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Photo of Scott Gary Franzblau

Scott Gary Franzblau

Director, Institute for Tuberculosis Research

Professor, Medicinal Chemistry and Pharmacognosy

INST AFFL, Program for Collaborative Research in the Pharmaceutical Sciences

Contact Information

833 South Wood Street
425 PHARM
Chicago, IL 60612

Phone: (312) 355-1715

Fax: (312) 355-2693

Website: http://www.tuberculosisdrugresearch.org/

Education

  • PhD, University of Arizon, 1982
  • MS, University of Arizona, 1978
  • BS, Rutgers University, 1976

Research Lab Summary

The Institute for Tuberculosis Research (ITR), located at the University of Illinois at Chicago, is a drug discovery research facility working on the development of new drugs to combat an old, but still evolving global public health threat. The ITR is unique in that it brings an industrial model of drug discovery into an academic environment. In Chicago we have assembled all of the necessary components - medicinal chemistry, natural products chemistry, microbiology, drug metabolism, pharmacokinetics and toxicology - under one roof to maximize efficiency and communication. In addition to in-house discovery projects, we also collaborate with many public and private sector institutions around the world to facilitate their efforts towards the same goal. Located in Chicago, our members come from China, Germany, India, Iran, Japan, Korea, Brazil, and the U.S. Our group includes four primary faculty, four affiliate faculty, two adjunct faculty, BS, MS and PhD staff scientists, and administrative staff. We occupy 5,500 sq. ft. of labs and offices in the College of Pharmacy at the University of Illinois at Chicago. Our research is supported by the Global Alliance for TB Drug Development, the National Institutes of Health, fee-for-service arrangements from industry, and a patent royalty stream. Our annual budget consists of over one million dollars in grants and contracts.

Research Interests

My motivation for finding new drugs for tuberculosis stems from a general desire to help alleviate suffering from diseases that disproportionately affect the poor and that have been neglected by the very countries that have the resources to make a difference. The success that we had in going from the lab to the clinic in leprosy in the 90s, gave me confidence that we can do the same for TB as these diseases are caused by related bacteria. The ITR is pursuing several strategies for discovery of new anti-TB agents. This includes large scale screening of both natural and synthetic compounds for those that demonstrate specificity of activity (i.e. inhibit the TB bacillus but not mammalian cells). Lead compounds are then optimized by semi-synthesis. In addition we are attempting to optimize the anti-TB activity of classes of antibiotics used for other infections but that have not been clinically active in tuberculosis. Activity of all lead compounds are assessed in macrophage and mouse models of TB. Ultimately clinical trials will be conducted with collaborators in TB-endemic regions.

