Shaonong Chen
Research Professor, Pharmaceutical Sciences
Associate Director of Technology Resources, Pharmacognosy Institute
Institute Affiliate, Pharmacognosy Institute
Institute Affiliate, Institute for Tuberculosis Research
Contact
Address:
833 S Wood St, Chicago, IL
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About
Overview:
Over two decades in UIC, my interdisciplinary expertise in chemistry and biology focuses on the analysis of natural products, discovery of bioactive principles from plants and other natural sources, and methodological development in natural product research. This includes combining chemical and biological evaluation of natural products with chromatography, nuclear magnetic resonance (NMR), as well as mass spectrometry (MS, LC/GC-MS) that are state-of-the-art in dereplication, structure elucidation and quantification. Familiar with all major classes of NPs through almost three decades of research, I have experience as key personnel in several NIH-supported cross-disciplinary programs which I developed several innovative chemical approaches in natural product research, such as NMR guiding metabolomic mining of new phytochemicals, multi-references standardization of complex extract with NMR methodology, qualification and quantification of metabolomics by mining NMR data. My work led to the establishment of (dynamic) residual complexity to explain biological profiles that change over time; and the chemical subtraction by countercurrent separation has been extended to produce “Knock-out” and “DESIGNER” extracts which were key materials in multiple biological targets study.
Research Interests:
My interesting is mainly on the analysis of natural products, discovery of bioactive principles from different natural sources, and methodological development in natural product research. These activities include combining evaluation of natural products with chromatography, nuclear magnetic resonance (NMR and quantitative NMR), as well as mass spectrometry (MS, LC/GC-MS) that are state-of-the-art in dereplication, structure elucidation and quantification.
Teaching and Supervision
Pathophysiology, Drug Action, & Therapeutics (PDAT) 6: Infectious Diseases (PHAR 506), 2/27/2023 – 3/2/2023
Selected Grants
Interoperable Ethnomedical Agents Library, California Community Foundation., 10/16/2024 - 10/15/2026, Obligated Amount: $228952.62; Anticipated Amount: $228952.62
Dentin Biomodification or Optimization of Bioadhesive Dental Restorations, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 6/24/2023 - 4/30/2026, Obligated Amount: $840402.48; Anticipated Amount: $840402.48
Residual Complexity (RC) of Antiviral Isoquercitrin (IQC), Institut de Recherches Cliniques de Montreal., 4/11/2023 - 12/31/2024, Obligated Amount: $125000; Anticipated Amount: $125000
Modularity in Oligomeric Phenol Chemistry for Biomodulation of Dental Structures, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 2/1/2023 - 1/31/2026, Obligated Amount: $445213; Anticipated Amount: $445213
Pharmacopoeial NMR and qNMR Method Development, US Pharmacopeial Convention., 5/1/2022 - 4/30/2023, Obligated Amount: $100000; Anticipated Amount: $100000
Dentin Biomodification for Optimization of Bioadhesive Dental Restorations, Marquette University., 5/1/2020 - 5/15/2023, Obligated Amount: $627339; Anticipated Amount: $627339
Dentin Biomodification for Optimization of Bioadhesive Dental Restorations, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 7/15/2019 - 3/31/2020, Obligated Amount: $553811; Anticipated Amount: $2652925
Biomodification of Dentin Matrix Structure, National Institutes of Health (National Cancer Institute)., 9/1/2017 - 8/31/2019, Obligated Amount: $647538; Anticipated Amount: $647538
Botanical Dietary Supplements for Women's Health, National Institutes of Health (National Center for Complementary and Integrative Health)., 9/1/2015 - 6/30/2022, Obligated Amount: $9708015; Anticipated Amount: $12588944
Selected Publications
Reis-Havlat, Mariana, Alania, Yvette, Jing, Shu-Xi, Bim-Junior, Odair, Liberato, Walleska, Chen, Shao-Nong, Pauli, Guido F, Bedran-Russo, Ana K. (2026). Advanced biomechanics and stability of the resin-dentin complex via modular A- and B-type proanthocyanidins. Biomaterials, 327, 123737. doi:10.1016/j.biomaterials.2025.123737.
