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Dr. Hyunyoung Jeong to receive ASPET Award

Dr. Jeong in her lab.

Dr. Jeong in her lab.

Dr. Hyunyoung Jeong has been named the 2017 recipient of the ASPET Division for Drug Metabolism Early Career Achievement Award.

This award was established to recognize excellent original research by early career investigators in the area of drug metabolism and disposition. With this award, we recognize Dr. Jeong for her pioneering work to elaborate the mechanisms of regulation of drug metabolism enzymes, and to understand the molecular basis of interindividual variability in drug metabolism.

Hyunyoung (Young) Jeong is an Associate Professor in the Departments of Pharmacy Practice and Biopharmaceutical Sciences at the College of Pharmacy, University of Illinois at Chicago (UIC).  Dr. Jeong received her PharmD and PhD in pharmacokinetics from UIC, followed by postdoctoral training in molecular pharmacology at UIC. Since joining the faculty at UIC in 2006, she has established a very strong research program in drug metabolism and pharmacokinetics (DMPK), funded by multiple agencies including NIH [R21 (2008-2011), K12 (Building Interdisciplinary Research Careers in Women’s Health; 2008-2011), and two R01s (2011-2017, 2015-2019)].

Her research has significantly advanced multiple areas in DMPK. Most importantly, she has studied the effects of complex physiological changes accompanying pregnancy on P450 expression and elucidated underlying mechanisms using innovative models including CYP-humanized mice. Her studies revealed previously unknown, important roles of pregnancy-related hormones in the regulation of hepatic drug-metabolizing enzymes.

Additionally, her research team has identified potential mechanisms underlying the induction of CYP2D6-mediated drug metabolism during pregnancy, the clinical finding that has intrigued the DMPK community as CYP2D6 was considered to be a non-inducible gene. Her study provided novel insights into the regulation of CYP2D6 expression, as well as into the interindividual variability in CYP2D6-mediated drug metabolism. Additionally, she identified a molecular basis for the association between novel genetic polymorphisms in CYP2C9 and warfarin dose, and has participated in multiple NIH-funded drug discovery and development projects providing expertise in DMPK.

The division will present this award at the ASPET Annual Meeting at Experimental Biology 2017 in Chicago, IL and Dr. Jeong will give a short lecture on Monday, April 24, 2017 during the Division for Drug Metabolism session from 3:00 p.m. - 5:30 p.m. in Room 474a of McCormick Place Convention Center, West Building.