Photo of Dr. Shao-Nong Chen

Shao-Nong Chen


Research Associate Professor, Pharmaceutical Sciences
INST AFFL, Institute for Tuberculosis Research
Research Associate Professor, Program for Collaborative Research in the Pharmaceutical Sciences

Contact

Building & Room:

315B

Address:

833 South Wood Street, Chicago, IL, 60612

Office Phone:

(312) 996-7253

Fax:

(312) 996-7107

Email:

sc4sa@uic.edu

CV Link:

Shao-Nong Chen

Selected Publications

  • Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen S, Nikolic DS, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women’s Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.. Chemical research in toxicology. 2015;28(11):2130-41. doi:10.1021/acs.chemrestox.5b00310.

  • Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen SS, Nikolic DF, Pauli GB, van Breemen RM, Dietz BL, Bolton J. Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women’s Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.. Chemical research in toxicology. 2015;28(11):2130-41. doi:10.1021/acs.chemrestox.5b00310.

  • Simmler C, Anderson JR, Gauthier LL, Lankin DC, McAlpine JB, Chen S, Pauli GF. Metabolite Profiling and Classification of DNA-Authenticated Licorice Botanicals.. Journal of natural products. 2015;78(8):2007-22. doi:10.1021/acs.jnatprod.5b00342.

  • Dunlap TL, Wang S, Simmler C, Chen S, Pauli GF, Dietz BM, Bolton JL. Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.. Chemical research in toxicology. 2015;28(8):1584-94. doi:10.1021/acs.chemrestox.5b00157.

  • Dunlap TL, Wang S, Simmler C, Chen S, Pauli GF, Dietz BM, Bolton JL. Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.. Chemical research in toxicology. 2015;28(8):1584-94. doi:10.1021/acs.chemrestox.5b00157.

  • Napolitano JG, Simmler C, McAlpine JB, Lankin DC, Chen S, Pauli GF. Digital NMR profiles as building blocks: assembling ¹H fingerprints of steviol glycosides.. Journal of natural products. 2015;78(4):658-65. doi:10.1021/np5008203.

  • Ramos Alvarenga RF, Friesen JB, Nikolic DS, Simmler C, Napolitano JG, van Breemen RB, Lankin DC, McAlpine JB, Pauli GF, Chen S. K-targeted metabolomic analysis extends chemical subtraction to DESIGNER extracts: selective depletion of extracts of hops (Humulus lupulus).. Journal of natural products. 2014;77(12):2595-604. doi:10.1021/np500376g.

  • Gao WY, Kim J, Chen S, Cho SU, Choi JY, Jaki BC, Jin YE, Lankin DY, Lee JG, Lee SG, Napolitano JW, Franzblau SF, Suh J, Pauli G. Discovery and characterization of the tuberculosis drug lead ecumicin.. Organic letters. 2014;16(23):6044-7. doi:10.1021/ol5026603.

  • Pauli GF, Chen S, Simmler C, Lankin DC, Gödecke TU, Jaki BB, Friesen JB, McAlpine JG, Napolitano J. Importance of purity evaluation and the potential of quantitative ¹H NMR as a purity assay.. Journal of medicinal chemistry. 2014;57(22):9220-31. doi:10.1021/jm500734a.

  • van Breemen RB, Yuan YP, Banuvar SF, Shulman L, Qiu XM, Alvarenga RL, Chen SF, Dietz BC, Bolton JS, Pauli G, Krause E, Viana M, Nikolic D. Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops.. Molecular nutrition & food research. 2014;58(10):1962-9. doi:10.1002/mnfr.201400245.

  • Simmler C, Jones TR, Anderson JC, Nikolić DB, van Breemen RD, Soejarto D, Chen SF, Pauli G. Species-specific Standardisation of Licorice by Metabolomic Profiling of Flavanones and Chalcones.. Phytochemical analysis : PCA. 2014;25(4):378-88.

  • Simmler C, Jones TR, Anderson JS, Nikolic DB, van Breemen RD, Soejarto D, Chen SF, Pauli G. Species-specific Standardisation of Licorice by Metabolomic Profiling of Flavanones and Chalcones.. Phytochemical analysis : PCA. 2014;25(4):378-88.

  • Yuan Y, Qiu XG, Nikolić DF, Chen SB, Huang K, Li G, Pauli G, van Breemen R. Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2014;53:55-61. doi:10.1016/j.ejps.2013.12.003.

  • Simmler C, Napolitano JG, McAlpine JB, Chen S, Pauli GF. Universal quantitative NMR analysis of complex natural samples.. Current opinion in biotechnology. 2014;25:51-9. doi:10.1016/j.copbio.2013.08.004.

  • Dong SH, Cai GG, Napolitano JC, Nikolić DB, Lankin DD, van Breemen RF, Soejarto D, Pauli G, Chen S. Lipidated steroid saponins from Dioscorea villosa (wild yam).. Fitoterapia. 2013;91:113-24. doi:10.1016/j.fitote.2013.07.018.

