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Photo of Hyunyoung (Young) Jeong

Hyunyoung (Young) Jeong

Professor, Pharmacy Practice

Center Affiliate, Center for Biomolecular Sciences

Contact Information

900 South Ashland Avenue (870)
MBRB 3220
Chicago, IL 60607

Phone: (312) 996-7820

Website: http://openwetware.org/wiki/Jeong_lab

Lab Phone: (312) 413-1771

Education

  • PhD, Pharmacokinetics, University of Illinois at Chicago, 2004
  • PharmD, University of Illinois at Chicago, 2001

Research Interests

Clinical/preclinical pharmacokinetics; pharmacogenomics;eukaryotic gene regulation

Intellectual Contributions

Journal Article

  • McClay K, Mehboob S, Yu J, Santarsiero BD, Deng J, Cook JL, Jeong H, Johnson ME, Steffan RJ. "Indole trimers with antibacterial activity against Gram-positive organisms produced using combinatorial biocatalysis.". AMB Express. 2015;5(1):125. doi:10.1186/s13568-015-0125-4.
  • Pan X, Jeong H. "Estrogen-Induced Cholestasis Leads to Repressed CYP2D6 Expression in CYP2D6-Humanized Mice.". Molecular pharmacology. 2015;88(1):106-12. doi:10.1124/mol.115.098822.
  • Pan X, Lee YK, Jeong H. "Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner.". Drug metabolism and disposition: the biological fate of chemicals. 2015;43(7):1002-7. doi:10.1124/dmd.115.064758.
  • Zhang S, Pan X, Jeong H. "GW4064, an agonist of farnesoid X receptor, represses CYP3A4 expression in human hepatocytes by inducing small heterodimer partner expression.". Drug metabolism and disposition: the biological fate of chemicals. 2015;43(5):743-8. doi:10.1124/dmd.114.062836.
  • Ning M, Koh KH, Pan X, Jeong H. "Hepatocyte nuclear factor (HNF) 4α transactivation of cytochrome P450 (Cyp) 2d40 promoter is enhanced during pregnancy in mice.". Biochemical pharmacology. 2015;94(1):46-52. doi:10.1016/j.bcp.2015.01.001.
  • Miller Z, Kim KS, Lee DM, Kasam V, Baek SE, Lee KH, Zhang YY, Ao L, Carmony K, Lee NR, Zhou S, Zhao Q, Jang Y, Jeong H, Zhan CG, Lee W, Kim DE, Kim KB. "Proteasome inhibitors with pyrazole scaffolds from structure-based virtual screening.". Journal of medicinal chemistry. 2015;58(4):2036-41. doi:10.1021/jm501344n.
  • Koh KH, Pan X, Zhang W, McLachlan A, Urrutia R, Jeong H. "Krüppel-like factor 9 promotes hepatic cytochrome P450 2D6 expression during pregnancy in CYP2D6-humanized mice.". Molecular pharmacology. 2014;86(6):727-35. doi:10.1124/mol.114.093666.
  • Zhang YY, , Mehboob S, Song JH, Boci T, Johnson ME, Ghosh AK, Jeong H. "Metabolism-directed structure optimization of benzimidazole-based Francisella tularensis enoyl-reductase (FabI) inhibitors.". Xenobiotica; the fate of foreign compounds in biological systems. 2014;44(5):404-16. doi:10.3109/00498254.2013.850553.
  • Li W, Ning M, Koh KH, Kim H, Jeong H. "17β-Estradiol induces sulfotransferase 2A1 expression through estrogen receptor α.". Drug metabolism and disposition: the biological fate of chemicals. 2014;42(4):796-802. doi:10.1124/dmd.113.055178.
  • Fischer JH, Sarto GE, Hardman J, Endres L, Jenkins TM, Kilpatrick SJ, Jeong H, Geller S, Deyo KL, Fischer PA, Rodvold KA. "Influence of gestational age and body weight on the pharmacokinetics of labetalol in pregnancy.". Clinical pharmacokinetics. 2014;53(4):373-83. doi:10.1007/s40262-013-0123-0.
