Bharath Chelluboina
Tenure track Assistant Professor, University of Illinois Chicago
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About Heading link
Overview:
Dr. Bharath Chelluboina is a Tenure-track Assistant Professor at the University of Illinois Chicago. Dr. Bharath is a pharmaceuticals professional and completed his postdoctoral training at the University of Illinois. Dr. Bharath was a scientist and principal investigator in the Department of Neurological Surgery at the University of Wisconsin-Madison. Dr. Bharath is an expert in preclinical model microsurgeries and a neuroscientist with expertise in studying brain damage in old age with comorbidities.
Research Interests:
Bharath Brain Lab focuses on understanding the pathogenesis of stroke in the context of aging and comorbidities such as hypertension and chronic kidney disease. Our lab explores innovative strategies to develop effective stroke therapies tailored to aging populations and individuals with comorbidities. We perform brain microsurgeries in rodent models and utilize advanced techniques, including MRI, ultrasound, laser speckle imaging for noninvasive tracking of disease progression, and techniques such as in vivo siRNA delivery and genetic manipulation through knockout and overexpression strategies to investigate molecular targets and enhance post-stroke neuroprotection.
Teaching and Supervision Heading link
Selected Grants
The effect of renal function in aging on post-stroke gut microbiomes and their metabolites (AHA TPA), American Heart Association., 10/1/2024 - 6/30/2025, Obligated Amount: $9000; Anticipated Amount: $9000
Pharmacomicrobiomic interactions in Post-stroke management of hypertension, American Heart Association., 7/1/2024 - 6/30/2025, Obligated Amount: $29624; Anticipated Amount: $29624
Involvement of Chronic Kidney Disease Induced Cardiac Fibrosis in Mediating Brain Damage After Ischemic Stroke, William E McElroy Charitable Foundation., 7/1/2017 - 6/30/2018, Obligated Amount: $22000; Anticipated Amount: $22000
Selected Publications
Chelluboina, Bharath, Cho, Tony, Park, Jin-Soo, Mehta, Suresh L, Bathula, Saivenkateshkomal, Jeong, Soomin, Vemuganti, Raghu. (2024). Intermittent fasting induced cerebral ischemic tolerance altered gut microbiome and increased levels of short-chain fatty acids to a beneficial phenotype. Neurochemistry International, 178, 105795. doi:10.1016/j.neuint.2024.105795.
Jeong, Soomin, Chokkalla, Anil K, Davis, Charles K, Jeong, Hyunmook, Chelluboina, Bharath, Arruri, Vijay, Kim, Bori, Narman, Ashlyn, Bathula, Saivenkateshkomal, Arumugam, Thiruma V, Bendlin, Barbara B, Vemuganti, Raghu. (2024). Circadian-Dependent Intermittent Fasting Influences Ischemic Tolerance and Dendritic Spine Remodeling. Stroke, 55, (8), 2139-2150. doi:10.1161/strokeaha.124.046400.
Mehta, Suresh L, Chelluboina, Bharath, Morris-Blanco, Kahlilia C, Bathula, Saivenkateshkomal, Jeong, Soomin, Arruri, Vijay, Davis, Charles K, Vemuganti, Raghu. (2024). Post-stroke brain can be protected by modulating the lncRNA FosDT. Cerebrovascular and Brain Metabolism Reviews, 44, (2), 239-251. doi:10.1177/0271678×231212378.
Chelluboina, Bharath, Jeong, Soomin, Davis, Charles Kozhikkadan, Mehta, Suresh L, Vemuganti, Raghu. (2023). Therapeutic Potential of Intravenous miR-21 Mimic after Stroke Following STAIR Criteria. Translational Stroke Research, 1-7. doi:10.1007/s12975-023-01223-8.
Mehta, Suresh L, Kim, TaeHee, Chelluboina, Bharath, Vemuganti, Raghu. (2023). Tau and GSK-3β are Critical Contributors to α-Synuclein-Mediated Post-Stroke Brain Damage. NeuroMolecular Medicine, 25, (1), 94-101. doi:10.1007/s12017-022-08731-0.
Mehta, Suresh L, Chokkalla, Anil K, Bathula, Saivenkateshkomal, Arruri, Vijay, Chelluboina, Bharath, Vemuganti, Raghu. (2023). CDR1as regulates α-synuclein-mediated ischemic brain damage by controlling miR-7 availability. Molecular Therapy – Nucleic Acids, 31, 57-67. doi:10.1016/j.omtn.2022.11.022.
Arruri, Vijay, Chokkalla, Anil K, Jeong, Soomin, Chelluboina, Bharath, Mehta, Suresh L, Veeravalli, Krishna Kumar, Vemuganti, Raghu. (2022). MMP-12 knockdown prevents secondary brain damage after ischemic stroke in mice. Neurochemistry International, 161, 105432. doi:10.1016/j.neuint.2022.105432.
Nalamolu, Koteswara Rao, Chelluboina, Bharath, Fornal, Casimir A, Challa, Siva Reddy, Pinson, David M, Wang, David Z, Klopfenstein, Jeffrey D, Veeravalli, Krishna Kumar. (2021). Stem cell treatment improves post stroke neurological outcomes: a comparative study in male and female rats. Stroke and Vascular Neurology, 6, (4), 519-527. doi:10.1136/svn-2020-000834.
Mehta, Suresh L, Chokkalla, Anil K, Kim, TaeHee, Bathula, Saivenkateshkomal, Chelluboina, Bharath, Morris-Blanco, Kahlilia C, Holmes, Aleah, Banerjee, Anik, Chauhan, Anjali, Lee, Juneyoung, Venna, Venugopal R, McCullough, Louise D, Vemuganti, Raghu. (2021). Long Noncoding RNA Fos Downstream Transcript Is Developmentally Dispensable but Vital for Shaping the Poststroke Functional Outcome. Stroke, 52, (7), 2381-2392. doi:10.1161/strokeaha.120.033547.