Photo of Dr. Jonathan  Bisson

Jonathan Bisson

Visiting Research Assistant Professor, Pharmaceutical Sciences



833 S. Wood Street, Chicago, IL, 60612


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Jonathan Bisson

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Research Interests: Interaction between natural products and Humans (western-world ethnobotany and ethnopharmacology). Natural product knowledge management. Natural product centered data and text mining (Ontologies and Natural Language Processing). Mass spectrometry. Nuclear magnetic resonance.
Teaching Interests: Programming (Python, Kotlin). Ontology (Biomedical). Nuclear Magnetic Resonance. Mass Spectrometry. Ethnobotany

Selected Publications

  • Bisson J, McMillan J, Pauli GF. (2017). Data Transparency and Sharing in NP Research. International Conference on the Science of Botanicals.
  • Bisson J, Simmler C, Pauli GF. (2017). Where lies the future of Natural Products research?. NIH CARBON Meeting, Chicago, IL.
  • Nelson KM, Dahlin JL, Bisson J, Graham JG, Pauli GF, Walters MA. “Curcumin May (Not) Defy Science”. ACS Medicinal Chemistry Letters. 2017;8(5):467–470. doi:10.1021/acsmedchemlett.7b00139.
  • Phansalkar RS, Simmler C, Bisson J, Chen S, Lankin DC, McAlpine JB, Niemitz M, Pauli GF. “Evolution of Quantitative Measures in NMR: Quantum Mechanical qHNMR Advances Chemical Standardization of a Red Clover (Trifolium pratense) Extract”. Journal of Natural Products. 2017;. doi:10.1021/acs.jnatprod.6b00923.
  • Nelson KM, Dahlin JL, Bisson J, Graham JG, Pauli GF, Walters MA. “The Essential Medicinal Chemistry of Curcumin”. Journal of Medicinal Chemistry. 2017;60(5):1620–1637. doi:10.1021/acs.jmedchem.6b00975.
  • Bisson J, McAlpine JB, Friesen JB, Chen S, Graham JG, Pauli G.. Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?. Journal of Medicinal Chemistry. 2016;59(5):1671–1690. doi:10.1021/acs.jmedchem.5b01009.
  • Bisson J, Simmler C, Chen S, Friesen JB, Lankin DC, McAlpine JB, Pauli GF. “Dissemination of original NMR data enhances reproducibility and integrity in chemical research”. Nat. Prod. Rep.. 2016;33(9):1028–1033. doi:10.1039/c6np00022c.
  • Bisson J, McAlpine JB, Graham JG, Pauli GF ed. “NAPRALERT, from an historical information silo to a linked resource able to address the new challenges in Natural Products Chemistry and Pharmacognosy.” . CEUR Workshop Proceedings. 2016.
  • Bisson J, Brunel M, Badoc A, DaCosta G, Richard T, Mérillon J, Waffo-Téguo P. “Hyphenating Centrifugal Partition Chromatography with Nuclear Magnetic Resonance through Automated Solid Phase Extraction”. Analytical Chemistry. 2016;88(20):9941–9948. doi:10.1021/acs.analchem.6b01429.
  • Bisson J, Simmler C, Graham JG, McAlpine JB, Friesen JB, Lankin DC, Chen S, Orjala J, Pauli GF ed. “A new dedicated center to connect scientists and advance natural product research” . Planta Med. March-2016.
  • Phansalkar RS, Nam JW, Chen S, Bisson J, Kulakowski D, McAlpine JB, Leme AA, Vidal CM, Aguiar TR, Bedran-Russo AK, Pauli GF ed. “Grape Seed Proanthocyanidins: A Novel Source Of Dental Biomaterials And Unique Phytochemistry” . Planta Med. March-2016.
