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Andrew Riley


Assistant Professor, College of Pharmacy - Pharmaceutical Sciences

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Teaching and Supervision Heading link

PSCI Ph.D. Thesis Research (PSCI 599), 8/26/2024 – 12/6/2024
Doctoral Restch in Med Chem (MDCH 599), 8/26/2024 – 12/6/2024
Research Presentation (PSCI 502), 8/26/2024 – 12/6/2024
PSCI Ph.D. Thesis Research (PSCI 599), 6/10/2024 – 8/2/2024
Doctoral Restch in Med Chem (MDCH 599), 6/10/2024 – 8/2/2024
PSCI Ph.D. Thesis Research (PSCI 599), 1/8/2024 – 4/26/2024
Doctoral Restch in Med Chem (MDCH 599), 1/8/2024 – 4/26/2024
Undergrad Res Exp Pharm Sci (PSCI 300), 1/8/2024 – 4/26/2024
PSCI Ph.D. Thesis Research (PSCI 599), 8/21/2023 – 12/1/2023

Selected Grants

?9?10 Nicotinic Acetylcholine Receptors in neuropathic pain, National Institutes of Health (National Institute of Neurological Disorders and Stroke)., 8/1/2024 - 6/30/2029, Obligated Amount: $624360; Anticipated Amount: $3121800

Pharmacological Potential of Combined Translation and Autophagy Inhibition in High Grade Serous Ovarian Cancer, National Institutes of Health (National Institute of General Medical Sciences)., 8/1/2024 - 7/31/2026, Obligated Amount: $120972; Anticipated Amount: $241944

Aristotelia Alkaloids as Probes for the Nicotinic Acetylcholine Receptors, National Institutes of Health (National Center for Complementary and Integrative Health)., 5/16/2024 - 5/15/2026, Obligated Amount: $48974; Anticipated Amount: $95388

Selective Targeting of Nicotinic Acetylcholine Receptor Subtypes for Cocaine Use Disorder, National Institutes of Health (National Institute on Drug Abuse)., 3/1/2024 - 12/31/2028, Obligated Amount: $703988; Anticipated Amount: $3373690

Defining ?9?10 nAChR Complex Using the ATLAS Kit, Sigma-Aldrich., 12/16/2022 - 9/15/2023, Obligated Amount: $30000; Anticipated Amount: $30000

Prodrug Development for Pharmaceutical Uses, Innovo Pharmaceuticals., 9/16/2022 - 9/15/2024, Obligated Amount: $44793; Anticipated Amount: $44793

Synthesis and Evaluation of Alkaloids to Probe Membrane Receptors, National Institutes of Health (National Institute of General Medical Sciences)., 8/1/2022 - 6/30/2027, Obligated Amount: $1521417; Anticipated Amount: $2097885

Hans W. Vahlteich Research Award, UIC College of Pharmacy., Date Not Set - Present, No Obligated Amount Set; No Anticipated Amount Set

Selected Publications

Kremiller, Kyle M, Kulkarni, Gauri C, Harris, Lauren M, Gunasekara, Hirushi, Kashyap, Yavnika, Ilktach, Giokdjen, Nguyen, Angela, Ondrus, Alison E, Hu, Ying S, Wang, Zaijie J, Riley, Andrew P, Peters, Christian J. (2024). Discovery of Antinociceptive α9α10 Nicotinic Acetylcholine Receptor Antagonists by Stable Receptor Expression. ACS Chemical Biology. doi:10.1021/acschembio.4c00330.

Heppner, David E, Bigi-Botterill, Simone V, Riley, Andrew P, Chibale, Kelly, Lindsley, Craig W. (2024). Structural Biology in Drug Discovery and Development: Call for Papers. ACS Medicinal Chemistry Letters, 15, (8), 1167-1168. doi:10.1021/acsmedchemlett.4c00318.

Heppner, David E, Bigi-Botterill, Simone V, Riley, Andrew P, Chibale, Kelly, Lindsley, Craig W. (2024). Structural Biology in Drug Discovery and Development: Call for Papers. Journal of Medicinal Chemistry, 67, (15), 12461-12462. doi:10.1021/acs.jmedchem.4c01492.

Riley, Andrew P. (2024). In This Issue, Volume 15, Issue 7. ACS Medicinal Chemistry Letters, 15, (7), 987-988. doi:10.1021/acsmedchemlett.4c00282.

Riley, Andrew P. (2024). In This Issue, Volume 15, Issue 4. ACS Medicinal Chemistry Letters, 15, (4), 434-435. doi:10.1021/acsmedchemlett.4c00123.

Rusali, Lisa E, Lopez-Hernandez, Ana M, Kremiller, Kyle M, Kulkarni, Gauri C, Gour, Abhishek, Straub, Carolyn J, Argade, Malaika D, Peters, Christian J, Sharma, Abhisheak, Toll, Lawrence, Cippitelli, Andrea, Riley, Andrew P. (2024). Synthesis of α3β4 Nicotinic Acetylcholine Receptor Modulators Derived from Aristoquinoline That Reduce Reinstatement of Cocaine-Seeking Behavior. Journal of Medicinal Chemistry, 67, (1), 529-542. doi:10.1021/acs.jmedchem.3c01758.

Hennessy, Madeline R, Gutridge, Anna M, French, Alexander R, Rhoda, Elizabeth S, Meqbil, Yazan J, Gill, Meghna, Kashyap, Yavnika, Appourchaux, Kevin, Paul, Barnali, Wang, Zaijie Jim, van Rijn, Richard M, Riley, Andrew P. (2023). Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor. Journal of Medicinal Chemistry, 66, (5), 3312-3326. doi:10.1021/acs.jmedchem.2c01707.

Straub, Carolyn J, Rusali, Lisa E, Kremiller, Kyle M, Riley, Andrew P. (2023). What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders. Journal of Medicinal Chemistry, 66, (1), 107-121. doi:10.1021/acs.jmedchem.2c01562.

Shelton, Catherine L, Meneely, Kathleen M, Ronnebaum, Trey A, Chilton, Annemarie S, Riley, Andrew P, Prisinzano, Thomas E, Lamb, Audrey L. (2022). Rational inhibitor design for Pseudomonas aeruginosa salicylate adenylation enzyme PchD. JBIC Journal of Biological Inorganic Chemistry, 27, (6), 541-551. doi:10.1007/s00775-022-01941-8.

Professional Leadership

Auditing Committee, American Society of Pharmacognosy, 8/7/2019 - Present

Auditing Committee, 8/7/2019 - Present

Notable Honors

2024, ACS MEDI Young Investigator Symposium, American Chemical Society

2024, UIC Rising Star in Basic Life Sciences, UIC

2023, Thieme Chemistry Journal Award, Thieme Journals

Education

Degrees:
BA, Ohio Wesleyan University, United States, 2010
PhD, The University of Kansas, USA, 2015

Postgraduate Training:
NRSA Postdoctoral Fellowship (NIH-F32), University of Illinois at Urbana-Champaign, United States, 2018