  • Koh KH, Pan X, Shen HW, Arnold SL, Yu AM, Gonzalez FJ, Isoherranen N, Jeong H. "Altered expression of small heterodimer partner governs cytochrome P450 (CYP) 2D6 induction during pregnancy in CYP2D6-humanized mice.". The Journal of biological chemistry. 2014;289(6):3105-13. doi:10.1074/jbc.M113.526798.
  • Cavallari LH, Vaynshteyn D, Freeman KM, Wang D, Perera MA, Takahashi H, Drozda K, Patel SR, Jeong H. "CYP2C9 promoter region single-nucleotide polymorphisms linked to the R150H polymorphism are functional suggesting their role in CYP2C9*8-mediated effects.". Pharmacogenetics and genomics. 2013;23(4):228-31. doi:10.1097/FPC.0b013e32835e95c7.
  • Choi SY, Koh KH, Jeong H. "Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone.". Drug metabolism and disposition: the biological fate of chemicals. 2013;41(2):263-9. doi:10.1124/dmd.112.046276.
  • Lee H, Zhu T, Patel K, Zhang YY, Truong L, Hevener KE, Gatuz JL, Subramanya G, Jeong H, Uprichard SL, Johnson ME. "High-throughput screening (HTS) and hit validation to identify small molecule inhibitors with activity against NS3/4A proteases from multiple hepatitis C virus genotypes.". PloS one. 2013;8(10):e75144. doi:10.1371/journal.pone.0075144.
  • Koh KH, Jurkovic S, Yang K, Choi SY, Jung JW, Kim K, Zhang W, Jeong H. "Estradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy.". Biochemical pharmacology. 2012;84(1):93-103. doi:10.1016/j.bcp.2012.03.016.
  • , Jeong H, Takahashi H, Drozda K, Patel SR, Shapiro NL, , Cavallari LH. "Decreased warfarin clearance associated with the CYP2C9 R150H (*8) polymorphism.". Clinical pharmacology and therapeutics. 2012;91(4):660-5. doi:10.1038/clpt.2011.269.
  • Choi SY, Fischer L, Yang K, Chung H, Jeong H. "Isoform-specific regulation of cytochrome P450 expression and activity by estradiol in female rats.". Biochemical pharmacology. 2011;81(6):777-82. doi:10.1016/j.bcp.2010.12.019.
  • Cavallari LH, Jeong H, Bress A. "Role of cytochrome P450 genotype in the steps toward personalized drug therapy.". Pharmacogenomics and personalized medicine. 2011;4:123-36. doi:10.2147/PGPM.S15497.
  • Della Torre M, Hibbard JU, Jeong H, Fischer JH. "Betamethasone in pregnancy: influence of maternal body weight and multiple gestation on pharmacokinetics.". American journal of obstetrics and gynecology. 2010;203(3):254.e1-12. doi:10.1016/j.ajog.2010.06.029.
  • Chen H, Yang K, Choi SA, Fischer JH, Jeong H. "Up-regulation of UDP-glucuronosyltransferase (UGT) 1A4 by 17beta-estradiol: a potential mechanism of increased lamotrigine elimination in pregnancy.". Drug metabolism and disposition: the biological fate of chemicals. 2009;37(9):1841-7. doi:10.1124/dmd.109.026609.
  • Shord SS, Cavallari LH, Gao W, Jeong H, Deyo KL, Patel SR, Camp JR, Labott SM, Molokie RE. "The pharmacokinetics of codeine and its metabolites in Blacks with sickle cell disease.". European journal of clinical pharmacology. 2009;65(7):651-8. doi:10.1007/s00228-009-0646-3.
  • Jeong H, Choi SA, Song JW, Chen H, Fischer JH. "Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination.". Xenobiotica; the fate of foreign compounds in biological systems. 2008;38(1):62-75. doi:10.1080/00498250701744633 .
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