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Andrew Riley

Assistant Professor, College of Pharmacy - Pharmaceutical Sciences

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Teaching and Supervision Heading link

PSCI Ph.D. Thesis Research (PSCI 599), 1/9/2023 – 4/28/2023
PhD Thesis Research (BPS 599), 1/9/2023 – 4/28/2023
Doctoral Restch in Med Chem (MDCH 599), 1/9/2023 – 4/28/2023
Medicinal Chemistry (PSCI 530), 1/9/2023 – 4/28/2023
PSCI Ph.D. Thesis Research (PSCI 599), 8/22/2022 – 12/2/2022
Research Presentation (PSCI 502), 8/22/2022 – 12/2/2022
PhD Thesis Research (BPS 599), 8/22/2022 – 12/2/2022
Fundamentals of Drug Action (PHAR 422), 8/22/2022 – 12/2/2022
Fundamentals of Drug Action (PHAR 422), 8/22/2022 – 12/2/2022

Selected Grants

Defining ?9?10 nAChR Complex Using the ATLAS Kit, Sigma-Aldrich., 12/16/2022 - 6/15/2023, Obligated Amount: $30000; Anticipated Amount: $30000

Prodrug Development for Pharmaceutical Uses, Innovo Pharmaceuticals., 9/16/2022 - 9/15/2023, Obligated Amount: $44793; Anticipated Amount: $44793

Synthesis and Evaluation of Alkaloids to Probe Membrane Receptors, National Institutes of Health (National Institute of General Medical Sciences)., 8/1/2022 - 6/30/2027, Obligated Amount: $378177; Anticipated Amount: $1890885

Hans W. Vahlteich Research Award, UIC College of Pharmacy., Date Not Set - Present, No Obligated Amount Set; No Anticipated Amount Set

Selected Publications

Straub, CJ, Rusali, LE, Kremiller, KM, Riley, AP. (2023). What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders. Journal of Medicinal Chemistry, 66, (1), 107-121. doi:10.1021/acs.jmedchem.2c01562.

Shelton, CL, Meneely, KM, Ronnebaum, TA, Chilton, AS, Riley, AP, Prisinzano, TE, Lamb, AL. (2022). Rational inhibitor design for Pseudomonas aeruginosa salicylate adenylation enzyme PchD. Journal of Biological Inorganic Chemistry, 27, (6), 541-551. doi:10.1007/s00775-022-01941-8.

Argade, MD, Riley, AP. (2022). Syntheses of Aristotelia Alkaloids: Reflections in the Chiral Pool. Synlett, 33, (13), 1209-1214. doi:10.1055/a-1856-7334.

Hennessy, MR, Gutridge, AM, French, AR, Rhoda, ES, Meqbil, YJ, Gill, M, Kashyap, Y, Appourchaux, K, Paul, B, Wang, ZJ, van Rijn, RM, Riley, AP. (2022). Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.2c01707.

Argade, MD, Straub, CJ, Rusali, LE, Santarsiero, BD, Riley, AP. (2021). Synthesis of Aristoquinoline Enantiomers and Their Evaluation at the α3β4 Nicotinic Acetylcholine Receptor. Organic Letters, 23, (20), 7693-7697. doi:10.1021/acs.orglett.1c02057.

Creed, SM, Gutridge, AM, Argade, MD, Hennessy, MR, Friesen, JB, Pauli, GF, Van Rijn, RM, Riley, AP. (2021). Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids. Journal of Natural Products, 84, (1), 71-80. doi:10.1021/acs.jnatprod.0c01036.

Crowley, RS, Riley, AP, Alder, AF, Anderson, RJ, Luo, D, Kaska, S, Maynez, P, Kivell, BM, Prisinzano, TE. (2020). Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ-Opioid Receptor. ACS Chemical Neuroscience, 11, (12), 1781-1790. doi:10.1021/acschemneuro.0c00191.

Richter, MF, Drown, BS, Riley, AP, Garcia, A, Shirai, T, Svec, RL, Hergenrother, PJ. (2017). Predictive compound accumulation rules yield a broad-spectrum antibiotic. Nature, 545, (7654), 299-304. doi:10.1038/nature22308.

Crowley, RS, Riley, AP, Sherwood, AM, Groer, CE, Shivaperumal, N, Biscaia, M, Paton, K, Schneider, S, Provasi, D, Kivell, BM, Filizola, M, Prisinzano, TE. (2016). Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. Journal of Medicinal Chemistry, 59, (24), 11027-11038. doi:10.1021/acs.jmedchem.6b01235.

Professional Leadership

Auditing Committee, American Society of Pharmacognosy, 8/7/2019 - Present


BA, Ohio Wesleyan University, United States, 2010
PhD, The University of Kansas, USA, 2015

Postgraduate Training:
NRSA Postdoctoral Fellowship (NIH-F32), University of Illinois at Urbana-Champaign, United States, 2018