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Department Directory - Program for Collaborative Research in the Pharmaceutical Sciences

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B

Photo of Jonathan Bisson

Jonathan Bisson

Postdoctoral Research Associate, Medicinal Chemistry and Pharmacognosy

Postdoctoral Research Associate, Program for Collaborative Research in the Pharmaceutical Sciences

Research Interests:

- interaction between natural products and Humans (western-world ethnobotany and ethnopharmacology) - natural product knowledge management - natural product centered data and text mining - mass spectrometry - nuclear magnetic resonance

C

Photo of Shao-Nong Chen

Shao-Nong Chen

Research Associate Professor, Medicinal Chemistry and Pharmacognosy

INST AFFL, Institute for Tuberculosis Research

Research Associate Professor, Program for Collaborative Research in the Pharmaceutical Sciences

F

Photo of Scott Gary Franzblau

Scott Gary Franzblau

Director, Institute for Tuberculosis Research

Professor, Medicinal Chemistry and Pharmacognosy

INST AFFL, Program for Collaborative Research in the Pharmaceutical Sciences

Research Interests:

My motivation for finding new drugs for tuberculosis stems from a general desire to help alleviate suffering from diseases that disproportionately affect the poor and that have been neglected by the very countries that have the resources to make a difference. The success that we had in going from the lab to the clinic in leprosy in the 90s, gave me confidence that we can do the same for TB as these diseases are caused by related bacteria. The ITR is pursuing several strategies for discovery of new anti-TB agents. This includes large scale screening of both natural and synthetic compounds for those that demonstrate specificity of activity (i.e. inhibit the TB bacillus but not mammalian cells). Lead compounds are then optimized by semi-synthesis. In addition we are attempting to optimize the anti-TB activity of classes of antibiotics used for other infections but that have not been clinically active in tuberculosis. Activity of all lead compounds are assessed in macrophage and mouse models of TB. Ultimately clinical trials will be conducted with collaborators in TB-endemic regions.

G

Photo of James G Graham

James G Graham

Research Assistant Professor, Medicinal Chemistry and Pharmacognosy

Assistant Program Director, Program for Collaborative Research in the Pharmaceutical Sciences

P

Photo of Guido Frank Pauli

Guido Frank Pauli

Professor, Medicinal Chemistry and Pharmacognosy

Associate Director, Institute for Tuberculosis Research

Professor, Program for Collaborative Research in the Pharmaceutical Sciences

S

Photo of Charlotte Simmler

Charlotte Simmler

Visiting Research Assistant Professor, Medicinal Chemistry and Pharmacognosy

Visiting Research Assistant Professor, Program for Collaborative Research in the Pharmaceutical Sciences

Research Interests:

Characterization and authentication of Natural Products, Metabolomics, Chemical ecology, preservation of biodiversity, Drug Discovery in Infectious and Neglected Diseases.

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