  • Simmler C, Pauli GF, Chen S. Phytochemistry and biological properties of glabridin.. Fitoterapia. 2013;90:160-84. doi:10.1016/j.fitote.2013.07.003.

  • Hajirahimkhan A, Simmler C, Yuan YR, Anderson J, Chen SM, Nikolić DF, Dietz BB, Pauli GL, van Breemen R, Bolton J. Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms.. PloS one. 2013;8(7):e67947. doi:10.1371/journal.pone.0067947.

  • Hajirahimkhan A, Simmler C, Yuan YR, Anderson J, Chen SS, Nikolic DM, Dietz BF, Pauli GB, van Breemen RL, Bolton J. Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms.. PloS one. 2013;8(7):e67947. doi:10.1371/journal.pone.0067947.

  • Dietz BM, Hagos GK, Eskra JN, Wijewickrama GT, Anderson JR, Nikolic DS, Guo JJ, Wright B, Chen SF, Pauli GB, van Breemen RL, Bolton J. Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo.. Molecular nutrition & food research. 2013;57(6):1055-66. doi:10.1002/mnfr.201200534.

  • Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones TD, Soejarto D, Chen SF, Pauli G. Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay.. Journal of agricultural and food chemistry. 2013;61(9):2146-57. doi:10.1021/jf304445p.

  • Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones TD, Soejarto D, Chen SF, Pauli G. Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay.. Journal of agricultural and food chemistry. 2013;61(9):2146-57. doi:10.1021/jf304445p.

  • Dong SH, Nikolic DS, Simmler C, Qiu FB, van Breemen RD, Soejarto DF, Pauli G, Chen S. Diarylheptanoids from Dioscorea villosa (Wild Yam).. Journal of natural products. 2012;75(12):2168-77. doi:10.1021/np300603z.

  • Dong SH, Nikolić D, Simmler CB, Qiu FD, van Breemen RF, Soejarto D, Pauli G, Chen S. Diarylheptanoids from Dioscorea villosa (Wild Yam).. Journal of natural products. 2012;75(12):2168-77. doi:10.1021/np300603z.

  • Toh MF, Sohn J, Chen SL, Yao PE, Bolton J, Burdette J. Biological characterization of non-steroidal progestins from botanicals used for women’s health.. Steroids. 2012;77(7):765-73. doi:10.1016/j.steroids.2012.03.013.

  • Nikolić D, Gödecke TC, Chen SF, White JB, Lankin D, Pauli G, van Breemen R. Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.).. Fitoterapia. 2012;83(3):441-60. doi:10.1016/j.fitote.2011.12.006.

  • Hemachandra LP, Madhubhani P, Chandrasena RC, Esala PA, Chen SM, Main MF, Lankin DR, Scism RL, Dietz B, Pauli G, Thatcher G, Bolton J. Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).. Cancer prevention research (Philadelphia, Pa.). 2012;5(1):73-81. doi:10.1158/1940-6207.CAPR-11-0348.

  • Gödecke TG, Yao PM, Napolitano JL, Nikolić DB, Dietz BR, Bolton J, van Breemen RC, Farnsworth NF, Chen S, Lankin D, Pauli G. Integrated standardization concept for Angelica botanicals using quantitative NMR.. Fitoterapia. 2012;83(1):18-32. doi:10.1016/j.fitote.2011.08.017.

  • Li J, Gödecke TC, Chen SR, Imai AF, Lankin DB, Farnsworth N, Pauli G, van Breemen R, Nikolić D. In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4.. Xenobiotica; the fate of foreign compounds in biological systems. 2011;. doi:10.3109/00498254.2011.603385.

  • Chen S, Webster DS, Nikolic DB, van Breemen R, Wang ZH, Fong HR, Farnsworth NF, Pauli G. Phytoconstituents from Vitex agnus-castus fruits.. Fitoterapia. 2011;82(4):528-33. doi:10.1016/j.fitote.2010.12.003.

  • Choi YJ, Jermihov KR, Nam S, Sturdy MD, Maloney KR, Qiu XF, Chadwick LM, Main MB, Chen S, Mesecar A, Farnsworth N, Pauli G, Fenical W, Pezzuto J, van Breemen R. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS.. Analytical chemistry. 2011;83(3):1048-52. doi:10.1021/ac1028424.

  • Cuendet M, Guo JP, Luo YC, Chen SB, Oteham CE, Moon RM, van Breemen R, Marler L, Pezzuto J. Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice.. Cancer prevention research (Philadelphia, Pa.). 2010;3(2):221-32. doi:10.1158/1940-6207.CAPR-09-0049.

  • van Breemen RB, Liang WP, Banuvar S, Shulman LS, Pang YM, Tao Y, Nikolic DL, Krock KF, Chen SE, Hedayat SC, Bolton JE, Pauli GR, Piersen C, Krause E, Geller S, Farnsworth N. Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh.. Clinical pharmacology and therapeutics. 2010;87(2):219-25. doi:10.1038/clpt.2009.251.