Awards and Honors

  • 2017, Albert Schatz Professorship, UIC

Intellectual Contributions

Journal Article

  • Macabeo APG , Letada AG, Budde S, Faderl C, Dahse HM, Franzblau SG, Alejandro GJD , Pierens GK, Garson MJ. "Antitubercular and Cytotoxic Chlorinated seco-Cyclohexenes from Uvaria alba.". Journal of natural products. 2017;80(12):3319-3323. doi:10.1021/acs.jnatprod.7b00679.
  • Choi PJ, Sutherland HS, Tong AST , Blaser A, Franzblau SG, Cooper CB, Lotlikar MU, Upton AM, Guillemont J, Motte M, Queguiner L, Andries K, Van den Broeck W, Denny WA, Palmer BD. "Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units.". Bioorganic & medicinal chemistry letters. 2017;27(23):5190-5196. doi:10.1016/j.bmcl.2017.10.042.
  • Börger C, Brütting C, Julich-Gruner KK, Hesse R, Kumar VP, Kutz SK, Rönnefahrt M, Thomas C, Wan B, Franzblau SG, Knölker HJ. "Anti-tuberculosis activity and structure-activity relationships of oxygenated tricyclic carbazole alkaloids and synthetic derivatives.". Bioorganic & medicinal chemistry. 2017;25(22):6167-6174. doi:10.1016/j.bmc.2016.12.038.
  • Thompson AM, Bonnet M, Lee H, Franzblau SG, Wan B, Wong GS, Cooper CB, Denny WA. "Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid.". ACS medicinal chemistry letters. 2017;8(12):1275-1280. doi:10.1021/acsmedchemlett.7b00356.
  • Gao W, McAlpine JB, Choules MP, Napolitano JG, Lankin DC, Simmler C, Ho NA, Lee H, Suh JW, Burton IW, Cho S, Franzblau SG, Chen S, Pauli GF. "Structural Sequencing of Oligopeptides Aided by 1H Iterative Full-Spin Analysis.". Journal of natural products. 2017;80(10):2630-2643. doi:10.1021/acs.jnatprod.7b00207.
  • Dos Santos Fernandes GF, de Souza PC, Moreno-Viguri E, Santivañez-Veliz M, Paucar R, Pérez-Silanes S, Chegaev K, Guglielmo S, Lazzarato L, Fruttero R, Man Chin C, da Silva PB, Chorilli M, Solcia MC, Ribeiro CM, Silva CSP , Marino LB, Bosquesi PL, Hunt DM, de Carvalho LPS , de Souza Costa CA, Cho S, Wang Y, Franzblau SG, Pavan FR, Dos Santos JL. "Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity.". Journal of medicinal chemistry. 2017;60(20):8647-8660. doi:10.1021/acs.jmedchem.7b01332.
  • Brengel C, Thomann A, Schifrin A, Allegretta G, Kamal AAM , Haupenthal J, Schnorr I, Cho S, Franzblau SG, Empting M, Eberhard J, Hartmann RW. "Biophysical Screening of a Focused Library for the Discovery of CYP121 Inhibitors as Novel Antimycobacterials.". ChemMedChem. 2017;12(19):1616-1626. doi:10.1002/cmdc.201700363.
  • Liu R, Lyu X, Batt SM, Hsu MH, Harbut MB, Vilchèze C, Cheng B, Ajayi K, Yang B, Yang Y, Guo H, Lin C, Gan F, Wang C, Franzblau SG, Jacobs, Jr WR, Besra GS, Johnson EF, Petrassi M, Chatterjee AK, Fütterer K, Wang F. "Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.". Angewandte Chemie (International ed. in English). 2017;56(42):13011-13015. doi:10.1002/anie.201707324.
  • Tong AST , Choi PJ, Blaser A, Sutherland HS, Tsang SKY , Guillemont J, Motte M, Cooper CB, Andries K, Van den Broeck W, Franzblau SG, Upton AM, Denny WA, Palmer BD, Conole D. "6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis.". ACS medicinal chemistry letters. 2017;8(10):1019-1024. doi:10.1021/acsmedchemlett.7b00196.
  • Warit S, Rukseree K, Prammananan T, Hongmanee P, Billamas P, Jaitrong S, Chaiprasert A, Jaki BU, Pauli GF, Franzblau SG, Palittapongarnpim P. "In Vitro Activities of Enantiopure and Racemic 1'-Acetoxychavicol Acetate against Clinical Isolates of Mycobacterium tuberculosis.". Scientia pharmaceutica. 2017;85(3). doi:10.3390/scipharm85030032.
  • Gomes MN, Braga RC, Grzelak E, Neves BJ, Muratov E, Ma R, Klein L, Cho S, Oliveira GR, Franzblau SG, Andrade CH. "QSAR-driven design, synthesis and discovery of potent chalcone derivatives with antitubercular activity.". European journal of medicinal chemistry. 2017;137:126-138. doi:10.1016/j.ejmech.2017.05.026.
  • Wavhale RD, Martis EAF , Ambre PK, Wan B, Franzblau SG, Iyer KR, Raikuvar K, Macegoniuk K, Berlicki , Nandan SR, Coutinho EC. "Discovery of new leads against Mycobacterium tuberculosis using scaffold hopping and shape based similarity.". Bioorganic & medicinal chemistry. 2017;25(17):4835-4844. doi:10.1016/j.bmc.2017.07.034.
  • Jiménez-Romero C, Rode JE, Pérez YM, Franzblau SG, Rodríguez AD. "Exploring the Sponge Consortium Plakortis symbiotica-Xestospongia deweerdtae as a Potential Source of Antimicrobial Compounds and Probing the Pharmacophore for Antituberculosis Activity of Smenothiazole A by Diverted Total Synthesis.". Journal of natural products. 2017;80(8):2295-2303. doi:10.1021/acs.jnatprod.7b00300.
  • Liu Y, Friesen JB, Grzelak E, Fan Q, Tang T, Durić K, Jaki BU, McAlpine JB, Franzblau SG, Chen S, Pauli GF. "Sweet spot matching: A thin-layer chromatography-based countercurrent solvent system selection strategy.". Journal of chromatography. A. 2017;1504:46-54. doi:10.1016/j.chroma.2017.04.055.
  • Thompson AM, Blaser A, Palmer BD, Anderson RF, Shinde SS, Launay D, Chatelain E, Maes L, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA. "6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases.". Bioorganic & medicinal chemistry letters. 2017;27(11):2583-2589. doi:10.1016/j.bmcl.2017.03.069.
  • Gomes MN, Alcântara LM, Neves BJ, Melo-Filho CC, Freitas-Junior LH, Moraes CB, Ma R, Franzblau SG, Muratov E, Andrade CH. "Computer-aided discovery of two novel chalcone-like compounds active and selective against Leishmania infantum.". Bioorganic & medicinal chemistry letters. 2017;27(11):2459-2464. doi:10.1016/j.bmcl.2017.04.010.
  • Thompson AM, O'Connor PD, Marshall AJ, Yardley V, Maes L, Gupta S, Launay D, Braillard S, Chatelain E, Franzblau SG, Wan B, Wang Y, Ma Z, Cooper CB, Denny WA. "7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis.". Journal of medicinal chemistry. 2017;60(10):4212-4233. doi:10.1021/acs.jmedchem.7b00034.
  • Velappan AB, Charan Raja MR, Datta D, Tsai YT, Halloum I, Wan B, Kremer L, Gramajo H, Franzblau SG, Kar Mahapatra S, Debnath J. "Attenuation of Mycobacterium species through direct and macrophage mediated pathway by unsymmetrical diaryl urea.". European journal of medicinal chemistry. 2017;125:825-841. doi:10.1016/j.ejmech.2016.09.083.
  • Mitachi K, Siricilla S, Yang D, Kong Y, Skorupinska-Tudek K, Swiezewska E, Franzblau SG, Kurosu M. "Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors.". Analytical biochemistry. 2016;512:78-90. doi:10.1016/j.ab.2016.08.008.
  • Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR. "Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.". Antimicrobial agents and chemotherapy. 2016;60(10):6271-80. doi:10.1128/AAC.01339-16.
  • Guan YF, Song X, Qiu MH, Luo S, Wang BJ, Van Hung N, Cuong NM, Soejarto DD, Fong HH, Franzblau SG, Li SH, He ZD, Zhang HJ. "Bioassay-Guided Isolation and Structural Modification of the Anti-TB Resorcinols from Ardisia gigantifolia.". Chemical biology & drug design. 2016;88(2):293-301. doi:10.1111/cbdd.12756.
  • Moraski GC, Cheng Y, Cho S, Cramer JW, Godfrey A, Masquelin T, Franzblau SG, Miller MJ, Schorey J. "Imidazo[1,2-a]Pyridine-3-Carboxamides Are Active Antimicrobial Agents against Mycobacterium avium Infection In Vivo.". Antimicrobial agents and chemotherapy. 2016;60(8):5018-22. doi:10.1128/AAC.00618-16.
  • Segretti ND, Simões CK, Corrêa MF, Felli VM, Miyata M, Cho S, Franzblau SG, Fernandes JP. "Antimycobacterial activity of pyrazinoate prodrugs in replicating and non-replicating Mycobacterium tuberculosis.". Tuberculosis (Edinburgh, Scotland). 2016;99:11-6. doi:10.1016/j.tube.2016.04.002.
  • Moraski GC, Seeger N, Miller PA, Oliver AG, Boshoff HI, Cho S, Mulugeta SG, Anderson JR, Franzblau SG, Miller MJ. "Arrival of Imidazo[2,1-b]thiazole-5-carboxamides: Potent Anti-tuberculosis Agents That Target QcrB.". ACS infectious diseases. 2016;2(6):393-8. doi:10.1021/acsinfecdis.5b00154.
  • Majewski MW, Tiwari R, Miller PA, Cho S, Franzblau SG, Miller MJ. "Design, syntheses, and anti-tuberculosis activities of conjugates of piperazino-1,3-benzothiazin-4-ones (pBTZs) with 2,7-dimethylimidazo [1,2-a]pyridine-3-carboxylic acids and 7-phenylacetyl cephalosporins.". Bioorganic & medicinal chemistry letters. 2016;26(8):2068-71. doi:10.1016/j.bmcl.2016.02.076.
  • Grzelak E, Hwang C, Cai G, Nam J, Choules MP, Gao W, Lankin DC, McAlpine JB, Mulugeta SG, Napolitano JG, Suh JW, Yang SH, Cheng J, Lee H, Kim JY, Cho S, Pauli GF, Franzblau SG, Jaki BU. "Bioautography with TLC-MS/NMR for Rapid Discovery of Anti-tuberculosis Lead Compounds from Natural Sources.". ACS infectious diseases. 2016;2(4):294-301. doi:10.1021/acsinfecdis.5b00150.
  • Thompson AM, O'Connor PD, Blaser A, Yardley V, Maes L, Gupta S, Launay D, Martin D, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA. "Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis.". Journal of medicinal chemistry. 2016;59(6):2530-50. doi:10.1021/acs.jmedchem.5b01699.
  • Nieves K, Prudhomme J, Le Roch KG, Franzblau SG, Rodríguez AD. "Natural product-based synthesis of novel anti-infective isothiocyanate- and isoselenocyanate-functionalized amphilectane diterpenes.". Bioorganic & medicinal chemistry letters. 2016;26(3):854-857. doi:10.1016/j.bmcl.2015.12.080.
  • Tiwari R, Miller PA, Chiarelli LR, Mori G, Šarkan M, Centárová I, Cho S, Mikušová K, Franzblau SG, Oliver AG, Miller MJ. "Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043.". ACS medicinal chemistry letters. 2016;7(3):266-70. doi:10.1021/acsmedchemlett.5b00424.
  • Majewski MW, Watson KD, Cho S, Miller PA, Franzblau SG, Miller MJ. "Syntheses and Biological Evaluations of Highly Functionalized Hydroxamate Containing and N-Methylthio Monobactams as Anti-Tuberculosis and β-Lactamase Inhibitory Agents.". MedChemComm. 2016;7(1):141-147. doi:10.1039/C5MD00340G.
  • Avilés E, Prudhomme J, Le Roch KG, Franzblau SG, Chandrasena K, Mayer AM, Rodríguez AD. "Synthesis and preliminary biological evaluation of a small library of hybrid compounds based on Ugi isocyanide multicomponent reactions with a marine natural product scaffold.". Bioorganic & medicinal chemistry letters. 2015;25(22):5339-43. doi:10.1016/j.bmcl.2015.09.033.
  • Majewski MW, Cho S, Miller PA, Franzblau SG, Miller MJ. "Syntheses and evaluation of substituted aromatic hydroxamates and hydroxamic acids that target Mycobacterium tuberculosis.". Bioorganic & medicinal chemistry letters. 2015;25(21):4933-6. doi:10.1016/j.bmcl.2015.04.099.
  • Gutka HJ, Wang Y, Franzblau SG, Movahedzadeh F. "glpx Gene in Mycobacterium tuberculosis Is Required for In Vitro Gluconeogenic Growth and In Vivo Survival.". PloS one. 2015;10(9):e0138436. doi:10.1371/journal.pone.0138436.
  • Thompson AM, Blaser A, Palmer BD, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA. "Biarylmethoxy 2-nitroimidazooxazine antituberculosis agents: Effects of proximal ring substitution and linker reversal on metabolism and efficacy.". Bioorganic & medicinal chemistry letters. 2015;25(18):3804-9. doi:10.1016/j.bmcl.2015.07.084.
  • Pieroni M, Wan B, Zuliani V, Franzblau SG, Costantino G, Rivara M. "Discovery of antitubercular 2,4-diphenyl-1H-imidazoles from chemical library repositioning and rational design.". European journal of medicinal chemistry. 2015;100:44-9. doi:10.1016/j.ejmech.2015.05.048.
