Photo of Dr. Richard B van Breemen

Richard B van Breemen


Adjunct Professor, Medicinal Chemistry and Pharmacognosy

Contact

Address:

833 South Wood Street, Chicago, IL, 60612

About

Cancer prevention by dietary antioxidants, and prostate cancer prevention by the carotenoid lycopene. Mass spectrometry-based pharmacological screening of natural products and combinatorial libraries for drug discovery, and high throughput screening to asses drug metabolism, toxicity and bioavailibility.

Selected Publications

  • Kondratyuk TP, Adrian JA, Wright BJ, Park EJ, van Breemen RB, Morris KR, Pezzuto JM. Evidence supporting the conceptual framework of cancer chemoprevention in canines.. Scientific reports. 2016;6:26500. doi:10.1038/srep26500.
  • Hauck ZZ, Feinstein DL, van Breemen RB. LC-MS-MS Analysis of Brodifacoum Isomers in Rat Tissue.. Journal of analytical toxicology. 2016;40(4):304-9. doi:10.1093/jat/bkw008.
  • Zhou Q, Chen T, Zhang W, Bozkanat M, Li Y, Xiao L, van Breemen RB, Christman JW, Sznajder JI, Zhou G. Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis.. American journal of respiratory cell and molecular biology. 2016;54(5):728-39. doi:10.1165/rcmb.2015-0111OC.
  • Stahlhut RW, van Breemen RB, Gerona RR, Taylor JA, Welshons WV, Vom Saal FS. Comment on “Optimal Exposure Biomarkers for Nonpersistent Chemicals in Environmental Epidemiology”.. Environmental health perspectives. 2016;124(4):A66. doi:10.1289/ehp.1511057.
  • Imai A, Lankin DC, Nikolić D, Ahn S, van Breemen RB, Farnsworth NR, McAlpine JB, Chen S, Pauli GF. Cycloartane Triterpenes from the Aerial Parts of Actaea racemosa.. Journal of natural products. 2016;79(3):541-54. doi:10.1021/acs.jnatprod.5b00927.
  • Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V, Vom Saal FS, Woodruff TJ. (2016). Erratum to: A round robin approach to the analysis of bisphenol a (BPA) in human blood samples.. Environmental health : a global access science source. Vol. 15. Page(s) 43.
  • Kataria Y, Deaton RJ, Enk E, Jin M, Petrauskaite M, Dong L, Goldenberg JR, Cotler SJ, Jensen DM, van Breemen RB, Gann PH. Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer.. BMC gastroenterology. 2016;16:30. doi:10.1186/s12876-016-0432-5.
  • Newsome AG, Li Y, van Breemen RB. Improved Quantification of Free and Ester-Bound Gallic Acid in Foods and Beverages by UHPLC-MS/MS.. Journal of agricultural and food chemistry. 2016;64(6):1326-34. doi:10.1021/acs.jafc.5b04966.
  • Hauck ZZ, Huang KG, Li G, van Breemen RB. Determination of bisphenol A-glucuronide in human urine using ultrahigh-pressure liquid chromatography/tandem mass spectrometry.. Rapid communications in mass spectrometry : RCM. 2016;30(3):400-6. doi:10.1002/rcm.7450.
  • Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen SS, Nikolic DF, Pauli GB, van Breemen RM, Dietz BL, Bolton J. Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women’s Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.. Chemical research in toxicology. 2015;28(11):2130-41. doi:10.1021/acs.chemrestox.5b00310.
  • Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen S, Nikolic DS, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women’s Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.. Chemical research in toxicology. 2015;28(11):2130-41. doi:10.1021/acs.chemrestox.5b00310.
  • van Breemen RB. Development of Safe and Effective Botanical Dietary Supplements.. Journal of medicinal chemistry. 2015;58(21):8360-72. doi:10.1021/acs.jmedchem.5b00417.
  • Li G, Huang KG, Nikolic DS, van Breemen RB. High-Throughput Cytochrome P450 Cocktail Inhibition Assay for Assessing Drug-Drug and Drug-Botanical Interactions.. Drug metabolism and disposition: the biological fate of chemicals. 2015;43(11):1670-8. doi:10.1124/dmd.115.065987.
  • Sprouse A, van Breemen RB. Pharmacokinetic Interactions between Drugs and Botanical Dietary Supplements.. Drug metabolism and disposition: the biological fate of chemicals. 2015;. doi:10.1124/dmd.115.066902.
  • Huang KG, Huang L, van Breemen RB. Detection of reactive metabolites using isotope-labeled glutathione trapping and simultaneous neutral loss and precursor ion scanning with ultra-high-pressure liquid chromatography triple quadruple mass spectrometry.. Analytical chemistry. 2015;87(7):3646-54. doi:10.1021/ac504737x.
  • Parvinian A, Casadaban LC, Hauck ZZ, van Breemen RB, Gaba RC. Pharmacokinetic study of conventional sorafenib chemoembolization in a rabbit VX2 liver tumor model.. Diagnostic and interventional radiology (Ankara, Turkey). 2015;. doi:10.5152/dir.2014.14394.
  • Gann PH, Deaton RJ, Rueter EE, van Breemen RB, Nonn L, Macias V, Han M, Ananthanarayanan V. A Phase II Randomized Trial of Lycopene-Rich Tomato Extract Among Men with High-Grade Prostatic Intraepithelial Neoplasia.. Nutrition and cancer. 2015;67(7):1104-12. doi:10.1080/01635581.2015.1075560.
  • Ramos Alvarenga RF, Friesen JB, Nikolic DS, Simmler C, Napolitano JG, van Breemen RB, Lankin DC, McAlpine JB, Pauli GF, Chen S. K-targeted metabolomic analysis extends chemical subtraction to DESIGNER extracts: selective depletion of extracts of hops (Humulus lupulus).. Journal of natural products. 2014;77(12):2595-604. doi:10.1021/np500376g.
  • Moyano AL, Li G, Lopez-Rosas A, Månsson JE, van Breemen RB, Givogri MI. Distribution of C16:0, C18:0, C24:1, and C24:0 sulfatides in central nervous system lipid rafts by quantitative ultra-high-pressure liquid chromatography tandem mass spectrometry.. Analytical biochemistry. 2014;467:31-9. doi:10.1016/j.ab.2014.08.033.
  • Nikolić D, Li J, van Breemen RB. Metabolism of Nω -methylserotonin, a serotonergic constituent of black cohosh (Cimicifuga racemosa, L. (Nutt.)), by human liver microsomes.. Biomedical chromatography : BMC. 2014;28(12):1647-51. doi:10.1002/bmc.3197.
  • van Breemen RB, Yuan YP, Banuvar SF, Shulman L, Qiu XM, Alvarenga RL, Chen SF, Dietz BC, Bolton JS, Pauli G, Krause E, Viana M, Nikolic D. Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops.. Molecular nutrition & food research. 2014;58(10):1962-9. doi:10.1002/mnfr.201400245.
  • Simmler C, Nikolic DS, Lankin DC, Yu Y, Friesen JB, van Breemen RB, Lecomte AF, Le Quémener C, Audo G, Pauli G. Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice.. Journal of natural products. 2014;77(8):1806-16. doi:10.1021/np5001945.
  • Simmler C, Nikolić D, Lankin DC, Yu Y, van Breemen RB, Lecomte A, Le Quémener C, Audo G, Pauli GF. Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice.. Journal of natural products. 2014;. doi:10.1021/np5001945.
  • García ME, Nicotra VE, Oberti JC, Ríos-Luci C, León LG, Marler L, Li G, Pezzuto JM, van Breemen RB, Padrón JM, Hueso-Falcón I, Estévez-Braun A. Antiproliferative and quinone reductase-inducing activities of withanolides derivatives.. European journal of medicinal chemistry. 2014;82:68-81. doi:10.1016/j.ejmech.2014.05.045.
  • Newsome AG, Culver CA, van Breemen RB. Nature’s palette: the search for natural blue colorants.. Journal of agricultural and food chemistry. 2014;62(28):6498-511. doi:10.1021/jf501419q.
  • Simmler C, Jones TR, Anderson JS, Nikolic DB, van Breemen RD, Soejarto D, Chen SF, Pauli G. Species-specific Standardisation of Licorice by Metabolomic Profiling of Flavanones and Chalcones.. Phytochemical analysis : PCA. 2014;25(4):378-88.
  • Simmler C, Jones T, Anderson JR, Nikolić DC, van Breemen RB, Soejarto DD, Chen S, Pauli GF. Species-specific Standardisation of Licorice by Metabolomic Profiling of Flavanones and Chalcones.. Phytochemical analysis : PCA. 2014;25(4):378-88.
  • Krause EC, Yuan Y, Hajirahimkhan A, Dong HM, Dietz BS, Nikolic DF, Pauli GL, Bolton JB, van Breemen R. Biological and chemical standardization of a hop (Humulus lupulus) botanical dietary supplement.. Biomedical chromatography : BMC. 2014;28(6):729-34. doi:10.1002/bmc.3177.
  • Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V, Vom Saal FS, Woodruff TJ. A round robin approach to the analysis of bisphenol A (BPA) in human blood samples.. Environmental health : a global access science source. 2014;13(1):25. doi:10.1186/1476-069X-13-25.
  • Yu LF, Brek Eaton J, Zhang HK, Sabath E, Hanania T, Li GN, van Breemen RB, Whiteaker P, Liu Q, Wu J, Chang YC, Lukas RJ, Brunner D, Kozikowski AP. The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile.. Pharmacology research & perspectives. 2014;2(2):e00026. doi:10.1002/prp2.26.
  • Yuan Y, Qiu X, Nikolić D, Chen S, Huang KG, Li G, Pauli GF, van Breemen RB. Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2014;53:55-61. doi:10.1016/j.ejps.2013.12.003.
  • Prins GS, Hu WY, Shi GB, , Majumdar S, Li G, Huang KG, Nelles JL, Ho SM, Walker CL, Kajdacsy-Balla A, van Breemen RB. Bisphenol A promotes human prostate stem-progenitor cell self-renewal and increases in vivo carcinogenesis in human prostate epithelium.. Endocrinology. 2014;155(3):805-17. doi:10.1210/en.2013-1955.
  • Van Loo-Bouwman CA, Naber TH, Minekus M, van Breemen RB, Hulshof PJ, Schaafsma G. Food matrix effects on bioaccessibility of β-carotene can be measured in an in vitro gastrointestinal model.. Journal of agricultural and food chemistry. 2014;62(4):950-5. doi:10.1021/jf403312v.
  • Karalius VP, Harbison JE, Plange-Rhule J, van Breemen RB, Li G, Huang KG, Durazo-Arvizu RA, Mora N, Dugas LR, Vail L, Tuchman NC, Forrester T, Luke A. Bisphenol A (BPA) Found in Humans and Water in Three Geographic Regions with Distinctly Different Levels of Economic Development.. Environmental health insights. 2014;8:1-3. doi:10.4137/EHI.S13130.
  • Dong SH, Cai G, Napolitano JG, Nikolić D, Lankin DC, , van Breemen RB, Soejarto DD, Pauli GF, Chen S. Lipidated steroid saponins from Dioscorea villosa (wild yam).. Fitoterapia. 2013;91:113-24. doi:10.1016/j.fitote.2013.07.018.
  • Abdelkarim H, Brunsteiner M, Neelarapu R, Bai H, Madriaga A, van Breemen RB, Blond SY, Gaponenko V, Petukhov PA. Photoreactive “nanorulers” detect a novel conformation of full length HDAC3-SMRT complex in solution.. ACS chemical biology. 2013;8(11):2538-49. doi:10.1021/cb400601g.
  • Andreani A, Leoni A, Locatelli A, Morigi R, Rambaldi M, Cervellati R, Greco E, Kondratyuk TP, Park EJ, Huang KG, van Breemen RB, Pezzuto JM. Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.. European journal of medicinal chemistry. 2013;68:412-21. doi:10.1016/j.ejmech.2013.07.052.
  • Eilati E, Hales K, Zhuge Y, Ansenberger Fricano K, Yu R, van Breemen RB, Hales DB. Flaxseed enriched diet-mediated reduction in ovarian cancer severity is correlated to the reduction of prostaglandin E(2) in laying hen ovaries.. Prostaglandins, leukotrienes, and essential fatty acids. 2013;89(4):179-87. doi:10.1016/j.plefa.2013.08.001.
  • Mo S, Dong L, Hurst WJ, van Breemen RB. Quantitative analysis of phytosterols in edible oils using APCI liquid chromatography-tandem mass spectrometry.. Lipids. 2013;48(9):949-56. doi:10.1007/s11745-013-3813-3.
  • Hajirahimkhan A, Simmler C, Yuan YR, Anderson J, Chen SS, Nikolic DM, Dietz BF, Pauli GB, van Breemen RL, Bolton J. Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms.. PloS one. 2013;8(7):e67947. doi:10.1371/journal.pone.0067947.
  • Hajirahimkhan A, Simmler C, Yuan YR, Anderson J, Chen SM, Nikolić DF, Dietz BB, Pauli GL, van Breemen R, Bolton J. Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms.. PloS one. 2013;8(7):e67947. doi:10.1371/journal.pone.0067947.
  • Kabirov KK, Kapetanovic IM, Benbrook DM, Dinger N, Mankovskaya I, Zakharov A, Detrisac C, Pereira M, Martín-Jiménez T, Onua E, Banerjee A, van Breemen RB, Nikolić D, , Lyubimov AV. Oral toxicity and pharmacokinetic studies of SHetA2, a new chemopreventive agent, in rats and dogs.. Drug and chemical toxicology. 2013;36(3):284-95. doi:10.3109/01480545.2012.710632.
  • Dietz BM, Hagos GK, Eskra JN, Wijewickrama GT, Anderson JR, Nikolic DS, Guo JJ, Wright B, Chen SF, Pauli GB, van Breemen RL, Bolton J. Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo.. Molecular nutrition & food research. 2013;57(6):1055-66. doi:10.1002/mnfr.201200534.
  • Jana A, Modi KK, Roy A, Anderson JA, van Breemen RB, Pahan K. Up-regulation of neurotrophic factors by cinnamon and its metabolite sodium benzoate: therapeutic implications for neurodegenerative disorders.. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2013;8(3):739-55. doi:10.1007/s11481-013-9447-7.
  • Qiu X, Yuan Y, Vaishnav A, Tessel MA, Nonn L, van Breemen RB. Effects of lycopene on protein expression in human primary prostatic epithelial cells.. Cancer prevention research (Philadelphia, Pa.). 2013;6(5):419-27. doi:10.1158/1940-6207.CAPR-12-0364.
  • van Breemen RB. Robert J. Cotter (1943-2012).. Journal of the American Society for Mass Spectrometry. 2013;24(5):655-6. doi:10.1007/s13361-013-0611-3.
  • Gaba RC, Yap FY, Martinez EM, Li Y, Guzman G, Parvinian A, van Breemen RB, Kumar N. Transarterial sorafenib chemoembolization: preliminary study of technical feasibility in a rabbit model.. Journal of vascular and interventional radiology : JVIR. 2013;24(5):744-50. doi:10.1016/j.jvir.2013.01.488.
  • Conda-Sheridan M, Park EJ, Beck DE, Reddy PV, Nguyen TX, Hu B, , White JJ, van Breemen RB, Pezzuto JM, Cushman M. Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential.. Journal of medicinal chemistry. 2013;56(6):2581-605. doi:10.1021/jm400026k.
  • Nikolić D, van Breemen RB. Analytical methods for quantitation of prenylated flavonoids from hops.. Current analytical chemistry. 2013;9(1):71-85.
  • Yu R, Zhao G, Christman JW, Xiao L, van Breemen RB. Method development and validation for ultra-high pressure liquid chromatography/tandem mass spectrometry determination of multiple prostanoids in biological samples.. Journal of AOAC International. 2013;96(1):67-76.
  • Yuan Y, Yu LF, Qiu X, Kozikowski AP, van Breemen RB. Pharmacokinetics and brain penetration of LF-3-88, (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol), a selective α4β2-nAChR partial agonist and promising antidepressant.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013;912:38-42. doi:10.1016/j.jchromb.2012.11.011.
  • Zhao G, Yu R, Deng J, Zhao Q, Li Y, Joo M, van Breemen RB, Christman JW, Xiao L. Pivotal role of reactive oxygen species in differential regulation of lipopolysaccharide-induced prostaglandins production in macrophages.. Molecular pharmacology. 2013;83(1):167-78. doi:10.1124/mol.112.080762.
  • Dong SH, Nikolic DS, Simmler C, Qiu FB, van Breemen RD, Soejarto DF, Pauli G, Chen S. Diarylheptanoids from Dioscorea villosa (Wild Yam).. Journal of natural products. 2012;75(12):2168-77. doi:10.1021/np300603z.
  • Dong SH, Nikolić D, Simmler C, Qiu F, van Breemen RB, Soejarto DD, Pauli GF, Chen S. Diarylheptanoids from Dioscorea villosa (Wild Yam).. Journal of natural products. 2012;75(12):2168-77. doi:10.1021/np300603z.
  • Cinelli MA, Reddy PV, Lv PC, Liang JH, , Agama K, Pommier Y, van Breemen RB, Cushman M. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons.. Journal of medicinal chemistry. 2012;55(24):10844-62. doi:10.1021/jm300519w.
  • Baumgarten S, Gaba RC, van Breemen RB. Confirmation of drug delivery after liver chemoembolization: direct tissue doxorubicin measurement by UHPLC-MS-MS.. Biomedical chromatography : BMC. 2012;26(12):1529-33. doi:10.1002/bmc.2727.
  • Yuan Y, Qiu X, Nikolic DS, Dahl JH, van Breemen RB. Method development and validation for ultra-high-pressure LC/MS/MS determination of hop prenylflavonoids in human serum.. Journal of AOAC International. 2012;95(6):1744-9.
