Shaonong Chen
Research Associate Professor, Pharmaceutical Sciences
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833 S Wood St, Chicago, IL
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About Heading link
Overview:
Over two decades in UIC, my interdisciplinary expertise in chemistry and biology focuses on the analysis of natural products, discovery of bioactive principles from plants and other natural sources, and methodological development in natural product research. This includes combining chemical and biological evaluation of natural products with chromatography, nuclear magnetic resonance (NMR), as well as mass spectrometry (MS, LC/GC-MS) that are state-of-the-art in dereplication, structure elucidation and quantification. Familiar with all major classes of NPs through almost three decades of research, I have experience as key personnel in several NIH-supported cross-disciplinary programs which I developed several innovative chemical approaches in natural product research, such as NMR guiding metabolomic mining of new phytochemicals, multi-references standardization of complex extract with NMR methodology, qualification and quantification of metabolomics by mining NMR data. My work led to the establishment of (dynamic) residual complexity to explain biological profiles that change over time; and the chemical subtraction by countercurrent separation has been extended to produce “Knock-out” and “DESIGNER” extracts which were key materials in multiple biological targets study.
Research Interests:
My interesting is mainly on the analysis of natural products, discovery of bioactive principles from different natural sources, and methodological development in natural product research. These activities include combining evaluation of natural products with chromatography, nuclear magnetic resonance (NMR and quantitative NMR), as well as mass spectrometry (MS, LC/GC-MS) that are state-of-the-art in dereplication, structure elucidation and quantification.
Teaching and Supervision Heading link
Selected Grants
Pharmacopoeial NMR and qNMR Method Development, US Pharmacopeial Convention., 5/1/2022 - 4/30/2023, Obligated Amount: $100000; Anticipated Amount: $100000
Dentin Biomodification for Optimization of Bioadhesive Dental Restorations, Marquette University., 5/1/2020 - 4/30/2023, Obligated Amount: $627339; Anticipated Amount: $627339
Dentin Biomodification for Optimization of Bioadhesive Dental Restorations, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 7/15/2019 - 3/31/2020, Obligated Amount: $553811; Anticipated Amount: $2652925
Biomodification of Dentin Matrix Structure, National Institutes of Health (National Cancer Institute)., 9/1/2017 - 8/31/2019, Obligated Amount: $647538; Anticipated Amount: $647538
Botanical Dietary Supplements for Women's Health, National Institutes of Health (National Center for Complementary and Integrative Health)., 9/1/2015 - 6/30/2022, Obligated Amount: $9708015; Anticipated Amount: $12588944
Center for Natural Product Technologies at UIC, National Institutes of Health (National Center for Complementary and Integrative Health)., 9/1/2015 - 6/30/2020, Obligated Amount: $1456875; Anticipated Amount: $1456875
Biomodification of Dentin Matrix Structure, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 9/1/2011 - 8/31/2016, Obligated Amount: $2125792; Anticipated Amount: $2125792
Botanical Dietary Supplements For Women's Health, National Institutes of Health (National Center for Complementary and Integrative Health)., 9/1/2010 - 8/31/2015, Obligated Amount: $7418005; Anticipated Amount: $7420771
Spectrometric Validation of Botanical Materials and References Standards, National Institutes of Health (National Center for Complementary and Integrative Health)., 9/30/2009 - 9/29/2012, Obligated Amount: $1231805; Anticipated Amount: $1231805
Selected Publications
Zhou, B, Alania, Y, Reis, M, Jing, SX, McAlpine, JB, Bedran-Russo, AK, Chen, SN, Ferreira, D, Pauli, GF. (2022). Seco B-Type Oligomers from Pinus massoniana Expand the Procyanidin Chemical Space and Exhibit Dental Bioactivity. Journal of Natural Products, 85, (12), 2753-2768. doi:10.1021/acs.jnatprod.2c00664.
Liu, Jialin, Banuvar, Suzanne, Viana, Marlos, Barengolts, Elena, Chen, Shao-Nong, Pauli, Guido F, Van Breemen, Richard B. (2022). Pharmacokinetic Interactions of a Licorice Dietary Supplement with Cytochrome P450 Enzymes in Female Participants. Drug Metabolism and Disposition, dmd-ar-2022-001050. doi:10.1124/dmd.122.001050.
Zhou, B, Shetye, G, Wolf, NM, Chen, SN, Qader, M, Ray, GJ, Lankin, DC, Cho, S, Cheng, J, Suh, JW, Franzblau, SG, McAlpine, JB, Pauli, GF. (2022). New Rufomycins from Streptomyces atratus MJM3502 Expand Anti- Mycobacterium tuberculosis Structure-Activity Relationships. Organic Letters, 24, (40), 7265-7270. doi:10.1021/acs.orglett.2c02493.