  • Luo S, Kang HS, Krunic A, Chen W, Yang J, Woodard JL, Fuchs JR, Hyun Cho S, Franzblau SG, Swanson SM, Orjala J. "Trichormamides C and D, antiproliferative cyclic lipopeptides from the cultured freshwater cyanobacterium cf. Oscillatoria sp. UIC 10045.". Bioorganic & medicinal chemistry. 2015;23(13):3153-62. doi:10.1016/j.bmc.2015.04.073.
  • Mullowney MW, Hwang CH, Newsome AG, Wei X, Tanouye U, Wan B, Carlson SN, Barranis NJ, hAinmhire E, Chen W, Krishnamoorthy K, White J, Blair R, Lee H, Burdette JE, Rathod PK, Parish T, Cho S, Franzblau SG, Murphy BT. "Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosis.". ACS infectious diseases. 2015;1(4):168-174. doi:10.1021/acsinfecdis.5b00005.
  • Palmer BD, Sutherland HS, Blaser A, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA, Thompson AM. "Synthesis and Structure-Activity Relationships for Extended Side Chain Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).". Journal of medicinal chemistry. 2015;58(7):3036-59. doi:10.1021/jm501608q.
  • Moraski GC, Miller PA, Bailey MA, Ollinger J, Parish T, Boshoff HI, Cho S, Anderson JR, Mulugeta SG, Franzblau SG, Miller MJ. "Putting Tuberculosis (TB) To Rest: Transformation of the Sleep Aid, Ambien, and "Anagrams" Generated Potent Antituberculosis Agents.". ACS infectious diseases. 2015;1(2):85-90. doi:10.1021/id500008t.
  • Tiwari R, Miller PA, Cho S, Franzblau SG, Miller MJ. "Syntheses and Antituberculosis Activity of 1,3-Benzothiazinone Sulfoxide and Sulfone Derived from BTZ043.". ACS medicinal chemistry letters. 2015;6(2):128-33. doi:10.1021/ml5003458.
  • Gao W, Kim JY, Anderson JR, Akopian T, Hong S, Jin YY, Kandror O, Kim JW, Lee IA, Lee SY, , Mulugeta SG, Sunoqrot S, Wang Y, Yang SH, Yoon TM, Goldberg AL, Pauli GF, Suh JW, Franzblau SG, Cho S. "The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo.". Antimicrobial agents and chemotherapy. 2015;59(2):880-9. doi:10.1128/AAC.04054-14.
  • Upton AM, Cho S, Yang TJ, Kim Y, Wang Y, Lu Y, Wang B, Xu J, Mdluli K, Ma Z, Franzblau SG. "In vitro and in vivo activities of the nitroimidazole TBA-354 against Mycobacterium tuberculosis.". Antimicrobial agents and chemotherapy. 2015;59(1):136-44. doi:10.1128/AAC.03823-14.
  • Macabeo AP, Martinez FP, Kurtán T, Tóth L, Mándi A, Schmidt S, Heilmann J, Alejandro GJ, Knorn M, Dahse HM, Franzblau SG. "Tetrahydroxanthene-1,3(2H)-dione derivatives from Uvaria valderramensis.". Journal of natural products. 2014;77(12):2711-5. doi:10.1021/np500538c.
  • Gao W, Kim JY, Chen S, Cho S, Choi J, Jaki BU, Jin YY, Lankin DC, Lee JE, Lee SY, , Napolitano JG, Franzblau SG, Suh JW, Pauli GF. "Discovery and characterization of the tuberculosis drug lead ecumicin.". Organic letters. 2014;16(23):6044-7. doi:10.1021/ol5026603.
  • Li W, Upadhyay A, Fontes FL, North EJ, Wang Y, Crans DC, Grzegorzewicz AE, Jones V, Franzblau SG, Lee RE, Crick DC, Jackson M. "Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis.". Antimicrobial agents and chemotherapy. 2014;58(11):6413-23. doi:10.1128/AAC.03229-14.
  • Siricilla S, Mitachi K, Wan B, Franzblau SG, Kurosu M. "Discovery of a capuramycin analog that kills nonreplicating Mycobacterium tuberculosis and its synergistic effects with translocase I inhibitors.". The Journal of antibiotics. 2014;. doi:10.1038/ja.2014.133.
  • Moraski GC, Oliver AG, Markley LD, Cho S, Franzblau SG, Miller MJ. "Scaffold-switching: an exploration of 5,6-fused bicyclic heteroaromatics systems to afford antituberculosis activity akin to the imidazo[1,2-a]pyridine-3-carboxylates.". Bioorganic & medicinal chemistry letters. 2014;24(15):3493-8. doi:10.1016/j.bmcl.2014.05.062.
  • Lirio SB, Macabeo AP, Paragas EM, Knorn M, Kohls P, Franzblau SG, Wang Y, Aguinaldo MA. "Antitubercular constituents from Premna odorata Blanco.". Journal of ethnopharmacology. 2014;154(2):471-4. doi:10.1016/j.jep.2014.04.015.
  • Tiwari R, Möllmann U, Cho S, Franzblau SG, Miller PA, Miller MJ. "Design and Syntheses of Anti-Tuberculosis Agents Inspired by BTZ043 Using a Scaffold Simplification Strategy.". ACS medicinal chemistry letters. 2014;5(5):587-91. doi:10.1021/ml500039g.
  • Schinkovitz A, Kaur A, Urban E, Zehl M, Páchniková G, Wang Y, Kretschmer N, Slaninová I, Pauli GF, Franzblau SG, Krupitza G, Bauer R, Kopp B. "Cytotoxic constituents from Lobaria scrobiculata and a comparison of two bioassays for their evaluation.". Journal of natural products. 2014;77(4):1069-73. doi:10.1021/np4008574.
  • Ramos Alvarenga RF, Wan B, Inui T, Franzblau SG, Pauli GF, Jaki BU. "Airborne antituberculosis activity of Eucalyptus citriodora essential oil.". Journal of natural products. 2014;77(3):603-10. doi:10.1021/np400872m.
  • Elkington BG, Sydara K, Newsome A, Hwang CH, Lankin DC, Simmler C, Napolitano JG, Ree R, Graham JG, Gyllenhaal C, Bouamanivong S, Souliya O, Pauli GF, Franzblau SG, Soejarto DD. "New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos.". Journal of ethnopharmacology. 2014;151(2):903-11. doi:10.1016/j.jep.2013.11.057.
  • Elkington BG, Sydara K, Newsome A, Hwang CH, Lankin DC, Simmler C, Napolitano JG, Ree R, Graham JG, Gyllenhaal C, Bouamanivong S, Souliya O, Pauli GF, Franzblau SG, Soejarto DD. "New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos.". Journal of ethnopharmacology. 2014;151(2):903-11. doi:10.1016/j.jep.2013.11.057.
  • Pieroni M, Wan B, Cho S, Franzblau SG, Costantino G. "Design, synthesis and investigation on the structure-activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents.". European journal of medicinal chemistry. 2014;72:26-34. doi:10.1016/j.ejmech.2013.11.007.
  • Luo S, Kang HS, Krunic A, Chlipala GE, Cai G, Chen W, Franzblau SG, Swanson SM, Orjala J. "Carbamidocyclophanes F and G with Anti-Mycobacterium tuberculosis Activity from the Cultured Freshwater Cyanobacterium Nostoc sp.". Tetrahedron letters. 2014;55(3):686-689. doi:10.1016/j.tetlet.2013.11.112.
  • Klein L, Petukhova V, Wan B, Wang Y, Santasiero BD, Lankin DC, Pauli GF, Franzblau SG. "A novel indigoid anti-tuberculosis agent.". Bioorganic & medicinal chemistry letters. 2014;24(1):268-70. doi:10.1016/j.bmcl.2013.11.024.
  • Lv W, Banerjee B, Molland KL, Seleem MN, Ghafoor A, Hamed MI, Wan B, Franzblau SG, Mesecar AD, Cushman M. "Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase.". Bioorganic & medicinal chemistry. 2014;22(1):406-18. doi:10.1016/j.bmc.2013.11.011.
  • Cai G, Napolitano JG, , Wang Y, Jaki BU, Suh JW, Yang SH, Lee IA, Franzblau SG, Pauli GF, Cho S. "Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain.". Journal of natural products. 2013;76(11):2009-18. doi:10.1021/np400145u.
  • Schmidt AW, Choi TA, Theumer G, Franzblau SG, Knölker HJ. "Inhibitory effect of oxygenated cholestan-3β-ol derivatives on the growth of Mycobacterium tuberculosis.". Bioorganic & medicinal chemistry letters. 2013;23(22):6111-3. doi:10.1016/j.bmcl.2013.09.013.
  • Bukhari SN, Franzblau SG, Jantan I, Jasamai M. "Current prospects of synthetic curcumin analogs and chalcone derivatives against mycobacterium tuberculosis.". Medicinal chemistry (Shariqah (United Arab Emirates)). 2013;9(7):897-903.
  • Hwang CH, Jaki BU, Klein L, Lankin DC, , Napolitano JG, Fryling NA, Franzblau SG, Cho S, Stamets PE, Wang Y, Pauli GF. "Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.". Journal of natural products. 2013;76(10):1916-22. doi:10.1021/np400497f.
  • Wijeratne EM, He H, Franzblau SG, Hoffman AM, Gunatilaka AA. "Phomapyrrolidones A-C, antitubercular alkaloids from the endophytic fungus Phoma sp. NRRL 46751.". Journal of natural products. 2013;76(10):1860-5. doi:10.1021/np400391p.
  • Grant SS, Kawate T, Nag PP, Silvis MR, , Stanley SA, Kazyanskaya E, Nietupski R, Golas A, Cho S, Franzblau SG, Hung DT. "Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model.". ACS chemical biology. 2013;8(10):2224-34. doi:10.1021/cb4004817.
  • Lauinger IL, Vivas L, Perozzo R, Stairiker C, Tarun A, Zloh M, Zhang X, Xu H, Tonge PJ, Franzblau SG, Pham DH, Esguerra CV, Crawford AD, Maes L, Tasdemir D. "Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.". Journal of natural products. 2013;76(6):1064-70. doi:10.1021/np400083k.
  • Pavan FR, Poelhsitz GV, da Cunha LV, Barbosa MI, Leite SR, Batista AA, Cho S, Franzblau SG, de Camargo MS, Resende FA, Varanda EA, Leite CQ. "In vitro and in vivo activities of ruthenium(II) phosphine/diimine/picolinate complexes (SCAR) against Mycobacterium tuberculosis.". PloS one. 2013;8(5):e64242. doi:10.1371/journal.pone.0064242.
  • Ekins S, Reynolds RC, Franzblau SG, Wan B, Freundlich JS, Bunin BA. "Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models.". PloS one. 2013;8(5):e63240. doi:10.1371/journal.pone.0063240.
  • Cai G, Pauli GF, Wang Y, Jaki BU, Franzblau SG. "Rapid determination of growth inhibition of Mycobacterium tuberculosis by GC-MS/MS quantitation of tuberculostearic acid.". Tuberculosis (Edinburgh, Scotland). 2013;93(3):322-9. doi:10.1016/j.tube.2012.12.004.
  • Hwang JM, Oh T, Kaneko T, Upton AM, Franzblau SG, Ma Z, Cho S, Kim P. "Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents.". Journal of natural products. 2013;76(3):354-67. doi:10.1021/np3007167.
  • Qiu F, Cai G, Jaki BU, Lankin DC, Franzblau SG, Pauli GF. "Quantitative purity-activity relationships of natural products: the case of anti-tuberculosis active triterpenes from Oplopanax horridus.". Journal of natural products. 2013;76(3):413-9. doi:10.1021/np3007809.
  • Mehnaz S, Saleem RS, Yameen B, Pianet I, Schnakenburg G, Pietraszkiewicz H, Valeriote F, Josten M, Sahl HG, Franzblau SG, Gross H. "Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain Pseudomonas aurantiaca PB-St2.". Journal of natural products. 2013;76(2):135-41. doi:10.1021/np3005166.
  • Pegan SD, Rukseree K, Capodagli GC, Baker EA, Krasnykh O, Franzblau SG, Mesecar AD. "Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis.". Biochemistry. 2013;52(5):912-25. doi:10.1021/bi300928u.
  • Poce G, Bates RH, Alfonso S, Cocozza M, Porretta GC, Ballell L, Rullas J, Ortega F, De Logu A, Agus E, La Rosa V, Pasca MR, De Rossi E, Wae B, Franzblau SG, Manetti F, Botta M, Biava M. "Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection.". PloS one. 2013;8(2):e56980. doi:10.1371/journal.pone.0056980.
  • Brugarolas P, Movahedzadeh F, Wang Y, Zhang N, Bartek IL, Gao YN, Voskuil MI, Franzblau SG, He C. "The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis.". The Journal of biological chemistry. 2012;287(45):37703-12. doi:10.1074/jbc.M112.388611.
  • Franzblau SG, DeGroote MA, Cho S, Andries K, Nuermberger E, Orme IM, Mdluli K, Angulo-Barturen I, Dick T, Dartois V, Lenaerts AJ. "Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis.". Tuberculosis (Edinburgh, Scotland). 2012;92(6):453-88. doi:10.1016/j.tube.2012.07.003.
  • Tukulula M, Little S, Gut J, Rosenthal PJ, Wan B, Franzblau SG, Chibale K. "The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives.". European journal of medicinal chemistry. 2012;57:259-67. doi:10.1016/j.ejmech.2012.08.047.
  • Silveira GP, Ferreira M, Fernandes L, Moraski GC, Cho S, Hwang C, Franzblau SG, Sá MM. "Allylic thiocyanates as a new class of antitubercular agents.". Bioorganic & medicinal chemistry letters. 2012;22(20):6486-9. doi:10.1016/j.bmcl.2012.08.048.