  • Vaidya AS, Neelarapu R, Madriaga A, Bai H, Mendonca E, Abdelkarim H, van Breemen RB, Blond SY, Petukhov PA. Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an ‘upside-down’ binding pose.. Bioorganic & medicinal chemistry letters. 2012;22(21):6621-7. doi:10.1016/j.bmcl.2012.08.104.
  • Vaidya AS, Karumudi B, Mendonca E, Madriaga A, Abdelkarim H, van Breemen RB, Petukhov PA. Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2.. Bioorganic & medicinal chemistry letters. 2012;22(15):5025-30. doi:10.1016/j.bmcl.2012.06.017.
  • Zhu H, Lopez-Rosas A, Qiu X, van Breemen RB, Bongarzone ER. (2012). Detection of the neurotoxin psychosine in samples of peripheral blood: application in diagnostics and follow-up of Krabbe disease.. Archives of pathology & laboratory medicine. Vol. 136. Issue 7. Page(s) 709-10.
  • Chen L, Conda-Sheridan M, Reddy PV, Morrell A, Park EJ, Kondratyuk TP, Pezzuto JM, van Breemen RB, Cushman M. Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3′-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.. Journal of medicinal chemistry. 2012;55(12):5965-81. doi:10.1021/jm3006806.
  • Al-Alem U, Gann PH, Dahl J, van Breemen RB, Mistry V, Lam PM, Evans MD, Van Horn L, Wright ME. Associations between functional polymorphisms in antioxidant defense genes and urinary oxidative stress biomarkers in healthy, premenopausal women.. Genes & nutrition. 2012;7(2):191-5. doi:10.1007/s12263-011-0257-3.
  • Nikolić D, Gödecke T, Chen S, White J, Lankin DC, Pauli GF, van Breemen RB. Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.).. Fitoterapia. 2012;83(3):441-60. doi:10.1016/j.fitote.2011.12.006.
  • van Breemen RB, Dong L, Pajkovic ND. Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry of Carotenoids.. International journal of mass spectrometry. 2012;312:163-172. doi:10.1016/j.ijms.2011.07.030.
  • Gaba RC, Baumgarten S, Omene BO, van Breemen RB, Garcia KD, Larson AC, Omary RA. Ethiodized oil uptake does not predict doxorubicin drug delivery after chemoembolization in VX2 liver tumors.. Journal of vascular and interventional radiology : JVIR. 2012;23(2):265-73. doi:10.1016/j.jvir.2011.10.022.
  • Kondratyuk TP, Park EJ, Yu R, van Breemen RB, Asolkar RN, Murphy BT, Fenical W, Pezzuto JM. Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents.. Marine drugs. 2012;10(2):451-64. doi:10.3390/md10020451.
  • Hu C, Nikolic DS, Eggler AL, Mesecar AD, van Breemen RB. Screening for natural chemoprevention agents that modify human Keap1.. Analytical biochemistry. 2012;421(1):108-14. doi:10.1016/j.ab.2011.10.028.
  • Gödecke TG, Yao PM, Napolitano JL, Nikolić DB, Dietz BR, Bolton J, van Breemen RC, Farnsworth NF, Chen S, Lankin D, Pauli G. Integrated standardization concept for Angelica botanicals using quantitative NMR.. Fitoterapia. 2012;83(1):18-32. doi:10.1016/j.fitote.2011.08.017.
  • Yu R, Xiao L, Zhao G, Christman JW, van Breemen RB. Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2.. The Journal of pharmacology and experimental therapeutics. 2011;339(2):716-25. doi:10.1124/jpet.111.185405.
  • Li J, Gödecke T, Chen S, Imai A, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Nikolić D. In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4.. Xenobiotica; the fate of foreign compounds in biological systems. 2011;. doi:10.3109/00498254.2011.603385.
  • Kondratyuk TP, Park EJ, Marler LE, Ahn S, Yuan Y, Choi Y, Yu R, van Breemen RB, Sun B, Hoshino J, Cushman M, Jermihov KC, Mesecar AD, Grubbs CJ, Pezzuto JM. Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity.. Molecular nutrition & food research. 2011;55(8):1249-65. doi:10.1002/mnfr.201100122.
  • Chen S, Webster D, Nikolic DS, van Breemen RB, Wang Z, Fong HH, Farnsworth NR, Pauli GF. Phytoconstituents from Vitex agnus-castus fruits.. Fitoterapia. 2011;82(4):528-33. doi:10.1016/j.fitote.2010.12.003.
  • van Breemen RB, Sharifi R, Viana M, Pajkovic N, Zhu D, Yuan L, Yang Y, Bowen PE, Stacewicz-Sapuntzakis M. Antioxidant effects of lycopene in African American men with prostate cancer or benign prostate hyperplasia: a randomized, controlled trial.. Cancer prevention research (Philadelphia, Pa.). 2011;4(5):711-8. doi:10.1158/1940-6207.CAPR-10-0288.
  • Hu C, Eggler AL, Mesecar AD, van Breemen RB. Modification of keap1 cysteine residues by sulforaphane.. Chemical research in toxicology. 2011;24(4):515-21. doi:10.1021/tx100389r.
  • Park EJ, Kondratyuk TP, Morrell A, Kiselev E, Conda-Sheridan M, Cushman M, Ahn S, Choi Y, White JJ, van Breemen RB, Pezzuto JM. Induction of retinoid X receptor activity and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells.. Cancer prevention research (Philadelphia, Pa.). 2011;4(4):592-607. doi:10.1158/1940-6207.CAPR-10-0004.
  • Yang JH, Kondratyuk TP, Jermihov KC, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy M, Huang R, , Wang LQ, Mesecar AD, van Breemen RB, Pezzuto JM, Fong HH, Chen YG, Zhang HJ. Bioactive compounds from the fern Lepisorus contortus.. Journal of natural products. 2011;74(2):129-36. doi:10.1021/np100373f.
  • Choi Y, Jermihov K, Nam SJ, Sturdy M, Maloney K, Qiu X, Chadwick LR, Main M, Chen S, Mesecar AD, Farnsworth NR, Pauli GF, Fenical W, Pezzuto JM, van Breemen RB. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS.. Analytical chemistry. 2011;83(3):1048-52. doi:10.1021/ac1028424.
  • Cao H, Yu R, Tao Y, Nikolic DS, van Breemen RB. Measurement of cyclooxygenase inhibition using liquid chromatography-tandem mass spectrometry.. Journal of pharmaceutical and biomedical analysis. 2011;54(1):230-5. doi:10.1016/j.jpba.2010.08.001.
  • van Breemen RB, Tao Y, Li W. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale).. Fitoterapia. 2011;82(1):38-43. doi:10.1016/j.fitote.2010.09.004.
  • Dong L, Shion H, Davis RG, Terry-Penak B, Castro-Perez J, van Breemen RB. Collision cross-section determination and tandem mass spectrometric analysis of isomeric carotenoids using electrospray ion mobility time-of-flight mass spectrometry.. Analytical chemistry. 2010;82(21):9014-21. doi:10.1021/ac101974g.
  • Dahl JH, van Breemen RB. Rapid quantitative analysis of 8-iso-prostaglandin-F(2alpha) using liquid chromatography-tandem mass spectrometry and comparison with an enzyme immunoassay method.. Analytical biochemistry. 2010;404(2):211-6. doi:10.1016/j.ab.2010.05.023.
  • Wang Z, Chandrasena ER, Yuan YW, Peng KB, van Breemen RR, Thatcher GL, Bolton J. Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens.. Chemical research in toxicology. 2010;23(8):1365-73. doi:10.1021/tx1001282.
  • Hoshino J, Park EJ, Kondratyuk TP, Marler L, Pezzuto JM, van Breemen RB, Mo S, Li Y, Cushman M. Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.. Journal of medicinal chemistry. 2010;53(13):5033-43. doi:10.1021/jm100274c.
  • Bolca S, Li J, Nikolic DS, Roche N, Blondeel P, Possemiers S, De Keukeleire D, Bracke M, Heyerick A, van Breemen RB, Depypere H. Disposition of hop prenylflavonoids in human breast tissue.. Molecular nutrition & food research. 2010;54 Suppl 2:S284-94. doi:10.1002/mnfr.200900519.
  • Guo J, Peng D, Dai Q, Liao S, Wright BJ, van Breemen RB. Quantitative analysis of 3alpha,6alpha,24-trihydroxy-24,24-di(trifluoromethyl)-5beta-cholane, a potent synthetic steroidal liver X receptor agonist in plasma using liquid chromatography-tandem mass spectrometry.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010;878(21):1885-8. doi:10.1016/j.jchromb.2010.05.009.
  • Cao H, Yu R, Choi Y, Ma ZZ, Zhang H, Xiang W, Lee DY, Berman BM, Moudgil KD, Fong HH, van Breemen RB. Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.. Pharmacological research : the official journal of the Italian Pharmacological Society. 2010;61(6):519-24. doi:10.1016/j.phrs.2010.02.007.
  • Van Loo-Bouwman CA, Naber TH, van Breemen RB, Zhu D, Dicke H, Siebelink E, Hulshof PJ, Russel FG, Schaafsma G, West CE. Vitamin A equivalency and apparent absorption of beta-carotene in ileostomy subjects using a dual-isotope dilution technique.. The British journal of nutrition. 2010;103(12):1836-43. doi:10.1017/S0007114509993849.
