Karol S. Bruzik
Assistant Head for Curriculum, College of Pharmacy - Medicinal Chemistry and Pharmacognosy
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Intro to Pharmaceutic Sciences (PHAR 200), 8/22/2022 – 12/2/2022
Special Proj Pharm Sci (PSCI 390), 8/22/2022 – 12/2/2022
Undergrad Res Pharm Sci (PSCI 380), 8/22/2022 – 12/2/2022
Fundamentals of Drug Action (PHAR 422), 8/22/2022 – 12/2/2022
Fundamentals of Drug Action (PHAR 422), 8/22/2022 – 12/2/2022
Fundamentals of Drug Action (PHAR 422), 8/22/2022 – 12/2/2022
Fundamentals of Drug Action (PHAR 422), 8/22/2022 – 12/2/2022
Doctoral Restch in Med Chem (MDCH 599), 8/22/2022 – 12/2/2022
Introduction to Pharmaceutical Sciences (PHAR 200), 8/22/2022 – 12/2/2022
Selected Grants
Molecular Pharmacology of the Synaptic and Extrasynaptic GABA(A) Receptors, Massachusetts General Hospital., 4/1/2020 - 2/28/2023, Obligated Amount: $596617; Anticipated Amount: $596617
DACCPM Miller Research Sundry Activities, Partners Healthcare., 3/16/2020 - 3/15/2021, Obligated Amount: $107181; Anticipated Amount: $107181
General Anesthetic Sites on Ligand-Gated Ion Channels, Massachusetts General Hospital., 9/1/2014 - 8/31/2020, Obligated Amount: $1064640; Anticipated Amount: $1064640
General Anesthetic Sites in GABA-A Receptor Subunit Interfacial Pockets, Massachusetts General Hospital., 8/1/2014 - 7/31/2017, Obligated Amount: $74648; Anticipated Amount: $74648
Nanoparticle-Based Photo-Activator of Voltage-Gated Sodium Channels, National Institutes of Health (National Eye Institute)., 5/1/2013 - 4/30/2016, Obligated Amount: $447531; Anticipated Amount: $451500
General Anesthetic Sites On Ligand-Gates Ion Channels, Massachusetts General Hospital., 9/30/2009 - 8/31/2014, Obligated Amount: $728485; Anticipated Amount: $728485
Verification Of The Results Described In US Paatent #5968976, Foley & Lardner LLP., 2/19/2007 - 3/30/2007, Obligated Amount: $13670; Anticipated Amount: $13670
Functional Composite Nanofibers By Coelectrospinning: Funtional Nanoobjects For Life Sciences, VolkswagenStiftung Fdn., 1/1/2007 - 12/31/2007, Obligated Amount: $51045; Anticipated Amount: $51045
Subcontract Grant To Cellular And Molecular Targets Of General Anestheics, Cornell University., 8/1/2006 - 7/31/2007, Obligated Amount: $340330; Anticipated Amount: $340330
Selected Publications
Koinas, DA, Wu, B, Zhou, X, Pajak, AY, Miller, KW, Bruzik, KS. (2022). Design and Development of Site Specific Null Allosteric Ligands for γ-Aminobutyric Acid Type A Receptor as Reversal Agents for General Anesthesia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36. doi:10.1096/fasebj.2022.36.S1.R4350.
Jayakar, SS, Chiara, DC, Zhou, X, Wu, B, Bruzik, KS, Miller, KW, Cohen, JB. (2020). Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors. Journal of Biological Chemistry, 295, (33), 11495-11512. doi:10.1074/jbc.ra120.013452.
Shalabi, AR, Yu, Z, Zhou, X, Jounaidi, Y, Chen, H, Dai, J, Kent, DE, Feng, HJ, Forman, SA, Cohen, JB, Bruzik, KS, Miller, KW. (2020). A potent photoreactive general anesthetic with novel binding site selectivity for GABAA receptors. European Journal of Medicinal Chemistry, 194. doi:10.1016/j.ejmech.2020.112261.
Kent, DE, Savechenkov, PY, Bruzik, KS, Miller, KW. (2019). Binding site location on GABAA receptors determines whether mixtures of intravenous general anaesthetics interact synergistically or additively in vivo. British Journal of Pharmacology, 176, (24), 4760-4772. doi:10.1111/bph.14843.
Yu, Z, Chiara, DC, Savechenkov, PY, Bruzik, KS, Cohen, JB. (2019). A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor. Journal of Biological Chemistry, 294, (19), 7892-7903. doi:10.1074/jbc.RA118.007172.
Wu, B, Jayakar, SS, Zhou, X, Titterton, K, Chiara, DC, Szabo, AL, Savechenkov, PY, Kent, DE, Cohen, JB, Forman, SA, Miller, KW, Bruzik, KS. (2019). Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors. European Journal of Medicinal Chemistry, 162, 810-824. doi:10.1016/j.ejmech.2018.11.019.
Ozevin, D, Ataei, H, Modares, M, Gurgun, AP, Yazdani, S, Singh, A. (2019). Preface.
Jayakar, Selwyn S, Zhou, Xiaojuan, Wu, Bo, Miller, Keith W, Bruzik, Karol S, Cohen, Jonathan B. (2019). Pharmacological Selectivity of a Steroid Binding Site at the Beta(+)-Alpha Interface of Alphal Beta3 Gaba-A Receptors. BIOPHYSICAL JOURNAL, 116, (3), 392A-392A. doi:10.1016/j.bpj.2018.11.2122.
Chiara, David C, Wu, Bo, Zhou, Xiaojuan, Jayakar, Selwyn S, Titterton, Katherine, Forman, Stuart A, Miller, Keith W, Bruzik, Karol S, Cohen, Jonathan B. (2019). Identification of a High-Affinity Neurosteroid Binding Site in Human Alpha1Beta3 Gaba(A)R using a Photoreactive Thdoc Analog. BIOPHYSICAL JOURNAL, 116, (3), 392A-392A. doi:10.1016/j.bpj.2018.11.2123.
Education
Degrees:
D.Sc., Institute of Organic Chemistry, Poland, 1988
M.Sc., Technical University of Lodz, Poland, 1972
Ph.D., Polish Academy of Sciences, Poland, 1980
Selected Presentations
Bruzik, Karol. (2021 July 06). Phosphoinositides Chemistry and Biology – A 40-Year Retrospective. 23rd International Conference on Phosphorus Chemistry. Czestochowa, Poland.