  • Juárez-Hernández RE, Franzblau SG, Miller MJ. "Syntheses of mycobactin analogs as potent and selective inhibitors of Mycobacterium tuberculosis.". Organic & biomolecular chemistry. 2012;10(37):7584-93. doi:10.1039/c2ob26077h.
  • Macabeo AP, Tudla FA, Krohn K, Franzblau SG. "Antitubercular activity of the semi-polar extractives of Uvaria rufa.". Asian Pacific journal of tropical medicine. 2012;5(10):777-80. doi:10.1016/S1995-7645(12)60142-4.
  • Inui T, Wang Y, Pro SM, Franzblau SG, Pauli GF. "Unbiased evaluation of bioactive secondary metabolites in complex matrices.". Fitoterapia. 2012;83(7):1218-25. doi:10.1016/j.fitote.2012.06.012.
  • Kim H, Lantvit DD, Hwang CH, Kroll DJ, Swanson SM, Franzblau SG, Orjala J. "Indole alkaloids from two cultured cyanobacteria, Westiellopsis sp. and Fischerella muscicola.". Bioorganic & medicinal chemistry. 2012;20(17):5290-5. doi:10.1016/j.bmc.2012.06.030.
  • Kunciw DL, Liechty JJ, Mitchell MO, Wan B, Franzblau SG. "Structural requirements for the antitubercular quaternized triflupromazine pharmacophore.". Bioorganic & medicinal chemistry letters. 2012;22(17):5679-80. doi:10.1016/j.bmcl.2012.06.095.
  • Dulla B, Wan B, Franzblau SG, Kapavarapu R, Reiser O, Iqbal J, Pal M. "Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents.". Bioorganic & medicinal chemistry letters. 2012;22(14):4629-35. doi:10.1016/j.bmcl.2012.05.096.
  • Chopra S, Koolpe GA, Tambo-Ong AA, Matsuyama KN, Ryan KJ, Tran TB, Doppalapudi RS, Riccio ES, Iyer LV, Green CE, Wan B, Franzblau SG, Madrid PB. "Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis.". Journal of medicinal chemistry. 2012;55(13):6047-60. doi:10.1021/jm300123s.
  • Kumarasamy M, Theivendren P, Govindarajan R, Franzblau SG, Ramalingam K. "Carcinogenic effects of N-nitroso-3-(substituted phenylimino)-indolin-2-one derivatives.". Journal of pharmacy & bioallied sciences. 2012;4(3):207-11. doi:10.4103/0975-7406.99035.
  • Macabeo AP, Gehle D, Krohn K, Franzblau SG, Aguinaldo AM. "Photoactivated [3+2] addition of 6,7-seco-angustilobine B to fullerene [C60].". Natural product communications. 2012;7(6):743-5.
  • Ji C, Lin W, Moraski GC, Thanassi JA, Pucci MJ, Franzblau SG, Möllmann U, Miller MJ. "Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels-Alder reaction.". Bioorganic & medicinal chemistry. 2012;20(11):3422-8. doi:10.1016/j.bmc.2012.04.026.
  • Macabeo AP, Avila JA, Alejandro GJ, Franzblau SG, Kouam SF, Hussain H, Krohn K. "Villarinol, a new alkenoyloxyalkenol derivative from the endemic Philippine Rubiaceae species Villaria odorata.". Natural product communications. 2012;7(6):779-80.
  • Debnath J, Siricilla S, Wan B, Crick DC, Lenaerts AJ, Franzblau SG, Kurosu M. "Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis.". Journal of medicinal chemistry. 2012;55(8):3739-55. doi:10.1021/jm201608g.
  • Gill SK, Xu H, Kirchhoff PD, Cierpicki T, Turbiak AJ, Wan B, Zhang N, Peng KW, Franzblau SG, Garcia GA, Showalter HD. "Structure-based design of novel benzoxazinorifamycins with potent binding affinity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerases.". Journal of medicinal chemistry. 2012;55(8):3814-26. doi:10.1021/jm201716n.
  • Moraski GC, Markley LD, Chang M, Cho S, Franzblau SG, Hwang CH, Boshoff H, Miller MJ. "Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds.". Bioorganic & medicinal chemistry. 2012;20(7):2214-20. doi:10.1016/j.bmc.2012.02.025.
  • Lu X, Liu X, Wan B, Franzblau SG, Chen L, Zhou C, You Q. "Synthesis and evaluation of anti-tubercular and antibacterial activities of new 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives. Part 2.". European journal of medicinal chemistry. 2012;49:164-71. doi:10.1016/j.ejmech.2012.01.007.
  • Chopra S, Matsuyama K, Tran T, Malerich JP, Wan B, Franzblau SG, Lun S, Guo H, Maiga MC, Bishai WR, Madrid PB. "Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.". The Journal of antimicrobial chemotherapy. 2012;67(2):415-21. doi:10.1093/jac/dkr449.
  • Blaser A, Palmer BD, Sutherland HS, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Thompson AM, Denny WA. "Structure-activity relationships for amide-, carbamate-, and urea-linked analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).". Journal of medicinal chemistry. 2012;55(1):312-26. doi:10.1021/jm2012276.
  • Soejarto DD, Gyllenhaal C, Kadushin MR, Southavong B, Sydara K, Bouamanivong S, Xaiveu M, Zhang HJ, Franzblau SG, Tan GT, Pezzuto JM, Riley MC, Elkington BG, Waller DP. "An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development.". Pharmaceutical biology. 2012;50(1):42-60. doi:10.3109/13880209.2011.619700.
  • Lilienkampf A, Pieroni M, Franzblau SG, Bishai WR, Kozikowski AP. "Derivatives of 3-isoxazolecarboxylic acid esters: a potent and selective compound class against replicating and nonreplicating Mycobacterium tuberculosis.". Current topics in medicinal chemistry. 2012;12(7):729-34.
  • Gyllenhaal C, Kadushin MR, Southavong B, Sydara K, Bouamanivong S, Xaiveu M, Xuan LT, Hiep NT, Hung NV, Loc PK, Dac LX, Bich TQ, Cuong NM, Ly HM, Zhang HJ, Franzblau SG, Xie H, Riley MC, Elkington BG, Nguyen HT, Waller DP, Ma CY, Tamez P, Tan GT, Pezzuto JM, Soejarto DD. "Ethnobotanical approach versus random approach in the search for new bioactive compounds: support of a hypothesis.". Pharmaceutical biology. 2012;50(1):30-41. doi:10.3109/13880209.2011.634424.
  • Lawal TO, Adeniyi BA, Adegoke AO, Franzblau SG, Mahady GB. "In vitro susceptibility of Mycobacterium tuberculosis to extracts of Eucalyptus camaldulensis and Eucalyptus torelliana and isolated compounds.". Pharmaceutical biology. 2012;50(1):92-8. doi:10.3109/13880209.2011.625953.
  • Jin Y, Gill SK, Kirchhoff PD, Wan B, Franzblau SG, Garcia GA, Showalter HD. "Synthesis and structure-activity relationships of novel substituted 8-amino, 8-thio, and 1,8-pyrazole congeners of antitubercular rifamycin S and rifampin.". Bioorganic & medicinal chemistry letters. 2011;21(20):6094-9. doi:10.1016/j.bmcl.2011.08.054.
  • Thompson AM, Sutherland HS, Palmer BD, Kmentova I, Blaser A, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA. "Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5h-imidazo[2,1-b][1,3]oxazine (PA-824).". Journal of medicinal chemistry. 2011;54(19):6563-85. doi:10.1021/jm200377r.
  • Pavan FR, Poelhsitz GV, Barbosa MI, Leite SR, Batista AA, Ellena J, Sato LS, Franzblau SG, Moreno V, Gambino D, Leite CQ. "Ruthenium(II) phosphine/diimine/picolinate complexes: inorganic compounds as agents against tuberculosis.". European journal of medicinal chemistry. 2011;46(10):5099-107. doi:10.1016/j.ejmech.2011.08.023.
  • Lu X, Wan B, Franzblau SG, You Q. "Design, synthesis and anti-tubercular evaluation of new 2-acylated and 2-alkylated amino-5-(4-(benzyloxy)phenyl)thiophene-3-carboxylic acid derivatives. Part 1.". European journal of medicinal chemistry. 2011;46(9):3551-63. doi:10.1016/j.ejmech.2011.05.018.
  • Gutka HJ, Rukseree K, Wheeler PR, Franzblau SG, Movahedzadeh F. "glpX gene of Mycobacterium tuberculosis: heterologous expression, purification, and enzymatic characterization of the encoded fructose 1,6-bisphosphatase II.". Applied biochemistry and biotechnology. 2011;164(8):1376-89. doi:10.1007/s12010-011-9219-x.
  • Bungihan ME, Tan MA, Kitajima M, Kogure N, Franzblau SG, Dela Cruz TE, Takayama H, Nonato MG. "Bioactive metabolites of Diaporthe sp. P133, an endophytic fungus isolated from Pandanus amaryllifolius.". Journal of natural medicines. 2011;65(3-4):606-9. doi:10.1007/s11418-011-0518-x.
  • Macabeo AP, Vidar WS, Chen X, Decker M, Heilmann J, Wan B, Franzblau SG, Galvez EV, Aguinaldo MA, Cordell GA. "Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.". European journal of medicinal chemistry. 2011;46(7):3118-23. doi:10.1016/j.ejmech.2011.04.025.
  • Vázquez-Laslop N, Klepacki D, Mulhearn DC, Ramu H, Krasnykh O, Franzblau SG, Mankin A. "Role of antibiotic ligand in nascent peptide-dependent ribosome stalling.". Proceedings of the National Academy of Sciences of the United States of America. 2011;108(26):10496-501. doi:10.1073/pnas.1103474108.
  • Moraski GC, Markley LD, Hipskind PA, Boshoff H, Cho S, Franzblau SG, Miller MJ. "Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity.". ACS medicinal chemistry letters. 2011;2(6):466-470. doi:10.1021/ml200036r.
  • Lu JP, Yuan XH, Yuan H, Wang WL, Wan B, Franzblau SG, Ye QZ. "Inhibition of Mycobacterium tuberculosis methionine aminopeptidases by bengamide derivatives.". ChemMedChem. 2011;6(6):1041-8. doi:10.1002/cmdc.201100003.
  • Gutka HJ, Franzblau SG, Movahedzadeh F, Abad-Zapatero C. "Crystallization and preliminary X-ray characterization of the glpX-encoded class II fructose-1,6-bisphosphatase from Mycobacterium tuberculosis.". Acta crystallographica. Section F, Structural biology and crystallization communications. 2011;67(Pt 6):710-3. doi:10.1107/S1744309111014722.
  • Truong NB, Pham CV, Doan HT, Nguyen HV, Nguyen CM, Nguyen HT, Zhang HJ, Fong HH, Franzblau SG, Soejarto DD, Chau MV. "Antituberculosis cycloartane triterpenoids from Radermachera boniana.". Journal of natural products. 2011;74(5):1318-22. doi:10.1021/np200022b.
  • Hans RH, Wiid IJ, van Helden PD, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. "Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents.". Bioorganic & medicinal chemistry letters. 2011;21(7):2055-8. doi:10.1016/j.bmcl.2011.02.008.
  • Higuchi CT, Sannomiya M, Pavan FR, Leite SR, Sato DN, Franzblau SG, Sacramento LV, Vilegas W, Leite CQ. "Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity.". Evidence-based complementary and alternative medicine : eCAM. 2011;2011:128349. doi:10.1093/ecam/nen077.
  • Kmentova I, Sutherland HS, Palmer BD, Blaser A, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA, Thompson AM. "Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).". Journal of medicinal chemistry. 2010;53(23):8421-39. doi:10.1021/jm101288t.
  • Mo S, Krunic A, Santarsiero BD, Franzblau SG, Orjala J. "Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua.". Phytochemistry. 2010;71(17-18):2116-23. doi:10.1016/j.phytochem.2010.09.004.
  • Mo S, Krunic A, Santarsiero BD, Franzblau SG, Orjala J. "Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua.". Phytochemistry. 2010;71(17-18):2116-23. doi:10.1016/j.phytochem.2010.09.004.
  • Raman N, Jeyamurugan R, Senthilkumar R, Rajkapoor B, Franzblau SG. "In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model.". European journal of medicinal chemistry. 2010;45(11):5438-51. doi:10.1016/j.ejmech.2010.09.004.
  • Chen L, Zhou B, Zhang S, Wu L, Wang Y, Franzblau SG, Zhang ZY. "Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis.". ACS medicinal chemistry letters. 2010;1(7):355-359. doi:10.1021/ml1001135.
  • Pieroni M, Lilienkampf A, Wang Y, Wan B, Cho S, Franzblau SG, Kozikowski AP. "NOC chemistry for tuberculosis-further investigations on the structure-activity relationships of antitubercular isoxazole-3-carboxylic acid ester derivatives.". ChemMedChem. 2010;5(10):1667-72. doi:10.1002/cmdc.201000169.
