Photo of John Michael Pezzuto

John Michael Pezzuto


Adjunct Professor, Medicinal Chemistry and Pharmacognosy

Selected Publications

  • García ME, Nicotra VE, Oberti JC, Ríos-Luci CG, León LM, Marler LB, Li GM, Pezzuto J, van Breemen R, Padrón J, Hueso-Falcón I, Estévez-Braun A. Antiproliferative and quinone reductase-inducing activities of withanolides derivatives.. European journal of medicinal chemistry. 2014;82:68-81. doi:10.1016/j.ejmech.2014.05.045.
  • Andreani AP, Leoni AJ, Locatelli AG, Morigi RB, Rambaldi MM, Cervellati R, Greco E, Kondratyuk T, Park E, Huang K, van Breemen R, Pezzuto J. Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.. European journal of medicinal chemistry. 2013;68:412-21. doi:10.1016/j.ejmech.2013.07.052.
  • Carlson SN, Marler LJ, Nam SD, Santarsiero BM, Pezzuto JT, Murphy B. Potential chemopreventive activity of a new macrolide antibiotic from a marine-derived Micromonospora sp.. Marine drugs. 2013;11(4):1152-61. doi:10.3390/md11041152.
  • Conda-Sheridan MJ, Park EE, Beck DV, Reddy PX, Nguyen TJ, Hu BB, White JM, van Breemen R, Pezzuto J, Cushman M. Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential.. Journal of medicinal chemistry. 2013;56(6):2581-605. doi:10.1021/jm400026k.
  • Chen LV, Conda-Sheridan MJ, Reddy PP, Morrell AM, Park EB, Kondratyuk T, Pezzuto J, van Breemen R, Cushman M. Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3′-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.. Journal of medicinal chemistry. 2012;55(12):5965-81. doi:10.1021/jm3006806.
  • Kondratyuk TP, Park EJ, Yu RB, van Breemen RN, Asolkar RT, Murphy BM, Fenical W, Pezzuto J. Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents.. Marine drugs. 2012;10(2):451-64. doi:10.3390/md10020451.
  • Soejarto DD, Gyllenhaal CR, Kadushin MJ, Southavong BG, Sydara KT, Bouamanivong SM, Xaiveu MC, Zhang HG, Franzblau SP, Tan G, Pezzuto J, Riley M, Elkington B, Waller D. An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development.. Pharmaceutical biology. 2012;50(1):42-60. doi:10.3109/13880209.2011.619700.
  • Gyllenhaal CR, Kadushin MT, Southavong BT, Sydara KV, Bouamanivong SK, Xaiveu MX, Xuan LQ, Hiep NM, Hung NM, Loc PJ, Dac LG, Bich TC, Cuong NG, Ly HT, Zhang HP, Franzblau SY, Xie HT, Riley MM, Elkington BD, Nguyen H, Waller D, Ma C, Tamez P, Tan G, Pezzuto J, Soejarto D. Ethnobotanical approach versus random approach in the search for new bioactive compounds: support of a hypothesis.. Pharmaceutical biology. 2012;50(1):30-41. doi:10.3109/13880209.2011.634424.
  • Kondratyuk TP, Park EJ, Marler LE, Ahn SB, Yuan YC, Choi YD, Yu RJ, van Breemen RM, Sun B, Hoshino J, Cushman M, Jermihov K, Mesecar A, Grubbs C, Pezzuto J. Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity.. Molecular nutrition & food research. 2011;55(8):1249-65. doi:10.1002/mnfr.201100122.
  • Park EJ, Kondratyuk TP, Morrell AJ, Kiselev EB, Conda-Sheridan MM, Cushman M, Ahn S, Choi Y, White J, van Breemen R, Pezzuto J. Induction of retinoid X receptor activity and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells.. Cancer prevention research (Philadelphia, Pa.). 2011;4(4):592-607. doi:10.1158/1940-6207.CAPR-10-0004.
  • Yang JH, Kondratyuk TP, Jermihov KC, Marler LE, Qiu XQ, Choi YD, Cao HB, Yu RM, Sturdy MH, Huang RG, Wang LJ, Mesecar A, van Breemen R, Pezzuto J, Fong H, Chen Y, Zhang H. Bioactive compounds from the fern Lepisorus contortus.. Journal of natural products. 2011;74(2):129-36. doi:10.1021/np100373f.
  • Choi YJ, Jermihov KR, Nam S, Sturdy MD, Maloney KR, Qiu XF, Chadwick LM, Main MB, Chen S, Mesecar A, Farnsworth N, Pauli G, Fenical W, Pezzuto J, van Breemen R. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS.. Analytical chemistry. 2011;83(3):1048-52. doi:10.1021/ac1028424.
