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Photo of Shao-Nong Chen

Shao-Nong Chen

Research Associate Professor, Medicinal Chemistry and Pharmacognosy

INST AFFL, Institute for Tuberculosis Research

Research Associate Professor, Program for Collaborative Research in the Pharmaceutical Sciences

Contact Information

833 South Wood Street (781)
315
Chicago, IL 60612

Phone: (312) 996-7253

Intellectual Contributions

Journal Article

  • Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen S, Nikolic DS, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. "Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.". Chemical research in toxicology. 2015;28(11):2130-41. doi:10.1021/acs.chemrestox.5b00310.
  • Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen S, Nikolic DS, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. "Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.". Chemical research in toxicology. 2015;28(11):2130-41. doi:10.1021/acs.chemrestox.5b00310.
  • Simmler C, Anderson JR, Gauthier LL, Lankin DC, McAlpine JB, Chen S, Pauli GF. "Metabolite Profiling and Classification of DNA-Authenticated Licorice Botanicals.". Journal of natural products. 2015;78(8):2007-22. doi:10.1021/acs.jnatprod.5b00342.
  • Dunlap TL, Wang S, Simmler C, Chen S, Pauli GF, Dietz BM, Bolton JL. "Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.". Chemical research in toxicology. 2015;28(8):1584-94. doi:10.1021/acs.chemrestox.5b00157.
  • Dunlap TL, Wang S, Simmler C, Chen S, Pauli GF, Dietz BM, Bolton JL. "Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.". Chemical research in toxicology. 2015;28(8):1584-94. doi:10.1021/acs.chemrestox.5b00157.
  • Napolitano JG, Simmler C, McAlpine JB, Lankin DC, Chen S, Pauli GF. "Digital NMR profiles as building blocks: assembling ¹H fingerprints of steviol glycosides.". Journal of natural products. 2015;78(4):658-65. doi:10.1021/np5008203.
  • Ramos Alvarenga RF, Friesen JB, Nikolic DS, Simmler C, Napolitano JG, van Breemen RB, Lankin DC, McAlpine JB, Pauli GF, Chen S. "K-targeted metabolomic analysis extends chemical subtraction to DESIGNER extracts: selective depletion of extracts of hops (Humulus lupulus).". Journal of natural products. 2014;77(12):2595-604. doi:10.1021/np500376g.
  • Gao W, Kim JY, Chen S, Cho S, Choi J, Jaki BU, Jin YY, Lankin DC, Lee JE, Lee SY, Napolitano JG, Franzblau SG, Suh JW, Pauli GF. "Discovery and characterization of the tuberculosis drug lead ecumicin.". Organic letters. 2014;16(23):6044-7. doi:10.1021/ol5026603.
  • Pauli GF, Chen S, Simmler C, Lankin DC, Gödecke T, Jaki BU, Friesen JB, McAlpine JB, Napolitano JG. "Importance of purity evaluation and the potential of quantitative ¹H NMR as a purity assay.". Journal of medicinal chemistry. 2014;57(22):9220-31. doi:10.1021/jm500734a.
  • van Breemen RB, Yuan Y, Banuvar S, Shulman LP, Qiu X, Alvarenga RF, Chen S, Dietz BM, Bolton JL, Pauli GF, Krause EC, Viana M, Nikolic DS. "Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops.". Molecular nutrition & food research. 2014;58(10):1962-9. doi:10.1002/mnfr.201400245.
  • Simmler C, Jones T, Anderson JR, Nikolic DS, van Breemen RB, Soejarto DD, Chen S, Pauli GF. "Species-specific Standardisation of Licorice by Metabolomic Profiling of Flavanones and Chalcones.". Phytochemical analysis : PCA. 2014;25(4):378-88.
  • Simmler C, Jones T, Anderson JR, Nikolić DC, van Breemen RB, Soejarto DD, Chen S, Pauli GF. "Species-specific Standardisation of Licorice by Metabolomic Profiling of Flavanones and Chalcones.". Phytochemical analysis : PCA. 2014;25(4):378-88.
  • Yuan Y, Qiu X, Nikolić D, Chen S, Huang KG, Li G, Pauli GF, van Breemen RB. "Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols.". European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2014;53:55-61. doi:10.1016/j.ejps.2013.12.003.
  • Simmler C, Napolitano JG, McAlpine JB, Chen S, Pauli GF. "Universal quantitative NMR analysis of complex natural samples.". Current opinion in biotechnology. 2014;25:51-9. doi:10.1016/j.copbio.2013.08.004.
