Nora C. Vazquez-Laslop
Research Professor, College of Pharmacy- Center for Biomolecular Sciences
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Biochemistry (GEMS 501), 8/22/2022 – 12/2/2022
Molecular Biology (GEMS 502), 8/22/2022 – 12/2/2022
Cell Biology (GEMS 503), 8/22/2022 – 12/2/2022
Critical thinking, Prep Scholars, 4/2022 – 4/2022
Topics in Biochem and Mol Genetics (BCMG 575), 2/14/2022 – 2/18/2022
GEMS Cell Biology, 9/13/2021 – Present
Biochemistry (GEMS 501), 8/23/2021 – 12/3/2021
Molecular Biology (GEMS 502), 8/23/2021 – 12/3/2021
Cell Biology (GEMS 503), 8/23/2021 – 12/3/2021
Selected Grants
Elucidating the role of peptidyl-tRNA hydrolase activities in translation regulation, National Science Foundation., 3/1/2024 - 2/29/2028, Obligated Amount: $1200000; Anticipated Amount: $1200000
UIC Portal to Biomedical Research Careers (UIC PBRC) PREP, National Institutes of Health (National Institute of General Medical Sciences)., 2/1/2024 - 1/31/2029, Obligated Amount: $415994; Anticipated Amount: $2079970
Unraveling context specificity of translation by elucidating the mechanism of action of auxiliary translation factors, National Institutes of Health., 12/1/2023 - Present, No Obligated Amount Set; Anticipated Amount: $3175340
Determining the mechanism and impact of streptococcal RaS-RiPPs on the human oral microbiome, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 8/1/2023 - 7/31/2025, Obligated Amount: $111701; Anticipated Amount: $223402
Antibiotics targeting translation, McMaster University., 6/1/2023 - 11/30/2023, Obligated Amount: $50000; Anticipated Amount: $50000
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, NIH/NIAID., 2/8/2022 - 1/31/2027, Obligated Amount: $454250; Anticipated Amount: $3299182
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, NIH/NIAID., 2/8/2022 - 1/31/2027, Obligated Amount: $454250; Anticipated Amount: $3299182
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, NIH/NIAID., 7/16/2021 - 2/7/2022, Obligated Amount: $730027; Anticipated Amount: $730027
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, NIH/NIAID., 7/16/2021 - 2/7/2022, Obligated Amount: $730027; Anticipated Amount: $730027
Selected Publications
Judd, Heather NG, Martínez, Allyson K, Klepacki, Dorota, Vázquez-Laslop, Nora, Sachs, Matthew S, Cruz-Vera, Luis R. (2024). Functional domains of a ribosome arresting peptide are affected by surrounding nonconserved residues. Journal of Biological Chemistry, 300, (3), 105780. doi:10.1016/j.jbc.2024.105780.
Svetlov, Maxim S, Dunand, Clémence F, Nakamoto, Jose A, Atkinson, Gemma C, Safdari, Haaris A, Wilson, Daniel N, Vázquez-Laslop, Nora, Mankin, Alexander S. (2024). Peptidyl-tRNA hydrolase is the nascent chain release factor in bacterial ribosome-associated quality control. Molecular Cell, 84, (4), 715-726.e5. doi:10.1016/j.molcel.2023.12.002.
Vázquez-Laslop, Nora, Polikanov, Yury S. (2023). Motif-ation matters. Nature Chemical Biology, 19, (9), 1044-1045. doi:10.1038/s41589-023-01365-8.
Mangano, Kyle, Klepacki, Dorota, Ohanmu, Irueosa, Baliga, Chetana, Huang, Weiping, Brakel, Alexandra, Krizsan, Andor, Polikanov, Yury S, Hoffmann, Ralf, Vázquez-Laslop, Nora, Mankin, Alexander S. (2023). Inhibition of translation termination by the antimicrobial peptide Drosocin. Nature Chemical Biology, 19, (9), 1082-1090. doi:10.1038/s41589-023-01300-x.
Mangano, Kyle, Marks, James, Klepacki, Dorota, Saha, Chayan Kumar, Atkinson, Gemma C, Vázquez-Laslop, Nora, Mankin, Alexander S. (2022). Context-based sensing of orthosomycin antibiotics by the translating ribosome. Nature Chemical Biology, 18, (11), 1277-1286. doi:10.1038/s41589-022-01138-9.
Meydan, Sezen, Klepacki, Dorota, Karthikeyan, Subbulakshmi, Margus, Tõnu, Thomas, Paul, Jones, John E, Khan, Yousuf A, Briggs, Joseph, Dinman, Jonathan D, Vázquez-Laslop, Nora, Mankin, Alexander S. (2022). Response to: Lack of evidence for ribosomal frameshifting in ATP7B mRNA decoding. Molecular Cell, 82, (19), 3523. doi:10.1016/j.molcel.2022.08.025.
Laczkovich, Irina, Mangano, Kyle, Shao, Xinhao, Hockenberry, Adam J, Gao, Yu, Mankin, Alexander, Vázquez-Laslop, Nora, Federle, Michael J. (2022). Discovery of Unannotated Small Open Reading Frames in Streptococcus pneumoniae D39 Involved in Quorum Sensing and Virulence Using Ribosome Profiling. mBio, 13, (4), e01247-e01222. doi:10.1128/mbio.01247-22.
Syroegin, Egor A, Flemmich, Laurin, Klepacki, Dorota, Vazquez-Laslop, Nora, Micura, Ronald, Polikanov, Yury S. (2022). Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol. Nature Structural & Molecular Biology, 29, (2), 152-161. doi:10.1038/s41594-022-00720-y.
Tsai, Kaitlyn, Stojković, Vanja, Lee, D John, Young, Iris D, Szal, Teresa, Klepacki, Dorota, Vázquez-Laslop, Nora, Mankin, Alexander S, Fraser, James S, Fujimori, Danica Galonić. (2022). Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nature Structural & Molecular Biology, 29, (2), 162-171. doi:10.1038/s41594-022-00723-9.
Education
Degrees:
B.S., Universidad Nacional Autonoma de Mexico, Mexico, 1986
M.Sci., Universidad Nacional Autonoma de Mexico, Mexico, 1990
Ph.D., Universidad Nacional Autonoma de Mexico, Mexico, 1990