Brian T. Murphy
Professor, College of Pharmacy - Pharmaceutical Sciences
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PSCI Ph.D. Thesis Research (PSCI 599), 6/12/2023 – 8/4/2023
Biomedicinal Chemistry – PSCI 423 (PSCI 423), 2/2023 – Present
Undergrad Res Pharm Sci (PSCI 380), 1/9/2023 – 4/28/2023
PSCI Ph.D. Thesis Research (PSCI 599), 1/9/2023 – 4/28/2023
Doctoral Research in Pharmacog (PMPG 599), 1/9/2023 – 4/28/2023
Science Writing (PSCI 504), 1/9/2023 – 3/3/2023
PSCI Ph.D. Thesis Research (PSCI 599), 8/22/2022 – 12/2/2022
Doctoral Research in Pharmacog (PMPG 599), 8/22/2022 – 12/2/2022
PSCI Ph.D. Thesis Research (PSCI 599), 5/16/2022 – 7/21/2022
Selected Grants
Botanical derived progestins and their impact on women's health, National Institutes of Health (National Center for Complementary and Integrative Health)., 5/1/2023 - 2/29/2028, Obligated Amount: $399750; Anticipated Amount: $1998750
Discovery of a pigment produced by Streptococcus pyogenes, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 3/1/2023 - 2/28/2025, Obligated Amount: $193496; Anticipated Amount: $423776
Partnering with Community Centers to Perform 'Environment-to-Bioassay' Antbiotic Discovery, Purdue University., 6/1/2022 - 9/30/2023, Obligated Amount: $8970; Anticipated Amount: $8970
Illinois-Indiana Sea Grant 2022-2023 Omnibus (Parent Record), Purdue University., 2/1/2022 - 4/30/2024, Obligated Amount: $207175; Anticipated Amount: $207175
Establishing two new bacterial phyla to produce the next generation of biomedical drug leads,�, Chicago Biomedical Consortium., 10/1/2021 - 9/30/2023, Obligated Amount: $125000; Anticipated Amount: $125000
Identification of antimicrobial reagents against TB and ESKAPE pathogens from bacteria collected in Vietnam�., Vietnam Academy of Science & Technology (Inst of Marine Biochemistry)., 5/5/2021 - 4/30/2023, Obligated Amount: $39975; Anticipated Amount: $39975
Development of a bacterial host for natural product discovery and production, National Institutes of Health (National Institute of General Medical Sciences)., 9/20/2020 - 6/30/2024, Obligated Amount: $1532645; Anticipated Amount: $1532645
A new paradigm for the creation and mining of microbial libraries for drug discovery, National Institutes of Health (National Institute of General Medical Sciences)., 8/10/2018 - 7/31/2023, Obligated Amount: $2069671; Anticipated Amount: $2069671
Antiparasitic Disease Screening in collaboration with UCSD, University of California - San Diego., 10/1/2017 - 12/31/2019, Obligated Amount: $10000; Anticipated Amount: $10000
Selected Publications
Nepomuceno, Vanessa M, Tylor, Kaitlyn M, Carlson, Skylar, Federle, Michael J, Murphy, Brian T, Morales, Tiara Perez. (2023). A Streptomyces tendae Specialized Metabolite Inhibits Quorum Sensing in Group A Streptococcus. Microbiology Spectrum, 11, (4), e05279-e05222. doi:10.1128/spectrum.05279-22.
Lee, Jung-Ho, Ma, Rui, Nguyen, Linh, Khan, Shahebraj, Qader, Mallique, Mpofu, Enock, Shetye, Gauri, Krull, Nyssa K, Augustinović, Mario, Omarsdottir, Sesselja, Cho, Sanghyun, Franzblau, Scott G, Murphy, Brian T. (2023). Discovery of a New Antibiotic Demethoxytetronasin Using a Dual-Sided Agar Plate Assay (DAPA). ACS Infectious Diseases, 9, (8), 1593-1601. doi:10.1021/acsinfecdis.3c00171.
Nguyen, Thi Hoang Anh, Quynh, Thi, Nguyen, Thuy Linh, Le Thi, Hong Minh, Nguyen, Mai Anh, Murphy, Brian T, Dam, Thanh Xuan, Huong, Doan Thi Mai, Van Cuong, Pham. (2023). New Sesterterpenoid from the Marine Fungus Penicillium oxalicum M893. Natural Product Communications, 18, (8), 1934578×231191636. doi:10.1177/1934578×231191636.
Corona‐Avila, Irene, Lee, Jeongho, Hernandez, Antonio, Krull, Nyssa, Augustinovic, Mario, Jones, Derick, Ndekwe, Tatyana, Murphy, Brian T. (2022). Isolation and Characterization of Antimicrobials from Icelandic Aquatic Bacteria. The FASEB Journal, 36, (S1). doi:10.1096/fasebj.2022.36.s1.0r442.
Li, Kailiang, Diakite, Djeneba, Austin, Julia, Lee, Jung-Ho, Lantvit, Daniel D, Murphy, Brian T, Burdette, Joanna E. (2022). The Flavonoid Baicalein Negatively Regulates Progesterone Target Genes in the Uterus in Vivo. Journal of Natural Products, 85, (1), 237-247. doi:10.1021/acs.jnatprod.1c01008.
Austin, Julia R, Li, Kailiang, Rodríguez, Rocío Rivera, Lantvit, Daniel D, Murphy, Brian T, Burdette, Joanna E. (2021). Irilone, a Red Clover Isoflavone, Combined with Progesterone Enhances PR Signaling through the Estrogen and Glucocorticoid Receptors. Journal of Natural Products, 84, (12), 3090-3099. doi:10.1021/acs.jnatprod.1c00835.
Elfeki, Maryam, Mantri, Shrikant, Clark, Chase M, Green, Stefan J, Ziemert, Nadine, Murphy, Brian T. (2021). Evaluating the Distribution of Bacterial Natural Product Biosynthetic Genes across Lake Huron Sediment. ACS Chemical Biology, 16, (11), 2623-2631. doi:10.1021/acschembio.1c00653.
Lee, Jung-Ho, Austin, Julia R, Burdette, Joanna E, Murphy, Brian T. (2021). Secoiridoids from Dogwood (Cornus officinalis) Potentiate Progesterone Signaling. Journal of Natural Products, 84, (9), 2612-2616. doi:10.1021/acs.jnatprod.1c00516.
Austin, Julia R, Lee, Jeongho, Murphy, Brian T, Burdette, Joanna Elizabeth. (2021). Mechanism of Action of Irilone as a Potentiator of Progesterone Receptor Signaling. Journal of the Endocrine Society, 5, (Suppl 1), a812-a812. doi:10.1210/jendso/bvab048.1653.
Professional Leadership
Executive Committee, American Society of Pharmacognosy, 1/1/2021 - Present
Executive Committee, American Society of Pharmacognosy, 1/1/2021 - Present
Diversity & Inclusion Committee, American Society of Pharmacognosy, 1/1/2021 - Present
NIH NCCIH Training and Education Review Panel, 3/20/2020 - Present
ASP Diversity and Inclusion Committee, 1/2018 - 12/2023
Notable Honors
2023, American Society for Microbiology Distinguished Lecturer, American Society for Microbiology
2022, UIC Global Engagement Faculty Award, University of Illinois Chicago
2020, Teacher of the Semester Award, Pharmacy P1 Class of 2023
Education
Degrees:
PhD, Virginia Polytechnic Institute, United States, 2007
MS, University of Massachusetts Dartmouth, United States, 2003
BS, University of Massachusetts Dartmouth, United States, 2002