  • Dong SH, Cai G, Napolitano JG, Nikolić D, Lankin DC, van Breemen RB, Soejarto DD, Pauli GF, Chen S. "Lipidated steroid saponins from Dioscorea villosa (wild yam).". Fitoterapia. 2013;91:113-24. doi:10.1016/j.fitote.2013.07.018.
  • Simmler C, Pauli GF, Chen S. "Phytochemistry and biological properties of glabridin.". Fitoterapia. 2013;90:160-84. doi:10.1016/j.fitote.2013.07.003.
  • Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen S, Nikolic DS, Dietz BM, Pauli GF, van Breemen RB, Bolton JL. "Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms.". PloS one. 2013;8(7):e67947. doi:10.1371/journal.pone.0067947.
  • Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen S, Nikolić D, Dietz BM, Pauli GF, van Breemen RB, Bolton JL. "Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms.". PloS one. 2013;8(7):e67947. doi:10.1371/journal.pone.0067947.
  • Dietz BM, Hagos GK, Eskra JN, Wijewickrama GT, Anderson JR, Nikolic DS, Guo J, Wright BJ, Chen S, Pauli GF, van Breemen RB, Bolton JL. "Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo.". Molecular nutrition & food research. 2013;57(6):1055-66. doi:10.1002/mnfr.201200534.
  • Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones T, Soejarto DD, Chen S, Pauli GF. "Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay.". Journal of agricultural and food chemistry. 2013;61(9):2146-57. doi:10.1021/jf304445p.
  • Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones T, Soejarto DD, Chen S, Pauli GF. "Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay.". Journal of agricultural and food chemistry. 2013;61(9):2146-57. doi:10.1021/jf304445p.
  • Dong SH, Nikolić D, Simmler C, Qiu F, van Breemen RB, Soejarto DD, Pauli GF, Chen S. "Diarylheptanoids from Dioscorea villosa (Wild Yam).". Journal of natural products. 2012;75(12):2168-77. doi:10.1021/np300603z.
  • Dong SH, Nikolic DS, Simmler C, Qiu F, van Breemen RB, Soejarto DD, Pauli GF, Chen S. "Diarylheptanoids from Dioscorea villosa (Wild Yam).". Journal of natural products. 2012;75(12):2168-77. doi:10.1021/np300603z.
  • Toh MF, Sohn J, Chen S, Yao P, Bolton JL, Burdette JE. "Biological characterization of non-steroidal progestins from botanicals used for women's health.". Steroids. 2012;77(7):765-73. doi:10.1016/j.steroids.2012.03.013.
  • Nikolić D, Gödecke T, Chen S, White J, Lankin DC, Pauli GF, van Breemen RB. "Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.).". Fitoterapia. 2012;83(3):441-60. doi:10.1016/j.fitote.2011.12.006.
  • Hemachandra LP, Madhubhani P, Chandrasena R, Esala P, Chen S, Main M, Lankin DC, Scism RA, Dietz BM, Pauli GF, Thatcher GR, Bolton JL. "Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).". Cancer prevention research (Philadelphia, Pa.). 2012;5(1):73-81. doi:10.1158/1940-6207.CAPR-11-0348.
  • Gödecke T, Yao P, Napolitano JG, Nikolić D, Dietz BM, Bolton JL, van Breemen RB, Farnsworth NR, Chen S, Lankin DC, Pauli GF. "Integrated standardization concept for Angelica botanicals using quantitative NMR.". Fitoterapia. 2012;83(1):18-32. doi:10.1016/j.fitote.2011.08.017.
  • Li J, Gödecke T, Chen S, Imai A, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Nikolić D. "In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4.". Xenobiotica; the fate of foreign compounds in biological systems. 2011;. doi:10.3109/00498254.2011.603385.
  • Chen S, Webster D, Nikolic DS, van Breemen RB, Wang Z, Fong HH, Farnsworth NR, Pauli GF. "Phytoconstituents from Vitex agnus-castus fruits.". Fitoterapia. 2011;82(4):528-33. doi:10.1016/j.fitote.2010.12.003.
  • Choi Y, Jermihov K, Nam SJ, Sturdy M, Maloney K, Qiu X, Chadwick LR, Main M, Chen S, Mesecar AD, Farnsworth NR, Pauli GF, Fenical W, Pezzuto JM, van Breemen RB. "Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS.". Analytical chemistry. 2011;83(3):1048-52. doi:10.1021/ac1028424.
  • Cuendet M, Guo J, Luo Y, Chen S, Oteham CP, Moon RC, van Breemen RB, Marler LE, Pezzuto JM. "Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice.". Cancer prevention research (Philadelphia, Pa.). 2010;3(2):221-32. doi:10.1158/1940-6207.CAPR-09-0049.
