischer JH. "Betamethasone in pregnancy: influence of maternal body weight and multiple gestation on pharmacokinetics.". American journal of obstetrics and gynecology. 2010;203(3):254.e1-12. doi:10.1016/j.ajog.2010.06.029.
  • Chen H, Yang K, Choi SA, Fischer JH, Jeong H. "Up-regulation of UDP-glucuronosyltransferase (UGT) 1A4 by 17beta-estradiol: a potential mechanism of increased lamotrigine elimination in pregnancy.". Drug metabolism and disposition: the biological fate of chemicals. 2009;37(9):1841-7. doi:10.1124/dmd.109.026609.
  • Miller LJ, Bishop JR, Fischer JH, Geller SE, Macmillan C. "Balancing risks: dosing strategies for antidepressants near the end of pregnancy.". The Journal of clinical psychiatry. 2008;69(2):323-4.
  • Jeong H, Choi SA, Song JW, Chen H, Fischer JH. "Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination.". Xenobiotica; the fate of foreign compounds in biological systems. 2008;38(1):62-75. doi:10.1080/00498250701744633 .
  • How PP, Fischer JH, Arruda JA, . "Effects of lanthanum carbonate on the absorption and oral bioavailability of ciprofloxacin.". Clinical journal of the American Society of Nephrology : CJASN. 2007;2(6):1235-40. doi:10.2215/CJN.01580407.
  • French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL, Theodore WH, Bazil C, Stern J, Schachter SC, Bergen D, Hirtz D, Montouris GD, Nespeca M, Gidal B, Marks, Jr WJ, Turk WR, Fischer JH, Bourgeois B, Wilner A, Faught, Jr RE, Sachdeo RC, Beydoun A, Glauser TA. "Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.". Epilepsia. 2004;45(5):401-9. doi:10.1111/j.0013-9580.2004.06204.x.
  • French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL, Theodore WH, Bazil C, Stern J, Schachter SC, Bergen D, Hirtz D, Montouris GD, Nespeca M, Gidal B, Marks, Jr WJ, Turk WR, Fischer JH, Bourgeois B, Wilner A, Faught, Jr RE, Sachdeo RC, Beydoun A, Glauser TA. "Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.". Epilepsia. 2004;45(5):410-23. doi:10.1111/j.0013-9580.2004.06304.x.
  • French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL, Theodore WH, Bazil C, Stern J, Schachter SC, Bergen D, Hirtz D, Montouris GD, Nespeca M, Gidal B, Marks, Jr WJ, Turk WR, Fischer JH, Bourgeois B, Wilner A, Faught, Jr RE, Sachdeo RC, Beydoun A, Glauser TA. "Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society.". Neurology. 2004;62(8):1252-60.
  • French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL, Theodore WH, Bazil C, Stern J, Schachter SC, Bergen D, Hirtz D, Montouris GD, Nespeca M, Gidal B, Marks, Jr WJ, Turk WR, Fischer JH, Bourgeois B, Wilner A, Faught, Jr RE, Sachdeo RC, Beydoun A, Glauser TA. "Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society.". Neurology. 2004;62(8):1261-73.
  • Fischer JH, Patel TV, Fischer PA. "Fosphenytoin: clinical pharmacokinetics and comparative advantages in the acute treatment of seizures.". Clinical pharmacokinetics. 2003;42(1):33-58. doi:10.2165/00003088-200342010-00002.
  • Itokazu GS, Fischer JH, Manitpisitkul P, Hariharan R, Danziger LH. "Lack of effect of nizatidine-induced elevation of gastric pH on the oral bioavailability of dapsone in healthy volunteers.". Pharmacotherapy. 2002;22(11):1420-5.
  • Anderson GD, Lin Y, Temkin NR, Fischer JH, Winn HR. "Incidence of intravenous site reactions in neurotrauma patients receiving valproate or phenytoin.". The Annals of pharmacotherapy. 2000;34(6):697-702.