  • Yang JH, Kondratyuk TP, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy M, Pegan S, , Wang LQ, Mesecar AD, van Breemen RB, Pezzuto JM, Fong HH, Chen YG, Zhang HJ. Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata.. Phytochemistry. 2010;71(5-6):641-7. doi:10.1016/j.phytochem.2010.01.002.
  • Cuendet M, Guo J, Luo Y, Chen S, Oteham CP, Moon RC, van Breemen RB, Marler LE, Pezzuto JM. Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice.. Cancer prevention research (Philadelphia, Pa.). 2010;3(2):221-32. doi:10.1158/1940-6207.CAPR-09-0049.
  • van Breemen RB, Liang WP, Banuvar S, Shulman LS, Pang YM, Tao Y, Nikolic DL, Krock KF, Chen SE, Hedayat SC, Bolton JE, Pauli GR, Piersen C, Krause E, Geller S, Farnsworth N. Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh.. Clinical pharmacology and therapeutics. 2010;87(2):219-25. doi:10.1038/clpt.2009.251.
  • Mao J, Yuan HB, Wang YP, Wan BG, Pieroni M, Huang Q, van Breemen R, Kozikowski A, Franzblau S. From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters.. Journal of medicinal chemistry. 2009;52(22):6966-78. doi:10.1021/jm900340a.
  • Tao Y, Li W, Liang W, van Breemen RB. Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry.. Journal of agricultural and food chemistry. 2009;57(21):10014-21. doi:10.1021/jf9020224.
  • Geller SE, Shulman LP, van Breemen RB, Banuvar SS, Zhou YC, Epstein GE, Hedayat SL, Nikolic DF, Krause ER, Piersen C, Bolton J, Pauli G, Farnsworth N. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial.. Menopause (New York, N.Y.). 2009;16(6):1156-66. doi:10.1097/gme.0b013e3181ace49b.
  • Calderón AI, Wright BJ, Hurst WJ, van Breemen RB. Screening antioxidants using LC-MS: case study with cocoa.. Journal of agricultural and food chemistry. 2009;57(13):5693-9. doi:10.1021/jf9014203.
  • Van Loo-Bouwman CA, West CE, van Breemen RB, Zhu D, Siebelink E, Versloot P, Hulshof PJ, van Lieshout M, Russel FG, Schaafsma G, Naber TH. Vitamin A equivalency of beta-carotene in healthy adults: limitation of the extrinsic dual-isotope dilution technique to measure matrix effect.. The British journal of nutrition. 2009;101(12):1837-45. doi:10.1017/S0007114508131762.
  • Wang Z, Wijewickrama GT, Peng KW, Dietz BM, Yuan LB, van Breemen RL, Bolton JR, Thatcher G. Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus.. The Journal of biological chemistry. 2009;284(13):8633-42. doi:10.1074/jbc.M807860200.
  • Gödecke T, Lankin DC, Nikolic DS, Chen S, van Breemen RB, Farnsworth NR, Pauli GF. Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa).. Journal of natural products. 2009;72(3):433-7. doi:10.1021/np8006952.
  • Gödecke TS, Nikolic DC, Lankin D, Chen SL, Powell SM, Dietz BL, Bolton JB, van Breemen RR, Farnsworth NF, Pauli G. Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.. Phytochemical analysis : PCA. 2009;20(2):120-33. doi:10.1002/pca.1106.
  • Qin ZT, Kastrati ID, Ashgodom RR, Lantvit DB, Overk CL, Choi YR, van Breemen R, Bolton J, Thatcher G. Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators.. Drug metabolism and disposition: the biological fate of chemicals. 2009;37(1):161-9. doi:10.1124/dmd.108.023408.
  • Powell SL, Gödecke TS, Nikolic D, Chen SM, Ahn SR, Dietz BB, Farnsworth NC, van Breemen RF, Lankin DL, Pauli G, Bolton J. In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent.. Journal of agricultural and food chemistry. 2008;56(24):11718-26. doi:10.1021/jf803298z.
  • Overk CR, Guo JR, Chadwick LD, Lantvit D, Minassi AC, Appendino GR, Chen SF, Lankin DB, Farnsworth NL, Pauli G, van Breemen R, Bolton J. In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.. Chemico-biological interactions. 2008;176(1):30-9. doi:10.1016/j.cbi.2008.06.005.
  • van Breemen RB, Pajkovic N. Multitargeted therapy of cancer by lycopene.. Cancer letters. 2008;269(2):339-51. doi:10.1016/j.canlet.2008.05.016.
  • Dietz BM, Liu DK, Hagos GM, Yao PR, Schinkovitz AF, Pro SB, Deng SL, Farnsworth N, Pauli G, van Breemen R, Bolton J. Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1.. Chemical research in toxicology. 2008;21(10):1939-48. doi:10.1021/tx8001274.
  • Guo J, Liu A, Cao H, Luo Y, Pezzuto JM, van Breemen RB. Biotransformation of the chemopreventive agent 2′,4′,4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases.. Drug metabolism and disposition: the biological fate of chemicals. 2008;36(10):2104-12. doi:10.1124/dmd.108.021857.
  • Ding SL, Wang YB, Kolbanovskiy AE, Durandin A, Bolton J, van Breemen R, Broyde S, Geacintov N. Determination of absolute configurations of 4-hydroxyequilenin-cytosine and -adenine adducts by optical rotatory dispersion, electronic circular dichroism, density functional theory calculations, and mass spectrometry.. Chemical research in toxicology. 2008;21(9):1739-48. doi:10.1021/tx800095f.
  • Chen S, Turner A, Jaki BU, Nikolic DS, van Breemen RB, Pauli GF. An experimental implementation of chemical subtraction.. Journal of pharmaceutical and biomedical analysis. 2008;46(4):692-8. doi:10.1016/j.jpba.2007.12.014.
  • van Breemen RB, Fong HH, Farnsworth NR. Ensuring the safety of botanical dietary supplements.. The American journal of clinical nutrition. 2008;87(2):509S-13S.
  • Guo J, Liu D, Nikolic DS, Zhu D, Pezzuto JM, van Breemen RB. In vitro metabolism of isoliquiritigenin by human liver microsomes.. Drug metabolism and disposition: the biological fate of chemicals. 2008;36(2):461-8. doi:10.1124/dmd.107.018721.
  • Barnes S, Birt DF, Cassileth BR, Cefalu WT, Chilton FH, Farnsworth NR, Raskin I, van Breemen RB, Weaver CM. Technologies and experimental approaches at the National Institutes of Health Botanical Research Centers.. The American journal of clinical nutrition. 2008;87(2):476S-80S.
  • Farnsworth NR, Krause EC, Bolton JL, Pauli GF, van Breemen RB, Graham JG. The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women’s Health: from plant to clinical use.. The American journal of clinical nutrition. 2008;87(2):504S-8S.
  • Cao H, Xiao L, Park G, Wang X, Azim AC, Christman JW, van Breemen RB. An improved LC-MS/MS method for the quantification of prostaglandins E(2) and D(2) production in biological fluids.. Analytical biochemistry. 2008;372(1):41-51. doi:10.1016/j.ab.2007.08.041.
  • Choi Y, van Breemen RB. Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS.. Combinatorial chemistry & high throughput screening. 2008;11(1):1-6.
  • Liu D, Guo J, Luo Y, Broderick DJ, Schimerlik MI, Pezzuto JM, van Breemen RB. Screening for ligands of human retinoid X receptor-alpha using ultrafiltration mass spectrometry.. Analytical chemistry. 2007;79(24):9398-402. doi:10.1021/ac701701k.
  • Eggler AL, Luo Y, van Breemen RB, Mesecar AD. Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent.. Chemical research in toxicology. 2007;20(12):1878-84. doi:10.1021/tx700217c.
  • Azim AC, Wang X, Park GY, Sadikot RT, Cao H, Mathew B, Atchison M, van Breemen RB, Joo M, Christman JW. NF-kappaB-inducing kinase regulates cyclooxygenase 2 gene expression in macrophages by phosphorylation of PU.1.. Journal of immunology (Baltimore, Md. : 1950). 2007;179(11):7868-75.
  • Luo Y, Eggler AL, Liu D, Liu G, Mesecar AD, van Breemen RB. Sites of alkylation of human Keap1 by natural chemoprevention agents.. Journal of the American Society for Mass Spectrometry. 2007;18(12):2226-32. doi:10.1016/j.jasms.2007.09.015.
  • Azim AC, Cao H, Gao X, Joo M, Malik AB, van Breemen RB, Sadikot RT, Park G, Christman JW. Regulation of cyclooxygenase-2 expression by small GTPase Rac2 in bone marrow macrophages.. American journal of physiology. Lung cellular and molecular physiology. 2007;293(3):L668-73. doi:10.1152/ajplung.00043.2007.
