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John Michael Pezzuto

Adjunct Professor, Medicinal Chemistry and Pharmacognosy

Contact Information

Intellectual Contributions

Journal Article

  • García ME, Nicotra VE, Oberti JC, Ríos-Luci C, León LG, Marler L, Li G, Pezzuto JM, van Breemen RB, Padrón JM, Hueso-Falcón I, Estévez-Braun A. "Antiproliferative and quinone reductase-inducing activities of withanolides derivatives.". European journal of medicinal chemistry. 2014;82:68-81. doi:10.1016/j.ejmech.2014.05.045.
  • Andreani A, Leoni A, Locatelli A, Morigi R, Rambaldi M, Cervellati R, Greco E, Kondratyuk TP, Park EJ, Huang KG, van Breemen RB, Pezzuto JM. "Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.". European journal of medicinal chemistry. 2013;68:412-21. doi:10.1016/j.ejmech.2013.07.052.
  • Carlson SN, Marler L, Nam SJ, Santarsiero BD, Pezzuto JM, Murphy BT. "Potential chemopreventive activity of a new macrolide antibiotic from a marine-derived Micromonospora sp.". Marine drugs. 2013;11(4):1152-61. doi:10.3390/md11041152.
  • Conda-Sheridan M, Park EJ, Beck DE, Reddy PV, Nguyen TX, Hu B, White JJ, van Breemen RB, Pezzuto JM, Cushman M. "Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential.". Journal of medicinal chemistry. 2013;56(6):2581-605. doi:10.1021/jm400026k.
  • Chen L, Conda-Sheridan M, Reddy PV, Morrell A, Park EJ, Kondratyuk TP, Pezzuto JM, van Breemen RB, Cushman M. "Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.". Journal of medicinal chemistry. 2012;55(12):5965-81. doi:10.1021/jm3006806.
  • Kondratyuk TP, Park EJ, Yu R, van Breemen RB, Asolkar RN, Murphy BT, Fenical W, Pezzuto JM. "Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents.". Marine drugs. 2012;10(2):451-64. doi:10.3390/md10020451.
  • Soejarto DD, Gyllenhaal C, Kadushin MR, Southavong B, Sydara K, Bouamanivong S, Xaiveu M, Zhang HJ, Franzblau SG, Tan GT, Pezzuto JM, Riley MC, Elkington BG, Waller DP. "An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development.". Pharmaceutical biology. 2012;50(1):42-60. doi:10.3109/13880209.2011.619700.
  • Gyllenhaal C, Kadushin MR, Southavong B, Sydara K, Bouamanivong S, Xaiveu M, Xuan LT, Hiep NT, Hung NV, Loc PK, Dac LX, Bich TQ, Cuong NM, Ly HM, Zhang HJ, Franzblau SG, Xie H, Riley MC, Elkington BG, Nguyen HT, Waller DP, Ma CY, Tamez P, Tan GT, Pezzuto JM, Soejarto DD. "Ethnobotanical approach versus random approach in the search for new bioactive compounds: support of a hypothesis.". Pharmaceutical biology. 2012;50(1):30-41. doi:10.3109/13880209.2011.634424.
  • Kondratyuk TP, Park EJ, Marler LE, Ahn S, Yuan Y, Choi Y, Yu R, van Breemen RB, Sun B, Hoshino J, Cushman M, Jermihov KC, Mesecar AD, Grubbs CJ, Pezzuto JM. "Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity.". Molecular nutrition & food research. 2011;55(8):1249-65. doi:10.1002/mnfr.201100122.
  • Park EJ, Kondratyuk TP, Morrell A, Kiselev E, Conda-Sheridan M, Cushman M, Ahn S, Choi Y, White JJ, van Breemen RB, Pezzuto JM. "Induction of retinoid X receptor activity and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells.". Cancer prevention research (Philadelphia, Pa.). 2011;4(4):592-607. doi:10.1158/1940-6207.CAPR-10-0004.
  • Yang JH, Kondratyuk TP, Jermihov KC, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy M, Huang R, Wang LQ, Mesecar AD, van Breemen RB, Pezzuto JM, Fong HH, Chen YG, Zhang HJ. "Bioactive compounds from the fern Lepisorus contortus.". Journal of natural products. 2011;74(2):129-36. doi:10.1021/np100373f.
  • Choi Y, Jermihov K, Nam SJ, Sturdy M, Maloney K, Qiu X, Chadwick LR, Main M, Chen S, Mesecar AD, Farnsworth NR, Pauli GF, Fenical W, Pezzuto JM, van Breemen RB. "Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS.". Analytical chemistry. 2011;83(3):1048-52. doi:10.1021/ac1028424.
