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Jeremy J. Johnson

Associate Professor, Pharmacy Practice

Contact Information

833 South Wood Street
Chicago, IL 60612

Phone: (312) 996-4368

Fax: (312) 996-0379

Education

  • Clinical and Translational Science, NIH, Fellowship, 2010
  • PhD, Cancer Chemoprevention / Translational Research, University of Wisconsin - Comparative and Biomedical Sciences , WI, 2010
  • PharmD, Pharmacy, University of Wisconsin School of Pharmacy , WI, 2007
  • BS, Biology, University of Wisconsin-Stevens Point, WI, 2001

Research Interests

Our research group is focused on creating a model to successfully evaluate promising phytochemicals or semi-synthetic derivatives for applications related to cancer and inflammation from pre-clinical research to early phase human clinical trials. Ongoing projects are evaluating phytochemicals from the Mediterranean herb rosemary and the south east Asian Mangosteen fruit. We are especially interested in understanding the pharmacological properties and pharmacokinetic properties of pure phytochemicals or phytochemicals in standardized extracts. We also have experience in clinical trials evaluating the pharmacokinetic properties of resveratrol in human subjects.

Teaching Interests

Dietary supplements, cancer, translational research, pharmacognosy

Professional Organizations

  • ASPET (American Society of Pharmacology and Experimental Therapeutics)
  • PSNA (Phytochemical Society of North America)
  • ACCP (American College of Clinical Pharmacy)
  • AACR (American Association of Cancer Research)

Licenses and Certifications

  • State of Illinois (Active), Registered Pharmacist (R.Ph.), 2011
  • APHA, Pharmacy-Based Immunization Delivery, 2009
  • State of Wisconsin (Active), Registered Pharmacist (R.Ph.), 2007

Awards and Honors

  • 2015, Hans W. Vahlteich UIC Research Scholar , UIC
  • 2010, CTSA Scholar, UW-Madison
  • 2009, CTSA Scholar, UW-Madison
  • 2009, Scholar-In-Training Award (Frontiers in Cancer Prevention Research, December 6-9th 2009, Houston TX), Susan G. Komen AACR
  • 2008, CTSA Scholar, UW-Madison
  • 2008, Scholar-In-Training Award (Frontiers in Cancer Prevention Research, November 16-19th, National Harbor MD), Susan G. Komen AACR
  • 2007, CTSA Scholar, UW-Madison
  • 2007, TEAM Scholar, UW-Madison
  • 2004, Student Research Travel Award, Merck Pharmacy
  • 2001, Dean’s Distinguished Achievement Award, University of Wisconsin–Stevens Point

Intellectual Contributions

Other

  • Ng VC, Johnson JJ, Cuellar S. (2014). "Targeting the mammalian target of rapamycin pathway with everolimus: Implications for the management of metastatic breast cancer.". Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.

Journal Article

  • Petiwala SM, Li G, Ramaiya A, Kumar A, Gill RK, Saksena S, Johnson JJ. "Pharmacokinetic characterization of mangosteen (Garcinia mangostana) fruit extract standardized to α-mangostin in C57BL/6 mice.". Nutrition research (New York, N.Y.). 2014;34(4):336-45. doi:10.1016/j.nutres.2014.03.002.
  • Petiwala SM, Berhe S, Li G, Puthenveetil AG, Rahman O, Nonn L, Johnson JJ. "Rosemary (Rosmarinus officinalis) extract modulates CHOP/GADD153 to promote androgen receptor degradation and decreases xenograft tumor growth.". PloS one. 2014;9(3):e89772. doi:10.1371/journal.pone.0089772.
  • Li G, Thomas S, Johnson JJ. "Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer.". Frontiers in pharmacology. 2013;4:80. doi:10.3389/fphar.2013.00080.
  • Petiwala SM, Puthenveetil AG, Johnson JJ. "Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer.". Frontiers in pharmacology. 2013;4:29. doi:10.3389/fphar.2013.00029.
  • Li G, Petiwala SM, Pierce DR, Nonn L, Johnson JJ. "Selective modulation of endoplasmic reticulum stress markers in prostate cancer cells by a standardized mangosteen fruit extract.". PloS one. 2013;8(12):e81572. doi:10.1371/journal.pone.0081572.
  • Ramaiya A, Li G, Petiwala SM, Johnson JJ. "Single dose oral pharmacokinetic profile of α-mangostin in mice.". Current drug targets. 2012;13(14):1698-704.
  • Johnson JJ, Petiwala SM, Syed DN, Rasmussen JT, Adhami VM, Siddiqui IA, Kohl AM, Mukhtar H. "α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth.". Carcinogenesis. 2012;33(2):413-9. doi:10.1093/carcin/bgr291.
  • Johnson JJ, Nihal M, Siddiqui IA, Scarlett CO, Bailey HH, Mukhtar H, Ahmad N. "Enhancing the bioavailability of resveratrol by combining it with piperine.". Molecular nutrition & food research. 2011;55(8):1169-76. doi:10.1002/mnfr.201100117.
  • Johnson JJ. "Carnosol: a promising anti-cancer and anti-inflammatory agent.". Cancer letters. 2011;305(1):1-7. doi:10.1016/j.canlet.2011.02.005.
  • Syed DN, Afaq F, Maddodi N, Johnson JJ, Sarfaraz S, Ahmad A, Setaluri V, Mukhtar H. "Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased Mitf levels.". The Journal of investigative dermatology. 2011;131(6):1291-9. doi:10.1038/jid.2011.6.
  • Johnson JJ, Syed DN, Suh Y, Heren CR, Saleem M, Siddiqui IA, Mukhtar H. "Disruption of androgen and estrogen receptor activity in prostate cancer by a novel dietary diterpene carnosol: implications for chemoprevention.". Cancer prevention research (Philadelphia, Pa.). 2010;3(9):1112-23. doi:10.1158/1940-6207.CAPR-10-0168.
  • Johnson JJ, Bailey HH, Mukhtar H. "Green tea polyphenols for prostate cancer chemoprevention: a translational perspective.". Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010;17(1):3-13. doi:10.1016/j.phymed.2009.09.011.
  • Saleem M, Murtaza I, Tarapore RS, Suh Y, Adhami VM, Johnson JJ, Siddiqui IA, Khan N, Asim M, Hafeez BB, Shekhani MT, Li B, Mukhtar H. "Lupeol inhibits proliferation of human prostate cancer cells by targeting beta-catenin signaling.". Carcinogenesis. 2009;30(5):808-17. doi:10.1093/carcin/bgp044.
  • Suh Y, Afaq F, Johnson JJ, Mukhtar H. "A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways.". Carcinogenesis. 2009;30(2):300-7. doi:10.1093/carcin/bgn269.
  • Johnson JJ, Syed DN, Heren CR, Suh Y, Adhami VM, Mukhtar H. "Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 5'-AMP-activated protein kinase (AMPK) pathway.". Pharmaceutical research. 2008;25(9):2125-34. doi:10.1007/s11095-008-9552-0.
  • Pomplun M, Johnson JJ, Johnston S, Kolesar JM. "Stability of a heparin-free 50% ethanol lock solution for central venous catheters.". Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2007;13(1):33-7. doi:10.1177/1078155207077598.
  • Saleem M, Kweon MH, Johnson JJ, Adhami VM, Elcheva I, Khan N, Bin Hafeez B, Bhat KM, Sarfaraz S, Reagan-Shaw S, Spiegelman VS, Setaluri V, Mukhtar H. "S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9.". Proceedings of the National Academy of Sciences of the United States of America. 2006;103(40):14825-30. doi:10.1073/pnas.0606747103.

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