  • Calamini BG, Ratia KM, Malkowski MD, Cuendet MD, Pezzuto J, Santarsiero B, Mesecar A. Pleiotropic mechanisms facilitated by resveratrol and its metabolites.. The Biochemical journal. 2010;429(2):273-82. doi:10.1042/BJ20091857.
  • Hoshino JJ, Park EP, Kondratyuk TM, Marler LB, Pezzuto J, van Breemen R, Mo S, Li Y, Cushman M. Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.. Journal of medicinal chemistry. 2010;53(13):5033-43. doi:10.1021/jm100274c.
  • Yang JH, Kondratyuk TP, Marler LE, Qiu XQ, Choi YD, Cao HB, Yu RM, Sturdy MH, Pegan SG, Wang LJ, Mesecar A, van Breemen R, Pezzuto J, Fong H, Chen Y, Zhang H. Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata.. Phytochemistry. 2010;71(5-6):641-7. doi:10.1016/j.phytochem.2010.01.002.
  • Cuendet M, Guo JP, Luo YC, Chen SB, Oteham CE, Moon RM, van Breemen R, Marler L, Pezzuto J. Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice.. Cancer prevention research (Philadelphia, Pa.). 2010;3(2):221-32. doi:10.1158/1940-6207.CAPR-09-0049.
  • Guo JM, Liu AB, Cao H, Luo Y, Pezzuto J, van Breemen R. Biotransformation of the chemopreventive agent 2′,4′,4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases.. Drug metabolism and disposition: the biological fate of chemicals. 2008;36(10):2104-12. doi:10.1124/dmd.108.021857.
  • Guo JS, Liu DM, Nikolic DB, Zhu D, Pezzuto J, van Breemen R. In vitro metabolism of isoliquiritigenin by human liver microsomes.. Drug metabolism and disposition: the biological fate of chemicals. 2008;36(2):461-8. doi:10.1124/dmd.107.018721.
  • Liu DJ, Guo JI, Luo YM, Broderick DB, Schimerlik M, Pezzuto J, van Breemen R. Screening for ligands of human retinoid X receptor-alpha using ultrafiltration mass spectrometry.. Analytical chemistry. 2007;79(24):9398-402. doi:10.1021/ac701701k.
  • Soejarto DD, Zhang HJ, Fong HH, Tan GT, Ma CY, Gyllenhaal CC, Riley MR, Kadushin MG, Franzblau SQ, Bich TM, Cuong NT, Hiep NK, Loc PV, le Xuan TV, Hai NQ, Hung NM, Chien NM, le Binh TM, Vu BC, Ly HR, Southavong BE, Sydara KV, Bouamanivong S, Pezzuto J, Rose W, Dietzman G, Miller B, Thuy T. “Studies on biodiversity of Vietnam and Laos” 1998-2005: examining the impact.. Journal of natural products. 2006;69(3):473-81. doi:10.1021/np058107t.
  • Homhual SJ, Zhang HP, Bunyapraphatsara ND, Kondratyuk TD, Santarsiero BM, Mesecar AH, Herunsalee A, Chaukul W, Pezzuto J, Fong H. Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza.. Planta medica. 2006;72(3):255-60. doi:10.1055/s-2005-873171.
  • Zhang HJ, Ma CH, Nguyen VC, Nguyen MT, Tan GD, Santarsiero BD, Mesecar AD, Soejarto DM, Pezzuto JH, Fong H. Miliusanes, a class of cytotoxic agents from Miliusa sinensis.. Journal of medicinal chemistry. 2006;49(2):693-708. doi:10.1021/jm0509492.
  • Liu GL, Eggler AM, Dietz BD, Mesecar AL, Bolton JM, Pezzuto JB, van Breemen R. Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1.. Analytical chemistry. 2005;77(19):6407-14. doi:10.1021/ac050892r.
  • Soejarto DD, Fong HH, Tan GT, Zhang HJ, Ma CY, Franzblau SG, Gyllenhaal CC, Riley MR, Kadushin MM, Pezzuto JT, Xuan LT, Hiep NV, Hung NM, Vu BK, Loc PX, Dac LT, Binh LQ, Chien NV, Hai NQ, Bich TM, Cuong NM, Southavong BV, Sydara KC, Bouamanivong SR, Ly H, Thuy T, Rose W, Dietzman G. Ethnobotany/ethnopharmacology and mass bioprospecting: issues on intellectual property and benefit-sharing.. Journal of ethnopharmacology. 2005;100(1-2):15-22. doi:10.1016/j.jep.2005.05.031.
  • Chow AW, Murillo GB, Yu CW, van Breemen RM, Boddie AK, Pezzuto JG, Das Gupta T, Mehta R. Resveratrol inhibits rhabdomyosarcoma cell proliferation.. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2005;14(4):351-6.
