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Photo of Terry W Moore

Terry W Moore

Assistant Professor, Medicinal Chemistry and Pharmacognosy

Contact Information

833 South Wood Street, Rm 539 (781)
504 PHARM
Chicago, IL 60612

Phone: (312) 413-1846

Website: http://moorelab.publish.uic.edu/

Lab Phone: (312) 355-2773

Education

  • PhD, Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 2008
  • BA, Summa cum laude, Biochemistry, Abilene Christian University, Abilene, TX, 2000

Research Lab Summary

The work in our lab uses the tools of synthetic medicinal chemistry and chemical biology to develop new tools for studying therapeutically important protein-protein interactions. Our work currently focuses on two classes of protein-protein interactions: the nuclear receptor/steroid receptor coactivator interaction and the Keap1/Nrf2 interaction.

Research Interests

Dr. Moore is a synthetic medicinal chemist. His lab is interested in developing small molecules and peptides to inhibit protein-protein interactions.

Teaching Interests

Dr. Moore teaches in the medicinal chemistry PhD and first-year PharmD curricula.

Awards and Honors

  • 2018, 2017 Rising Star Researcher of the Year in Basic Life Sciences, UIC

Intellectual Contributions

Journal Article

  • Speltz TE, Danes JM, Stender JD, Frasor J, Moore T. "A cell-permeable stapled peptide inhibitor of the estrogen receptor/coactivator interaction". ACS Chemical Biology. 2018;.
  • Yao Y, Delgado-Rivera L, Afsari HS, Yin L, Thatcher, Gregory R. J. , Moore T, Miller LW. "Time-Gated Luminescence Detection of Enzymatically Produced Hydrogen Sulfide: Design, Synthesis, and Application of a Lanthanide-Based Probe". INORGANIC CHEMISTRY. 2018;57(2):681-688. doi:10.1021/acs.inorgchem.7b02533.
  • Speltz TE, Mayne CG, Fanning SW, Siddiqui Z, Tajkhorshid E, Greene GL, Moore T. "A "cross-stitched" peptide with improved helicity and proteolytic stability.". Organic & biomolecular chemistry. 2018;16(20):3702-3706. doi:10.1039/c8ob00790j.
  • Popovich NG, Okorie-Awé C, Crawford SY, Balcazar FE, Vellurattil RP, Moore T, Schriever AE. "Assessing Students' Impressions of the Cultural Awareness of Pharmacy Faculty and Students.". American journal of pharmaceutical education. 2018;82(1):6161. doi:10.5688/ajpe6161.
  • Yao Y, Kong C, Yin L, Jain AD, Ratia KM, Thatcher GR, Moore T, Driver TG, Miller LW. "Time-Gated Detection of Cystathionine $\gamma$-Lyase Activity and Inhibition with a Selective, Luminogenic Hydrogen Sulfide Sensor". Chemistry-A European Journal. 2017;23(4):752--756.
  • Speltz TE, Fanning SW, Mayne CG, Fowler C, Tajkhorshid E, Greene GL, Moore T. "Stapled Peptides with $\gamma$-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction". Angewandte Chemie International Edition. 2016;55(13):4252--4255.
  • Moore T, Gunther JR, Katzenellenbogen JA. "Estrogen Receptor Alpha/Co-activator Interaction Assay: TR-FRET". Protein-Protein Interactions: Methods and Applications. 2015;:545--553.
  • Richardson B, Jain A, Speltz T, Moore T. "Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway". Bioorganic \& medicinal chemistry letters. 2015;25(11):2261--2268.
  • Zhu S, Kisiel W, Lu YJ, Petersen LC, Ndungu JM, Moore T, Parker ET, Sun A, Sarkaria JN, Snyder JP, others . "Visualizing cancer and response to therapy in vivo using Cy5. 5-labeled factor VIIa and anti-tissue factor antibody". Journal of drug targeting. 2015;23(3):257--265.
  • Xiong R, Patel H, Gutgesell LM, Zhao J, Delgado-Rivera L, Pham TN, Zhao H, Carlson K, Martin T, Katzenellenbogen JA, Moore T, Tonetti D, Thatcher GR. "Selective Human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer.". Journal of medicinal chemistry. 2015;. doi:10.1021/acs.jmedchem.5b01276.
  • Jain AD, Potteti H, Richardson BG, Kingsley L, Luciano JP, Ryuzoji AF, Lee H, Krunic A, Mesecar AD, Reddy SP, Moore T. "Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.". European journal of medicinal chemistry. 2015;103:252-68. doi:10.1016/j.ejmech.2015.08.049.
  • Grimmer C, Moore T, Padwa A, Prussia A, Wells G, Wu S, Sun A, Snyder JP. "Antiviral atropisomers: Conformational energy surfaces by NMR for host-directed myxovirus blockers". Journal of chemical information and modeling. 2014;54(8):2214--2223.