  • Allard P, Péresse T, Bisson J, Gindro K, Marcourt L, Van Cuong Pham , Roussi F, Litaudon M, Wolfender J. “Integration of Molecular Networking and In-Silico MS/MS Fragmentation for Natural Products Dereplication”. Analytical Chemistry. 2016;88(6):3317–3323. doi:10.1021/acs.analchem.5b04804.
  • Bisson J, Graham JG, Pauli GF ed. “Reviving NAPRALERT and Making It Ready For Improvement and New Challenges In Natural Products Chemistry and Pharmacognosy” . Planta Med. March-2016.
  • Pauli GF, Niemitz M, Bisson J, Lodewyk MW, Soldi C, Shaw JT, Tantillo DJ, Saya JM, Vos K, Kleinnijenhuis RA, Hiemstra H, Chen S, McAlpine JB, Lankin DC, Friesen JB. “Toward Structural Correctness: Aquatolide and the Importance of 1D Proton NMR FID Archiving”. The Journal of Organic Chemistry. 2016;81(3):878–889. doi:10.1021/acs.joc.5b02456.
  • Leme AA, Vidal CM, Sousa A., Phansalkar RS, Nam J, Bisson J, Chen S, Pauli GF, Bedran-Russo AK. “Bioadhesive properties of enriched proanthocyanidins primers”. Dental Materials. 2015;31:e59–e60. doi:10.1016/
  • Nam J, Phansalkar RS, Lankin DC, Bisson J, McAlpine JB, Leme AA, Vidal CM, Ramirez B, Niemitz M, Bedran-Russo AK, Chen S, Pauli GF. “Subtle Chemical Shifts Explain the NMR Fingerprints of Oligomeric Proanthocyanidins with High Dentin Biomodification Potency”. The Journal of Organic Chemistry. 2015;80(15):7495–7507. doi:10.1021/acs.joc.5b01082.
  • Nam J, Phansalkar RS, Lankin DC, Bisson J, McAlpine JB, Leme AA, Vidal CM, Bedran-Russo AK, Chen S, Pauli GF ed. “Chemical nano shifts explain the NMR fingerprints of dentin-enhancing oligomeric proanthocyanidins” . Planta Med. June-2015.
  • Pauli GF, Friesen JB, Niemitz M, Bisson J, Lankin DC, Soldi C, Shaw JT, Tantillo DJ, Chen S, McAlpine JB ed. “Dissemination of original NMR data enhances the reproducibility of natural product research” . Planta Med. June-2015.
  • Kulakowski D, Bisson J, Chen S, Friesen JB, Pauli GF ed. “K-targeted isolation of C-glycosylflavones from Vitex agnus-castus by countercurrent methodology” . Planta Med. June-2015.
  • McAlpine JB, Bisson J, Pauli GF ed. “Minimizing the problems with PIMPs” . Planta Med. June-2015.
  • Vidal CM, Leme AA, Aguiar TR, Phansalkar RS, Nam J, Bisson J, McAlpine JB, Chen S, Pauli GF, Bedran-Russo AK. Mimicking the hierarchical functions of dentin collagen cross-links with plant derived phenols and phenolic acids. Langmuir. 2014;30(49):14887–14893. doi:10.1021/la5034383.
  • Papastamoulis Y, Bisson J, Temsamani H, Richard T, Marchal A, Mérillon J, Waffo-Téguo P. New E-miyabenol isomer isolated from grapevine cane using centrifugal partition chromatography guided by mass spectrometry. Tetrahedron. 2014;. doi:10.1016/j.tet.2014.08.029.
  • Leme AA, Vidal CM, Aguiar TR, Sousa AB, Phansalkar RS, Nam J, Bisson J, Chen S, Pauli GF, Bedran-Russo AK. “Phytochemical profile and dentin bioactivity of non-galloylated proanthocyanidins”. Dental Materials. 2014;30:e161. doi:10.1016/
  • Buffeteau T, Cavagnat D, Bisson J, Marchal A, Kapche GD, Battistini I, DaCosta G, Badoc A, Monti J, Mérillon J, Waffo-Téguo P. Unambiguous determination of the absolute configuration of dimeric stilbene glucosides from the rhizomes of Gnetum africanum. Journal of Natural Products. 2014;77(8):1981–1985. doi:10.1021/np500427v.