  • Eggler AL, Liu GM, Pezzuto JB, van Breemen RD, Mesecar A. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2.. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(29):10070-5. doi:10.1073/pnas.0502402102.
  • Li YS, Grubjesic SW, Nikolic DM, Zhu DM, Kosmeder JB, Moriarty R, Pezzuto J, van Breemen R. In vitro assessment of intestinal permeability and hepatic metabolism of 4′-bromoflavone, a promising cancer chemopreventive agent.. Xenobiotica; the fate of foreign compounds in biological systems. 2004;34(6):535-47. doi:10.1080/00498250410001713159.
  • Nguyen QC, Nguyen VH, Santarsiero BD, Mesecar AD, Nguyen MC, Soejarto DD, Pezzuto JM, Fong HH, Tan GT. New 3-O-acyl betulinic acids from Strychnos vanprukii Craib.. Journal of natural products. 2004;67(6):994-8. doi:10.1021/np030469i.
  • Hwang BY, Su BN, Chai HB, Mi QJ, Kardono LD, Afriastini JD, Riswan SR, Santarsiero BD, Mesecar AC, Wild RR, Fairchild CA, Vite GM, Rose WM, Farnsworth ND, Cordell G, Pezzuto J, Swanson S, Kinghorn A. Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.. The Journal of organic chemistry. 2004;69(10):3350-8. doi:10.1021/jo040120f.
  • Liu JE, Burdette JM, Sun YS, Deng SB, Schlecht SB, Zheng WH, Nikolic DM, Mahady GL, van Breemen RR, Fong H, Pezzuto J, Bolton J, Farnsworth N. Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry).. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2004;11(1):18-23. doi:10.1078/0944-7113-00331.
  • Li YG, Shin YW, Yu CH, Kosmeder JM, Hirschelman WB, Pezzuto J, van Breemen R. Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: application to resveratrol absorption and metabolism.. Combinatorial chemistry & high throughput screening. 2003;6(8):757-67.
  • Burdette JE, Liu J, Chen SE, Piersen CL, Barker EM, Pezzuto JB, Mesecar AR, van Breemen RL, Farnsworth N, Bolton J. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.. Journal of agricultural and food chemistry. 2003;51(19):5661-70. doi:10.1021/jf034264r.
  • Su BN, Kang YH, Pinos RE, Santarsiero BD, Mesecar AD, Soejarto DD, Fong HH, Pezzuto JM, Kinghorn AD. Isolation and absolute stereochemistry of coussaric acid, a new bioactive triterpenoid from the stems of Coussarea brevicaulis.. Phytochemistry. 2003;64(1):293-302.
  • Su BN, Park EJ, Nikolic DS, Schunke Vigo JG, Graham JB, Cabieses FH, van Breemen RR, Fong HM, Farnsworth N, Pezzuto J. Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora.. Journal of natural products. 2003;66(8):1089-93. doi:10.1021/np030081n.
  • Gu JQ, Li WH, Kang YN, Su BH, Fong HB, van Breemen RM, Pezzuto J. Minor withanolides from Physalis philadelphica: structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation as artifacts.. Chemical & pharmaceutical bulletin. 2003;51(5):530-9.
  • Zhang HJ, Tan GT, Santarsiero BD, Mesecar AD, Hung NV, Cuong NM, Doel Soejarto DM, Pezzuto JH, Fong H. New Sesquiterpenes from Litsea verticillata.. Journal of natural products. 2003;66(5):609-15. doi:10.1021/np020508a.
  • Jang DS, Park EJ, Hawthorne ME, Vigo JS, Graham JG, Cabieses FD, Santarsiero BD, Mesecar AH, Fong HG, Mehta RM, Pezzuto JD, Kinghorn A. Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean).. Journal of natural products. 2003;66(5):583-7. doi:10.1021/np020522n.
  • Gafner SL, Bergeron CT, Batcha LE, Reich JM, Arnason JK, Burdette J, Pezzuto J, Angerhofer C. Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora.. Journal of natural products. 2003;66(4):535-7. doi:10.1021/np0205102.
  • Su BN, Park EJ, Nikolic DS, Santarsiero BD, Mesecar AD, Vigo JS, Graham JG, Cabieses FB, van Breemen RH, Fong HR, Farnsworth NM, Pezzuto JD, Kinghorn A. Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.. The Journal of organic chemistry. 2003;68(6):2350-61. doi:10.1021/jo020542u.
  • Su BN, Park EJ, Nikolic DS, Santarsiero BD, Mesecar AD, Vigo JS, Graham JG, Cabieses FB, van Breemen RH, Fong HR, Farnsworth NM, Pezzuto J. Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.. The Journal of organic chemistry. 2003;68(6):2350-61. doi:10.1021/jo020542u.