  • Villaflores OB, Macabeo AP, Gehle D, Krohn K, Franzblau SG, Aguinaldo AM. "Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis.". Pharmacognosy magazine. 2010;6(24):339-44. doi:10.4103/0973-1296.71785.
  • Stout EP, Prudhomme J, Roch KL, Fairchild CR, Franzblau SG, Aalbersberg W, Hay ME, Kubanek J. "Unusual antimalarial meroditerpenes from tropical red macroalgae.". Bioorganic & medicinal chemistry letters. 2010;20(19):5662-5. doi:10.1016/j.bmcl.2010.08.031.
  • Gordien AY, Gray AI, Ingleby K, Franzblau SG, Seidel V. "Activity of Scottish plant, lichen and fungal endophyte extracts against Mycobacterium aurum and Mycobacterium tuberculosis.". Phytotherapy research : PTR. 2010;24(5):692-8. doi:10.1002/ptr.2988.
  • Moraski GC, Chang M, Villegas-Estrada A, Franzblau SG, Möllmann U, Miller MJ. "Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters.". European journal of medicinal chemistry. 2010;45(5):1703-16. doi:10.1016/j.ejmech.2009.12.074.
  • Pavan FR, da Maia PI, Leite SR, Deflon VM, Batista AA, Sato DN, Franzblau SG, Leite CQ. "Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: anti-Mycobacterium tuberculosis activity and cytotoxicity.". European journal of medicinal chemistry. 2010;45(5):1898-905. doi:10.1016/j.ejmech.2010.01.028.
  • Inui T, Wang Y, Nikolic DS, Smith DC, Franzblau SG, Pauli GF. "Sesquiterpenes from Oplopanax horridus.". Journal of natural products. 2010;73(4):563-7. doi:10.1021/np900674d.
  • Scher JM, Schinkovitz A, Zapp J, Wang Y, Franzblau SG, Becker H, Lankin DC, Pauli GF. "Structure and anti-TB activity of trachylobanes from the liverwort Jungermannia exsertifolia ssp. cordifolia.". Journal of natural products. 2010;73(4):656-63. doi:10.1021/np900806j.
  • Aponte JC, Vaisberg AJ, Castillo D, Gonzalez G, Estevez Y, Arevalo J, Quiliano M, Zimic M, Verástegui M, Málaga E, Gilman RH, Bustamante JM, Tarleton RL, Wang Y, Franzblau SG, Pauli GF, Sauvain M, Hammond GB. "Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines.". Bioorganic & medicinal chemistry. 2010;18(8):2880-6. doi:10.1016/j.bmc.2010.03.018.
  • Fang M, Toogood RD, Macova A, Ho K, Franzblau SG, McNeil MR, Sanders DA, Palmer DR. "Succinylphosphonate esters are competitive inhibitors of MenD that show active-site discrimination between homologous alpha-ketoglutarate-decarboxylating enzymes.". Biochemistry. 2010;49(12):2672-9. doi:10.1021/bi901432d.
  • Zhou B, He Y, Zhang X, Xu J, Luo Y, Wang Y, Franzblau SG, Yang Z, Chan RJ, , Zheng J, Zhang ZY. "Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents.". Proceedings of the National Academy of Sciences of the United States of America. 2010;107(10):4573-8. doi:10.1073/pnas.0909133107.
  • Moraski GC, Franzblau SG, Miller MJ. "UTILIZTION OF THE SUZUKI COUPLING TO ENHANCE THE ANTITUBERCULOSIS ACTIVITY OF ARYL OXAZOLES.". Heterocycles. 2010;80(2):977-988. doi:10.3987/COM-09-S(S)69.
  • Lin AS, Stout EP, Prudhomme J, Le Roch K, Fairchild CR, Franzblau SG, Aalbersberg W, Hay ME, Kubanek J. "Bioactive bromophycolides R-U from the Fijian red alga Callophycus serratus.". Journal of natural products. 2010;73(2):275-8. doi:10.1021/np900686w.
  • Hong Q, Minter DE, Franzblau SG, Arfan M, Amin H, Reinecke MG. "Anti-tuberculosis compounds from Mallotus philippinensis.". Natural product communications. 2010;5(2):211-7.
  • Pavan FR, Poelhsitz GV, do Nascimento FB, Leite SR, Batista AA, Deflon VM, Sato DN, Franzblau SG, Leite CQ. "Ruthenium (II) phosphine/picolinate complexes as antimycobacterial agents.". European journal of medicinal chemistry. 2010;45(2):598-601. doi:10.1016/j.ejmech.2009.10.049.
  • Mao J, Yuan H, Wang Y, Wan B, Pak D, He R, Franzblau SG. "Synthesis and antituberculosis activity of novel mefloquine-isoxazole carboxylic esters as prodrugs.". Bioorganic & medicinal chemistry letters. 2010;20(3):1263-8. doi:10.1016/j.bmcl.2009.11.105.
  • Hans RH, Guantai EM, Lategan C, Smith PJ, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. "Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.". Bioorganic & medicinal chemistry letters. 2010;20(3):942-4. doi:10.1016/j.bmcl.2009.12.062.
  • Guo S, Song Y, Huang Q, Yuan H, Wan B, Wang Y, He R, Beconi MG, Franzblau SG, Kozikowski AP. "Identification, synthesis, and pharmacological evaluation of tetrahydroindazole based ligands as novel antituberculosis agents.". Journal of medicinal chemistry. 2010;53(2):649-59. doi:10.1021/jm901235p.
  • Lilienkampf A, Pieroni M, Wan B, Wang Y, Franzblau SG, Kozikowski AP. "Rational design of 5-phenyl-3-isoxazolecarboxylic acid ethyl esters as growth inhibitors of Mycobacterium tuberculosis. a potent and selective series for further drug development.". Journal of medicinal chemistry. 2010;53(2):678-88. doi:10.1021/jm901273n.
  • Sutherland HS, Blaser A, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Palmer BD, Denny WA, Thompson AM. "Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains.". Journal of medicinal chemistry. 2010;53(2):855-66. doi:10.1021/jm901378u.
  • Maroz A, Shinde SS, Franzblau SG, Ma Z, Denny WA, Palmer BD, Anderson RF. "Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent.". Organic & biomolecular chemistry. 2010;8(2):413-8. doi:10.1039/b915877d.
  • Palmer BD, Thompson AM, Sutherland HS, Blaser A, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA. "Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).". Journal of medicinal chemistry. 2010;53(1):282-94. doi:10.1021/jm901207n.
  • Gordien AY, Gray AI, Franzblau SG, Seidel V. "Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae).". Journal of ethnopharmacology. 2009;126(3):500-5. doi:10.1016/j.jep.2009.09.007.
  • Mao J, Yuan H, Wang Y, Wan B, Pieroni M, Huang Q, van Breemen RB, Kozikowski AP, Franzblau SG. "From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters.". Journal of medicinal chemistry. 2009;52(22):6966-78. doi:10.1021/jm900340a.
  • Huang Q, Mao J, Wan B, Wang Y, Brun R, Franzblau SG, Kozikowski AP. "Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles.". Journal of medicinal chemistry. 2009;52(21):6757-67. doi:10.1021/jm901112f.
  • Mo S, Krunic A, Pegan SD, Franzblau SG, Orjala J. "An antimicrobial guanidine-bearing sesterterpene from the cultured cyanobacterium Scytonema sp.". Journal of natural products. 2009;72(11):2043-5. doi:10.1021/np900288x.
  • Pieroni M, Lilienkampf A, Wan B, Wang Y, Franzblau SG, Kozikowski AP. "Synthesis, biological evaluation, and structure-activity relationships for 5-[(E)-2-arylethenyl]-3-isoxazolecarboxylic acid alkyl ester derivatives as valuable antitubercular chemotypes.". Journal of medicinal chemistry. 2009;52(20):6287-96. doi:10.1021/jm900513a.
  • Guo S, Tipparaju SK, Pegan SD, Wan B, Mo S, Orjala J, Mesecar AD, Franzblau SG, Kozikowski AP. "Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents.". Bioorganic & medicinal chemistry. 2009;17(20):7126-30. doi:10.1016/j.bmc.2009.08.061.
  • Zhao Y, Bacher A, Illarionov B, Fischer M, Georg G, Ye QZ, Fanwick PE, Franzblau SG, Wan B, Cushman M. "Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis.". The Journal of organic chemistry. 2009;74(15):5297-303. doi:10.1021/jo900768c.
  • Lilienkampf A, Mao J, Wan B, Wang Y, Franzblau SG, Kozikowski AP. "Structure-activity relationships for a series of quinoline-based compounds active against replicating and nonreplicating Mycobacterium tuberculosis.". Journal of medicinal chemistry. 2009;52(7):2109-18. doi:10.1021/jm900003c.
  • Lane AL, Stout EP, Lin AS, Prudhomme J, Le Roch K, Fairchild CR, Franzblau SG, Hay ME, Aalbersberg W, Kubanek J. "Antimalarial bromophycolides J-Q from the Fijian red alga Callophycus serratus.". The Journal of organic chemistry. 2009;74(7):2736-42. doi:10.1021/jo900008w.
  • Pegan SD, Rukseree K, Franzblau SG, Mesecar AD. "Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis.". Journal of molecular biology. 2009;386(4):1038-53. doi:10.1016/j.jmb.2009.01.003.
  • Thompson AM, Blaser A, Anderson RF, Shinde SS, Franzblau SG, Ma Z, Denny WA, Palmer BD. "Synthesis, reduction potentials, and antitubercular activity of ring A/B analogues of the bioreductive drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).". Journal of medicinal chemistry. 2009;52(3):637-45. doi:10.1021/jm801087e.
  • Figueiredo R, Moiteiro C, Medeiros MA, da Silva PA, Ramos D, Spies F, Ribeiro MO, Lourenço MC, Júnior IN, Gaspar MM, Cruz ME, Curto MJ, Franzblau SG, Orozco H, Aguilar D, Hernandez-Pando R, Costa MC. "Synthesis and evaluation of rifabutin analogs against Mycobacterium avium and H(37)Rv, MDR and NRP Mycobacterium tuberculosis.". Bioorganic & medicinal chemistry. 2009;17(2):503-11. doi:10.1016/j.bmc.2008.12.006.
  • Elkington BG, Southavong B, Sydara K, Souliya O, Vanthanouvong M, Nettavong K, Thammachack B, Pak DH, Riley MC, Franzblau SG, Soejarto DD. "Biological evaluation of plants of Laos used in the treatment of tuberculosis in Lao traditional medicine.". Pharmaceutical biology. 2009;47(1):26-33. doi:10.1080/13880200802398002.
  • Karioti A, Skaltsa H, Zhang X, Tonge PJ, Perozzo R, Kaiser M, Franzblau SG, Tasdemir D. "Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata.". Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008;15(12):1125-9. doi:10.1016/j.phymed.2008.02.018.
  • Hurdle JG, Lee RB, Budha NR, Carson EI, Qi J, Scherman MS, Cho S, McNeil MR, Lenaerts AJ, Franzblau SG, Meibohm B, Lee RE. "A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents.". The Journal of antimicrobial chemotherapy. 2008;62(5):1037-45. doi:10.1093/jac/dkn307.
  • Wei X, Rodríguez AD, Wang Y, Franzblau SG. "Synthesis and in vitro biological evaluation of ring B abeo-sterols as novel inhibitors of Mycobacterium tuberculosis.". Bioorganic & medicinal chemistry letters. 2008;18(20):5448-50. doi:10.1016/j.bmcl.2008.09.029.
  • Yuan H, He R, Wan B, Wang Y, Pauli GF, Franzblau SG, Kozikowski AP. "Modification of the side chain of micromolide, an anti-tuberculosis natural product.". Bioorganic & medicinal chemistry letters. 2008;18(19):5311-5. doi:10.1016/j.bmcl.2008.08.027.
  • Jaki BU, Franzblau SG, Chadwick LR, Lankin DC, Zhang F, Wang Y, Pauli GF. "Purity-activity relationships of natural products: the case of anti-TB active ursolic acid.". Journal of natural products. 2008;71(10):1742-8. doi:10.1021/np800329j.
  • Mao J, Eoh H, He R, Wang Y, Wan B, Franzblau SG, Crick DC, Kozikowski AP. "Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase.". Bioorganic & medicinal chemistry letters. 2008;18(19):5320-3. doi:10.1016/j.bmcl.2008.08.034.
  • Vicente E, Villar R, Burguete A, Solano B, Pérez-Silanes S, Aldana I, Maddry JA, Lenaerts AJ, Franzblau SG, Cho S, Monge A, Goldman RC. "Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis.". Antimicrobial agents and chemotherapy. 2008;52(9):3321-6. doi:10.1128/AAC.00379-08.
  • Villar R, Vicente E, Solano B, Pérez-Silanes S, Aldana I, Maddry JA, Lenaerts AJ, Franzblau SG, Cho S, Monge A, Goldman RC. "In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide.". The Journal of antimicrobial chemotherapy. 2008;62(3):547-54. doi:10.1093/jac/dkn214.
