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Photo of Manelle BenAissa

Manelle BenAissa

Research Assistant Professor, Pharmaceutical Sciences

Related Sites:

Teaching and Supervision Heading link

Phenotypic Drug Discovery PSCI 501 (PSCI 501), 9/1/2022 – Present
Phenotypic Drug Discovery PSCI 501 (PSCI 501), 8/31/2021 – Present
Drug discovery for neurodegenerative diseases: Approaches and challenges. (NEUS525/ANAT525), 4/17/2019 – Present

Selected Grants

A selective LXRβ modulator (SLiM) strategy to treat Type 2 diabetes and related comorbidities, UIC Proof of Concept Award program., 12/19/2022 - Present, Obligated Amount: $50000; No Anticipated Amount Set

Selectively targeting pathological tau signaling in AD and related dementia, National Institutes of Health (National Institute on Aging)., 9/15/2020 - 8/31/2023, Obligated Amount: $439725; Anticipated Amount: $439725

Using a Novel Model of Antidepressant Efficacy to Discover New Compounds and Personalized Treatments, Pax Neuroscience., 9/20/2017 - 8/31/2020, Obligated Amount: $350309; Anticipated Amount: $350309

Selected Publications

Lewandowski, CT, Khan, MW, BenAissa, M, Dubrovskyi, O, Ackerman-Berrier, M, LaDu, MJ, Layden, BT, Thatcher, GRJ. (2021). Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development. EBioMedicine, 66. doi:10.1016/j.ebiom.2021.103287.

Ben Aissa, M, Lewandowski, CT, Ratia, KM, Lee, SH, Layden, BT, Ladu, MJ, Thatcher, GRJ. (2021). Discovery of Nonlipogenic ABCA1 Inducing Compounds with Potential in Alzheimer’s Disease and Type 2 Diabetes. ACS Pharmacology and Translational Science, 4, (1), 143-154. doi:10.1021/acsptsci.0c00149.

Lewandowski, Cutler, Khan, Md Wasim, Ben Aissa, Manel, Layden, Brian, Thatcher, Gregory. (2020). Abstract 15297: Discovery and Preclinical Optimization of Selective ABCA1 Inducers as Multifunctional Therapeutic Candidates. Circulation, 142, (Suppl_3). doi:10.1161/circ.142.suppl_3.15297.

Knopp, RC, Lee, SH, Hollas, M, Nepomuceno, E, Gonzalez, D, Tam, K, Aamir, D, Wang, Y, Pierce, E, BenAissa, M, Thatcher, GRJ. (2020). Interaction of oxidative stress and neurotrauma in ALDH2−/− mice causes significant and persistent behavioral and pro-inflammatory effects in a tractable model of mild traumatic brain injury. Redox Biology, 32. doi:10.1016/j.redox.2020.101486.

Aissa, Manel Ben, Lewandowski, Cutler T, Ratia, Kiira, Ladu, Mary Jo, Thatcher, Gregory R. (2019). P1‐078: NOVEL MULTIFUNCTIONAL TISSUE SELECTIVE ABCA1 INDUCER FOR AD AND ADRD. Alzheimer’s & Dementia, 15, p264-p265. doi:10.1016/j.jalz.2019.06.103.

Gordon-Blake, Jesse, Karumudi, Bhargava, Ratia, Kiira, Knopp, Rachel C, Dye, Katherine, Aissa, Manel Ben, Thatcher, Gregory R. (2019). P1‐083: NOVEL NAMPT ACTIVATORS ATTENUATE NEUROTOXICITY AND NEUROINFLAMMATION ASSOCIATED WITH NEURODEGENERATION. Alzheimer’s & Dementia, 15, p266-p267. doi:10.1016/j.jalz.2019.06.108.

Lewandowski, Cutler T, Khan, Wasim, Karumudi, Bhargava, Aissa, Manel Ben, Lee, Sue H, Ladu, Mary Jo, Layden, Brian T, Thatcher, Gregory R. (2019). P1‐087: DEVELOPMENT OF MULTIFUNCTIONAL ABCA1 INDUCERS AS ALZHEIMER’S DISEASE THERAPEUTICS. Alzheimer’s & Dementia, 15, p268-p268. doi:10.1016/j.jalz.2019.06.112.

Hollas, MA, Ben Aissa, M, Lee, SH, Gordon-Blake, JM, Thatcher, GRJ. (2019). Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery. Nitric Oxide – Biology and Chemistry, 82, 59-74. doi:10.1016/j.niox.2018.10.006.

Huang, FF, Ben Aissa, M, Lévesque, G, Carreau, M. (2018). FANCC localizes with UNC5A at neurite outgrowth and promotes neuritogenesis. BMC Research Notes, 11, (1). doi:10.1186/s13104-018-3763-1.