Photo of Dorota  Klepacki

Dorota Klepacki


Senior Research Specialist, Center for Biomolecular Sciences

Contact

Building & Room:

MBRB Rm 3018

Address:

900 S. Ashland Avenue, Chicago, IL, 60607

Office Phone:

(312) 996-4002

Selected Publications

  • Sothiselvam S, Liu BC, Han W, Ramu H, Klepacki D, Atkinson G, Brauer A, Remm M, Tenson T, Schulten K, Vázquez-Laslop N, Mankin A. Macrolide antibiotics allosterically predispose the ribosome for translation arrest.. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(27):9804-9. doi:10.1073/pnas.1403586111.
  • Martínez AK, Gordon E, Sengupta AM, Shirole NJ, Klepacki D, Martinez-Garriga BC, Brown LS, Benedik MR, Yanofsky C, Mankin A, Vazquez-Laslop N, Sachs M, Cruz-Vera L. Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan.. Nucleic acids research. 2014;42(2):1245-56. doi:10.1093/nar/gkt923.
  • Orelle CM, Szal T, Klepacki DJ, Shaw K, Vázquez-Laslop N, Mankin A. Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition.. Nucleic acids research. 2013;41(14):e144. doi:10.1093/nar/gkt526.
  • Vázquez-Laslop N, Klepacki DC, Mulhearn DG, Ramu H, Krasnykh O, Franzblau S, Mankin A. Role of antibiotic ligand in nascent peptide-dependent ribosome stalling.. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(26):10496-501. doi:10.1073/pnas.1103474108.
  • Ramu H, Vázquez-Laslop N, Klepacki D, Dai Q, Piccirilli J, Micura R, Mankin A. Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center.. Molecular cell. 2011;41(3):321-30. doi:10.1016/j.molcel.2010.12.031.
  • Llano-Sotelo B, Dunkle JH, Klepacki D, Zhang W, Fernandes P, Cate J, Mankin A. Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.. Antimicrobial agents and chemotherapy. 2010;54(12):4961-70. doi:10.1128/AAC.00860-10.
  • Vázquez-Laslop N, Ramu H, Klepacki D, Kannan K, Mankin A. The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide.. The EMBO journal. 2010;29(18):3108-17. doi:10.1038/emboj.2010.180.
  • Auerbach T, Mermershtain I, Davidovich C, Bashan A, Belousoff M, Wekselman I, Zimmerman E, Xiong L, Klepacki D, Arakawa K, Kinashi H, Mankin A, Yonath A. The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics.. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(5):1983-8. doi:10.1073/pnas.0914100107.
  • Llano-Sotelo B, Klepacki D, Mankin A. Selection of small peptides, inhibitors of translation.. Journal of molecular biology. 2009;391(5):813-9. doi:10.1016/j.jmb.2009.06.069.