  • van Breemen RB, Liang W, Banuvar S, Shulman LP, Pang Y, Tao Y, Nikolic DS, Krock KM, Chen S, Hedayat S, Bolton JL, Pauli GF, Piersen CE, Krause EC, Geller SE, Farnsworth NR. "Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh.". Clinical pharmacology and therapeutics. 2010;87(2):219-25. doi:10.1038/clpt.2009.251.
  • Gödecke T, Lankin DC, Nikolic DS, Chen S, van Breemen RB, Farnsworth NR, Pauli GF. "Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa).". Journal of natural products. 2009;72(3):433-7. doi:10.1021/np8006952.
  • Gödecke T, Nikolic DS, Lankin DC, Chen S, Powell SL, Dietz BM, Bolton JL, van Breemen RB, Farnsworth NR, Pauli GF. "Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.". Phytochemical analysis : PCA. 2009;20(2):120-33. doi:10.1002/pca.1106.
  • Powell SL, Gödecke T, Nikolic DS, Chen S, Ahn S, Dietz BM, Farnsworth NR, van Breemen RB, Lankin DC, Pauli GF, Bolton JL. "In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent.". Journal of agricultural and food chemistry. 2008;56(24):11718-26. doi:10.1021/jf803298z.
  • Overk CR, Guo J, Chadwick LR, Lantvit DD, Minassi A, Appendino G, Chen S, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL. "In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.". Chemico-biological interactions. 2008;176(1):30-9. doi:10.1016/j.cbi.2008.06.005.
  • Deng S, Wang Y, Inui T, Chen S, Farnsworth NR, Cho S, Franzblau SG, Pauli GF. "Anti-TB polyynes from the roots of Angelica sinensis.". Phytotherapy research : PTR. 2008;22(7):878-82. doi:10.1002/ptr.2303.
  • Overk CR, Yao P, Chen S, Deng S, Imai A, Main M, Schinkovitz A, Farnsworth NR, Pauli GF, Bolton JL. "High-content screening and mechanism-based evaluation of estrogenic botanical extracts.". Combinatorial chemistry & high throughput screening. 2008;11(4):283-93.
  • Chen S, Turner A, Jaki BU, Nikolic DS, van Breemen RB, Pauli GF. "An experimental implementation of chemical subtraction.". Journal of pharmaceutical and biomedical analysis. 2008;46(4):692-8. doi:10.1016/j.jpba.2007.12.014.
  • Chen S, Lankin DC, Nikolic DS, Lu ZZ, Ramirez B, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. "Chlorination diversifies Cimicifuga racemosa triterpene glycosides.". Journal of natural products. 2007;70(6):1016-23. doi:10.1021/np0700319.
  • Deng S, Chen S, Lu J, Wang Z, Nikolic DS, van Breemen RB, Santarsiero BD, Mesecar A, Fong HH, Farnsworth NR, Pauli GF. "GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels.". Phytochemical analysis : PCA. 2006;17(6):398-405.
  • Deng S, Chen S, Lu J, Wang Z, Nikolic DS, van Breemen RB, Santarsiero BD, Mesecar A, Fong HH, Farnsworth NR, Pauli GF. "GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels.". Phytochemical analysis : PCA. 2006;17(6):398-405.
  • Deng S, Chen S, Yao P, Nikolic DS, van Breemen RB, Bolton JL, Fong HH, Farnsworth NR, Pauli GF. "Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.". Journal of natural products. 2006;69(4):536-41. doi:10.1021/np050301s.
  • Booth NL, Overk CR, Yao P, Burdette JE, Nikolic DS, Chen S, Bolton JL, van Breemen RB, Pauli GF, Farnsworth NR. "The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract.". Journal of alternative and complementary medicine (New York, N.Y.). 2006;12(2):133-9. doi:10.1089/acm.2006.12.133.
  • Nikolic DS, Lankin DC, Chen S, Jaki BU, Krunic A, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. "Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa.". Journal of natural products. 2005;68(8):1266-70. doi:10.1021/np050066d.
  • Burdette JE, Liu J, Chen S, Piersen CE, Barker EL, Pezzuto JM, Mesecar A, van Breemen RB, Farnsworth NR, Bolton JL. "Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.". Journal of agricultural and food chemistry. 2003;51(19):5661-70. doi:10.1021/jf034264r.
  • Burdette JE, Chen S, Lu ZZ, Xu H, White B, Liu J, Fong HH, Farnsworth NR, Constantinou AI, van Breemen RB, Pezzuto JM, Bolton JL. "Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.". Journal of agricultural and food chemistry. 2002;50(24):7022-8.
  • Chen S, Li W, Fabricant DS, Santarsiero BD, Mesecar A, Fitzloff JF, Fong HH, Farnsworth NR. "Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein.". Journal of natural products. 2002;65(4):601-5.
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