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Andrew Riley

Assistant Professor, College of Pharmacy - Pharmaceutical Sciences

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Teaching and Supervision Heading link

PSCI Ph.D. Thesis Research (PSCI 599), 8/21/2023 – 12/1/2023
PhD Thesis Research (BPS 599), 8/21/2023 – 12/1/2023
Doctoral Restch in Med Chem (MDCH 599), 8/21/2023 – 12/1/2023
Research Presentation (PSCI 502), 8/21/2023 – 12/1/2023
Fundamentals of Drug Action (PHAR 422), 8/21/2023 – 12/1/2023
Fundamentals of Drug Action (PHAR 422), 8/21/2023 – 12/1/2023
PSCI Ph.D. Thesis Research (PSCI 599), 6/12/2023 – 8/4/2023
Doctoral Restch in Med Chem (MDCH 599), 6/12/2023 – 8/4/2023
PhD Thesis Research (BPS 599), 6/12/2023 – 8/4/2023

Selected Grants

Defining ?9?10 nAChR Complex Using the ATLAS Kit, Sigma-Aldrich., 12/16/2022 - 9/15/2023, Obligated Amount: $30000; Anticipated Amount: $30000

Prodrug Development for Pharmaceutical Uses, Innovo Pharmaceuticals., 9/16/2022 - 9/15/2024, Obligated Amount: $44793; Anticipated Amount: $44793

Synthesis and Evaluation of Alkaloids to Probe Membrane Receptors, National Institutes of Health (National Institute of General Medical Sciences)., 8/1/2022 - 6/30/2027, Obligated Amount: $823585; Anticipated Amount: $2073134

Hans W. Vahlteich Research Award, UIC College of Pharmacy., Date Not Set - Present, No Obligated Amount Set; No Anticipated Amount Set

Selected Publications

Rusali, Lisa E, Lopez-Hernandez, Ana M, Kremiller, Kyle M, Kulkarni, Gauri C, Gour, Abhishek, Straub, Carolyn J, Argade, Malaika D, Peters, Christian J, Sharma, Abhisheak, Toll, Lawrence, Cippitelli, Andrea, Riley, Andrew P. (2024). Synthesis of α3β4 Nicotinic Acetylcholine Receptor Modulators Derived from Aristoquinoline That Reduce Reinstatement of Cocaine-Seeking Behavior. Journal of Medicinal Chemistry, 67, (1), 529-542. doi:10.1021/acs.jmedchem.3c01758.

Hennessy, Madeline R, Gutridge, Anna M, French, Alexander R, Rhoda, Elizabeth S, Meqbil, Yazan J, Gill, Meghna, Kashyap, Yavnika, Appourchaux, Kevin, Paul, Barnali, Wang, Zaijie Jim, van Rijn, Richard M, Riley, Andrew P. (2023). Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor. Journal of Medicinal Chemistry, 66, (5), 3312-3326. doi:10.1021/acs.jmedchem.2c01707.

Straub, Carolyn J, Rusali, Lisa E, Kremiller, Kyle M, Riley, Andrew P. (2023). What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders. Journal of Medicinal Chemistry, 66, (1), 107-121. doi:10.1021/acs.jmedchem.2c01562.

Shelton, Catherine L, Meneely, Kathleen M, Ronnebaum, Trey A, Chilton, Annemarie S, Riley, Andrew P, Prisinzano, Thomas E, Lamb, Audrey L. (2022). Rational inhibitor design for Pseudomonas aeruginosa salicylate adenylation enzyme PchD. JBIC Journal of Biological Inorganic Chemistry, 27, (6), 541-551. doi:10.1007/s00775-022-01941-8.

Argade, Malaika D, Riley, Andrew P. (2022). Syntheses of Aristotelia Alkaloids: Reflections in the Chiral Pool. Synlett, 33, (13), 1209-1214. doi:10.1055/a-1856-7334.

Argade, Malaika D, Straub, Carolyn J, Rusali, Lisa E, Santarsiero, Bernard D, Riley, Andrew P. (2021). Synthesis of Aristoquinoline Enantiomers and Their Evaluation at the α3β4 Nicotinic Acetylcholine Receptor. Organic Letters, 23, (20), 7693-7697. doi:10.1021/acs.orglett.1c02057.

Creed, Simone M, Gutridge, Anna M, Argade, Malaika D, Hennessy, Madeline R, Friesen, J Brent, Pauli, Guido F, van Rijn, Richard M, Riley, Andrew P. (2021). Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids. Journal of Natural Products, 84, (1), 71-80. doi:10.1021/acs.jnatprod.0c01036.

Crowley, Rachel S, Riley, Andrew P, Alder, Amy F, Anderson, Richard J, Luo, Dan, Kaska, Sophia, Maynez, Pamela, Kivell, Bronwyn M, Prisinzano, Thomas E. (2020). Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G‑protein Activation Bias at the μ‑Opioid Receptor. ACS Chemical Neuroscience, 11, (12), 1781-1790. doi:10.1021/acschemneuro.0c00191.

Richter, Michelle F, Drown, Bryon S, Riley, Andrew P, Garcia, Alfredo, Shirai, Tomohiro, Svec, Riley L, Hergenrother, Paul J. (2017). Predictive compound accumulation rules yield a broad-spectrum antibiotic. Nature, 545, (7654), 299-304. doi:10.1038/nature22308.

Professional Leadership

Auditing Committee, American Society of Pharmacognosy, 8/7/2019 - Present

Auditing Committee, 8/7/2019 - Present

Notable Honors

2023, Thieme Chemistry Journal Award, Thieme Journals


BA, Ohio Wesleyan University, United States, 2010
PhD, The University of Kansas, USA, 2015

Postgraduate Training:
NRSA Postdoctoral Fellowship (NIH-F32), University of Illinois at Urbana-Champaign, United States, 2018