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Hyun Lee

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About Heading link

Hyun Lee, PhD, is a Research Associate Professor in the Department of Pharmaceutical Sciences and the Director of the Biophysics Core at the University of Illinois at Chicago. Dr. Lee has a broad background with compound synthesis, protein-ligand interaction by surface plasmon resonance (SPR) and nuclear magnetic resonance (NMR), protein structure determination by NMR and X-ray crystallography, and enzyme assay development that can benefit drug discovery. She has been focusing on antimicrobial drug development against four flaviviruses (Hepatitis C virus, Zika, Dengue and West Nile viruses) and three coronaviruses (SARS-CoV-1, SARS-CoV-2 and MERS-CoV) using various biochemical and biophysical techniques. She has been actively working on developing anti-Tuberculosis drugs recent years.
The SPR technique is a powerful tool that can be used in every stage of drug discovery from high-throughput screening (HTS) to hit validation and hit characterization, with which she has extensive knowledge and experience for more than 20 years. She has expertise and experience in compound synthesis, more than 50 different protein purifications, HTS, enzymatic and biophysical assays, structure-activity relationship (SAR) analysis of lead inhibitor candidates, protein-protein/ligand interactions, and structural studies. She has published almost 60 peer-reviewed publications.

Teaching and Supervision Heading link

Research Methods I (GEMS 504), 8/23/2021 – 12/3/2021

Selected Grants

Development of Small Molecule Inhibitors of G12 / Alpha-SNAP-dependent vWF Secretion, Chicago Biomedical Consortium., 10/1/2021 - 9/30/2022, Obligated Amount: $100000; Anticipated Amount: $100000

Modulation of Protein production and Degradation as an integrated approach to rapid sterilization of Drug sensitive and resistant Mtb, Global Alliance for TB Drug Development., 4/1/2019 - 3/31/2023, Obligated Amount: $7080805; Anticipated Amount: $7080805

Identification and Development of Small Molecules that Inhibit the VraSRT Operon, Which Maintains Oxacillin Resistance in Methicillin-Resistant S. Aureus (MRSA), Chicago Biomedical Consortium., 6/1/2016 - 11/30/2017, Obligated Amount: $20000; Anticipated Amount: $20000

Identification and Development of Small Molecule Inhibitors Against Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Chicago Biomedical Consortium., 8/1/2014 - 7/31/2015, Obligated Amount: $5000; Anticipated Amount: $5000

Development of broad spectrum Hepatitis C Virus NS3/4A protease inhibitors, National Institute of Allergy and Infectious Diseases., 6/20/2014 - 5/31/2017, Obligated Amount: $600000; No Anticipated Amount Set

Selected Publications

Samrat, Subodh Kumar, Xu, Jimin, Xie, Xuping, Gianti, Eleonora, Chen, Haiying, Zou, Jing, Pattis, Jason G, Elokely, Khaled, Lee, Hyun, Li, Zhong, Klein, Michael L, Shi, Pei-Yong, Zhou, Jia, Li, Hongmin. (2022). Allosteric inhibitors of the main protease of SARS-CoV-2. Antiviral Research, 205, 105381. doi:10.1016/j.antiviral.2022.105381.

Youn, Isoo, Han, Kyu-Yeon, Gurgul, Aleksandra, Wu, Zhenlong, Lee, Hyun, Che, Chun-Tao. (2022). Chemical constituents of Entandrophragma angolense and their anti-inflammatory activity. Phytochemistry, 201, 113276. doi:10.1016/j.phytochem.2022.113276.

Shen, Zhengnan, Ratia, Kiira, Cooper, Laura, Kong, Deyu, Lee, Hyun, Kwon, Youngjin, Li, Yangfeng, Alqarni, Saad, Huang, Fei, Dubrovskyi, Oleksii, Rong, Lijun, Thatcher, Gregory RJ, Xiong, Rui. (2021). Design of SARS-CoV‑2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity. Journal of Medicinal Chemistry, 65, (4), 2940-2955. doi:10.1021/acs.jmedchem.1c01307.

Zhou, Bin, Achanta, Prabhakar S, Shetye, Gauri, Chen, Shao-Nong, Lee, Hyun, Jin, Ying-Yu, Cheng, Jinhua, Lee, Mi-Jin, Suh, Joo-Won, Cho, Sanghyun, Franzblau, Scott G, Pauli, Guido F, McAlpine, James B. (2021). Rufomycins or Ilamycins: Naming Clarifications and Definitive Structural Assignments. Journal of Natural Products, 84, (10), 2644-2663. doi:10.1021/acs.jnatprod.1c00198.

Rice, Amy J, Pesavento, Russell P, Ren, Jinhong, Youn, Isoo, Kwon, Youngjin, Ellepola, Kassapa, Che, Chun-Tao, Johnson, Michael E, Lee, Hyun. (2021). Identification of Small Molecule Inhibitors against Staphylococcus aureus Dihydroorotase via HTS. International Journal of Molecular Sciences, 22, (18), 9984. doi:10.3390/ijms22189984.

Son, Kyung‐No, Lee, Hyun, Shah, Dhara, Kalmodia, Sushma, Miller, Ryan Cree, Ali, Marwan, Balasubramaniam, Arun, Cologna, Stephanie M, Kong, Hyunjoon, Shukla, Deepak, Aakalu, Vinay Kumar. (2021). Histatin‐1 is an endogenous ligand of the sigma‐2 receptor. The FEBS Journal, 288, (23), 6815-6827. doi:10.1111/febs.16108.

Drayman, Nir, DeMarco, Jennifer K, Jones, Krysten A, Azizi, Saara-Anne, Froggatt, Heather M, Tan, Kemin, Maltseva, Natalia Ivanovna, Chen, Siquan, Nicolaescu, Vlad, Dvorkin, Steve, Furlong, Kevin, Kathayat, Rahul S, Firpo, Mason R, Mastrodomenico, Vincent, Bruce, Emily A, Schmidt, Madaline M, Jedrzejczak, Robert, Muñoz-Alía, Miguel Á, Schuster, Brooke, Nair, Vishnu, Han, Kyu-Yeon, O’Brien, Amornrat, Tomatsidou, Anastasia, Meyer, Bjoern, Vignuzzi, Marco, Missiakas, Dominique, Botten, Jason W, Brooke, Christopher B, Lee, Hyun, Baker, Susan C, Mounce, Bryan C, Heaton, Nicholas S, Severson, William E, Palmer, Kenneth E, Dickinson, Bryan C, Joachimiak, Andrzej, Randall, Glenn, Tay, Savaş. (2021). Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. Science, 373, (6557), 931-936. doi:10.1126/science.abg5827.

Du, Ruikun, Cooper, Laura, Chen, Zinuo, Lee, Hyun, Rong, Lijun, Cui, Qinghua. (2021). Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro. Antiviral Research, 190, 105075. doi:10.1016/j.antiviral.2021.105075.

Anirudhan, Varada, Lee, Hyun, Cheng, Han, Cooper, Laura, Rong, Lijun. (2021). Targeting SARS‐CoV‐2 viral proteases as a therapeutic strategy to treat COVID‐19. Journal of Medical Virology, 93, (5), 2722-2734. doi:10.1002/jmv.26814.


PhD, The Ohio State University, United States, 2006
M.S., Chonnam National University, South Korea, 1998
B.S., Chonnam National University, South Korea, 1995