Bryan J. Lampkin
Assistant Professor, Pharmaceutical Sciences
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About
Overview:
Trained as an organic chemist, I have always been fascinated at the role synthetic chemistry can play in biochemical research. The ability to intimately perturb a complex biological system atom by atom offers a level of molecular understanding that is not attainable by other biochemical methods. We are a widely interdisciplinary lab that pulls techniques from chemical biology, protein engineering, organic synthesis, physical organic chemistry, computational chemistry, and bioinformatics to discover and develop chemical tools and probes that are used to deconvolute biochemical networks implicated in disease.
Teaching and Supervision
Medicinal Chemistry (PSCI 530), 2/10/2025 – 2/14/2025
Undergrad Res Pharm Sci (PSCI 380), 1/13/2025 – 5/2/2025
Selected Grants
Spliceosome assembly inhibition as a novel anti-cancer therapeutic strategy, University of Illinois Cancer Center., 5/1/2025 - 4/30/2026, Obligated Amount: $50000; No Anticipated Amount Set
Selected Publications
Lampkin, Bryan J, Goldberg, Benjamin J, Kritzer, Joshua A. (2024). Multiplexed no-wash cellular imaging using BenzoTag, an evolved self-labeling protein. Chemical Science, 15, (42), 17337-17347. doi:10.1039/d4sc05090h.
Lampkin, Bryan J, Kritzer, Joshua A. (2023). Engineered fluorogenic HaloTag ligands for turn-on labelling in live cells. Chemical Communications, 60, (2), 200-203. doi:10.1039/d3cc05536a.
Lampkin, Bryan J, VanVeller, Brett. (2021). Hydrogen Bond and Geometry Effects of Thioamide Backbone Modifications. The Journal of Organic Chemistry, 86, (24), 18287-18291. doi:10.1021/acs.joc.1c02373.
Pace, Jennifer R, Lampkin, Bryan J, Abakah, Charles, Moyer, Adam, Miao, Jiayuan, Deprey, Kirsten, Cerulli, Robert A, Lin, Yu-Shan, Baleja, James D, Baker, David, Kritzer, Joshua A. (2021). Stapled β‑Hairpins Featuring 4‑Mercaptoproline. Journal of the American Chemical Society, 143, (37), 15039-15044. doi:10.1021/jacs.1c04378.
Lampkin, Bryan J, Karadakov, Peter B, VanVeller, Brett. (2020). Detailed Visualization of Aromaticity Using Isotropic Magnetic Shielding. Angewandte Chemie, 132, (43), 19437-19443. doi:10.1002/ange.202008362.
Lampkin, Bryan J, Karadakov, Peter B, VanVeller, Brett. (2020). Detailed Visualization of Aromaticity Using Isotropic Magnetic Shielding. Angewandte Chemie International Edition, 59, (43), 19275-19281. doi:10.1002/anie.202008362.
Wijesekara, Anuradha V, Venkatesh, Amrit, Lampkin, Bryan J, VanVeller, Brett, Lubach, Joseph W, Nagapudi, Karthik, Hung, Ivan, Gor’kov, Peter L, Gan, Zhehong, Rossini, Aaron J. (2020). Fast Acquisition of Proton‐Detected HETCOR Solid‐State NMR Spectra of Quadrupolar Nuclei and Rapid Measurement of NH Bond Lengths by Frequency Selective HMQC and RESPDOR Pulse Sequences. Chemistry – A European Journal, 26, (35), 7881-7888. doi:10.1002/chem.202000390.
Norris, Sean, Warner, Caroline C, Thooft, Andrea M, Demirci, Selin K, Lampkin, Bryan J, Miner, Kyle, Ellern, Arkady, VanVeller, Brett. (2020). Blue-Light Photocleavable Protecting Groups Based on Benzothiadiazole Scaffolds. Organic Letters, 22, (1), 270-273. doi:10.1021/acs.orglett.9b04268.
Camacho, Luis A, Lampkin, Bryan J, VanVeller, Brett. (2019). A Bottom-Up Approach To Preserve Thioamide Residue Stereochemistry during Fmoc Solid-Phase Peptide Synthesis. Organic Letters, 21, (17), 7015-7018. doi:10.1021/acs.orglett.9b02598.
Education
Degrees:
PhD, Iowa State University, United States, 2020
Postgraduate Training:
Postdoctoral Fellowship, Tufts University, United States, 2024