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Photo of Sang Hyun Cho

Sang Hyun Cho

Research Associate Professor, Institute for Tuberculosis Research

Associate Director, Institute for Tuberculosis Research

Research Associate Professor of Medicinal Chemistry, Medicinal Chemistry and Pharmacognosy

Contact Information

833 S. Wood Street
412
Chicago, IL 60612

Phone: (312) 355-4521

Fax: (312) 996-2693

Lab Positions Available: pharmacy.uic.edu/research/tuberculosis-research

Education

  • PhD, Mycobacteriology, Konkuk Univ, Seoul, Korea, 1999

Professional Organizations

  • American Society of Microbiology

Patents and Intellectual Property

  • Cyclic peptide from Nonomuraea Sp., process for the production thereof, and pharmaceutical composition for the prevention or treatment of Mycobacteria related disease comprising the same:

Intellectual Contributions

Journal Article

  • Tiwari R, Miller PA, Cho S, Franzblau SG, Miller MJ. "Syntheses and Antituberculosis Activity of 1,3-Benzothiazinone Sulfoxide and Sulfone Derived from BTZ043.". ACS medicinal chemistry letters. 2015;6(2):128-33. doi:10.1021/ml5003458.
  • Gao W, Kim JY, Anderson JR, Akopian T, Hong S, Jin YY, Kandror O, Kim JW, Lee IA, Lee SY, Mulugeta SG, Sunoqrot S, Wang Y, Yang SH, Yoon TM, Goldberg AL, Pauli GF, Suh JW, Franzblau SG, Cho S. "The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo.". Antimicrobial agents and chemotherapy. 2015;59(2):880-9. doi:10.1128/AAC.04054-14.
  • Upton AM, Cho S, Yang TJ, Kim Y, Wang Y, Lu Y, Wang B, Xu J, Mdluli K, Ma Z, Franzblau SG. "In vitro and in vivo activities of the nitroimidazole TBA-354 against Mycobacterium tuberculosis.". Antimicrobial agents and chemotherapy. 2015;59(1):136-44. doi:10.1128/AAC.03823-14.
  • Gao W, Kim JY, Chen S, Cho S, Choi J, Jaki BU, Jin YY, Lankin DC, Lee JE, Lee SY, Napolitano JG, Franzblau SG, Suh JW, Pauli GF. "Discovery and characterization of the tuberculosis drug lead ecumicin.". Organic letters. 2014;16(23):6044-7. doi:10.1021/ol5026603.
  • Moraski GC, Oliver AG, Markley LD, Cho S, Franzblau SG, Miller MJ. "Scaffold-switching: an exploration of 5,6-fused bicyclic heteroaromatics systems to afford antituberculosis activity akin to the imidazo[1,2-a]pyridine-3-carboxylates.". Bioorganic & medicinal chemistry letters. 2014;24(15):3493-8. doi:10.1016/j.bmcl.2014.05.062.
  • Tiwari R, Möllmann U, Cho S, Franzblau SG, Miller PA, Miller MJ. "Design and Syntheses of Anti-Tuberculosis Agents Inspired by BTZ043 Using a Scaffold Simplification Strategy.". ACS medicinal chemistry letters. 2014;5(5):587-91. doi:10.1021/ml500039g.
  • Pieroni M, Wan B, Cho S, Franzblau SG, Costantino G. "Design, synthesis and investigation on the structure-activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents.". European journal of medicinal chemistry. 2014;72:26-34. doi:10.1016/j.ejmech.2013.11.007.
  • Cai G, Napolitano JG, Wang Y, Jaki BU, Suh JW, Yang SH, Lee IA, Franzblau SG, Pauli GF, Cho S. "Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain.". Journal of natural products. 2013;76(11):2009-18. doi:10.1021/np400145u.
  • Hwang CH, Jaki BU, Klein L, Lankin DC, Napolitano JG, Fryling NA, Franzblau SG, Cho S, Stamets PE, Wang Y, Pauli GF. "Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.". Journal of natural products. 2013;76(10):1916-22. doi:10.1021/np400497f.
  • Grant SS, Kawate T, Nag PP, Silvis MR, Stanley SA, Kazyanskaya E, Nietupski R, Golas A, Cho S, Franzblau SG, Hung DT. "Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model.". ACS chemical biology. 2013;8(10):2224-34. doi:10.1021/cb4004817.
  • Pavan FR, Poelhsitz GV, da Cunha LV, Barbosa MI, Leite SR, Batista AA, Cho S, Franzblau SG, de Camargo MS, Resende FA, Varanda EA, Leite CQ. "In vitro and in vivo activities of ruthenium(II) phosphine/diimine/picolinate complexes (SCAR) against Mycobacterium tuberculosis.". PloS one. 2013;8(5):e64242. doi:10.1371/journal.pone.0064242.
  • Hwang JM, Oh T, Kaneko T, Upton AM, Franzblau SG, Ma Z, Cho S, Kim P. "Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents.". Journal of natural products. 2013;76(3):354-67. doi:10.1021/np3007167.
