Andrew Riley
Assistant Professor, College of Pharmacy - Pharmaceutical Sciences
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PSCI Ph.D. Thesis Research (PSCI 599), 8/26/2024 – 12/6/2024
Doctoral Restch in Med Chem (MDCH 599), 8/26/2024 – 12/6/2024
Research Presentation (PSCI 502), 8/26/2024 – 12/6/2024
PSCI Ph.D. Thesis Research (PSCI 599), 6/10/2024 – 8/2/2024
Doctoral Restch in Med Chem (MDCH 599), 6/10/2024 – 8/2/2024
PSCI Ph.D. Thesis Research (PSCI 599), 1/8/2024 – 4/26/2024
Doctoral Restch in Med Chem (MDCH 599), 1/8/2024 – 4/26/2024
Undergrad Res Exp Pharm Sci (PSCI 300), 1/8/2024 – 4/26/2024
PSCI Ph.D. Thesis Research (PSCI 599), 8/21/2023 – 12/1/2023
Selected Grants
?9?10 Nicotinic Acetylcholine Receptors in neuropathic pain, National Institutes of Health (National Institute of Neurological Disorders and Stroke)., 8/1/2024 - 6/30/2029, Obligated Amount: $624360; Anticipated Amount: $3121800
Pharmacological Potential of Combined Translation and Autophagy Inhibition in High Grade Serous Ovarian Cancer, National Institutes of Health (National Institute of General Medical Sciences)., 8/1/2024 - 7/31/2026, Obligated Amount: $120972; Anticipated Amount: $241944
Aristotelia Alkaloids as Probes for the Nicotinic Acetylcholine Receptors, National Institutes of Health (National Center for Complementary and Integrative Health)., 5/16/2024 - 5/15/2026, Obligated Amount: $48974; Anticipated Amount: $95388
Selective Targeting of Nicotinic Acetylcholine Receptor Subtypes for Cocaine Use Disorder, National Institutes of Health (National Institute on Drug Abuse)., 3/1/2024 - 12/31/2028, Obligated Amount: $703988; Anticipated Amount: $3373690
Defining ?9?10 nAChR Complex Using the ATLAS Kit, Sigma-Aldrich., 12/16/2022 - 9/15/2023, Obligated Amount: $30000; Anticipated Amount: $30000
Prodrug Development for Pharmaceutical Uses, Innovo Pharmaceuticals., 9/16/2022 - 9/15/2024, Obligated Amount: $44793; Anticipated Amount: $44793
Synthesis and Evaluation of Alkaloids to Probe Membrane Receptors, National Institutes of Health (National Institute of General Medical Sciences)., 8/1/2022 - 6/30/2027, Obligated Amount: $1521417; Anticipated Amount: $2097885
Hans W. Vahlteich Research Award, UIC College of Pharmacy., Date Not Set - Present, No Obligated Amount Set; No Anticipated Amount Set
Selected Publications
Hennessy, Madeline R, Creed, Simone M, Gutridge, Anna M, Rusali, Lisa E, Luo, Dan, Sepehri, Bakhtyar, Rhoda, Elizabeth S, Villegas, José A, van Rijn, Richard M, Riley, Andrew P. (2024). Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.4c00736.
Kremiller, Kyle M, Kulkarni, Gauri C, Harris, Lauren M, Gunasekara, Hirushi, Kashyap, Yavnika, Ilktach, Giokdjen, Nguyen, Angela, Ondrus, Alison E, Hu, Ying S, Wang, Zaijie J, Riley, Andrew P, Peters, Christian J. (2024). Discovery of Antinociceptive α9α10 Nicotinic Acetylcholine Receptor Antagonists by Stable Receptor Expression. ACS Chemical Biology, 19, (11), 2291-2303. doi:10.1021/acschembio.4c00330.
Heppner, David E, Bigi-Botterill, Simone V, Riley, Andrew P, Chibale, Kelly, Lindsley, Craig W. (2024). Structural Biology in Drug Discovery and Development: Call for Papers. ACS Medicinal Chemistry Letters, 15, (8), 1167-1168. doi:10.1021/acsmedchemlett.4c00318.
Heppner, David E, Bigi-Botterill, Simone V, Riley, Andrew P, Chibale, Kelly, Lindsley, Craig W. (2024). Structural Biology in Drug Discovery and Development: Call for Papers. Journal of Medicinal Chemistry, 67, (15), 12461-12462. doi:10.1021/acs.jmedchem.4c01492.
Riley, Andrew P. (2024). In This Issue, Volume 15, Issue 7. ACS Medicinal Chemistry Letters, 15, (7), 987-988. doi:10.1021/acsmedchemlett.4c00282.
Riley, Andrew P. (2024). In This Issue, Volume 15, Issue 4. ACS Medicinal Chemistry Letters, 15, (4), 434-435. doi:10.1021/acsmedchemlett.4c00123.
Rusali, Lisa E, Lopez-Hernandez, Ana M, Kremiller, Kyle M, Kulkarni, Gauri C, Gour, Abhishek, Straub, Carolyn J, Argade, Malaika D, Peters, Christian J, Sharma, Abhisheak, Toll, Lawrence, Cippitelli, Andrea, Riley, Andrew P. (2024). Synthesis of α3β4 Nicotinic Acetylcholine Receptor Modulators Derived from Aristoquinoline That Reduce Reinstatement of Cocaine-Seeking Behavior. Journal of Medicinal Chemistry, 67, (1), 529-542. doi:10.1021/acs.jmedchem.3c01758.
Hennessy, Madeline R, Gutridge, Anna M, French, Alexander R, Rhoda, Elizabeth S, Meqbil, Yazan J, Gill, Meghna, Kashyap, Yavnika, Appourchaux, Kevin, Paul, Barnali, Wang, Zaijie Jim, van Rijn, Richard M, Riley, Andrew P. (2023). Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor. Journal of Medicinal Chemistry, 66, (5), 3312-3326. doi:10.1021/acs.jmedchem.2c01707.
Straub, Carolyn J, Rusali, Lisa E, Kremiller, Kyle M, Riley, Andrew P. (2023). What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders. Journal of Medicinal Chemistry, 66, (1), 107-121. doi:10.1021/acs.jmedchem.2c01562.
Professional Leadership
Auditing Committee, American Society of Pharmacognosy, 8/7/2019 - Present
Auditing Committee, 8/7/2019 - Present
Notable Honors
2024, ACS MEDI Young Investigator Symposium, American Chemical Society
2024, UIC Rising Star in Basic Life Sciences, UIC
2023, Thieme Chemistry Journal Award, Thieme Journals
Education
Degrees:
BA, Ohio Wesleyan University, United States, 2010
PhD, The University of Kansas, USA, 2015
Postgraduate Training:
NRSA Postdoctoral Fellowship (NIH-F32), University of Illinois at Urbana-Champaign, United States, 2018