Jing, SX, Reis, M, Alania, Y, McAlpine, JB, Chen, SN, Bedran-Russo, AK, Pauli, GF. (2022). B-type Proanthocyanidins with Dentin Biomodification Activity from Cocoa (Theobroma cacao). Journal of Agricultural and Food Chemistry, 70, (39), 12456-12468. doi:10.1021/acs.jafc.2c04288.
Achanta, PS, Niemitz, M, Friesen, JB, Tadjimukhamedov, FK, Bzhelyansky, A, Giancaspro, GI, Chen, SN, Pauli, GF. (2022). Pharmaceutical analysis by NMR can accommodate strict impurity thresholds: The case of choline. Journal of Pharmaceutical and Biomedical Analysis, 214. doi:10.1016/j.jpba.2022.114709.
Kulakowski, D, Phansalkar, RM, Leme-Kraus, AA, McAlpine, JB, Chen, SN, Pauli, GF, Ravindran, S, Bedran-Russo, AK. (2022). Galloylated proanthocyanidins in dentin matrix exhibit biocompatibility and induce differentiation in dental stem cells. Journal of Bioactive and Compatible Polymers, 37, (3), 220-230. doi:10.1177/08839115221095154.
Ohtsuki, T, Friesen, JB, Chen, SN, McAlpine, JB, Pauli, GF. (2022). Selective Preparation and High Dynamic-Range Analysis of Cannabinoids in “cBD Oil” and Other Cannabis sativa Preparations. Journal of Natural Products, 85, (3), 634-646. doi:10.1021/acs.jnatprod.1c00976.
Jing, SX, Alania, Y, Reis, M, McAlpine, JB, Chen, SN, Bedran-Russo, AK, Pauli, GF. (2022). Proanthocyanidin Tetramers and Pentamers from Cinnamomum verum Bark and Their Dentin Biomodification Bioactivities. Journal of Natural Products, 85, (2), 391-404. doi:10.1021/acs.jnatprod.1c00972.
Hajirahimkhan, Atieh, Chen, Shao-Nong, Pauli, Guido F, Bartom, Elizabeth, Clare, Susan, Khan, Seema A. (2022). Abstract P1-11-01: Modulation of the high risk postmenopausal breast tissue genomic profiles with licorice and its bioactive compounds. Cancer Research, 82, (4_Supplement), p1-11-01-p1-11-01. doi:10.1158/1538-7445.sabcs21-p1-11-01.
Education
Degrees:
Ph.D, Lanzhou University, China, 1997
Postgraduate Training:
Post-doctoral Research Associate, Shanghai Institute of Materia Medica, China, 1999
Post-doctoral Research Associate, University of Virginia, United States, 2000
Selected Presentations
Mbachu, O, Howell, C, Dong, H, Simmler, C, Chen, SN, Garcia, GM, Nikolic, D, Pauli, GF, Dietz, Birgit, Bolton, JL. (2019 February 01). Differential modulation of estrogenic activity in estrogen receptor (ER)α and β by flavonoids in women’s health botanicals. 21st Annual Graduate Students Awards Ceremony. Chicago, USA.
Cho, Sang Hyun, Grzelak, E, Liu, Y, Friesen, JB, Lankin, DC, Nikolic, D, Chen, S, McAlpine, JB, Suh, J, Yang, S, Cheng, J, Lee, H, Kim, J, Pauli, GF, Franzblau, SG, Jaki, BU. (2019 January 01). Targeted separation of anti-Mycobacterium tuberculosis compounds from Actinomycetes extracts.. ASP. Madison, USA.
Grzelak, EM, Liu, Y, Friesen, JB, Lankin, DC, Chen, SN, McAlpine, JB, Yang, SH, Cheng, J, Lee, H, Kim, JY, Cho, SH, Pauli, GF, Franzblau, SG, Jaki, Birgit. (2018 August 02). TLC-Bioautography-GUESS strategy for target countercurrent separation of anti-mycobacterium TB compounds from actinomycete culture extracts. 10th International Conference on Countercurrent Chromatography. Braunschweig, Germany.
Mbachu, O, Howell, CE, Hajirahimkhan, A, Simmler, C, Dong, H, Chen, SN, Pauli, GF, Dietz, Birgit, Bolton, JL. (2018 May 01). SAR study of flavonoids/isoflavonoids on estrogen receptor α and β selectivity: prenylation enhances flavonoid estrogenicity but decreases isoflavonoid activity. Society of Toxicology, Midwest Regional Chapter Meeting. Mundelein, USA.
Mbachu, O, Howell, C, Hajirahimkhan, A, Simmler, C, Dong, H, Chen, SN, Pauli, GF, Dietz, Birgit, Bolton, JL. (2018 May 01). “SAR study of flavonoids/isoflavonoids on estrogen receptor α and β selectivity: prenylation enhances flavonoid estrogenicity but decreases isoflavonoid activity.”. Great Lakes Drug Metabolism and Disposition Group Meeting. Indianapolis, USA.