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Photo of Dorota Klepacki

Dorota Klepacki

Senior Research Specialist, Center for Biomolecular Sciences

Contact Information

900 S. Ashland Avenue (870)
MBRB Rm 3018
Chicago, IL 60607

Phone: (312) 996-4002

Intellectual Contributions

Journal Article

  • Sothiselvam S, Liu B, Han W, Ramu H, Klepacki D, Atkinson GC, Brauer A, Remm M, Tenson T, Schulten K, Vázquez-Laslop N, Mankin A. "Macrolide antibiotics allosterically predispose the ribosome for translation arrest.". Proceedings of the National Academy of Sciences of the United States of America. 2014;111(27):9804-9. doi:10.1073/pnas.1403586111.
  • Martínez AK, Gordon E, Sengupta A, Shirole N, Klepacki D, Martinez-Garriga B, Brown LM, Benedik MJ, Yanofsky C, Mankin A, Vazquez-Laslop NC, Sachs MS, Cruz-Vera LR. "Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan.". Nucleic acids research. 2014;42(2):1245-56. doi:10.1093/nar/gkt923.
  • Orelle C, Szal TM, Klepacki D, Shaw KJ, Vázquez-Laslop N, Mankin A. "Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition.". Nucleic acids research. 2013;41(14):e144. doi:10.1093/nar/gkt526.
  • Vázquez-Laslop N, Klepacki D, Mulhearn DC, Ramu H, Krasnykh O, Franzblau SG, Mankin A. "Role of antibiotic ligand in nascent peptide-dependent ribosome stalling.". Proceedings of the National Academy of Sciences of the United States of America. 2011;108(26):10496-501. doi:10.1073/pnas.1103474108.
  • Ramu H, Vázquez-Laslop N, Klepacki D, Dai Q, Piccirilli J, Micura R, Mankin A. "Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center.". Molecular cell. 2011;41(3):321-30. doi:10.1016/j.molcel.2010.12.031.
  • Llano-Sotelo B, Dunkle J, Klepacki D, Zhang W, Fernandes P, Cate JH, Mankin A. "Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.". Antimicrobial agents and chemotherapy. 2010;54(12):4961-70. doi:10.1128/AAC.00860-10.
  • Vázquez-Laslop N, Ramu H, Klepacki D, Kannan K, Mankin A. "The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide.". The EMBO journal. 2010;29(18):3108-17. doi:10.1038/emboj.2010.180.
  • Auerbach T, Mermershtain I, Davidovich C, Bashan A, Belousoff M, Wekselman I, Zimmerman E, Xiong L, Klepacki D, Arakawa K, Kinashi H, Mankin A, Yonath A. "The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics.". Proceedings of the National Academy of Sciences of the United States of America. 2010;107(5):1983-8. doi:10.1073/pnas.0914100107.
  • Llano-Sotelo B, Klepacki D, Mankin A. "Selection of small peptides, inhibitors of translation.". Journal of molecular biology. 2009;391(5):813-9. doi:10.1016/j.jmb.2009.06.069.
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