  • Gödecke TC, Lankin DS, Nikolic D, Chen SB, van Breemen RR, Farnsworth NF, Pauli G. Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa).. Journal of natural products. 2009;72(3):433-7. doi:10.1021/np8006952.

  • Gödecke TS, Nikolic DC, Lankin D, Chen SL, Powell SM, Dietz BL, Bolton JB, van Breemen RR, Farnsworth NF, Pauli G. Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.. Phytochemical analysis : PCA. 2009;20(2):120-33. doi:10.1002/pca.1106.

  • Powell SL, Gödecke TS, Nikolic D, Chen SM, Ahn SR, Dietz BB, Farnsworth NC, van Breemen RF, Lankin DL, Pauli G, Bolton J. In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent.. Journal of agricultural and food chemistry. 2008;56(24):11718-26. doi:10.1021/jf803298z.

  • Overk CR, Guo JR, Chadwick LD, Lantvit D, Minassi AC, Appendino GR, Chen SF, Lankin DB, Farnsworth NL, Pauli G, van Breemen R, Bolton J. In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.. Chemico-biological interactions. 2008;176(1):30-9. doi:10.1016/j.cbi.2008.06.005.

  • Deng S, Wang YR, Inui T, Chen SG, Farnsworth NF, Cho S, Franzblau S, Pauli G. Anti-TB polyynes from the roots of Angelica sinensis.. Phytotherapy research : PTR. 2008;22(7):878-82. doi:10.1002/ptr.2303.

  • Overk CR, Yao P, Chen SR, Deng SF, Imai AL, Main M, Schinkovitz A, Farnsworth N, Pauli G, Bolton J. High-content screening and mechanism-based evaluation of estrogenic botanical extracts.. Combinatorial chemistry & high throughput screening. 2008;11(4):283-93.

  • Chen S, Turner AU, Jaki BS, Nikolic DB, van Breemen RF, Pauli G. An experimental implementation of chemical subtraction.. Journal of pharmaceutical and biomedical analysis. 2008;46(4):692-8. doi:10.1016/j.jpba.2007.12.014.

  • Chen S, Lankin DC, Nikolic DS, Lu ZZ, Ramirez BB, van Breemen RH, Fong HR, Farnsworth NF, Pauli G. Chlorination diversifies Cimicifuga racemosa triterpene glycosides.. Journal of natural products. 2007;70(6):1016-23. doi:10.1021/np0700319.

  • Deng S, Chen S, Lu JS, Wang ZB, Nikolic DD, van Breemen RH, Santarsiero BR, Mesecar AF, Fong H, Farnsworth N, Pauli G. GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels.. Phytochemical analysis : PCA. 2006;17(6):398-405.

  • Deng S, Chen S, Lu JS, Wang ZB, Nikolic DD, van Breemen RH, Santarsiero BR, Mesecar AF, Fong H, Farnsworth N, Pauli G. GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels.. Phytochemical analysis : PCA. 2006;17(6):398-405.

  • Deng S, Chen SS, Yao PB, Nikolic DL, van Breemen RH, Bolton JR, Fong HF, Farnsworth N, Pauli G. Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.. Journal of natural products. 2006;69(4):536-41. doi:10.1021/np050301s.

  • Booth NL, Overk CR, Yao PE, Burdette JS, Nikolic D, Chen SL, Bolton JB, van Breemen RF, Pauli GR, Farnsworth N. The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract.. Journal of alternative and complementary medicine (New York, N.Y.). 2006;12(2):133-9. doi:10.1089/acm.2006.12.133.

  • Nikolic DS, Lankin DC, Chen S, Jaki BU, Krunic A, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa.. Journal of natural products. 2005;68(8):1266-70. doi:10.1021/np050066d.

  • Burdette JE, Liu J, Chen SE, Piersen CL, Barker EM, Pezzuto JB, Mesecar AR, van Breemen RL, Farnsworth N, Bolton J. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.. Journal of agricultural and food chemistry. 2003;51(19):5661-70. doi:10.1021/jf034264r.

  • Burdette JE, Chen S, Lu ZZ, Xu H, White BH, Liu JR, Fong HI, Farnsworth NB, Constantinou AM, van Breemen RL, Pezzuto J, Bolton J. Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.. Journal of agricultural and food chemistry. 2002;50(24):7022-8.

  • Chen S, Li WS, Fabricant DD, Santarsiero BF, Mesecar AH, Fitzloff JR, Fong H, Farnsworth N. Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein.. Journal of natural products. 2002;65(4):601-5.

    • Education

  • Organic Chemistry, Univerisity of Virginia, Charlottesville, VA

  • Organic Chemistry - Phytochemistry, Shanghai Institute of Materia Medica, Shanghai, China

  • PhD, Organic Chemistry, Lanzhou University, Lanzhou, China