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Photo of David C Lankin

David C Lankin

Research Associate Professor, Medicinal Chemistry and Pharmacognosy

Contact Information

833 S. Wood Street (781)
Chicago, IL 60612

Intellectual Contributions

Journal Article

  • Simmler C, Anderson JR, Gauthier LL, Lankin DC, McAlpine JB, Chen S, Pauli GF. "Metabolite Profiling and Classification of DNA-Authenticated Licorice Botanicals.". Journal of natural products. 2015;78(8):2007-22. doi:10.1021/acs.jnatprod.5b00342.
  • Napolitano JG, Simmler C, McAlpine JB, Lankin DC, Chen S, Pauli GF. "Digital NMR profiles as building blocks: assembling ¹H fingerprints of steviol glycosides.". Journal of natural products. 2015;78(4):658-65. doi:10.1021/np5008203.
  • Ramos Alvarenga RF, Friesen JB, Nikolic DS, Simmler C, Napolitano JG, van Breemen RB, Lankin DC, McAlpine JB, Pauli GF, Chen S. "K-targeted metabolomic analysis extends chemical subtraction to DESIGNER extracts: selective depletion of extracts of hops (Humulus lupulus).". Journal of natural products. 2014;77(12):2595-604. doi:10.1021/np500376g.
  • Gao W, Kim JY, Chen S, Cho S, Choi J, Jaki BU, Jin YY, Lankin DC, Lee JE, Lee SY, Napolitano JG, Franzblau SG, Suh JW, Pauli GF. "Discovery and characterization of the tuberculosis drug lead ecumicin.". Organic letters. 2014;16(23):6044-7. doi:10.1021/ol5026603.
  • Pauli GF, Chen S, Simmler C, Lankin DC, Gödecke T, Jaki BU, Friesen JB, McAlpine JB, Napolitano JG. "Importance of purity evaluation and the potential of quantitative ¹H NMR as a purity assay.". Journal of medicinal chemistry. 2014;57(22):9220-31. doi:10.1021/jm500734a.
  • Simmler C, Nikolic DS, Lankin DC, Yu Y, Friesen JB, van Breemen RB, Lecomte A, Le Quémener C, Audo G, Pauli GF. "Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice.". Journal of natural products. 2014;77(8):1806-16. doi:10.1021/np5001945.
  • Simmler C, Nikolić D, Lankin DC, Yu Y, van Breemen RB, Lecomte A, Le Quémener C, Audo G, Pauli GF. "Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice.". Journal of natural products. 2014;. doi:10.1021/np5001945.
  • Elkington BG, Sydara K, Newsome A, Hwang CH, Lankin DC, Simmler C, Napolitano JG, Ree R, Graham JG, Gyllenhaal C, Bouamanivong S, Souliya O, Pauli GF, Franzblau SG, Soejarto DD. "New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos.". Journal of ethnopharmacology. 2014;151(2):903-11. doi:10.1016/j.jep.2013.11.057.
  • Elkington BG, Sydara K, Newsome A, Hwang CH, Lankin DC, Simmler C, Napolitano JG, Ree R, Graham JG, Gyllenhaal C, Bouamanivong S, Souliya O, Pauli GF, Franzblau SG, Soejarto DD. "New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos.". Journal of ethnopharmacology. 2014;151(2):903-11. doi:10.1016/j.jep.2013.11.057.
  • Klein L, Petukhova V, Wan B, Wang Y, Santasiero BD, Lankin DC, Pauli GF, Franzblau SG. "A novel indigoid anti-tuberculosis agent.". Bioorganic & medicinal chemistry letters. 2014;24(1):268-70. doi:10.1016/j.bmcl.2013.11.024.
  • Dong SH, Cai G, Napolitano JG, Nikolić D, Lankin DC, van Breemen RB, Soejarto DD, Pauli GF, Chen S. "Lipidated steroid saponins from Dioscorea villosa (wild yam).". Fitoterapia. 2013;91:113-24. doi:10.1016/j.fitote.2013.07.018.
  • Hwang CH, Jaki BU, Klein L, Lankin DC, Napolitano JG, Fryling NA, Franzblau SG, Cho S, Stamets PE, Wang Y, Pauli GF. "Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.". Journal of natural products. 2013;76(10):1916-22. doi:10.1021/np400497f.
  • Qiu F, Cai G, Jaki BU, Lankin DC, Franzblau SG, Pauli GF. "Quantitative purity-activity relationships of natural products: the case of anti-tuberculosis active triterpenes from Oplopanax horridus.". Journal of natural products. 2013;76(3):413-9. doi:10.1021/np3007809.
  • Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones T, Soejarto DD, Chen S, Pauli GF. "Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay.". Journal of agricultural and food chemistry. 2013;61(9):2146-57. doi:10.1021/jf304445p.
  • Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones T, Soejarto DD, Chen S, Pauli GF. "Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay.". Journal of agricultural and food chemistry. 2013;61(9):2146-57. doi:10.1021/jf304445p.
  • Nikolić D, Gödecke T, Chen S, White J, Lankin DC, Pauli GF, van Breemen RB. "Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.).". Fitoterapia. 2012;83(3):441-60. doi:10.1016/j.fitote.2011.12.006.
  • Hemachandra LP, Madhubhani P, Chandrasena R, Esala P, Chen S, Main M, Lankin DC, Scism RA, Dietz BM, Pauli GF, Thatcher GR, Bolton JL. "Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).". Cancer prevention research (Philadelphia, Pa.). 2012;5(1):73-81. doi:10.1158/1940-6207.CAPR-11-0348.
  • Gödecke T, Yao P, Napolitano JG, Nikolić D, Dietz BM, Bolton JL, van Breemen RB, Farnsworth NR, Chen S, Lankin DC, Pauli GF. "Integrated standardization concept for Angelica botanicals using quantitative NMR.". Fitoterapia. 2012;83(1):18-32. doi:10.1016/j.fitote.2011.08.017.
  • Li J, Gödecke T, Chen S, Imai A, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Nikolić D. "In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4.". Xenobiotica; the fate of foreign compounds in biological systems. 2011;. doi:10.3109/00498254.2011.603385.
  • Scher JM, Schinkovitz A, Zapp J, Wang Y, Franzblau SG, Becker H, Lankin DC, Pauli GF. "Structure and anti-TB activity of trachylobanes from the liverwort Jungermannia exsertifolia ssp. cordifolia.". Journal of natural products. 2010;73(4):656-63. doi:10.1021/np900806j.
  • Gödecke T, Lankin DC, Nikolic DS, Chen S, van Breemen RB, Farnsworth NR, Pauli GF. "Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa).". Journal of natural products. 2009;72(3):433-7. doi:10.1021/np8006952.
  • Gödecke T, Nikolic DS, Lankin DC, Chen S, Powell SL, Dietz BM, Bolton JL, van Breemen RB, Farnsworth NR, Pauli GF. "Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.". Phytochemical analysis : PCA. 2009;20(2):120-33. doi:10.1002/pca.1106.
  • Powell SL, Gödecke T, Nikolic DS, Chen S, Ahn S, Dietz BM, Farnsworth NR, van Breemen RB, Lankin DC, Pauli GF, Bolton JL. "In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent.". Journal of agricultural and food chemistry. 2008;56(24):11718-26. doi:10.1021/jf803298z.
  • Overk CR, Guo J, Chadwick LR, Lantvit DD, Minassi A, Appendino G, Chen S, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL. "In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.". Chemico-biological interactions. 2008;176(1):30-9. doi:10.1016/j.cbi.2008.06.005.
  • Jaki BU, Franzblau SG, Chadwick LR, Lankin DC, Zhang F, Wang Y, Pauli GF. "Purity-activity relationships of natural products: the case of anti-TB active ursolic acid.". Journal of natural products. 2008;71(10):1742-8. doi:10.1021/np800329j.
  • Chen S, Lankin DC, Nikolic DS, Lu ZZ, Ramirez B, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. "Chlorination diversifies Cimicifuga racemosa triterpene glycosides.". Journal of natural products. 2007;70(6):1016-23. doi:10.1021/np0700319.
  • Nikolic DS, Lankin DC, Chen S, Jaki BU, Krunic A, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. "Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa.". Journal of natural products. 2005;68(8):1266-70. doi:10.1021/np050066d.
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