  • Meek PD, Davis SN, Collins DM, Gidal BE, Rutecki PA, Burstein AH, Fischer JH, Leppik IE, Ramsay RE. "Guidelines for nonemergency use of parenteral phenytoin products: proceedings of an expert panel consensus process. Panel on Nonemergency Use of Parenteral Phenytoin Products.". Archives of internal medicine. 1999;159(22):2639-44.
  • Luer MS, Hamani C, Dujovny M, Gidal B, Cwik M, Deyo KL, Fischer JH. "Saturable transport of gabapentin at the blood-brain barrier.". Neurological research. 1999;21(6):559-62.
  • Fischer JH, Cwik MJ, Luer MS, Sibley CB, Deyo KL. "Stability of fosphenytoin sodium with intravenous solutions in glass bottles, polyvinyl chloride bags, and polypropylene syringes.". The Annals of pharmacotherapy. 1997;31(5):553-9.
  • Cunningham FE, Rogers S, Fischer JH, Jensen RC. "The pharmacokinetics of dexamethasone in the thoroughbred racehorse.". Journal of veterinary pharmacology and therapeutics. 1996;19(1):68-71.
  • Cunningham FE, Kraus DM, Brubaker L, Fischer JH. "Pharmacokinetics of intravaginal metronidazole gel.". Journal of clinical pharmacology. 1994;34(11):1060-5.
  • Andrews CO, Fischer JH. "Gabapentin: a new agent for the management of epilepsy.". The Annals of pharmacotherapy. 1994;28(10):1188-96.
  • Kraus DM, , Reitz SJ, Fischer JH. "Pharmacokinetic evaluation of two theophylline dosing methods for infants.". Therapeutic drug monitoring. 1994;16(3):270-6.
  • Fischer JH, Barr AN, Rogers SL, Fischer PA, Trudeau VL. "Lack of serious toxicity following gabapentin overdose.". Neurology. 1994;44(5):982-3.
  • Piscitelli SC, Occhipinti DJ, Danziger LH, Hill C, West DP, Fischer JH. "Therapeutic monitoring and pharmacist intervention in a Hansen's disease clinic.". The Annals of pharmacotherapy. 1993;27(12):1526-31.
  • Kraus DM, Fischer JH, Reitz SJ, Kecskes SA, Yeh TF, McCulloch KM, Tung EC, Cwik MJ. "Alterations in theophylline metabolism during the first year of life.". Clinical pharmacology and therapeutics. 1993;54(4):351-9.
  • Micali G, Bhatt RH, Distefano G, Caltabiano L, Cook B, Fischer JH, Solomon LM, West DP. "Evaluation of transdermal theophylline pharmacokinetics in neonates.". Pharmacotherapy. 1993;13(4):386-90.
  • Piscitelli SC, Danziger LH, Hill C, Slajchert AA, West DP, Fischer JH. "Effectiveness of a dapsone compliance program in leprosy.". International journal of dermatology. 1993;32(3):206-9.
  • Cloyd JC, Fischer JH, Kriel RL, Kraus DM. "Valproic acid pharmacokinetics in children. IV. Effects of age and antiepileptic drugs on protein binding and intrinsic clearance.". Clinical pharmacology and therapeutics. 1993;53(1):22-9.
  • West DP, Fischer JH, Barbour MM, Cwik MJ, Micali G, Fiedler VC. "Altered theophylline metabolism in patients with psoriasis.". DICP : the annals of pharmacotherapy. 1990;24(5):464-7.
  • Jensen RC, Fischer JH, Cwik MJ. "Effect of age and training status on pharmacokinetics of flunixin meglumine in thoroughbreds.". American journal of veterinary research. 1990;51(4):591-4.
  • Danziger LH, Furmaga KM, Rodvold KA, Bombeck CT, Fischer JH. "Nizatidine suppression of basal gastric acid output: a comparison of two intravenous dosage regimens.". Journal of clinical pharmacology. 1989;29(10):946-52.