  • Franzblau SG, DeGroote MA, Cho S, Andries K, Nuermberger E, Orme IM, Mdluli K, Angulo-Barturen I, Dick T, Dartois V, Lenaerts AJ. "Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis.". Tuberculosis (Edinburgh, Scotland). 2012;92(6):453-88. doi:10.1016/j.tube.2012.07.003.
  • Silveira GP, Ferreira M, Fernandes L, Moraski GC, Cho S, Hwang C, Franzblau SG, Sá MM. "Allylic thiocyanates as a new class of antitubercular agents.". Bioorganic & medicinal chemistry letters. 2012;22(20):6486-9. doi:10.1016/j.bmcl.2012.08.048.
  • Moraski GC, Markley LD, Chang M, Cho S, Franzblau SG, Hwang CH, Boshoff H, Miller MJ. "Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds.". Bioorganic & medicinal chemistry. 2012;20(7):2214-20. doi:10.1016/j.bmc.2012.02.025.
  • Moraski GC, Markley LD, Hipskind PA, Boshoff H, Cho S, Franzblau SG, Miller MJ. "Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity.". ACS medicinal chemistry letters. 2011;2(6):466-470. doi:10.1021/ml200036r.
  • Pieroni M, Lilienkampf A, Wang Y, Wan B, Cho S, Franzblau SG, Kozikowski AP. "NOC chemistry for tuberculosis-further investigations on the structure-activity relationships of antitubercular isoxazole-3-carboxylic acid ester derivatives.". ChemMedChem. 2010;5(10):1667-72. doi:10.1002/cmdc.201000169.
  • Hurdle JG, Lee RB, Budha NR, Carson EI, Qi J, Scherman MS, Cho S, McNeil MR, Lenaerts AJ, Franzblau SG, Meibohm B, Lee RE. "A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents.". The Journal of antimicrobial chemotherapy. 2008;62(5):1037-45. doi:10.1093/jac/dkn307.
  • Vicente E, Villar R, Burguete A, Solano B, Pérez-Silanes S, Aldana I, Maddry JA, Lenaerts AJ, Franzblau SG, Cho S, Monge A, Goldman RC. "Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis.". Antimicrobial agents and chemotherapy. 2008;52(9):3321-6. doi:10.1128/AAC.00379-08.
  • Villar R, Vicente E, Solano B, Pérez-Silanes S, Aldana I, Maddry JA, Lenaerts AJ, Franzblau SG, Cho S, Monge A, Goldman RC. "In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide.". The Journal of antimicrobial chemotherapy. 2008;62(3):547-54. doi:10.1093/jac/dkn214.
  • Ly LH, Barhoumi R, Cho S, Franzblau SG, McMurray DN. "Vaccination with Bacille-Calmette Guérin promotes mycobacterial control in guinea pig macrophages infected in vivo.". The Journal of infectious diseases. 2008;198(5):768-71. doi:10.1086/590436.
  • Deng S, Wang Y, Inui T, Chen S, Farnsworth NR, Cho S, Franzblau SG, Pauli GF. "Anti-TB polyynes from the roots of Angelica sinensis.". Phytotherapy research : PTR. 2008;22(7):878-82. doi:10.1002/ptr.2303.
  • Zhou Y, Beeler AB, Cho S, Wang Y, Franzblau SG, Snyder JK. "Library synthesis using 5,6,7,8-tetrahydro-1,6-naphthyridines as scaffolds.". Journal of combinatorial chemistry. 2008;10(4):534-40. doi:10.1021/cc800038r.
  • Cho S, Warit S, Wan B, Hwang CH, Pauli GF, Franzblau SG. "Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.". Antimicrobial agents and chemotherapy. 2007;51(4):1380-5. doi:10.1128/AAC.00055-06.
  • Bate AB, Kalin JH, Fooksman EM, Amorose EL, Price CM, Williams HM, Rodig MJ, Mitchell MO, Cho S, Wang Y, Franzblau SG. "Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives.". Bioorganic & medicinal chemistry letters. 2007;17(5):1346-8. doi:10.1016/j.bmcl.2006.11.091.
  • Case RJ, Franzblau SG, Wang Y, Cho S, Soejarto DD, Pauli GF. "Ethnopharmacological evaluation of the informant consensus model on anti-tuberculosis claims among the Manus.". Journal of ethnopharmacology. 2006;106(1):82-9. doi:10.1016/j.jep.2005.12.005.
  • Jaki BU, Franzblau SG, Cho S, Pauli GF. "Development of an extraction method for mycobacterial metabolome analysis.". Journal of pharmaceutical and biomedical analysis. 2006;41(1):196-200. doi:10.1016/j.jpba.2005.10.022.
  • Pauli GF, Case RJ, Inui T, Wang Y, Cho S, Fischer NH, Franzblau SG. "New perspectives on natural products in TB drug research.". Life sciences. 2005;78(5):485-94. doi:10.1016/j.lfs.2005.09.004.
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