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Biosafety level 3 laboratory
650 sq. ft. + 75 ft. shower/change room
- safety features: negative air flow, pass-through autoclave and ceiling mounted UV lights
- aerosol infection chamber
- two 4-ft. and one 6-ft. class II biosafety cabinets
- reach-in and CO2 incubators
- Anoxomat anaerobic environment generating system
- Victor X3 and Victor 3 microplate multi label readers
- electroporation instrument
Biosafety level 2 laboratory
485 sq. ft. for microbial and cell culture and molecular biology
- two 4-ft. and two 6 ft. class II biosafety cabinets
- clean bench for media prep
- CO2 incubators
- cup-horn and bath solicitors
180 sq. ft. serving both BSL-2 and BSL-3 laboratories.
Medicinal chemistry laboratory
686 sq. ft.
- three 4-ft. chemical fume hoods
- Shimadzu analytical and semi-prep HPLCs
- CEM microwave synthesizer
- Biotage solid phase purification system
- Shimadzu 2020 LC-MS
Molecular biology/fermentation lab
435 sq. ft.
- thermal cycler
- gel documentation system
- 2 centrifuges, refrigerated
- nanodrop spectrophotometer
- 6' biosafety cabinet
- 2 -80 freezers
- -30 freezer
The Biological Resources Laboratory at UIC is comprised of 104,000 sq. ft. on three levels. This includes 43 animal rooms for rodents and lagomorphs, each in a suite configuration with its own air handling system. Space is available for projects on an "as needed" basis. The ITR occupies a room with negative air pressure that is only used for infectious agents. It shares a 2nd room for uninfected mice which are used for tolerance and PK studies. Mice are housed in the Biological Resources Laboratory (BRL). Each floor of the BRL is managed by a team consisting of a Supervisor of Laboratory Animal Care, a board certified Laboratory Animal Veterinarian and a postdoctoral fellow. This management team oversees and works closely with a staff of certified laboratory animal care technicians. Working in collaboration with the investigators and their staff, the BRL staff provides support service for a wide variety of experimental protocols. The UIC Animal Care Program is accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and has consistently received positive evaluations from representatives of the Food and Drug Administration, the World Health Organization, the National Institutes of Health and several commercial pharmaceutical and contract laboratories.
Shared Analytical Resources
The following LC-MS instruments are available through the UIC Research Resources Center and are located on the 5th floor of the College of Pharmacy. They are used routinely by ITR personnel in the event that satisfactory results are not obtained using the single quad and trap-triple quad instruments available in the ITR ADMET lab.
|Agilent||19646A LC-MSD||Single Quad|
|Thermo||TSQ Quantum||Triple Quad|
|Waters||Waters SYNAPT||oa-Qtof SYNAPT|
|Shimadzu||LCMS IT-TOF||LCMS IT-TOF|
|Agilent||6410 QQQ||Triple Quad|
|Thermo||LTQ FT||ICR LC|
|Thermo||Orbitrap Velos Pro||Orbitrap Velos Pro|
In addition, an Agilent GC-triple quadrupole MS is available in the lab of affiliate faculty member, Guido Pauli.
The Research Resources Center has 360 and 500 MHz instruments available for sample submission and is located across the street in the Medical Sciences Building. The Department of Medicinal Chemistry and Pharmacognosy also maintains two 300 MHz and one 400 MHz instruments on the 5th floor of the College of Pharmacy. ITR faculty have their academic appointments in this department and therefore are eligible to use these shared instruments. In addition the Center for Structural Biology, located one block from the College of Pharmacy has 600, 800 and 900 MHz NMR available for use.