Andrew Riley
Associate Professor, College of Pharmacy - Pharmaceutical Sciences
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About
Teaching and Supervision
PSCI Ph.D. Thesis Research (PSCI 45175), 1/12/2026 – 5/1/2026
PSCI Ph.D. Thesis Research (PSCI 599), 8/25/2025 – 12/5/2025
Research Presentation (PSCI 502), 8/25/2025 – 12/5/2025
Fundamentals of Drug Action (PHAR 422), 8/25/2025 – 12/5/2025
Fundamentals of Drug Action (PHAR 422), 8/25/2025 – 12/5/2025
Undergrad Res Exp Pharm Sci (PSCI 300), 8/25/2025 – 12/5/2025
PSCI Ph.D. Thesis Research (PSCI 599), 6/16/2025 – 8/8/2025
PSCI Ph.D. Thesis Research (PSCI 599), 1/13/2025 – 5/2/2025
Research Presentation (PSCI 502), 8/26/2024 – 12/6/2024
Selected Grants
Pharmacological Potential of Combined Translation and Autophagy Inhibition in High Grade Serous Ovarian Cancer, National Institutes of Health (National Institute of General Medical Sciences)., 8/1/2024 - 7/31/2026, Obligated Amount: $241944; Anticipated Amount: $241944
?9?10 Nicotinic Acetylcholine Receptors in neuropathic pain, National Institutes of Health (National Institute of Neurological Disorders and Stroke)., 8/1/2024 - 6/30/2029, Obligated Amount: $1248720; Anticipated Amount: $3121800
α9α10 Nicotinic Acetylcholine Receptors in neuropathic pain, National Institute of Neurological Disorders and Stroke., 8/1/2024 - 6/30/2029, Obligated Amount: $1248720; No Anticipated Amount Set
Aristotelia Alkaloids as Probes for the Nicotinic Acetylcholine Receptors, National Institutes of Health (National Center for Complementary and Integrative Health)., 5/16/2024 - 5/15/2026, Obligated Amount: $98512; Anticipated Amount: $98512
Selective Targeting of Nicotinic Acetylcholine Receptor Subtypes for Cocaine Use Disorder, National Institutes of Health (National Institute on Drug Abuse)., 3/1/2024 - 12/31/2028, Obligated Amount: $2053230; Anticipated Amount: $3373690
Defining ?9?10 nAChR Complex Using the ATLAS Kit, Sigma-Aldrich., 12/16/2022 - 9/15/2023, Obligated Amount: $30000; Anticipated Amount: $30000
Prodrug Development for Pharmaceutical Uses, Innovo Pharmaceuticals., 9/16/2022 - 9/15/2024, Obligated Amount: $44793; Anticipated Amount: $44793
Synthesis and Evaluation of Alkaloids to Probe Membrane Receptors, National Institutes of Health (National Institute of General Medical Sciences)., 8/1/2022 - 6/30/2027, Obligated Amount: $1905708; Anticipated Amount: $2097885
Hans W. Vahlteich Research Award, UIC College of Pharmacy., Date Not Set - Present, No Obligated Amount Set; No Anticipated Amount Set
Selected Publications
Mingolelli, Gabrielle, Bashatwah, Rasha M, Jurek, Megan J, Chauvin, Isabel M, Orjala, Jimmy, Riley, Andrew P, Burdette, Joanna E, Henke, Matthew T. (2026). The Human Gut Microbiome Metabolizes Diverse Bioactive Coumarins via α,β-Unsaturated Lactone Reduction. Journal of Natural Products. doi:10.1021/acs.jnatprod.6c00329.
Kulkarni, Gauri C, Jurek, Megan J, Riley, Andrew P, Peters, Christian J. (2026). An accessory orthosteric ligand binding site in the (α3)3(β4)2 nicotinic acetylcholine receptor regulates channel activation. Cell Reports, 45, (4), 117077. doi:10.1016/j.celrep.2026.117077.
Timmons, Patricia, Hill, Katherine, Smith, Kirsten E, Riley, Andrew, Mun, Chung Jung. (2026). Akuamma Seed (Picralima nitida) Use in the U.S.: Findings from a Web-Based Survey. Journal of Psychoactive Drugs, ahead-of-print, (ahead-of-print), 1-8. doi:10.1080/02791072.2026.2618033.
Bigi-Botterill, Simone V, Borsari, Chiara, Dombrowski, Amanda W, Estrada, Michelle A, Farrell, Mark P, Riley, AndrewP, Woodland, John G. (2026). Fifteen Years, One Mission: Innovative, Inspirational, and Impactful Discoveries. ACS Medicinal Chemistry Letters, 17, (1), 1-19. doi:10.1021/acsmedchemlett.5c00709.
Riley, Andrew P. (2025). Semi-synthesis in the exploration of opioid-targeting natural products. Natural Product Reports, 42, (10), 1664-1675. doi:10.1039/d5np00029g.
Gour, Abhishek, Creed, Simone M, Riley, Andrew P, Sharma, Abhisheak. (2025). Comprehensive pharmacokinetics and ADME evaluation of Akuamma alkaloids. Journal of Chromatography B, 1263, 124713. doi:10.1016/j.jchromb.2025.124713.
Bland, Kathryn, Chen, Chongguang, Huang, Peng, Ho, Conrad, Howe, Theodora, Ocampo, Katrina, Zhao, Pingwei, Creed, Simone, Noel-Torres, Joseph, Riley, Andrew P, Liu-Chen, Lee-Yuan. (2025). Pharmacological characterization of the novel selective kappa opioid receptor agonists 10-Iodo-Akuammicine and 10-Bromo-akuammicine in mice. Neuropharmacology, 268, 110316. doi:10.1016/j.neuropharm.2025.110316.
Straub, Carolyn J, Rusali, Lisa E, Riley, Andrew P. (2025). Derivatives of Aristoquinoline Accessed through a Ritter-like Reaction. ACS Medicinal Chemistry Letters, 16, (3), 406-409. doi:10.1021/acsmedchemlett.4c00506.
Hennessy, Madeline R, Creed, Simone M, Gutridge, Anna M, Rusali, Lisa E, Luo, Dan, Sepehri, Bakhtyar, Rhoda, Elizabeth S, Villegas, José A, van Rijn, Richard M, Riley, Andrew P. (2024). Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine. Journal of Medicinal Chemistry, 67, (23), 20842-20857. doi:10.1021/acs.jmedchem.4c00736.
Professional Leadership
Auditing Committee, American Society of Pharmacognosy, 8/7/2019 - Present
Auditing Committee, 8/7/2019 - Present
Notable Honors
2024, ACS MEDI Young Investigator Symposium, American Chemical Society
2024, UIC Rising Star in Basic Life Sciences, UIC
2023, Thieme Chemistry Journal Award, Thieme Journals
Education
Degrees:
BA, Ohio Wesleyan University, United States, 2010
PhD, The University of Kansas, USA, 2015
Postgraduate Training:
NRSA Postdoctoral Fellowship (NIH-F32), University of Illinois at Urbana-Champaign, United States, 2018