Mohomed M. Qader
Contact
Address:
833 S Wood St, Chicago, IL
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About
Research Interests:
– Microbial natural products and drug discovery for infectious diseases, specifically for tuberculosis, non-tuberculosis mycobacteria, and Lyme disease
– Development of high throughput workflows for the isolation and prioritization of slow-growing or rare antibiotic-producing microbes from underrepresented environments
– Development of analytical and chromatographic techniques to identify bioactive compounds for scale-up fermentations and lead compound/s identification.
Teaching and Supervision
Selected Publications
Ratia, Kiira, Jin, Shengnan, Abad-Zapatero, Celerino, Shetye, Gauri S, Demissie, Robel, Qader, Mallique, Beautrait, Alexandre, Nikolic, Dejan S, Wolf, Nina M, Rubin, Eric J, Krandor, Olga, Serbina, Natalya, Li, Guiying, Pauli, Guido F, Klein, Larry L, Cho, Sanghyun, Franzblau, Scott G, Fotouhi, Nader, Kaneko, Takushi, Lee, Hyun. (2025). Unique Interactions of Novel Rufomycin “Click Chemistry” Analogs with Mtb ClpC1 and Implications. Journal of Medicinal Chemistry, 68, (24), 26298-26310. doi:10.1021/acs.jmedchem.5c02416.
Su, Chun, Tuan, Nguyen-Quang, Li, Wen-Hua, Cheng, Jin-Hua, Jin, Ying-Yu, Hong, Soon-Kwang, Lee, Hyun, Qader, Mallique, Klein, Larry, Shetye, Gauri, Pauli, Guido F, Flanzblau, Scott G, Cho, Sang-Hyun, Zhao, Xin-Qing, Suh, Joo-Won. (2025). Enhancing rufomycin production by CRISPR/Cas9-based genome editing and promoter engineering in Streptomyces sp. MJM3502. Synthetic and Systems Biotechnology, 10, (2), 421-432. doi:10.1016/j.synbio.2025.01.002.
Kauffman, John, Cuevas, Jake, Feiner, Janaya, Metzger, Margaret, Shetye, Gauri, Wan, Baojie, Qader, Mallique, Nguyen, Duc, Nugent, Angela, Hossain, Akil, Franzblau, Scott, Umesiri, Francis E. (2025). Discovery of ultra short β-peptoids with selective activity against drug-resistant Mycobacterium tuberculosis. European Journal of Medicinal Chemistry, 290, 117531. doi:10.1016/j.ejmech.2025.117531.
Ariyarathna, Pathumi, Wickramarachchi, Dhanushki, Visvanathan, Rizliya, Qader, Mallique, Deen, Afka, Rathnayaka, Isuri, Rateb, Mostafa E, Liyanage, Ruvini. (2025). In vitro anti-diabetic potential of medicinal herbs commonly used in the Ayurvedic system of Sri Lanka with comprehensive metabolite profiling of Phyllanthus emblica using GC-MS and LC-HRMS. Natural Product Research, ahead-of-print, (ahead-of-print), 1-9. doi:10.1080/14786419.2025.2454367.
Tan, Jin Yi, Augustinović, Mario, Omar, Ashraf M, Lourenzon, Vitor B, Krull, Nyssa, Lopez, Xochitl, Khin, Manead, Shetye, Gauri, Nguyen, Duc, Qader, Mallique, Nugent, Angela C, Mpofu, Enock, Williams, Camarria, Rodriguez, Jonathon, Burdette, Joanna E, Cho, Sanghyun, Franzblau, Scott G, Eustáquio, Alessandra S, Zhang, Qibin, Murphy, Brian T. (2024). Discovery of New Cyclic Lipodepsipeptide Orfamide N via Partnership with Middle School Students from the Boys and Girls Club. ACS Omega, 9, (44), 44749-44759. doi:10.1021/acsomega.4c07459.
Qader, Mallique, Mweetwa, Larry L, Rämä, Teppo, Thissera, Bathini, Milne, Bruce F, Abdelmohsen, Usama R, Orfali, Raha, Tawfike, Ahmed, Esheli, Manal, Oluwabusola, Emmanuel T, Jaysainghe, Lalith, Jaspars, Marcel, Rateb, Mostafa E. (2023). Discovery and structural assignment of (S)-sydosine from amphipod-derived Aspergillus sydowii MBC15-11F through HRMS, advanced Mosher, and molecular modelling analyses. Journal of Applied Microbiology, 134, (8), lxad158. doi:10.1093/jambio/lxad158.
Sui, Yixuan, Huang, Xiaoyue, Qader, Mallique, You, Pengtao, Gan, Guoping, Xi, Xueling, Zhang, Jianchao, Cao, Shugeng. (2021). Triterpenoid saponins from the rhizome of Impatiens pritzellii var. hupehensis. Phytochemistry Letters, 41, 175-179. doi:10.1016/j.phytol.2020.12.006.
Napagoda, Mayuri, Gerstmeier, Jana, Butschek, Hannah, De Soyza, Sudhara, Pace, Simona, Lorenz, Sybille, Qader, Mallique, Witharana, Sanjeeva, Nagahawatte, Ajith, Wijayaratne, Gaya, Svatoš, Aleš, Jayasinghe, Lalith, Koeberle, Andreas, Werz, Oliver. The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka. Molecules, 25, (8), 1894. doi:10.3390/molecules25081894.
Napagoda, Mayuri, Gerstmeier, Jana, Butschek, Hannah, Lorenz, Sybille, De Soyza, Sudhara, Qader, Mallique, Nagahawatte, Ajith, Wijayaratne, Gaya Bandara, Schneider, Bernd, Svatoš, Aleš, Jayasinghe, Lalith, Koeberle, Andreas, Werz, Oliver. Plectranthus zeylanicus: A Rich Source of Secondary Metabolites with Antimicrobial, Disinfectant and Anti-Inflammatory Activities. Pharmaceuticals, 15, (4), 436. doi:10.3390/ph15040436.
Education
Degrees:
PhD, University of Peradeniya, Sri Lanka
Postgraduate Training:
Marine microbial natural products, University of the West of Scotland, United Kingdom
Microbial natural products, University of Hawaii at Hilo, United States
Microbial natural products, University of Illinois at Chicago, United States
Professional Memberships
American Society for Microbiology, 6/23/2025 - Present
American Chemical Society, 1/1/2024 - Present
American Society of Pharmacognosy, 1/1/2020 - Present
Royal Society of Chemistry, 7/31/2017 - Present