  • Calamini B, Ratia K, Malkowski MG, Cuendet M, Pezzuto JM, Santarsiero BD, Mesecar AD. "Pleiotropic mechanisms facilitated by resveratrol and its metabolites.". The Biochemical journal. 2010;429(2):273-82. doi:10.1042/BJ20091857.
  • Hoshino J, Park EJ, Kondratyuk TP, Marler L, Pezzuto JM, van Breemen RB, Mo S, Li Y, Cushman M. "Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.". Journal of medicinal chemistry. 2010;53(13):5033-43. doi:10.1021/jm100274c.
  • Yang JH, Kondratyuk TP, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy M, Pegan S, Wang LQ, Mesecar AD, van Breemen RB, Pezzuto JM, Fong HH, Chen YG, Zhang HJ. "Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata.". Phytochemistry. 2010;71(5-6):641-7. doi:10.1016/j.phytochem.2010.01.002.
  • Cuendet M, Guo J, Luo Y, Chen S, Oteham CP, Moon RC, van Breemen RB, Marler LE, Pezzuto JM. "Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice.". Cancer prevention research (Philadelphia, Pa.). 2010;3(2):221-32. doi:10.1158/1940-6207.CAPR-09-0049.
  • Guo J, Liu A, Cao H, Luo Y, Pezzuto JM, van Breemen RB. "Biotransformation of the chemopreventive agent 2',4',4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases.". Drug metabolism and disposition: the biological fate of chemicals. 2008;36(10):2104-12. doi:10.1124/dmd.108.021857.
  • Guo J, Liu D, Nikolic DS, Zhu D, Pezzuto JM, van Breemen RB. "In vitro metabolism of isoliquiritigenin by human liver microsomes.". Drug metabolism and disposition: the biological fate of chemicals. 2008;36(2):461-8. doi:10.1124/dmd.107.018721.
  • Liu D, Guo J, Luo Y, Broderick DJ, Schimerlik MI, Pezzuto JM, van Breemen RB. "Screening for ligands of human retinoid X receptor-alpha using ultrafiltration mass spectrometry.". Analytical chemistry. 2007;79(24):9398-402. doi:10.1021/ac701701k.
  • Soejarto DD, Zhang HJ, Fong HH, Tan GT, Ma CY, Gyllenhaal C, Riley MC, Kadushin MR, Franzblau SG, Bich TQ, Cuong NM, Hiep NT, Loc PK, le Xuan T, Hai NV, Hung NV, Chien NQ, le Binh T, Vu BM, Ly HM, Southavong B, Sydara K, Bouamanivong S, Pezzuto JM, Rose WC, Dietzman GR, Miller BE, Thuy TV. ""Studies on biodiversity of Vietnam and Laos" 1998-2005: examining the impact.". Journal of natural products. 2006;69(3):473-81. doi:10.1021/np058107t.
  • Homhual S, Zhang HJ, Bunyapraphatsara N, Kondratyuk TP, Santarsiero BD, Mesecar AD, Herunsalee A, Chaukul W, Pezzuto JM, Fong HH. "Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza.". Planta medica. 2006;72(3):255-60. doi:10.1055/s-2005-873171.
  • Zhang HJ, Ma C, Nguyen VH, Nguyen MC, Tan GT, Santarsiero BD, Mesecar AD, Soejarto DD, Pezzuto JM, Fong HH. "Miliusanes, a class of cytotoxic agents from Miliusa sinensis.". Journal of medicinal chemistry. 2006;49(2):693-708. doi:10.1021/jm0509492.
  • Liu G, Eggler AL, Dietz BM, Mesecar AD, Bolton JL, Pezzuto JM, van Breemen RB. "Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1.". Analytical chemistry. 2005;77(19):6407-14. doi:10.1021/ac050892r.
  • Soejarto DD, Fong HH, Tan GT, Zhang HJ, Ma CY, Franzblau SG, Gyllenhaal C, Riley MC, Kadushin MR, Pezzuto JM, Xuan LT, Hiep NT, Hung NV, Vu BM, Loc PK, Dac LX, Binh LT, Chien NQ, Hai NV, Bich TQ, Cuong NM, Southavong B, Sydara K, Bouamanivong S, Ly HM, Thuy TV, Rose WC, Dietzman GR. "Ethnobotany/ethnopharmacology and mass bioprospecting: issues on intellectual property and benefit-sharing.". Journal of ethnopharmacology. 2005;100(1-2):15-22. doi:10.1016/j.jep.2005.05.031.