  • Pang Y, Nikolic DS, Zhu D, Chadwick LR, Pauli GF, Farnsworth NR, van Breemen RB. Binding of the hop (Humulus lupulus L.) chalcone xanthohumol to cytosolic proteins in Caco-2 intestinal epithelial cells.. Molecular nutrition & food research. 2007;51(7):872-9. doi:10.1002/mnfr.200600252.
  • Chen S, Lankin DC, Nikolic DS, Lu ZZ, Ramirez B, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. Chlorination diversifies Cimicifuga racemosa triterpene glycosides.. Journal of natural products. 2007;70(6):1016-23. doi:10.1021/np0700319.
  • Mathew B, Park GY, Cao H, Azim AC, Wang X, van Breemen RB, Sadikot RT, Christman JW. Inhibitory kappaB kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages.. American journal of respiratory cell and molecular biology. 2007;36(5):562-72. doi:10.1165/rcmb.2006-0245OC.
  • Goo YA, Li Z, Pajkovic N, Shaffer S, Taylor G, Chen J, Campbell D, Arnstein L, Goodlett DR, van Breemen RB. Systematic investigation of lycopene effects in LNCaP cells by use of novel large-scale proteomic analysis software.. Proteomics. Clinical applications. 2007;1(5):513-523. doi:10.1002/prca.200600511.
  • van Breemen RB, Fong HH, Farnsworth NR. The role of quality assurance and standardization in the safety of botanical dietary supplements.. Chemical research in toxicology. 2007;20(4):577-82. doi:10.1021/tx7000493.
  • Wang Z, Yuan H, Nikolic DS, van Breemen RB, Silverman RB. (+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway.. Biochemistry. 2006;45(48):14513-22. doi:10.1021/bi061592m.
  • Kapetanovic IM, Krishnaraj R, Martin-Jimenez T, Yuan L, van Breemen RB, Lyubimov A. Effects of oral dosing paradigms (gavage versus diet) on pharmacokinetics and pharmacodynamics.. Chemico-biological interactions. 2006;164(1-2):68-75. doi:10.1016/j.cbi.2006.08.019.
  • Melse-Boonstra A, Verhoef P, West CE, van Rhijn JA, van Breemen RB, Lasaroms JJ, Garbis SD, Katan MB, Kok FJ. A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses.. The American journal of clinical nutrition. 2006;84(5):1128-33.
  • Liu A, Pajkovic N, Pang Y, Zhu D, Calamini B, Mesecar AL, van Breemen RB. Absorption and subcellular localization of lycopene in human prostate cancer cells.. Molecular cancer therapeutics. 2006;5(11):2879-85. doi:10.1158/1535-7163.MCT-06-0373.
  • Deng S, Chen S, Lu JS, Wang ZB, Nikolic DD, van Breemen RH, Santarsiero BR, Mesecar AF, Fong H, Farnsworth N, Pauli G. GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels.. Phytochemical analysis : PCA. 2006;17(6):398-405.
  • Deng S, Chen S, Lu J, Wang Z, Nikolic DS, van Breemen RB, Santarsiero BD, Mesecar A, Fong HH, Farnsworth NR, Pauli GF. GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels.. Phytochemical analysis : PCA. 2006;17(6):398-405.
  • Guo J, Nikolic DS, Chadwick LR, Pauli GF, van Breemen RB. Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.).. Drug metabolism and disposition: the biological fate of chemicals. 2006;34(7):1152-9. doi:10.1124/dmd.105.008250.
  • Nikolic DS, Li Y, Chadwick LR, van Breemen RB. In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.).. Pharmaceutical research. 2006;23(5):864-72. doi:10.1007/s11095-006-9902-8.
  • Mallavadhani UV, Narasimhan K, Sudhakar AV, Mahapatra A, Li W, van Breemen RB. Three new pentacyclic triterpenes and some flavonoids from the fruits of an Indian Ayurvedic plant Dendrophthoe falcata and their estrogen receptor binding activity.. Chemical & pharmaceutical bulletin. 2006;54(5):740-4.
  • Deng S, Chen SS, Yao PB, Nikolic DL, van Breemen RH, Bolton JR, Fong HF, Farnsworth N, Pauli G. Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.. Journal of natural products. 2006;69(4):536-41. doi:10.1021/np050301s.
  • Booth NL, Overk CR, Yao PE, Burdette JS, Nikolic D, Chen SL, Bolton JB, van Breemen RF, Pauli GR, Farnsworth N. The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract.. Journal of alternative and complementary medicine (New York, N.Y.). 2006;12(2):133-9. doi:10.1089/acm.2006.12.133.
  • Zhu D, Wang Y, Pang Y, Liu A, Guo J, Bouwman CA, West CE, van Breemen RB. Quantitative analyses of beta-carotene and retinol in serum and feces in support of clinical bioavailability studies.. Rapid communications in mass spectrometry : RCM. 2006;20(16):2427-32. doi:10.1002/rcm.2601.
  • Li YB, Yang XL, van Breemen R, Bolton J. Characterization of two new variants of human catechol O-methyltransferase in vitro.. Cancer letters. 2005;230(1):81-9. doi:10.1016/j.canlet.2004.12.022.
  • Cheng X, van Breemen RB. Mass spectrometry-based screening for inhibitors of beta-amyloid protein aggregation.. Analytical chemistry. 2005;77(21):7012-5. doi:10.1021/ac050556a.
  • Liu GL, Eggler AM, Dietz BD, Mesecar AL, Bolton JM, Pezzuto JB, van Breemen R. Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1.. Analytical chemistry. 2005;77(19):6407-14. doi:10.1021/ac050892r.
  • Liu JB, Li QL, Yang XR, van Breemen R, Bolton J, Thatcher G. Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study.. Chemical research in toxicology. 2005;18(9):1485-96. doi:10.1021/tx0501738.
  • Overk CR, Yao PR, Chadwick LS, Nikolic DK, Ajayi OA, Cuendet MS, Deng YF, Hedayat AR, Pauli GB, Farnsworth NL, van Breemen R, Bolton J. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense).. Journal of agricultural and food chemistry. 2005;53(16):6246-53. doi:10.1021/jf050448p.
  • van Breemen RB, Li Y. Caco-2 cell permeability assays to measure drug absorption.. Expert opinion on drug metabolism & toxicology. 2005;1(2):175-85. doi:10.1517/17425255.1.2.175.
  • Nikolic DS, Lankin DC, Chen S, Jaki BU, Krunic A, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa.. Journal of natural products. 2005;68(8):1266-70. doi:10.1021/np050066d.
  • van Breemen RB. How do intermediate endpoint markers respond to lycopene in men with prostate cancer or benign prostate hyperplasia?. The Journal of nutrition. 2005;135(8):2062S-4S.
  • Chow AW, Murillo G, Yu C, van Breemen RB, Boddie AW, Pezzuto JM, Das Gupta TK, Mehta RG. Resveratrol inhibits rhabdomyosarcoma cell proliferation.. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2005;14(4):351-6.
  • Dietz BM, Kang YH, Liu GL, Eggler AR, Yao PF, Chadwick LR, Pauli GD, Farnsworth NB, Mesecar AL, van Breemen R, Bolton J. Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.. Chemical research in toxicology. 2005;18(8):1296-305. doi:10.1021/tx050058x.
  • Eggler AL, Liu G, Pezzuto JM, van Breemen RB, Mesecar AD. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2.. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(29):10070-5. doi:10.1073/pnas.0502402102.
  • Li YD, Yang XB, Chang ML, Yager J, van Breemen R, Bolton J. Functional and structural comparisons of cysteine residues in the Val108 wild type and Met108 variant of human soluble catechol O-methyltransferase.. Chemico-biological interactions. 2005;152(2-3):151-63. doi:10.1016/j.cbi.2005.03.001.
  • Sun Y, Li W, Fitzloff JF, van Breemen RB. Liquid chromatography/electrospray tandem mass spectrometry of terpenoid lactones in Ginkgo biloba.. Journal of mass spectrometry : JMS. 2005;40(3):373-9. doi:10.1002/jms.795.
  • Nikolic DS, Li Y, Chadwick LR, Pauli GF, van Breemen RB. Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes.. Journal of mass spectrometry : JMS. 2005;40(3):289-99. doi:10.1002/jms.753.
  • Constantinou AI, White B, Tonetti D, Yang Y, Liang W, Li W, van Breemen RB. The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours.. European journal of cancer (Oxford, England : 1990). 2005;41(4):647-54. doi:10.1016/j.ejca.2004.12.005.
  • Liu JB, Liu HR, van Breemen RL, Thatcher G, Bolton J. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides.. Chemical research in toxicology. 2005;18(2):174-82. doi:10.1021/tx0497752.
  • Liu HB, Liu JR, van Breemen RL, Thatcher G, Bolton J. Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4′-fluoro substitution prevents quinoid formation.. Chemical research in toxicology. 2005;18(2):162-73. doi:10.1021/tx049776u.
  • Sun YL, Gu CB, Liu X, Liang W, Yao P, Bolton J, van Breemen R. Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors.. Journal of the American Society for Mass Spectrometry. 2005;16(2):271-9. doi:10.1016/j.jasms.2004.11.002.