  • Pauli GF, Chen S, Lankin DC, Bisson J, Case RJ, Chadwick LR, Gödecke T, Inui T, Krunic A, Jaki BU, McAlpine JB, Mo S, Napolitano JG, Orjala J, Lehtivarjo J, Korhonen S, Niemitz M. “Essential Parameters for Structural Analysis and Dereplication by 1 H NMR Spectroscopy”. J. Nat. Prod.. 2014;:140604072603006. doi:10.1021/np5002384.
  • Slaghenaufi D, Marchand-Marion S, Richard T, Waffo-Téguo P, Bisson J, Monti J, Merillon J, de Revel G. “Centrifugal partition chromatography applied to the isolation of oak wood aroma precursors”. Food Chemistry. 2013;141(3):2238–2245. doi:10.1016/j.foodchem.2013.04.069.
  • Bisson J. (2013). Reverse-engineering of equipments and file-formats in academic research.. THSF 2013, Toulouse, France.
  • Lambert C, Richard T, Renouf E, Bisson J, Waffo-Téguo P, Bordenave L, Ollat N, Mérillon J, Cluzet S. “Comparative Analyses of Stilbenoids in Canes of Major Vitis vinifera L. Cultivars”. Journal of Agricultural and Food Chemistry. 2013;61(47):11392–11399. doi:10.1021/jf403716y.
  • Nassra M, Krisa S, Papastamoulis Y, Kapche GD, Bisson J, André C, Konsman J, Schmitter J, Mérillon J, Waffo-Téguo P. “Inhibitory Activity of Plant Stilbenoids against Nitric Oxide Production by Lipopolysaccharide-Activated Microglia”. Planta Med. 2013;79(11):966–970. doi:10.1055/s-0032-1328651.
  • Pawlus AD, Cantos-Villar E, Richard T, Bisson J, Poupard P, Papastamoulis Y, Monti J, Teissedre P, Waffo-Téguo P, Mérillon J. “Chemical dereplication of wine stilbenoids using high performance liquid chromatographymagnetic resonance spectroscopy”. Journal of Chromatography A. 2013;1289:19–26. doi:10.1016/j.chroma.2013.03.010.
  • Pawlus AD, Sahli R, Bisson J, Rivière C, Delaunay J, Richard T, Gomès E, Bordenave L, Waffo-Téguo P, Mérillon J. “Stilbenoid Profiles of Canes from Vitis and Muscadinia Species”. Journal of Agricultural and Food Chemistry. 2013;61(3):501–511. doi:10.1021/jf303843z.
  • Bisson J. (2012). Hyphenating Centrifugal Partition Chromatography with Analytical Techniques for Finding Biologically Active Stilbenoids. Pharmaceutical Society of Bordeaux (SPB).
  • Lambert C, Bisson J, Waffo-Téguo P, Papastamoulis Y, Richard T, Corio-Costet M, Mérillon J, Cluzet S. Phenolics and their antifungal role in grapevine wood decay: Focus on the Botryosphaeriaceae family. Journal of Agricultural and Food Chemistry. 2012;60(48):11859–11868. doi:10.1021/jf303290g.
  • Bisson J, Brunel M, Badoc A, Palos-Pinto A, Merillon J, Waffo-Téguo P. (2012). “Hyphenating countercurrent chromatography with NMR and mass spectrometry. How to enhance the range of the liquid phases”. Planta Med. Vol. 78. Issue 11.
  • Bisson J, Poupard P, Pawlus AD, Pons A, Darriet P, Mérillon J, Waffo-Téguo P. “Development of hybrid elution systems for efficient purification of stilbenoids using centrifugal partition chromatography coupled to mass spectrometry”. Journal of Chromatography A. 2011;1218(36):6079–6084. doi:10.1016/j.chroma.2011.03.020.
  • Bisson J, Waffo-Téguo P, Mérillon J. (2010). Analytical techniques used in vine and wine research: the stilbenoids case. CJ’ Mag AFSEP. Issue 2. Page(s) 18–23.
  • Bisson J. (2010). Phytochemistry of vine and wine stilbenoids: Developing Innovating Methods for finding New Compounds. Annual meeting ISVV.
  • Bisson J. (2010). Phytochemistry of vine and wine: what can hyphenated techniques bring, CPC-MS and HPLC-NMR. AFSEP Young researcher meeting.
  • Professional Memberships