  • Chow AW, Murillo G, Yu C, van Breemen RB, Boddie AW, Pezzuto JM, Das Gupta TK, Mehta RG. "Resveratrol inhibits rhabdomyosarcoma cell proliferation.". European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2005;14(4):351-6.
  • Eggler AL, Liu G, Pezzuto JM, van Breemen RB, Mesecar AD. "Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2.". Proceedings of the National Academy of Sciences of the United States of America. 2005;102(29):10070-5. doi:10.1073/pnas.0502402102.
  • Li Y, Grubjesic S, Nikolic DS, Zhu D, Kosmeder JW, Moriarty RM, Pezzuto JM, van Breemen RB. "In vitro assessment of intestinal permeability and hepatic metabolism of 4'-bromoflavone, a promising cancer chemopreventive agent.". Xenobiotica; the fate of foreign compounds in biological systems. 2004;34(6):535-47. doi:10.1080/00498250410001713159 .
  • Nguyen QC, Nguyen VH, Santarsiero BD, Mesecar AD, Nguyen MC, Soejarto DD, Pezzuto JM, Fong HH, Tan GT. "New 3-O-acyl betulinic acids from Strychnos vanprukii Craib.". Journal of natural products. 2004;67(6):994-8. doi:10.1021/np030469i.
  • Hwang BY, Su BN, Chai H, Mi Q, Kardono LB, Afriastini JJ, Riswan S, Santarsiero BD, Mesecar AD, Wild R, Fairchild CR, Vite GD, Rose WC, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kinghorn AD. "Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.". The Journal of organic chemistry. 2004;69(10):3350-8. doi:10.1021/jo040120f.
  • Liu J, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic DS, Mahady GB, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR. "Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry).". Phytomedicine : international journal of phytotherapy and phytopharmacology. 2004;11(1):18-23. doi:10.1078/0944-7113-00331.
  • Li Y, Shin YG, Yu C, Kosmeder JW, Hirschelman WH, Pezzuto JM, van Breemen RB. "Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: application to resveratrol absorption and metabolism.". Combinatorial chemistry & high throughput screening. 2003;6(8):757-67.
  • Burdette JE, Liu J, Chen S, Piersen CE, Barker EL, Pezzuto JM, Mesecar A, van Breemen RB, Farnsworth NR, Bolton JL. "Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.". Journal of agricultural and food chemistry. 2003;51(19):5661-70. doi:10.1021/jf034264r.
  • Su BN, Kang YH, Pinos RE, Santarsiero BD, Mesecar AD, Soejarto DD, Fong HH, Pezzuto JM, Kinghorn AD. "Isolation and absolute stereochemistry of coussaric acid, a new bioactive triterpenoid from the stems of Coussarea brevicaulis.". Phytochemistry. 2003;64(1):293-302.
  • Su BN, Park EJ, Nikolic DS, Schunke Vigo J, Graham JG, Cabieses F, van Breemen RB, Fong HH, Farnsworth NR, Pezzuto JM. "Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora.". Journal of natural products. 2003;66(8):1089-93. doi:10.1021/np030081n.
  • Gu JQ, Li W, Kang YH, Su BN, Fong HH, van Breemen RB, Pezzuto JM. "Minor withanolides from Physalis philadelphica: structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation as artifacts.". Chemical & pharmaceutical bulletin. 2003;51(5):530-9.
  • Zhang HJ, Tan GT, Santarsiero BD, Mesecar AD, Hung NV, Cuong NM, Doel Soejarto D, Pezzuto JM, Fong HH. "New Sesquiterpenes from Litsea verticillata.". Journal of natural products. 2003;66(5):609-15. doi:10.1021/np020508a.
  • Jang DS, Park EJ, Hawthorne ME, Vigo JS, Graham JG, Cabieses F, Santarsiero BD, Mesecar AD, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. "Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean).". Journal of natural products. 2003;66(5):583-7. doi:10.1021/np020522n.
  • Gafner S, Bergeron C, Batcha LL, Reich J, Arnason JT, Burdette JE, Pezzuto JM, Angerhofer CK. "Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora.". Journal of natural products. 2003;66(4):535-7. doi:10.1021/np0205102.
  • Su BN, Park EJ, Nikolic DS, Santarsiero BD, Mesecar AD, Vigo JS, Graham JG, Cabieses F, van Breemen RB, Fong HH, Farnsworth NR, Pezzuto JM, Kinghorn AD. "Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.". The Journal of organic chemistry. 2003;68(6):2350-61. doi:10.1021/jo020542u.
  • Su BN, Park EJ, Nikolic DS, Santarsiero BD, Mesecar AD, Vigo JS, Graham JG, Cabieses F, van Breemen RB, Fong HH, Farnsworth NR, Pezzuto JM. "Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.". The Journal of organic chemistry. 2003;68(6):2350-61. doi:10.1021/jo020542u.