Rebollar-Ramos, Daniela, Chen, Shao-Nong, Lankin, David C, Kleps, Robert A, Pauli, Guido F. (2026). Key considerations for phosphatidylserine quantification by 31P NMR in pharmaceutical analysis. Journal of Pharmaceutical and Biomedical Analysis, 270, 117248. doi:10.1016/j.jpba.2025.117248.
Ahmed, Mahmoud Sayed, Wang, Cheng‐Lei, Chen, Shaonong, Pauli, Guido F, Bedran‐Russo, Ana K. (2026). A Bioinspired Approach to Mechanically Reinforce Collagen‐Rich Tissues Using Modularly Defined Stilbenoids. Biopolymers, 117, (1), e70076. doi:10.1002/bip.70076.
Alania, Yvette, Reis-Havlat, Mariana, Jing, Shu-Xi, Tabatabaei, Fahimeh, McAlpine, James B, Chen, Shao-Nong, Pauli, Guido F, Bedran-Russo, Ana K. (2025). Structure-activity relationships of A-and B-type proanthocyanidins in long-term dentin biomodification and biocompatibility. Journal of Dentistry, 161, 105988. doi:10.1016/j.jdent.2025.105988.
Tang, Yu, Wang, Sinan, Fang, Cuifen, Zheng, Ruiqi, Xu, Ping, Friesen, J Brent, Chen, Shao-Nong, Wang, Yi, Pauli, Guido F, Cheng, Yiyu. (2025). Open Digital Reference Materials Unchain Controlled Substance Analysis. Analytical Chemistry, 97, (27), 14220-14229. doi:10.1021/acs.analchem.5c00109.
Neves, José Guilherme, Liberato, Walleska Feijó, Bim-Junior, Odair, Jing, Shu-Xi, Chen, Shao-Nong, Pauli, Guido F, Bedran-Russo, Ana K. (2025). Optimization of dental adhesive interfaces using tissue biomodulation with DESIGNER biopolymers. Dental Materials, 41, (7), 769-777. doi:10.1016/j.dental.2025.03.020.
Sayed, Mahmoud, Jing, Shuxi, Chen, Shao-Nong, Pauli, Guido F, Bedran-Russo, Ana K. (2025). A dual action approach of B-type proanthocyanidins for silencing enzymatic activity and sealing natural caries-affected dentin-resin interfaces. Journal of Dentistry, 158, 105777. doi:10.1016/j.jdent.2025.105777.
Zhou, Bin, Shetye, Gauri, Klein, Larry L, Wolf, Nina M, Lee, Hyun, McAlpine, James B, Harris, Guy, Chen, Shao-Nong, Suh, Joo Won, Cho, Sang-Hyun, Franzblau, Scott G, Abad-Zapatero, Celerino, Pauli, Guido F. (2025). Structure-Based Analysis of Semisynthetic Anti-TB Rufomycin Analogues. Journal of Natural Products, 88, (4), 907-925. doi:10.1021/acs.jnatprod.4c01266.
Bim‐Junior, Odair, Jing, Shuxi, McAlpine, James B, Chen, Shao‐Nong, Pauli, Guido F, Bedran‐Russo, Ana K. (2025). Regulatory Potency of Oligomeric Proanthocyanidins (PACs) on Extrafibrillar and Intrafibrillar Collagen Mineralization. Journal of Applied Polymer Science, 142, (14). doi:10.1002/app.56694.
Education
Degrees:
Ph.D, Lanzhou University, China, 1997
Postgraduate Training:
Post-doctoral Research Associate, Shanghai Institute of Materia Medica, China, 1999
Post-doctoral Research Associate, University of Virginia, United States, 2000