  • Moore T, Zhu S, Randolph R, Shoji M, Snyder JP. "Liver S9 fraction-derived metabolites of curcumin analogue UBS109". ACS medicinal chemistry letters. 2014;5(4):288--292.
  • Zhu S, W Moore T, Morii N, B Howard R, F Arrendale R, Reddy P, J Evers T, Zhang H, Sica G, G Chen Z, others . "Synthetic curcumin analog UBS109 inhibits the growth of head and neck squamous cell carcinoma xenografts". Current cancer drug targets. 2014;14(4):380--393.
  • Zhu S, Kisiel W, Lu YJ, Petersen LC, Ndungu JM, Moore T, Parker ET, Sun A, Liotta DC, El-Rayes BF, others . "Tumor angiogenesis therapy using targeted delivery of Paclitaxel to the vasculature of breast cancer metastases". Journal of drug delivery. 2014;2014.
  • Moore T, Sana K, Yan D, Thepchatri P, Ndungu JM, Saindane MT, Lockwood MA, Natchus MG, Liotta DC, Plemper RK, others . "Asymmetric synthesis of host-directed inhibitors of myxoviruses". Beilstein journal of organic chemistry. 2013;9:197.
  • Brown A, Shi Q, Moore T, Yoon Y, Prussia A, Maddox C, Liotta DC, Shim H, Snyder JP. "Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties". Journal of medicinal chemistry. 2013;56(9):3456--3466.
  • Moore T, Sana K, Yan D, Krumm SA, Thepchatri P, Snyder JP, Marengo, Jose´ , Arrendale RF, Prussia AJ, Natchus MG, others . "Synthesis and Metabolic Studies of Host-Directed Inhibitors for Antiviral Therapy". ACS medicinal chemistry letters. 2013;4(8):762--767.
  • Olivera A, Moore T, Hu F, Brown AP, Sun A, Liotta DC, Snyder JP, Yoon Y, Shim H, Marcus AI, others . "Inhibition of the NF-$\kappa$B signaling pathway by the curcumin analog, 3, 5-Bis (2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties". International immunopharmacology. 2012;12(2):368--377.
  • Yamaguchi M, Moore T, Sun A, Snyder JP, Shoji M. "Novel curcumin analogue UBS109 potently stimulates osteoblastogenesis and suppresses osteoclastogenesis: involvement in Smad activation and NF-$\kappa$B inhibition". Integrative Biology. 2012;4(8):905--913.
  • Zhu S, Moore T, Lin X, Morii N, Mancini A, Howard RB, Culver D, Arrendale RF, Reddy P, Evers TJ, others . "Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts". Integrative Biology. 2012;4(6):633--640.
  • Sun A, Moore T, Gunther JR, Kim M, Rhoden E, Du Y, Fu H, Snyder JP, Katzenellenbogen JA. "Discovering Small-Molecule Estrogen Receptor $\alpha$/Coactivator Binding Inhibitors: High-Throughput Screening, Ligand Development, and Models for Enhanced Potency". ChemMedChem. 2011;6(4):654--666.
  • Moore T, Mayne CG, Katzenellenbogen JA. "Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs)". Molecular Endocrinology. 2010;24(4):683--695.
  • Moore T, Gunther JR, Katzenellenbogen JA. "Probing the topological tolerance of multimeric protein interactions: evaluation of an estrogen/synthetic ligand for FK506 binding protein conjugate". Bioconjugate chemistry. 2010;21(10):1880--1889.
  • Gunther JR, Du Y, Rhoden E, Lewis I, Revennaugh B, Moore T, Kim SH, Dingledine R, Fu H, Katzenellenbogen JA. "A set of time-resolved fluorescence resonance energy transfer assays for the discovery of inhibitors of estrogen receptor-coactivator binding". Journal of biomolecular screening. 2009;14(2):181--193.
  • Moore T, Katzenellenbogen JA. "Inhibitors of nuclear hormone receptor/coactivator interactions". Annual reports in medicinal chemistry. 2009;44:443--457.
  • Gunther JR, Moore T, Collins ML, Katzenellenbogen JA. "Amphipathic benzenes are designed inhibitors of the estrogen receptor $\alpha$/steroid receptor coactivator interaction". ACS chemical biology. 2008;3(5):282--286.
  • Clews PK, Douthwaite RE, Kariuki BM, Moore T, Taboada M. "Layered Compounds Incorporating 9, 9 ‘-Spirobifluorene: Hydrogen-Bonded and Metal- Organic Networks Derived from 9, 9 ‘-Spirobifluorene-2, 2 ‘, 7, 7 ‘-tetracarboxylic Acid". Crystal growth \& design. 2006;6(9):1991--1994.
  • Moore T, Kiely C, Reeves P. "Electronic properties of the trimethylenemethaneiron tricarbonyl group". Journal of Organometallic Chemistry. 2001;620(1):308--312.

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