  • Ly LH, Barhoumi R, Cho S, Franzblau SG, McMurray DN. "Vaccination with Bacille-Calmette Guérin promotes mycobacterial control in guinea pig macrophages infected in vivo.". The Journal of infectious diseases. 2008;198(5):768-71. doi:10.1086/590436.
  • Zhu ZJ, Krasnykh O, Pan D, Petukhova V, Yu G, , Liu H, Hong S, Wang Y, Wan B, Liang W, Franzblau SG. "Structure-activity relationships of macrolides against Mycobacterium tuberculosis.". Tuberculosis (Edinburgh, Scotland). 2008;88 Suppl 1:S49-63. doi:10.1016/S1472-9792(08)70036-2.
  • Deng S, Wang Y, Inui T, Chen S, Farnsworth NR, Cho S, Franzblau SG, Pauli GF. "Anti-TB polyynes from the roots of Angelica sinensis.". Phytotherapy research : PTR. 2008;22(7):878-82. doi:10.1002/ptr.2303.
  • Zhou Y, Beeler AB, Cho S, Wang Y, Franzblau SG, Snyder JK. "Library synthesis using 5,6,7,8-tetrahydro-1,6-naphthyridines as scaffolds.". Journal of combinatorial chemistry. 2008;10(4):534-40. doi:10.1021/cc800038r.
  • Velaparthi S, Brunsteiner M, Uddin R, Wan B, Franzblau SG, Petukhov PA. "5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs.". Journal of medicinal chemistry. 2008;51(7):1999-2002. doi:10.1021/jm701372r.
  • Tan MA, Takayama H, Aimi N, Kitajima M, Franzblau SG, Nonato MG. "Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis.". Journal of natural medicines. 2008;62(2):232-5. doi:10.1007/s11418-007-0218-8.
  • Tasdemir D, Brun R, Franzblau SG, Sezgin Y, Calis I. "Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of Scrophularia cryptophila.". Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008;15(3):209-15. doi:10.1016/j.phymed.2007.07.032.
  • Sayed KA, Khalil AA, Yousaf M, Labadie G, Kumar GM, Franzblau SG, Mayer AM, Avery MA, Hamann MT. "Semisynthetic studies on the manzamine alkaloids.". Journal of natural products. 2008;71(3):300-8. doi:10.1021/np0703702.
  • Mao J, Wang Y, Wan B, Kozikowski AP, Franzblau SG. "Design, synthesis, and pharmacological evaluation of mefloquine-based ligands as novel antituberculosis agents.". ChemMedChem. 2007;2(11):1624-30. doi:10.1002/cmdc.200700112.
  • Lane AL, Stout EP, Hay ME, Prusak AC, Hardcastle K, Fairchild CR, Franzblau SG, Le Roch K, Prudhomme J, Aalbersberg W, Kubanek J. "Callophycoic acids and callophycols from the Fijian red alga Callophycus serratus.". The Journal of organic chemistry. 2007;72(19):7343-51. doi:10.1021/jo071210y.
  • Case RJ, Wang Y, Franzblau SG, Soejarto DD, Matainaho L, Piskaut P, Pauli GF. "Advanced applications of counter-current chromatography in the isolation of anti-tuberculosis constituents from Dracaena angustifolia.". Journal of chromatography. A. 2007;1151(1-2):169-74. doi:10.1016/j.chroma.2007.01.022.
  • Inui T, Wang Y, Deng S, Smith DC, Franzblau SG, Pauli GF. "Counter-current chromatography based analysis of synergy in an anti-tuberculosis ethnobotanical.". Journal of chromatography. A. 2007;1151(1-2):211-5. doi:10.1016/j.chroma.2007.01.127.
  • Mao J, Wan B, Wang Y, Franzblau SG, Kozikowski AP. "HTS, chemical hybridization, and drug design identify a chemically unique antituberculosis agent-coupling serendipity and rational approaches to drug discovery.". ChemMedChem. 2007;2(6):811-3. doi:10.1002/cmdc.200700048.
  • Cho S, Warit S, Wan B, Hwang CH, Pauli GF, Franzblau SG. "Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.". Antimicrobial agents and chemotherapy. 2007;51(4):1380-5. doi:10.1128/AAC.00055-06.
  • Bate AB, Kalin JH, Fooksman EM, Amorose EL, Price CM, Williams HM, Rodig MJ, Mitchell MO, Cho S, Wang Y, Franzblau SG. "Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives.". Bioorganic & medicinal chemistry letters. 2007;17(5):1346-8. doi:10.1016/j.bmcl.2006.11.091.
  • Bapela NB, Lall N, Fourie PB, Franzblau SG, Van Rensburg CE. "Activity of 7-methyljuglone in combination with antituberculous drugs against Mycobacterium tuberculosis.". Phytomedicine : international journal of phytotherapy and phytopharmacology. 2006;13(9-10):630-5. doi:10.1016/j.phymed.2006.08.001.
  • Tasdemir D, Brun R, Yardley V, Franzblau SG, Rüedi P. "Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies.". Chemistry & biodiversity. 2006;3(11):1230-7. doi:10.1002/cbdv.200690124.
  • Lee SH, Kong DH, Yun SH, Lee K, Lee K, Franzblau SG, Lee E, Chang CL. "Evaluation of a modified antimycobacterial susceptibility test using Middlebrook 7H10 agar containing 2,3-diphenyl-5-thienyl-(2)-tetrazolium chloride.". Journal of microbiological methods. 2006;66(3):548-51. doi:10.1016/j.mimet.2006.02.004.
  • Choi TA, Czerwonka R, Fröhner W, Krahl MP, Reddy KR, Franzblau SG, Knölker HJ. "Synthesis and activity of carbazole derivatives against Mycobacterium tuberculosis.". ChemMedChem. 2006;1(8):812-5. doi:10.1002/cmdc.200600002.
  • Rao KV, Donia MS, Peng J, Garcia-Palomero E, Alonso D, Martinez A, Medina M, Franzblau SG, Tekwani BL, Khan SI, Wahyuono S, Willett KL, Hamann MT. "Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases.". Journal of natural products. 2006;69(7):1034-40. doi:10.1021/np0601399.
  • Case RJ, Franzblau SG, Wang Y, Cho S, Soejarto DD, Pauli GF. "Ethnopharmacological evaluation of the informant consensus model on anti-tuberculosis claims among the Manus.". Journal of ethnopharmacology. 2006;106(1):82-9. doi:10.1016/j.jep.2005.12.005.
  • Jayaprakash S, Iso Y, Wan B, Franzblau SG, Kozikowski AP. "Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents.". ChemMedChem. 2006;1(6):593-7. doi:10.1002/cmdc.200600010.
  • Jaki BU, Franzblau SG, Cho S, Pauli GF. "Development of an extraction method for mycobacterial metabolome analysis.". Journal of pharmaceutical and biomedical analysis. 2006;41(1):196-200. doi:10.1016/j.jpba.2005.10.022.
  • Soejarto DD, Zhang HJ, Fong HH, Tan GT, Ma CY, Gyllenhaal C, Riley MC, Kadushin MR, Franzblau SG, Bich TQ, Cuong NM, Hiep NT, Loc PK, le Xuan T, Hai NV, Hung NV, Chien NQ, le Binh T, Vu BM, Ly HM, Southavong B, Sydara K, Bouamanivong S, Pezzuto JM, Rose WC, Dietzman GR, Miller BE, Thuy TV. ""Studies on biodiversity of Vietnam and Laos" 1998-2005: examining the impact.". Journal of natural products. 2006;69(3):473-81. doi:10.1021/np058107t.
  • Gu JQ, Wang Y, Franzblau SG, Montenegro G, Timmermann BN. "Dereplication of pentacyclic triterpenoids in plants by GC-EI/MS.". Phytochemical analysis : PCA. 2006;17(2):102-6.
  • Pauli GF, Case RJ, Inui T, Wang Y, Cho S, Fischer NH, Franzblau SG. "New perspectives on natural products in TB drug research.". Life sciences. 2005;78(5):485-94. doi:10.1016/j.lfs.2005.09.004.
  • Gutierrez-Lugo MT, Wang Y, Franzblau SG, Suarez E, Timmermann BN. "Antitubercular sterols from Thalia multiflora Horkel ex Koernicke.". Phytotherapy research : PTR. 2005;19(10):876-80. doi:10.1002/ptr.1731.
  • Soejarto DD, Fong HH, Tan GT, Zhang HJ, Ma CY, Franzblau SG, Gyllenhaal C, Riley MC, Kadushin MR, Pezzuto JM, Xuan LT, Hiep NT, Hung NV, Vu BM, Loc PK, Dac LX, Binh LT, Chien NQ, Hai NV, Bich TQ, Cuong NM, Southavong B, Sydara K, Bouamanivong S, Ly HM, Thuy TV, Rose WC, Dietzman GR. "Ethnobotany/ethnopharmacology and mass bioprospecting: issues on intellectual property and benefit-sharing.". Journal of ethnopharmacology. 2005;100(1-2):15-22. doi:10.1016/j.jep.2005.05.031.
  • Akihisa T, Franzblau SG, Tokuda H, Tagata M, Ukiya M, Matsuzawa T, Metori K, Kimura Y, Suzuki T, Yasukawa K. "Antitubercular activity and inhibitory effect on Epstein-Barr virus activation of sterols and polyisoprenepolyols from an edible mushroom, Hypsizigus marmoreus.". Biological & pharmaceutical bulletin. 2005;28(6):1117-9.
  • Macabeo AP, Krohn K, Gehle D, Read RW, Brophy JJ, Cordell GA, Franzblau SG, Aguinaldo AM. "Indole alkaloids from the leaves of Philippine Alstonia scholaris.". Phytochemistry. 2005;66(10):1158-62. doi:10.1016/j.phytochem.2005.02.018.
  • Falzari K, Zhu Z, Pan D, Liu H, Hongmanee P, Franzblau SG. "In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.". Antimicrobial agents and chemotherapy. 2005;49(4):1447-54. doi:10.1128/AAC.49.4.1447-1454.2005.
  • Ma C, Case RJ, Wang Y, Zhang HJ, Tan GT, Van Hung N, Cuong NM, Franzblau SG, Soejarto DD, Fong HH, Pauli GF. "Anti-tuberculosis constituents from the stem bark of Micromelum hirsutum.". Planta medica. 2005;71(3):261-7. doi:10.1055/s-2005-837826.
  • Akihisa T, Franzblau SG, Ukiya M, Okuda H, Zhang F, Yasukawa K, Suzuki T, Kimura Y. "Antitubercular activity of triterpenoids from Asteraceae flowers.". Biological & pharmaceutical bulletin. 2005;28(1):158-60.
  • Lall N, Meyer JJM , Wang Y, Bapela NB, van Rensburg CEJ , Fourie B, Franzblau SG. "Characterization of Intracellular Activity of Antitubercular Constituents the Roots of Euclea natalensis.". Pharmaceutical biology. 2005;43(4):353-357. doi:10.1080/13880200590951829.
  • Gua JQ, Wang Y, Franzblau SG, Montenegro G, Timmermann BN. "Constituents of Quinchamalium majus with potential antitubercular activity.". Zeitschrift fur Naturforschung. C, Journal of biosciences. 2004;59(11-12):797-802.
  • Gu JQ, Wang Y, Franzblau SG, Montenegro G, Timmermann BN. "Constituents of Senecio chionophilus with potential antitubercular activity.". Journal of natural products. 2004;67(9):1483-7. doi:10.1021/np049831z.
  • Gu JQ, Wang Y, Franzblau SG, Montenegro G, Yang D, Timmermann BN. "Antitubercular constituents of Valeriana laxiflora.". Planta medica. 2004;70(6):509-14. doi:10.1055/s-2004-827149.
  • Woldemichael GM, Gutierrez-Lugo MT, Franzblau SG, Wang Y, Suarez E, Timmermann BN. "Mycobacterium tuberculosis growth inhibition by constituents of Sapium haematospermum.". Journal of natural products. 2004;67(4):598-603. doi:10.1021/np0303411.
  • Changsen C, Franzblau SG, Palittapongarnpim P. "Improved green fluorescent protein reporter gene-based microplate screening for antituberculosis compounds by utilizing an acetamidase promoter.". Antimicrobial agents and chemotherapy. 2003;47(12):3682-7.
  • Peng J, Hu JF, Kazi AB, Li Z, Avery M, Peraud O, Hill RT, Franzblau SG, Zhang F, Schinazi RF, Wirtz SS, Tharnish P, Kelly M, Wahyuono S, Hamann MT. "Manadomanzamines A and B: a novel alkaloid ring system with potent activity against mycobacteria and HIV-1.". Journal of the American Chemical Society. 2003;125(44):13382-6. doi:10.1021/ja030087z.
  • Woldemichael GM, Franzblau SG, Zhang F, Wang Y, Timmermann BN. "Inhibitory effect of sterols from Ruprechtia triflora and diterpenes from Calceolaria pinnifolia on the growth of Mycobacterium tuberculosis.". Planta medica. 2003;69(7):628-31. doi:10.1055/s-2003-41109.
  • Murillo JI, Encarnación-Dimayuga R, Malmstrøm J, Christophersen C, Franzblau SG. "Antimycobacterial flavones from Haplopappus sonorensis.". Fitoterapia. 2003;74(3):226-30.
  • Luna-Herrera J, Martínez-Cabrera G, Parra-Maldonado R, Enciso-Moreno JA, Torres-López J, Quesada-Pascual F, Delgadillo-Polanco R, Franzblau SG. "Use of receiver operating characteristic curves to assess the performance of a microdilution assay for determination of drug susceptibility of clinical isolates of Mycobacterium tuberculosis.". European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2003;22(1):21-7. doi:10.1007/s10096-002-0855-5.