  • Zokufa HZ, Solem LD, Rodvold KA, Crossley KB, Fischer JH, Rotschafer JC. "The influence of serum albumin and alpha 1-acid glycoprotein on vancomycin protein binding in patients with burn injuries.". The Journal of burn care & rehabilitation. 1989;10(5):425-8.
  • Zokufa HZ, Rodvold KA, Blum RA, Riff LJ, Fischer JH, Crossley KB, Rotschafer JC. "Simulation of vancomycin peak and trough concentrations using five dosing methods in 37 patients.". Pharmacotherapy. 1989;9(1):10-6.
  • Fischer JH, Barr AN, Paloucek FP, Dorociak JV, Spunt AL. "Effect of food on the serum concentration profile of enteric-coated valproic acid.". Neurology. 1988;38(8):1319-22.
  • Raineri DL, Cwik MJ, Rodvold KA, Deyo KL, Scaros LP, Fischer JH. "Stability of nizatidine in commonly used intravenous fluids and containers.". American journal of hospital pharmacy. 1988;45(7):1523-9.
  • Rodvold KA, Blum RA, Fischer JH, Zokufa HZ, Rotschafer JC, Crossley KB, Riff LJ. "Vancomycin pharmacokinetics in patients with various degrees of renal function.". Antimicrobial agents and chemotherapy. 1988;32(6):848-52.
  • Dela Cruz FG, Kanter MZ, Fischer JH, Leikin JB. "Efficacy of individualized phenytoin sodium loading doses administered by intravenous infusion.". Clinical pharmacy. 1988;7(3):219-24.
  • Barr AN, Fischer JH, Koller WC, Spunt AL, Singhal A. "Serum haloperidol concentration and choreiform movements in Huntington's disease.". Neurology. 1988;38(1):84-8.
  • Fischer JH, Raineri DL. "Pentobarbital anesthesia for status epilepticus.". Clinical pharmacy. 1987;6(8):601-2.
  • Aronson IK, Rumsfield JA, West DP, Alexander J, Fischer JH, Paloucek FP. "Evaluation of topical metronidazole gel in acne rosacea.". Drug intelligence & clinical pharmacy. 1987;21(4):346-51.
  • Fischer JH, West DP, Worobec SM. "Evaluation of a continual compliance monitoring program for dapsone in an outpatient Hansen's disease clinic.". International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association. 1986;54(4):517-24.
  • Kriel RL, Fischer JH, Cloyd JC, Green KH, Fraser GL. "Valproic acid pharmacokinetics in children: III. Very high dosage requirements.". Pediatric neurology. 1986;2(4):202-8.
  • Cloyd JC, Kriel RL, Fischer JH. "Valproic acid pharmacokinetics in children. II. Discontinuation of concomitant antiepileptic drug therapy.". Neurology. 1985;35(11):1623-7.
  • Zell M, Curtis RA, Troyer, Jr WG, Fischer JH. "Volume of distribution of theophylline in acute exacerbations of reversible airway disease. Effect of body weight.". Chest. 1985;87(2):212-6.
  • Goff DA, Spunt AL, Jung D, Bellur SN, Fischer JH. "Absorption characteristics of three phenytoin sodium products after administration of oral loading doses.". Clinical pharmacy. 1984;3(6):634-8.
  • Fischer JH, Hedrick PJ, Riff LJ. "Pharmacokinetics and antibacterial activity of two gentamicin products given intramuscularly.". Clinical pharmacy. 1984;3(4):411-6.
  • Cloyd JC, Kriel RL, Fischer JH, Sawchuk RJ, Eggerth RM. "Pharmacokinetics of valproic acid in children: I. Multiple antiepileptic drug therapy.". Neurology. 1983;33(2):185-91.
  • Fischer JH, Lockman LA, Zaske D, Kriel R. "Phenobarbital maintenance dose requirements in treating neonatal seizures.". Neurology. 1981;31(8):1042-4.

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