Photo of Brian Thacher Murphy

Brian Thacher Murphy


Associate Professor, Pharmaceutical Sciences
Center Affiliate, Center for Biomolecular Sciences
INST AFFL, Institute for Tuberculosis Research
Faculty and Staff Committee, Diversity & Inclusion

Contact

Building & Room:

Molecular Biology Research Building, Room 3120

Address:

900 South Ashland Ave, Chicago, IL, 60607

Office Phone:

(312) 413-9057

About

Research Interests: Chemistry, drug-lead discovery, spectroscopy, aquatic microbiology
Teaching Interests: Science-based community outreach

Selected Publications

  • Clark C, Costa M, Conley E, Li E, Sanchez L, Murphy BT. Using the Open-Source MALDI TOF-MS IDBac Pipeline for Analysis of Microbial Protein and Specialized Metabolite Data.. Journal of visualized experiments : JoVE. 2019;(147). doi:10.3791/59219.
  • Braesel J, Clark C, Kunstman KJ, Green SJ, Maienschein-Cline M, Murphy BT, Eustáquio AS. Genome Sequence of Marine-Derived Streptomyces sp. Strain F001, a Producer of Akashin A and Diazaquinomycins.. Microbiology resource announcements. 2019;8(19). doi:10.1128/MRA.00165-19.
  • Braesel J, Lee J, Arnould B, Murphy BT, Eustáquio AS. Diazaquinomycin Biosynthetic Gene Clusters from Marine and Freshwater Actinomycetes.. Journal of natural products. 2019;82(4):937-946. doi:10.1021/acs.jnatprod.8b01028.
  • Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI , Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA, Jr F, Rivas SA, Ross R, Sarpong I, Sharma JT, Shaw Z, Xu B, Shen W, Shi , Stephenson CRJ AL, Verano DS, Tan Y, Tang RE, Taylor RJ, Thomson DA, Vosburg J, Wu WM, Wuest A, Zakarian Y, Zhang T, Ren Z, Zuo J, Inglese S, Michael A, Simeonov W, Zheng P, Shinn A, Jadhav MB, Boxer MD, Hall M, Xia R, Guha JM, Rohde . Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.. ACS central science. 2018;4(12):1727-1741. doi:10.1021/acscentsci.8b00747.
  • Petrovich M, Chu B, Wright D, Griffin J, Elfeki M, Murphy BT, Poretsky R, Wells G. Antibiotic resistance genes show enhanced mobilization through suspended growth and biofilm-based wastewater treatment processes.. FEMS microbiology ecology. 2018;94(11). doi:10.1093/femsec/fiy174.
  • Braesel J, Crnkovic C, Kunstman KJ, Green SJ, Maienschein-Cline M, Orjala J, Murphy BT, Eustáquio AS. Complete Genome of Micromonospora sp. Strain B006 Reveals Biosynthetic Potential of a Lake Michigan Actinomycete.. Journal of natural products. 2018;81(9):2057-2068. doi:10.1021/acs.jnatprod.8b00394.
  • Lee J, Dean MJ, Austin J, Burdette JE, Murphy BT. Irilone from Red Clover ( Trifolium pratense) Potentiates Progesterone Signaling.. Journal of natural products. 2018;81(9):1962-1967. doi:10.1021/acs.jnatprod.8b00131.
  • Elfeki M, Alanjary M, Green SJ, Ziemert N, Murphy BT. Assessing the Efficiency of Cultivation Techniques To Recover Natural Product Biosynthetic Gene Populations from Sediment.. ACS chemical biology. 2018;13(8):2074-2081. doi:10.1021/acschembio.8b00254.
  • Clark C, Costa M, Sanchez L, Murphy BT. Coupling MALDI-TOF mass spectrometry protein and specialized metabolite analyses to rapidly discriminate bacterial function.. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(19):4981-4986. doi:10.1073/pnas.1801247115.
  • Petrovich M, Chu B, Wright D, Griffin J, Elfeki M, Murphy BT, Poretsky R, Wells G. Antibiotic resistance genes show enhanced mobilization through suspended growth and biofilm-based wastewater treatment processes.. FEMS microbiology ecology. 2018;94(5). doi:10.1093/femsec/fiy041.
  • Dean MJ, Murphy BT, Burdette JE. Phytosteroids beyond estrogens: Regulators of reproductive and endocrine function in natural products.. Molecular and cellular endocrinology. 2017;442:98-105. doi:10.1016/j.mce.2016.12.013.
  • Wang M, Carver JJ, Phelan VV, Sanchez L, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CM, CAB P, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O’Neill EC, Briand E, Helfrich EJN , Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC , Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.. Nature biotechnology. 2016;34(8):828-837. doi:10.1038/nbt.3597.
  • Thi QV, Tran VH, Maia HD, Le CV, Hong Mle T, Murphy BT, Chau VM, Pham VC. Antimicrobial Metabolites from a Marine-Derived Actinomycete in Vietnam’s East Sea.. Natural product communications. 2016;11(1):49-51.
  • Mullowney MW, hAinmhire E, Tanouye U, Burdette JE, Pham VC, Murphy BT. A Pimarane Diterpene and Cytotoxic Angucyclines from a Marine-Derived Micromonospora sp. in Vietnam’s East Sea.. Marine drugs. 2015;13(9):5815-27. doi:10.3390/md13095815.
  • Mullowney MW, Hwang CH, Newsome AG, Wei X, Tanouye U, Wan B, Carlson SN, Barranis NJ, hAinmhire E, Chen W, Krishnamoorthy K, White J, Blair R, Lee H, Burdette JE, Rathod PK, Parish T, Cho S, Franzblau SG, Murphy BT. Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosis.. ACS infectious diseases. 2015;1(4):168-174. doi:10.1021/acsinfecdis.5b00005.
  • Carlson SN, Tanouye U, Omarsdottir S, Murphy BT. Phylum-specific regulation of resistomycin production in a Streptomyces sp. via microbial coculture.. Journal of natural products. 2015;78(3):381-7. doi:10.1021/np500767u.
  • Mullowney MW, hAinmhire EF, Shaikh AD, Wei XE, Tanouye UT, Santarsiero B, Burdette J, Murphy B. Diazaquinomycins E-G, novel diaza-anthracene analogs from a marine-derived Streptomyces sp.. Marine drugs. 2014;12(6):3574-86. doi:10.3390/md12063574.
  • Mullowney MW, hAinmhire EF, Shaikh AD, Wei XE, Tanouye UT, Santarsiero B, Burdette J, Murphy B. Diazaquinomycins E-G, novel diaza-anthracene analogs from a marine-derived Streptomyces sp.. Marine drugs. 2014;12(6):3574-86. doi:10.3390/md12063574.
  • Orelle CN, Carlson SM, Kaushal BC, Almutairi ML, Liu HT, Ochabowicz A, Quan S, Pham V, Squires C, Murphy B, Mankin A. Tools for characterizing bacterial protein synthesis inhibitors.. Antimicrobial agents and chemotherapy. 2013;57(12):5994-6004. doi:10.1128/AAC.01673-13.
  • Carlson SN, Marler LJ, Nam SD, Santarsiero BM, Pezzuto JT, Murphy B. Potential chemopreventive activity of a new macrolide antibiotic from a marine-derived Micromonospora sp.. Marine drugs. 2013;11(4):1152-61. doi:10.3390/md11041152.
  • Kondratyuk TP, Park EJ, Yu RB, van Breemen RN, Asolkar RT, Murphy BM, Fenical W, Pezzuto J. Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents.. Marine drugs. 2012;10(2):451-64. doi:10.3390/md10020451.