  • Foongladda S, Roengsanthia D, Arjrattanakool W, Chuchottaworn C, Chaiprasert A, Franzblau SG. "Rapid and simple MTT method for rifampicin and isoniazid susceptibility testing of Mycobacterium tuberculosis.". The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 2002;6(12):1118-22.
  • Saludes JP, Garson MJ, Franzblau SG, Aguinaldo AM. "Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae).". Phytotherapy research : PTR. 2002;16(7):683-5. doi:10.1002/ptr.1003.
  • Cantrell CL, Franzblau SG, Fischer NH. "Antimycobacterial plant terpenoids.". Planta medica. 2001;67(8):685-94. doi:10.1055/s-2001-18365.
  • Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG. "Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.". Phytotherapy research : PTR. 2001;15(7):638-42.
  • Wächter GA, Franzblau SG, Montenegro G, Hoffmann JJ, Maiese WM, Timmermann BN. "Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens.". Journal of natural products. 2001;64(11):1463-4.
  • Constantine GH, Karchesy JJ, Franzblau SG, LaFleur LE. "(+)-Totarol from Chamaecyparis nootkatensis and activity against Mycobacterium tuberculosis.". Fitoterapia. 2001;72(5):572-4.
  • Stephens CE, Tanious F, Kim S, Wilson WD, Schell WA, Perfect JR, Franzblau SG, Boykin DW. "Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents.". Journal of medicinal chemistry. 2001;44(11):1741-8.
  • Gezginci MH, Martin AR, Franzblau SG. "Antimycobacterial activity of substituted isosteres of pyridine- and pyrazinecarboxylic acids. 2.". Journal of medicinal chemistry. 2001;44(10):1560-3.
  • Ma Y, Stern RJ, Scherman MS, Vissa VD, Yan W, Jones VC, Zhang F, Franzblau SG, Lewis WH, McNeil MR. "Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose.". Antimicrobial agents and chemotherapy. 2001;45(5):1407-16. doi:10.1128/AAC.45.5.1407-1416.2001.
  • Wächter GA, Valcic S, Franzblau SG, Suarez E, Timmermann BN. "Antitubercular activity of triterpenoids from Lippia turbinata.". Journal of natural products. 2001;64(1):37-41.
  • Caldwell CG, Franzblau SG, Suarez E, Timmermann BN. "Oleanane triterpenes from Junellia tridens.". Journal of natural products. 2000;63(12):1611-4.
  • König GM, Wright AD, Franzblau SG. "Assessment of antimycobacterial activity of a series of mainly marine derived natural products.". Planta medica. 2000;66(4):337-42. doi:10.1055/s-2000-8534.
  • Cantrell CL, Rajab MS, Franzblau SG, Fronczek FR, Fischer NH. "Antimycobacterial ergosterol-5,8-endoperoxide from Ajuga remota.". Planta medica. 1999;65(8):732-4. doi:10.1055/s-1999-14053.
  • Wächter GA, Valcic S, Flagg ML, Franzblau SG, Montenegro G, Suarez E, Timmermann BN. "Antitubercular activity of pentacyclic triterpenoids from plants of Argentina and Chile.". Phytomedicine : international journal of phytotherapy and phytopharmacology. 1999;6(5):341-5. doi:10.1016/S0944-7113(99)80056-7.
  • Rugutt JK, Henry, 3rd CW, Franzblau SG, Warner IM. "NMR and molecular mechanics study of pyrethrins I and II.". Journal of agricultural and food chemistry. 1999;47(8):3402-10.
  • Adams LB, Sinha I, Franzblau SG, Krahenbuhl JL, Mehta RT. "Effective treatment of acute and chronic murine tuberculosis with liposome-encapsulated clofazimine.". Antimicrobial agents and chemotherapy. 1999;43(7):1638-43.
  • Cantrell CL, Abate L, Fronczek FR, Franzblau SG, Quijano L, Fischer NH. "Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa.". Planta medica. 1999;65(4):351-5. doi:10.1055/s-1999-14001.
  • Cantrell CL, Rajab MS, Franzblau SG, Fischer NH. "Antimycobacterial triterpenes from Melia volkensii.". Journal of natural products. 1999;62(4):546-8. doi:10.1021/np980288u.
  • Cantrell CL, Nuñez IS, Castañeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG. "Antimycobacterial activities of dehydrocostus lactone and its oxidation products.". Journal of natural products. 1998;61(10):1181-6. doi:10.1021/np970333i.
  • Fischer NH, Lu T, Cantrell CL, Castañeda-Acosta J, Quijano L, Franzblau SG. "Antimycobacterial evaluation of germacranolides.". Phytochemistry. 1998;49(2):559-64.
  • Wächter GA, Franzblau SG, Montenegro G, Suarez E, Fortunato RH, Saavedra E, Timmermann BN. "A new antitubercular mulinane diterpenoid from Azorella madreporica Clos.". Journal of natural products. 1998;61(7):965-8. doi:10.1021/np980066w.
  • Wächter GA, Davis MC, Martin AR, Franzblau SG. "Antimycobacterial activity of substituted isosteres of pyridine- and pyrazinecarboxylic acids.". Journal of medicinal chemistry. 1998;41(13):2436-8. doi:10.1021/jm9708745.
  • Davis MC, Franzblau SG, Martin AR. "Syntheses and evaluation of benzodiazaborine compounds against M. tuberculosis H37Rv in vitro.". Bioorganic & medicinal chemistry letters. 1998;8(7):843-6.
  • Cantrell CL, Fischer NH, Urbatsch L, McGuire MS, Franzblau SG. "Antimycobacterial crude plant extracts from South, Central, and North America.". Phytomedicine : international journal of phytotherapy and phytopharmacology. 1998;5(2):137-45. doi:10.1016/S0944-7113(98)80011-1.
  • Rajab MS, Cantrell CL, Franzblau SG, Fischer NH. "Antimycobacterial activity of (E)-phytol and derivatives: a preliminary structure-activity study.". Planta medica. 1998;64(1):2-4. doi:10.1055/s-2006-957354.
  • Collins LA, Torrero MN, Franzblau SG. "Green fluorescent protein reporter microplate assay for high-throughput screening of compounds against Mycobacterium tuberculosis.". Antimicrobial agents and chemotherapy. 1998;42(2):344-7.
  • Franzblau SG, Witzig RS, McLaughlin JC, Torres P, Madico G, Hernandez A, Degnan MT, Cook MB, Quenzer VK, Ferguson RM, Gilman RH. "Rapid, low-technology MIC determination with clinical Mycobacterium tuberculosis isolates by using the microplate Alamar Blue assay.". Journal of clinical microbiology. 1998;36(2):362-6.
  • Collins L, Franzblau SG. "Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium.". Antimicrobial agents and chemotherapy. 1997;41(5):1004-9.
  • Cantrell CL, Lu T, Fronczek FR, Fischer NH, Adams LB, Franzblau SG. "Antimycobacterial cycloartanes from Borrichia frutescens.". Journal of natural products. 1996;59(12):1131-6. doi:10.1021/np960551w.
  • Fajardo, Jr TT, Villahermosa LG, dela Cruz EC, Abalos RM, Franzblau SG, Walsh GP. "Minocycline in lepromatous leprosy.". International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association. 1995;63(1):8-17.
  • Lu T, Vargas D, Franzblau SG, Fischer NH. "Diterpenes from Solidago rugosa.". Phytochemistry. 1995;38(2):451-6.
  • Franzblau SG, Chan GP, Garcia-Ignacio BG, Chavez VE, Livelo JB, Jimenez CL, Parrilla ML, Calvo RF, Williams DL, Gillis TP. "Clinical trial of fusidic acid for lepromatous leprosy.". Antimicrobial agents and chemotherapy. 1994;38(7):1651-4.
  • Chan GP, Garcia-Ignacio BY, Chavez VE, Livelo JB, Jimenez CL, Parrilla ML, Franzblau SG. "Clinical trial of clarithromycin for lepromatous leprosy.". Antimicrobial agents and chemotherapy. 1994;38(3):515-7.
  • Chan GP, Garcia-Ignacio BY, Chavez VE, Livelo JB, Jimenez CL, Parrilla ML, Franzblau SG. "Clinical trial of sparfloxacin for lepromatous leprosy.". Antimicrobial agents and chemotherapy. 1994;38(1):61-5.
  • Witzig RS, Franzblau SG. "Susceptibility of Mycobacterium kansasii to ofloxacin, sparfloxacin, clarithromycin, azithromycin, and fusidic acid.". Antimicrobial agents and chemotherapy. 1993;37(9):1997-9.
  • Franzblau SG, Parrilla ML, Chan GP. "Sparfloxacin is more bactericidal than ofloxacin against Mycobacterium leprae in mice.". International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association. 1993;61(1):66-9.
  • Franzblau SG, Biswas AN, Jenner P, Colston MJ. "Double-blind evaluation of BACTEC and Buddemeyer-type radiorespirometric assays for in vitro screening of antileprosy agents.". Leprosy review. 1992;63(2):125-33.
  • Franzblau SG, Biswas AN, Harris EB. "Fusidic acid is highly active against extracellular and intracellular Mycobacterium leprae.". Antimicrobial agents and chemotherapy. 1992;36(1):92-4.
  • Ramasesh N, Adams LB, Franzblau SG, Krahenbuhl JL. "Effects of activated macrophages on Mycobacterium leprae.". Infection and immunity. 1991;59(9):2864-9.
  • Adams LB, Franzblau SG, Vavrin Z, Hibbs, Jr JB, Krahenbuhl JL. "L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae.". Journal of immunology (Baltimore, Md. : 1950). 1991;147(5):1642-6.
  • Franzblau SG. "In vitro activities of aminoglycosides, lincosamides, and rifamycins against Mycobacterium leprae.". Antimicrobial agents and chemotherapy. 1991;35(6):1232-4.
  • Franzblau SG, White KE. "Comparative in vitro activities of 20 fluoroquinolones against Mycobacterium leprae.". Antimicrobial agents and chemotherapy. 1990;34(2):229-31.
  • Franzblau SG. "Drug susceptibility testing of Mycobacterium leprae in the BACTEC 460 system.". Antimicrobial agents and chemotherapy. 1989;33(12):2115-7.
  • Franzblau SG, White KE, O'Sullivan JF. "Structure-activity relationships of tetramethylpiperidine-substituted phenazines against Mycobacterium leprae in vitro.". Antimicrobial agents and chemotherapy. 1989;33(11):2004-5.
  • Franzblau SG, Hastings RC. "In vitro and in vivo activities of macrolides against Mycobacterium leprae.". Antimicrobial agents and chemotherapy. 1988;32(12):1758-62.
  • Harris EB, Franzblau SG, Hastings RC. "Inhibition of phenolic glycolipid-I synthesis in extracellular Mycobacterium leprae as an indicator of antimicrobial activity.". International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association. 1988;56(4):588-91.
  • Franzblau SG, O'Sullivan JF. "Structure-activity relationships of selected phenazines against Mycobacterium leprae in vitro.". Antimicrobial agents and chemotherapy. 1988;32(10):1583-5.
  • Hastings RC, Gillis TP, Krahenbuhl JL, Franzblau SG. "Leprosy.". Clinical microbiology reviews. 1988;1(3):330-48.
  • Franzblau SG, Harris EB. "Biophysical optima for metabolism of Mycobacterium leprae.". Journal of clinical microbiology. 1988;26(6):1124-9.
  • Hastings RC, Franzblau SG. "Chemotherapy of leprosy.". Annual review of pharmacology and toxicology. 1988;28:231-45. doi:10.1146/annurev.pa.28.040188.001311.
  • Franzblau SG. "Oxidation of palmitic acid by Mycobacterium leprae in an axenic medium.". Journal of clinical microbiology. 1988;26(1):18-21.
  • Franzblau SG, Hastings RC. "Rapid in vitro metabolic screen for antileprosy compounds.". Antimicrobial agents and chemotherapy. 1987;31(5):780-3.
  • Sibley LD, Franzblau SG, Krahenbuhl JL. "Intracellular fate of Mycobacterium leprae in normal and activated mouse macrophages.". Infection and immunity. 1987;55(3):680-5.
  • Franzblau SG, Cross C. "Comparative in vitro antimicrobial activity of Chinese medicinal herbs.". Journal of ethnopharmacology. 1986;15(3):279-88.
  • Franzblau SG, Takeda T, Nakamura M. "Mycobacterial plasmids: screening and possible relationship to antibiotic resistance in Mycobacterium avium/Mycobacterium intracellulare.". Microbiology and immunology. 1986;30(9):903-7.
  • Franzblau SG, Hinnebusch BJ, Kelley LM, Sinclair NA. "Effect of noncoliforms on coliform detection in potable groundwater: improved recovery with an anaerobic membrane filter technique.". Applied and environmental microbiology. 1984;48(1):142-8.
  • Franzblau SG, Sinclair NA. "Induction of pyruvate decarboxylase in Candida utilis.". Mycopathologia. 1983;83(1):29-33.