  • Zhu Y, Nikolic DS, van Breemen RB, Silverman RB. Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification.. Journal of the American Chemical Society. 2005;127(3):858-68. doi:10.1021/ja0445645.
  • Kobayashi T, Yang X, Walker LA, van Breemen RB, Solaro RJ. A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C.. Journal of molecular and cellular cardiology. 2005;38(1):213-8. doi:10.1016/j.yjmcc.2004.10.014.
  • Booth NL, Nikolic DS, van Breemen RB, Geller SE, Banuvar S, Shulman LP, Farnsworth NR. Confusion regarding anticoagulant coumarins in dietary supplements.. Clinical pharmacology and therapeutics. 2004;76(6):511-6. doi:10.1016/j.clpt.2004.08.023.
  • Chadwick LR, Nikolic DS, Burdette JE, Overk CR, Bolton JL, van Breemen RB, Fröhlich RH, Fong HR, Farnsworth NF, Pauli G. Estrogens and congeners from spent hops (Humulus lupulus).. Journal of natural products. 2004;67(12):2024-32. doi:10.1021/np049783i.
  • Mariappan SV, Cheng X, van Breemen RB, Silks LA, Gupta G. Analysis of GAA/TTC DNA triplexes using nuclear magnetic resonance and electrospray ionization mass spectrometry.. Analytical biochemistry. 2004;334(2):216-26. doi:10.1016/j.ab.2004.07.036.
  • Yu LB, Liu HR, Li WL, Zhang F, Luckie C, van Breemen R, Thatcher G, Bolton J. Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones.. Chemical research in toxicology. 2004;17(7):879-88. doi:10.1021/tx0342722.
  • Piersen CE, Booth NL, Sun YE, Liang WB, Burdette JE, van Breemen RP, Geller SL, Gu CR, Banuvar S, Shulman L, Bolton J, Farnsworth N. Chemical and biological characterization and clinical evaluation of botanical dietary supplements: a phase I red clover extract as a model.. Current medicinal chemistry. 2004;11(11):1361-74.
  • Li Y, Grubjesic S, Nikolic DS, Zhu D, Kosmeder JW, Moriarty RM, Pezzuto JM, van Breemen RB. In vitro assessment of intestinal permeability and hepatic metabolism of 4′-bromoflavone, a promising cancer chemopreventive agent.. Xenobiotica; the fate of foreign compounds in biological systems. 2004;34(6):535-47. doi:10.1080/00498250410001713159.
  • Li YS, Yao JD, Chang MD, Nikolic DB, Yu LL, Yager J, Mesecar A, van Breemen R, Bolton J. Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase.. Chemical research in toxicology. 2004;17(4):512-20. doi:10.1021/tx0342464.
  • Nikolic DS, van Breemen RB. New metabolic pathways for flavanones catalyzed by rat liver microsomes.. Drug metabolism and disposition: the biological fate of chemicals. 2004;32(4):387-97. doi:10.1124/dmd.32.4.387.
  • Yang X, Wu H, Kobayashi T, Solaro RJ, van Breemen RB. Enhanced ionization of phosphorylated peptides during MALDI TOF mass spectrometry.. Analytical chemistry. 2004;76(5):1532-6. doi:10.1021/ac035203v.
  • Nikolic DS, Li Y, Chadwick LR, Grubjesic S, Schwab P, Metz P, van Breemen RB. Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes.. Drug metabolism and disposition: the biological fate of chemicals. 2004;32(2):272-9. doi:10.1124/dmd.32.2.272.
  • Singletary KW, Barnes SL, van Breemen RB. Ethanol inhibits benzo[a]pyrene-DNA adduct removal and increases 8-oxo-deoxyguanosine formation in human mammary epithelial cells.. Cancer letters. 2004;203(2):139-44.
  • Liu JE, Burdette JM, Sun YS, Deng SB, Schlecht SB, Zheng WH, Nikolic DM, Mahady GL, van Breemen RR, Fong H, Pezzuto J, Bolton J, Farnsworth N. Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry).. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2004;11(1):18-23. doi:10.1078/0944-7113-00331.
  • Singletary KW, Stansbury MJ, Giusti M, van Breemen RB, Wallig M, Rimando A. Inhibition of rat mammary tumorigenesis by concord grape juice constituents.. Journal of agricultural and food chemistry. 2003;51(25):7280-6. doi:10.1021/jf030278l.
  • Li Y, Shin YG, Yu C, Kosmeder JW, Hirschelman WH, Pezzuto JM, van Breemen RB. Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: application to resveratrol absorption and metabolism.. Combinatorial chemistry & high throughput screening. 2003;6(8):757-67.
  • Lu X, Nikolic DS, Mitchell DJ, van Breemen RB, Mersfelder JA, Hille R, Silverman RB. A mechanism for substrate-Induced formation of 6-hydroxyflavin mononucleotide catalyzed by C30A trimethylamine dehydrogenase.. Bioorganic & medicinal chemistry letters. 2003;13(22):4129-32.
  • Lyons MM, Yu C, Toma RB, Cho SY, Reiboldt W, , van Breemen RB. Resveratrol in raw and baked blueberries and bilberries.. Journal of agricultural and food chemistry. 2003;51(20):5867-70. doi:10.1021/jf034150f.
  • Burdette JE, Liu J, Chen SE, Piersen CL, Barker EM, Pezzuto JB, Mesecar AR, van Breemen RL, Farnsworth N, Bolton J. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.. Journal of agricultural and food chemistry. 2003;51(19):5661-70. doi:10.1021/jf034264r.
  • Van Lieshout M, West CE, Van De Bovenkamp P, Wang Y, Sun Y, van Breemen RB, Muhilal DP, Verhoeven MA, Creemers AF, Lugtenburg J. Extraction of carotenoids from feces, enabling the bioavailability of beta-carotene to be studied in Indonesian children.. Journal of agricultural and food chemistry. 2003;51(17):5123-30. doi:10.1021/jf0300240.
  • Kouloumbos VN, Tsipi DF, Hiskia AE, Nikolic DS, van Breemen RB. Identification of photocatalytic degradation products of diazinon in TiO2 aqueous suspensions using GC/MS/MS and LC/MS with quadrupole time-of-flight mass spectrometry.. Journal of the American Society for Mass Spectrometry. 2003;14(8):803-17. doi:10.1016/S1044-0305(03)00333-7.
  • Su BN, Park EJ, Nikolic DS, Schunke Vigo J, Graham JG, Cabieses F, van Breemen RB, Fong HH, Farnsworth NR, Pezzuto JM. Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora.. Journal of natural products. 2003;66(8):1089-93. doi:10.1021/np030081n.
  • Johnson BM, van Breemen RB. In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh).. Chemical research in toxicology. 2003;16(7):838-46. doi:10.1021/tx020108n.
  • Liu XE, Zhang FR, Liu HB, Burdette JM, Li YL, Overk C, Pisha E, Yao J, van Breemen R, Swanson S, Bolton J. Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin.. Chemical research in toxicology. 2003;16(6):741-9. doi:10.1021/tx030001f.
  • Johnson BM, Qiu SX, Zhang S, Zhang FE, Burdette JL, Yu LB, Bolton J, van Breemen R. Identification of novel electrophilic metabolites of piper methysticum Forst (Kava).. Chemical research in toxicology. 2003;16(6):733-40. doi:10.1021/tx020113r.
  • Yao JE, Li YD, Chang MB, Wu HD, Yang XL, Goodman J, Liu X, Liu H, Mesecar A, van Breemen R, Yager J, Bolton J. Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase.. Chemical research in toxicology. 2003;16(5):668-75. doi:10.1021/tx0340549.
  • Gu JQ, Li W, Kang YH, Su BN, Fong HH, van Breemen RB, Pezzuto JM. Minor withanolides from Physalis philadelphica: structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation as artifacts.. Chemical & pharmaceutical bulletin. 2003;51(5):530-9.
  • Su BN, Park EJ, Nikolic DS, Santarsiero BD, Mesecar AD, Vigo JS, Graham JG, Cabieses FB, van Breemen RH, Fong HR, Farnsworth NM, Pezzuto JD, Kinghorn A. Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.. The Journal of organic chemistry. 2003;68(6):2350-61. doi:10.1021/jo020542u.
  • Su BN, Park EJ, Nikolic DS, Santarsiero BD, Mesecar AD, Vigo JS, Graham JG, Cabieses F, van Breemen RB, Fong HH, Farnsworth NR, Pezzuto JM. Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.. The Journal of organic chemistry. 2003;68(6):2350-61. doi:10.1021/jo020542u.
  • Fang L, Pajkovic N, Wang Y, Gu C, van Breemen RB. Quantitative analysis of lycopene isomers in human plasma using high-performance liquid chromatography-tandem mass spectrometry.. Analytical chemistry. 2003;75(4):812-7.
  • Li W, Sun Y, Joseph J, Fitzloff JF, Fong HH, van Breemen RB. p-Hydroxybenzoic acid alkyl esters in Andrographis paniculata herbs, commercial extracts, and formulated products.. Journal of agricultural and food chemistry. 2003;51(2):524-9. doi:10.1021/jf0258712.