  • Yu C, Shin YG, Kosmeder JW, Pezzuto JM, van Breemen RB. "Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate.". Rapid communications in mass spectrometry : RCM. 2003;17(4):307-13. doi:10.1002/rcm.918.
  • Xu H, Piersen CE, Bolton JL, Pezzuto JM, Fong H, Totura S, Farnsworth NR, Constantinou AI. "A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health.". Phytomedicine : international journal of phytotherapy and phytopharmacology. 2002;9(8):757-62. doi:10.1078/094471102321621403.
  • Yu C, Shin YG, Chow A, Li Y, Kosmeder JW, Lee YS, Hirschelman WH, Pezzuto JM, Mehta RG, van Breemen RB. "Human, rat, and mouse metabolism of resveratrol.". Pharmaceutical research. 2002;19(12):1907-14.
  • Calderón AI, Terreaux C, Schenk K, Pattison P, Burdette JE, Pezzuto JM, Gupta MP, Hostettmann K. "Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis.". Journal of natural products. 2002;65(12):1749-53. doi:10.1021/np0201164.
  • Burdette JE, Chen S, Lu ZZ, Xu H, White B, Liu J, Fong HH, Farnsworth NR, Constantinou AI, van Breemen RB, Pezzuto JM, Bolton JL. "Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.". Journal of agricultural and food chemistry. 2002;50(24):7022-8.
  • Jang DS, Park EJ, Hawthorne ME, Vigo JS, Graham JG, Cabieses F, Santarsiero BD, Mesecar AD, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. "Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase.". Journal of agricultural and food chemistry. 2002;50(22):6330-4.
  • Su BN, Park EJ, Mbwambo ZH, Santarsiero BD, Mesecar AD, Fong HH, Pezzuto JM, Kinghorn AD. "New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes.". Journal of natural products. 2002;65(9):1278-82.
  • Su BN, Chang LC, Park EJ, Cuendet M, Santarsiero BD, Mesecar AD, Mehta RG, Fong HH, Pezzuto JM, Kinghorn AD. "Bioactive constituents of the seeds of Brucea javanica.". Planta medica. 2002;68(8):730-3. doi:10.1055/s-2002-33798.
  • Burdette JE, Liu J, Lantvit DD, Lim E, Booth N, Bhat KP, Hedayat S, van Breemen RB, Constantinou AI, Pezzuto JM, Farnsworth NR, Bolton JL. "Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats.". The Journal of nutrition. 2002;132(1):27-30.
  • Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL. "Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.". Journal of agricultural and food chemistry. 2001;49(5):2472-9.
  • Park EJ, Lee DD, Shin YG, Lantvit DD, van Breemen RB, Pezzuto JM. "Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry.". Journal of chromatography. B, Biomedical sciences and applications. 2001;754(2):327-32.
  • Constantinou AI, Lantvit DD, Hawthorne M, Xu X, van Breemen RB, Pezzuto JM. "Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats.". Nutrition and cancer. 2001;41(1-2):75-81. doi:10.1080/01635581.2001.9680615.
  • Westenburg HE, Lee K, Lee SK, Fong HH, van Breemen RB, Pezzuto JM. "Activity-guided isolation of antioxidative constituents of Cotinus coggygria.". Journal of natural products. 2000;63(12):1696-8.
  • Cho KH, Pezzuto JM, Bolton JL, Steele VE, Kelloff GJ, Lee SK, Constantinou A. "Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity.". European journal of cancer (Oxford, England : 1990). 2000;36(16):2146-56.
  • Nikolic DS, Habibi-Goudarzi S, Corley DG, Gafner S, Pezzuto JM, van Breemen RB. "Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration mass spectrometry.". Analytical chemistry. 2000;72(16):3853-9.
  • Chung HS, Chang LC, Lee SK, Shamon LA, van Breemen RB, Mehta RG, Farnsworth NR, Pezzuto JM. "Flavonoid constituents of Chorizanthe diffusa with potential cancer chemopreventive activity.". Journal of agricultural and food chemistry. 1999;47(1):36-41.
  • Bolton JL, Pisha E, Shen L, Krol ES, Iverson SL, Huang Z, van Breemen RB, Pezzuto JM. "The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells.". Chemico-biological interactions. 1997;106(2):133-48.
  • Shen L, Pisha E, Huang Z, Pezzuto JM, Krol E, Alam Z, van Breemen RB, Bolton JL. "Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity.". Carcinogenesis. 1997;18(5):1093-101.
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