Other

  • Tabarrini O, Sabatini S, Massari S, Pieroni M, Franzblau SG, Cecchetti V. (2012). "6-hydrogen-8-methylquinolones active against replicating and non-replicating Mycobacterium tuberculosis.". Chemical biology & drug design. Vol. 80. Issue 5. Page(s) 781-6.
  • Aguinaldo AM, Dalangin-Mallari VM, Macabeo AP, Byrne LT, Abe F, Yamauchi T, Franzblau SG. (2007). "Quinoline alkaloids from Lunasia amara inhibit Mycobacterium tuberculosis H37Rv in vitro.". International journal of antimicrobial agents. Vol. 29. Issue 6. Page(s) 744-6.
  • Mangalindan GC, Talaue MT, Cruz LJ, Franzblau SG, Adams LB, Richardson AD, Ireland CM, Concepcion GP. (2000). "Agelasine F from a Philippine Agelas sp. sponge exhibits in vitro antituberculosis activity.". Planta medica. Vol. 66. Issue 4. Page(s) 364-5.
  • Lu T, Cantrell CL, Robbs SL, Franzblau SG, Fischer NH. (1998). "Antimycobacterial matricaria esters and lactones from Astereae species.". Planta medica. Vol. 64. Issue 7. Page(s) 665-7.

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