  • Li W, Sun Y, Liang W, Fitzloff JF, van Breemen RB. Identification of caffeic acid derivatives in Actea racemosa (Cimicifuga racemosa, black cohosh) by liquid chromatography/tandem mass spectrometry.. Rapid communications in mass spectrometry : RCM. 2003;17(9):978-82. doi:10.1002/rcm.1008.
  • van Lieshout M, West CE, van Breemen RB. Isotopic tracer techniques for studying the bioavailability and bioefficacy of dietary carotenoids, particularly beta-carotene, in humans: a review.. The American journal of clinical nutrition. 2003;77(1):12-28.
  • Yu C, Shin YG, Kosmeder JW, Pezzuto JM, van Breemen RB. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate.. Rapid communications in mass spectrometry : RCM. 2003;17(4):307-13. doi:10.1002/rcm.918.
  • Cheng X, Shin YG, Levine BS, Smith AC, Tomaszewski JE, van Breemen RB. Quantitative analysis of betulinic acid in mouse, rat and dog plasma using electrospray liquid chromatography/mass spectrometry.. Rapid communications in mass spectrometry : RCM. 2003;17(18):2089-92. doi:10.1002/rcm.1155.
  • Yu C, Shin YG, Chow A, Li Y, Kosmeder JW, Lee YS, Hirschelman WH, Pezzuto JM, Mehta RG, van Breemen RB. Human, rat, and mouse metabolism of resveratrol.. Pharmaceutical research. 2002;19(12):1907-14.
  • Burdette JE, Chen S, Lu ZZ, Xu H, White BH, Liu JR, Fong HI, Farnsworth NB, Constantinou AM, van Breemen RL, Pezzuto J, Bolton J. Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.. Journal of agricultural and food chemistry. 2002;50(24):7022-8.
  • Yang Y, Nikolic DS, Swanson SM, van Breemen RB. Quantitative determination of N7-methyldeoxyguanosine and O6-methyldeoxyguanosine in DNA by LC-UV-MS-MS.. Analytical chemistry. 2002;74(20):5376-82.
  • Li W, Sun Y, Fitzloff JF, van Breemen RB. Evaluation of commercial ginkgo and echinacea dietary supplements for colchicine using liquid chromatography-tandem mass spectrometry.. Chemical research in toxicology. 2002;15(9):1174-8.
  • Prins GS, Chang WY, Wang Y, van Breemen RB. Retinoic acid receptors and retinoids are up-regulated in the developing and adult rat prostate by neonatal estrogen exposure.. Endocrinology. 2002;143(9):3628-40. doi:10.1210/en.2002-220184.
  • van Breemen RB, Xu X, Viana MA, Chen L, Stacewicz-Sapuntzakis M, Duncan C, Bowen PE, Sharifi R. Liquid chromatography-mass spectrometry of cis- and all-trans-lycopene in human serum and prostate tissue after dietary supplementation with tomato sauce.. Journal of agricultural and food chemistry. 2002;50(8):2214-9.
  • Liu XB, Yao JL, Pisha E, Yang Y, Hua Y, van Breemen R, Bolton J. Oxidative DNA damage induced by equine estrogen metabolites: role of estrogen receptor alpha.. Chemical research in toxicology. 2002;15(4):512-9.
  • Johnson BM, Nikolic DS, van Breemen RB. Applications of pulsed ultrafiltration-mass spectrometry.. Mass spectrometry reviews. 2002;21(2):76-86. doi:10.1002/mas.10020.
  • Geun Shin YL, Bolton JB, van Breemen R. Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometry.. Combinatorial chemistry & high throughput screening. 2002;5(1):59-64.
  • Wang Y, Catana F, Yang Y, Roderick R, van Breemen RB. An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice, and in wine.. Journal of agricultural and food chemistry. 2002;50(3):431-5.
  • Burdette JE, Liu JD, Lantvit DP, Lim EB, Booth NI, Bhat KM, Hedayat SR, van Breemen RL, Constantinou A, Pezzuto J, Farnsworth N, Bolton J. Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats.. The Journal of nutrition. 2002;132(1):27-30.
  • Zhang FM, Swanson SB, van Breemen RL, Liu X, Yang Y, Gu C, Bolton J. Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases.. Chemical research in toxicology. 2001;14(12):1654-9.
  • Yao DB, Zhang FL, Yu L, Yang Y, van Breemen R, Bolton J. Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones.. Chemical research in toxicology. 2001;14(12):1643-53.
  • Garbis SD, Melse-Boonstra A, West CE, van Breemen RB. Determination of folates in human plasma using hydrophilic interaction chromatography-tandem mass spectrometry.. Analytical chemistry. 2001;73(22):5358-64.
  • Johnson BM, Bolton JL, van Breemen RB. Screening botanical extracts for quinoid metabolites.. Chemical research in toxicology. 2001;14(11):1546-51.
  • Shin YG, van Breemen RB. Analysis and screening of combinatorial libraries using mass spectrometry.. Biopharmaceutics & drug disposition. 2001;22(7-8):353-72.
  • Wang Y, Chang WY, Prins GS, van Breemen RB. Simultaneous determination of all-trans, 9-cis, 13-cis retinoic acid and retinol in rat prostate using liquid chromatography-mass spectrometry.. Journal of mass spectrometry : JMS. 2001;36(8):882-8. doi:10.1002/jms.189.
  • Mitchell DJ, Nikolic DS, Jang MH, van Breemen RB, Hille R, Silverman RB. Inactivation of C30A trimethylamine dehydrogenase by N-cyclopropyl-alpha-methylbenzylamine, 1-phenylcyclopropylamine, and phenylhydrazine.. Biochemistry. 2001;40(29):8523-30.
  • Mitchell DJ, Nikolic DS, van Breemen RB, Silverman RB. Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: mass spectral evidence for the flavin adduct.. Bioorganic & medicinal chemistry letters. 2001;11(13):1757-60.
  • Zhang FB, Yao DL, Hua Y, van Breemen R, Bolton J. Synthesis and reactivity of the catechol metabolites from the equine estrogen, 8,9-dehydroestrone.. Chemical research in toxicology. 2001;14(6):754-63.
  • Mitchell DJ, Nikolic DS, Rivera E, Sablin SO, Choi SA, van Breemen RB, Singer TP, Silverman RB. Spectrometric evidence for the flavin-1-phenylcyclopropylamine inactivator adduct with monoamine oxidase N.. Biochemistry. 2001;40(18):5447-56.
  • van Lieshout M, West CE, Muhilal , Permaesih D, Wang Y, Xu X, van Breemen RB, Creemers AF, Verhoeven MA, Lugtenburg J. Bioefficacy of beta-carotene dissolved in oil studied in children in Indonesia.. The American journal of clinical nutrition. 2001;73(5):949-58.
  • Liu JE, Burdette JB, Xu HP, Gu CI, van Breemen RM, Bhat KH, Booth NR, Constantinou AL, Pezzuto J, Fong H, Farnsworth N, Bolton J. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.. Journal of agricultural and food chemistry. 2001;49(5):2472-9.
  • Park EJ, Lee DD, Shin YG, Lantvit DD, van Breemen RB, Pezzuto JM. Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry.. Journal of chromatography. B, Biomedical sciences and applications. 2001;754(2):327-32.
  • Chang MG, Shin YB, van Breemen RY, Blond SL, Bolton J. Structural and functional consequences of inactivation of human glutathione S-transferase P1-1 mediated by the catechol metabolite of equine estrogens, 4-hydroxyequilenin.. Biochemistry. 2001;40(15):4811-20.
  • Nikolic DS, van Breemen RB. DNA oxidation induced by cyclooxygenase-2.. Chemical research in toxicology. 2001;14(4):351-4.
  • Constantinou AI, Lantvit DD, Hawthorne M, Xu X, van Breemen RB, Pezzuto JM. Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats.. Nutrition and cancer. 2001;41(1-2):75-81. doi:10.1080/01635581.2001.9680615.
  • Hua YB, Wainhaus SL, Yang YB, Shen L, Xiong Y, Xu X, Zhang F, Bolton J, van Breemen R. Comparison of negative and positive ion electrospray tandem mass spectrometry for the liquid chromatography tandem mass spectrometry analysis of oxidized deoxynucleosides.. Journal of the American Society for Mass Spectrometry. 2001;12(1):80-7. doi:10.1016/S1044-0305(00)00191-4.
  • Westenburg HE, Lee K, Lee SK, Fong HH, van Breemen RB, Pezzuto JM. Activity-guided isolation of antioxidative constituents of Cotinus coggygria.. Journal of natural products. 2000;63(12):1696-8.
  • Li W, Gu C, Zhang H, Awang DV, Fitzloff JF, Fong HH, van Breemen RB. Use of high-performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C. A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng).. Analytical chemistry. 2000;72(21):5417-22.
  • Wang Y, Xu X, van Lieshout M, West CE, Lugtenburg J, Verhoeven MA, Creemers AF, Muhilal , van Breemen RB. A liquid chromatography-mass spectrometry method for the quantification of bioavailability and bioconversion of beta-carotene to retinol in humans.. Analytical chemistry. 2000;72(20):4999-5003.