  • Yu CG, Shin YW, Kosmeder JM, Pezzuto JB, van Breemen R. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate.. Rapid communications in mass spectrometry : RCM. 2003;17(4):307-13. doi:10.1002/rcm.918.
  • Xu HE, Piersen CL, Bolton JM, Pezzuto JR, Fong HI, Totura S, Farnsworth N, Constantinou A. A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women’s health.. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2002;9(8):757-62. doi:10.1078/094471102321621403.
  • Yu CG, Shin YW, Chow AS, Li YH, Kosmeder JM, Lee YG, Hirschelman WB, Pezzuto J, Mehta R, van Breemen R. Human, rat, and mouse metabolism of resveratrol.. Pharmaceutical research. 2002;19(12):1907-14.
  • Calderón AI, Terreaux CE, Schenk KM, Pattison PP, Burdette J, Pezzuto J, Gupta M, Hostettmann K. Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis.. Journal of natural products. 2002;65(12):1749-53. doi:10.1021/np0201164.
  • Burdette JE, Chen S, Lu ZZ, Xu H, White BH, Liu JR, Fong HI, Farnsworth NB, Constantinou AM, van Breemen RL, Pezzuto J, Bolton J. Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.. Journal of agricultural and food chemistry. 2002;50(24):7022-8.
  • Jang DS, Park EJ, Hawthorne ME, Vigo JS, Graham JG, Cabieses FD, Santarsiero BD, Mesecar AH, Fong HG, Mehta RM, Pezzuto JD, Kinghorn A. Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase.. Journal of agricultural and food chemistry. 2002;50(22):6330-4.
  • Su BN, Park EJ, Mbwambo ZH, Santarsiero BD, Mesecar AD, Fong HH, Pezzuto JM, Kinghorn AD. New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes.. Journal of natural products. 2002;65(9):1278-82.
  • Su BN, Chang LC, Park EJ, Cuendet MD, Santarsiero BD, Mesecar AG, Mehta RH, Fong HM, Pezzuto JD, Kinghorn A. Bioactive constituents of the seeds of Brucea javanica.. Planta medica. 2002;68(8):730-3. doi:10.1055/s-2002-33798.
  • Burdette JE, Liu JD, Lantvit DP, Lim EB, Booth NI, Bhat KM, Hedayat SR, van Breemen RL, Constantinou A, Pezzuto J, Farnsworth N, Bolton J. Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats.. The Journal of nutrition. 2002;132(1):27-30.
  • Liu JE, Burdette JB, Xu HP, Gu CI, van Breemen RM, Bhat KH, Booth NR, Constantinou AL, Pezzuto J, Fong H, Farnsworth N, Bolton J. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.. Journal of agricultural and food chemistry. 2001;49(5):2472-9.
  • Park EJ, Lee DD, Shin YG, Lantvit DD, van Breemen RB, Pezzuto JM. Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry.. Journal of chromatography. B, Biomedical sciences and applications. 2001;754(2):327-32.
  • Constantinou AI, Lantvit DD, Hawthorne MB, Xu XM, van Breemen R, Pezzuto J. Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats.. Nutrition and cancer. 2001;41(1-2):75-81. doi:10.1080/01635581.2001.9680615.
  • Westenburg HE, Lee K, Lee SK, Fong HH, van Breemen RB, Pezzuto JM. Activity-guided isolation of antioxidative constituents of Cotinus coggygria.. Journal of natural products. 2000;63(12):1696-8.
  • Cho KH, Pezzuto JM, Bolton JL, Steele VE, Kelloff GJ, Lee SK, Constantinou A. Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity.. European journal of cancer (Oxford, England : 1990). 2000;36(16):2146-56.
  • Nikolic DS, Habibi-Goudarzi SG, Corley DM, Gafner SB, Pezzuto J, van Breemen R. Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration mass spectrometry.. Analytical chemistry. 2000;72(16):3853-9.
  • Chung HS, Chang LC, Lee SK, Shamon LA, van Breemen RB, Mehta RG, Farnsworth NR, Pezzuto JM. Flavonoid constituents of Chorizanthe diffusa with potential cancer chemopreventive activity.. Journal of agricultural and food chemistry. 1999;47(1):36-41.
  • Bolton JL, Pisha ES, Shen LL, Krol EB, Iverson SM, Huang Z, van Breemen R, Pezzuto J. The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells.. Chemico-biological interactions. 1997;106(2):133-48.
  • Shen LM, Pisha EB, Huang ZL, Pezzuto J, Krol E, Alam Z, van Breemen R, Bolton J. Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity.. Carcinogenesis. 1997;18(5):1093-101.