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2013 FAQs

December

What is the comparative efficacy of brand Plavix and generic clopidogrel bisulfate?

Are there data to support the use of medroxyprogesterone for postpartum hemorrhage?

Can dexmedetomidine be used off-label in the management of alcohol withdrawal syndromes?

November

What are the most recent recommendations for occupational postexposure prophylaxis(PEP)?

What are the safety concerns with electronic cigarettes (“e-cigarettes”),and do they have a role in smoking cessation?

What data are available to direct dosing of intravenous immunoglobulin G based on total versus ideal or adjusted body weight?

October

Should perioperative beta blockers be used to prevent cardiac complications in non-cardiac surgeries?

What comparative data are available for biologics in the setting of rheumatoidarthritis?

Is it necessary to bridge with heparin in high-risk patients before pacemaker or defibrillator surgery?

September

What is the recommended treatment for shivering related to therapeutic hypothermia?

What data support the addition of metronidazole to empiric antibiotic regimens in the treatment of aspiration pneumonia?

Are most classically described side effects of beta-blocker therapy in heart failure actually due to the medication?

August

Does the development of direct acting antivirals for hepatitis C virus mark the end of an era for treatment with interferon?

What evidence led to the boxed warning on hydroxyethyl starch solutions?

What literature is available supporting short-term use of systemic antibiotics for prevention of ventilator-associated pneumonia?

July

Does azithromycin increase the risk of cardiovascular death?

What safety risks prompted the labeling change that recommend against epidural administration of triamcinolone acetonide (Kenalog)?

What is the efficacy of prothrombin complex concentrates in the management of vitamin K antagonist-related major bleeding?

June

What are the differences and similarities between the Medical Letter antimicrobial prophylaxis guidelines and the guidelines from ASHP/IDSA/SIS/SHEA?

Should zolpidem use be minimized due to increased risk of falls in hospitalized patients?

What are the updated guideline recommendations for management of opportunistic infections in patients with HIV?

May

What available alternatives are there to papaverine for the prevention and management of vasospasm during cardiac procedures?

What are the alternatives to alteplase for catheter clearance?

How do methylene blue and isosulfan blue compare for use in sentinel lymph node biopsy?

April

What are the differences between the recent ASCO guideline on antibiotic use for neutropenia and those from the Infectious Diseases Society of America?

What data are available to guide appropriate off-label use of the peripheral mu-opioid receptor antagonists, methylnaltrexone and alvimopan?

What are the risk factors associated with supratherapeutic dosing of acetaminophen in hospitalized patients?

March

What are aminophylline alternatives for the reversal of adenosine agonists used in pharmacologic stress testing?

What are the new recommendations for frequency of platelet monitoring in patients with heparin-induced thrombocytopenia?

What are the new guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients?

Feburary

What are the updated guideline recommendations for management of pain, agitation, and delirium in critically ill adult patients?

Drug-induced QT prolongation (Part 2): a focus on select medications

What are the new clinical guidelines for the management of gastroparesis?

January

Does parenteral iron administration increase the risk of infection?

Drug-induced QT prolongation (Part 1): presentation, risks, and management

Should tamoxifen therapy be extended up to 10 years in women with early breast cancer?

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