  • Henry LK, Puspitasari-Nienaber NL, Jarén-Galán M, van Breemen RB, Catignani GL, Schwartz SJ. Effects of ozone and oxygen on the degradation of carotenoids in an aqueous model system.. Journal of agricultural and food chemistry. 2000;48(10):5008-13.
  • Nikolic DS, Habibi-Goudarzi S, Corley DG, Gafner S, Pezzuto JM, van Breemen RB. Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration mass spectrometry.. Analytical chemistry. 2000;72(16):3853-9.
  • Chen YI, Liu XB, Pisha EC, Constantinou AY, Hua YL, Shen L, van Breemen R, Elguindi E, Blond S, Zhang F, Bolton J. A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines.. Chemical research in toxicology. 2000;13(5):342-50.
  • Zhang F, Fan PW, Liu X, Shen L, van Breemen RB, Bolton JL. Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone.. Chemical research in toxicology. 2000;13(1):53-62.
  • Gu C, Nikolic DS, Lai J, Xu X, van Breemen RB. Assays of ligand-human serum albumin binding using pulsed ultrafiltration and liquid chromatography-mass spectrometry.. Combinatorial chemistry & high throughput screening. 1999;2(6):353-9.
  • Hadden WL, Watkins RH, Levy LW, Regalado E, Rivadeneira DM, van Breemen RB, Schwartz SJ. Carotenoid composition of marigold (Tagetes erecta) flower extract used as nutritional supplement.. Journal of agricultural and food chemistry. 1999;47(10):4189-94.
  • Xu X, Wang Y, Constantinou AI, Stacewicz-Sapuntzakis M, Bowen PE, van Breemen RB. Solubilization and stabilization of carotenoids using micelles: delivery of lycopene to cells in culture.. Lipids. 1999;34(10):1031-6.
  • Korecka M, Nikolic DS, van Breemen RB, Shaw LM. The apparent inhibition of inosine monophosphate dehydrogenase by mycophenolic acid glucuronide is attributable to the presence of trace quantities of mycophenolic acid.. Clinical chemistry. 1999;45(7):1047-50.
  • Nikolic DS, Fan PW, Bolton JL, van Breemen RB. Screening for xenobiotic electrophilic metabolites using pulsed ultrafiltration-mass spectrometry.. Combinatorial chemistry & high throughput screening. 1999;2(3):165-75.
  • Zhang FB, Chen YL, Pisha E, Shen L, Xiong Y, van Breemen R, Bolton J. The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone.. Chemical research in toxicology. 1999;12(2):204-13. doi:10.1021/tx980217v.
  • Chung HS, Chang LC, Lee SK, Shamon LA, van Breemen RB, Mehta RG, Farnsworth NR, Pezzuto JM. Flavonoid constituents of Chorizanthe diffusa with potential cancer chemopreventive activity.. Journal of agricultural and food chemistry. 1999;47(1):36-41.
  • Chen YS, Shen LB, Zhang FS, Lau SL, van Breemen R, Nikolic D, Bolton J. The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro.. Chemical research in toxicology. 1998;11(9):1105-11. doi:10.1021/tx980083l.
  • Chang MB, Zhang FY, Shen LL, Pauss N, Alam I, van Breemen R, Blond S, Bolton J. Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens.. Chemical research in toxicology. 1998;11(7):758-65. doi:10.1021/tx9702190.
  • Nikolic DS, van Breemen RB. Screening for inhibitors of dihydrofolate reductase using pulsed ultrafiltration mass spectrometry.. Combinatorial chemistry & high throughput screening. 1998;1(1):47-55.
  • Shen LB, Qiu SS, Chen YL, Zhang F, van Breemen R, Nikolic D, Bolton J. Alkylation of 2′-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical.. Chemical research in toxicology. 1998;11(2):94-101. doi:10.1021/tx970181r.
  • van Breemen RB, Nikolic DS, Bolton JL. Metabolic screening using on-line ultrafiltration mass spectrometry.. Drug metabolism and disposition: the biological fate of chemicals. 1998;26(2):85-90.
  • van Breemen RB, Nikolic DS, Xu X, Xiong Y, van Lieshout M, West CE, Schilling AB. Development of a method for quantitation of retinol and retinyl palmitate in human serum using high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.. Journal of chromatography. A. 1998;794(1-2):245-51.
  • Zhao YZ, van Breemen RB, Nikolic DS, Huang CR, Woodbury CP, Schilling A, . Screening solution-phase combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry.. Journal of medicinal chemistry. 1997;40(25):4006-12. doi:10.1021/jm960729b.
  • Bolton JL, Pisha ES, Shen LL, Krol EB, Iverson SM, Huang Z, van Breemen R, Pezzuto J. The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells.. Chemico-biological interactions. 1997;106(2):133-48.
  • van Breemen RB, Huang CR, Nikolic DS, Woodbury CP, Zhao YZ, . Pulsed ultrafiltration mass spectrometry: a new method for screening combinatorial libraries.. Analytical chemistry. 1997;69(11):2159-64.
  • Shen LM, Pisha EB, Huang ZL, Pezzuto J, Krol E, Alam Z, van Breemen R, Bolton J. Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity.. Carcinogenesis. 1997;18(5):1093-101.
  • van Breemen RB, Huang CR. High-performance liquid chromatography-electrospray mass spectrometry of retinoids.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1996;10(9):1098-101.
  • Spanos GA, Schwartz SJ, van Breemen RB, Huang CH. High-performance liquid chromatography with light-scattering detection and desorption chemical-ionization tandem mass spectrometry of milk fat triacylglycerols.. Lipids. 1995;30(1):85-90.
  • Blackburn RK, van Breemen RB. Application of an immobilized digestive enzyme assay to measure chemical and enzymatic hydrolysis of the cyclic peptide antibiotic lysobactin.. Drug metabolism and disposition: the biological fate of chemicals. 1993;21(4):573-9.
  • van Breemen RB, Davis RG. Rates of peptide proteolysis measured using liquid chromatography and continuous-flow fast atom bombardment mass spectrometry.. Analytical chemistry. 1992;64(19):2233-7.
  • van Breemen RB, Bartlett MG, Tsou YH, Culver C, Swaisgood H, Unger SE. Degradation of peptide drugs by immobilized digestive proteases.. Drug metabolism and disposition: the biological fate of chemicals. 1991;19(3):683-90.
  • van Breemen RB, Martin LB, Le JC. Continuous-flow fast atom bombardment mass spectrometry of oligonucleotides.. Journal of the American Society for Mass Spectrometry. 1991;2(2):157-63. doi:10.1016/1044-0305(91)80009-V.
  • Martin LB, 3rd AF, Schreiner RB, van Breemen . Characterization of cisplatin adducts of oligonucleotides by fast atom bombardment mass spectrometry.. Analytical biochemistry. 1991;193(1):6-15.
  • Goodlett DR, Armstrong FB, Creech RJ, van Breemen RB. Formylated peptides from cyanogen bromide digests identified by fast atom bombardment mass spectrometry.. Analytical biochemistry. 1990;186(1):116-20.
  • van Breemen RB, Le JC. Enhanced sensitivity of peptide analysis by fast-atom bombardment mass spectrometry using nitrocellulose as a substrate.. Rapid communications in mass spectrometry : RCM. 1989;3(2):20-4. doi:10.1002/rcm.1290030203.
  • van Breemen RB, Stogniew M, Fenselau C. Characterization of acyl-linked glucuronides by electron impact and fast atom bombardment mass spectrometry.. Biomedical & environmental mass spectrometry. 1988;17(2):97-103.
  • van Breemen RB, Fenselau CC, Cotter RJ, Curtis AJ, Connolly G. Derivatives of dicyclopentadiene in ground water.. Biomedical & environmental mass spectrometry. 1987;14(3):97-102. doi:10.1002/bms.1200140302.
  • van Breemen RB, Fenselau C, Mogilevsky W, Odell GB. Reaction of bilirubin glucuronides with serum albumin.. Journal of chromatography. 1986;383(2):387-92.
  • van Breemen RB, Fenselau CC. Reaction of 1-O-acyl glucuronides with 4-(p-nitrobenzyl)pyridine.. Drug metabolism and disposition: the biological fate of chemicals. 1986;14(2):197-201.
  • van Breemen RB, Fenselau CC, Dulik DM. Activated phase II metabolites: comparison of alkylation by 1-O-acyl glucuronides and acyl sulfates.. Advances in experimental medicine and biology. 1986;197:423-9.
  • van Breemen RB, Fenselau C. Acylation of albumin by 1-O-acyl glucuronides.. Drug metabolism and disposition: the biological fate of chemicals. 1985;13(3):318-20.
  • van Breemen RB, Tabet JC, Cotter RJ. Characterization of oxygen-linked glucuronides by laser desorption mass spectrometry.. Biomedical mass spectrometry. 1984;11(6):278-83. doi:10.1002/bms.1200110606.
  • Education

  • PhD, , Johns Hopkins University,