Photo of Brian T. Murphy

Brian T. Murphy


Professor, College of Pharmacy - Pharmaceutical Sciences

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Teaching and Supervision

Science writing and storytelling (PSCI 504), 8/25/2021 – Present
PSCI Ph.D. Thesis Research (PSCI 599), 8/23/2021 – 12/3/2021
Doctoral Research in Pharmacog (PMPG 599), 8/23/2021 – 12/3/2021
Structure Elucidation of Natural Products (PSCI 521), 1/15/2021 – Present
Biomedicinal Chemistry (PHAR 423), 1/11/2021 – 4/30/2021
Biomedicinal Chemistry (PHAR 423), 1/11/2021 – 4/30/2021
Doctoral Research in Pharmacog (PMPG 599), 1/11/2021 – 4/30/2021
Advanced Pharmacognosy (PMPG 511), 8/25/2020 – Present
Research Techniques in Pharmacognosy (PSCI 520), 8/25/2020 – Present

Selected Grants

Development of a bacterial host for natural product discovery and production, National Institutes of Health (National Institute of General Medical Sciences)., 9/20/2020 - 6/30/2024, Obligated Amount: $793438; Anticipated Amount: $1532645

A new paradigm for the creation and mining of microbial libraries for drug discovery, National Institutes of Health., 2019 - Present, Obligated Amount: $182367; No Anticipated Amount Set

A new paradigm for the creation and mining of microbial libraries for drug discovery, National Institutes of Health (National Institute of General Medical Sciences)., 8/10/2018 - 7/31/2022, Obligated Amount: $2069671; Anticipated Amount: $2069671

Antiparasitic Disease Screening in collaboration with UCSD, University of California - San Diego., 10/1/2017 - 12/31/2019, Obligated Amount: $10000; Anticipated Amount: $10000

Exploration and Mapping of Sponge Populations in the Great Lakes, National Geographic Society., 8/1/2017 - 7/30/2018, Obligated Amount: $19650; Anticipated Amount: $19650

Enhancing basic and translational TB research in northern Vietnam, National Institutes of Health (Fogarty International Center)., 6/1/2017 - 2/28/2022, Obligated Amount: $1083818; Anticipated Amount: $1083818

Botanical Derived Progestins and Their Impact on Women's Health, National Institutes of Health (National Center for Complementary and Integrative Health)., 4/1/2016 - 3/31/2022, Obligated Amount: $1798875; Anticipated Amount: $1798875

Botanical derived progestins and their impact on women’s health, National Institutes of Health., 4/2016 - 6/2021, Obligated Amount: $1125000; Anticipated Amount: $1125000

Droplet Digital PCR to Assess the Abundance of Antibiotic Resistance Genes in Lake Michigan, Chicago Biomedical Consortium., 1/1/2016 - 6/30/2017, Obligated Amount: $15000; Anticipated Amount: $15000

Selected Publications

Lee, JH, Austin, JR, Burdette, JE, Murphy, BT. (2021). Secoiridoids from Dogwood (Cornus officinalis) Potentiate Progesterone Signaling. Journal of Natural Products, 84, (9), 2612-2616. doi:10.1021/acs.jnatprod.1c00516.

Austin, Julia R, Lee, Jeongho, Murphy, Brian T, Burdette, Joanna Elizabeth. (2021). Mechanism of Action of Irilone as a Potentiator of Progesterone Receptor Signaling. Journal of the Endocrine Society, 5, (Suppl 1), a812-a812. doi:10.1210/jendso/bvab048.1653.

Hernandez, A, Nguyen, LT, Dhakal, R, Murphy, BT. (2021). The need to innovate sample collection and library generation in microbial drug discovery: A focus on academia. Natural Product Reports, 38, (2), 292-300. doi:10.1039/d0np00029a.

Elfeki, M, Mantri, S, Clark, CM, Green, SJ, Ziemert, N, Murphy, BT. (2021). Evaluating the Distribution of Bacterial Natural Product Biosynthetic Genes across Lake Huron Sediment. ACS Chemical Biology. doi:10.1021/acschembio.1c00653.

Hoa, TTT, Van Nam, V, Huong, DTM, Dao, PT, Phuong, NN, Minh, LTH, Quyen, VT, Anh, NM, Murphy, BT, Ly, HTM, Van Cuong, P. (2020). Flavonoids and Alkaloids from Marine-Derived Actinomycete Streptomyces sp. C011. Vietnam Journal of Chemistry, 58, (5), 610-614. doi:10.1002/vjch.202000046.

Condren, AR, Costa, MS, Sanchez, NR, Konkapaka, S, Gallik, KL, Saxena, A, Murphy, BT, Sanchez, LM. (2020). Addition of insoluble fiber to isolation media allows for increased metabolite diversity of lab-cultivable microbes derived from zebrafish gut samples. Gut Microbes, 11, (4), 1064-1076. doi:10.1080/19490976.2020.1740073.

Clark, CM, Murphy, BT, Sanchez, LM. (2020). A call to action: The need for standardization in developing open-source mass spectrometry-based methods for microbial subspecies discrimination. mSystems, 5, (1). doi:10.1128/mSystems.00813-19.

Condren, Alanna R, Costa, Maria S, Sanchez, Natalia Rivera, Konkapaka, Sindhu, Gallik, Kristin L, Saxena, Ankur, Murphy, Brian T, Sanchez, Laura M. (2019). Addition of insoluble fiber to isolation media allows for increased metabolite diversity of lab-cultivable microbes derived from zebrafish gut samples. , 854109. doi:10.1101/854109.

Petrovich, ML, Ben Maamar, S, Hartmann, EM, Murphy, BT, Poretsky, RS, Wells, GF. (2019). Viral composition and context in metagenomes from biofilm and suspended growth municipal wastewater treatment plants. Microbial Biotechnology, 12, (6), 1324-1336. doi:10.1111/1751-7915.13464.

Professional Leadership

Executive Committee, American Society of Pharmacognosy, 1/1/2021 - Present

Executive Committee, American Society of Pharmacognosy, 1/1/2021 - Present

Diversity & Inclusion Committee, American Society of Pharmacognosy, 1/1/2021 - Present

NIH NCCIH Training and Education Review Panel, 3/20/2020 - Present

Education

Degrees:
PhD, Virginia Polytechnic Institute, United States, 2007
MS, University of Massachusetts Dartmouth, United States, 2003
BS, University of Massachusetts Dartmouth, United States, 2002

Selected Presentations

Nair, Shreya, Lee, J, Ma, R, Nguyen, L, Franzblau, S, Murphy, BT. (2019 January 01). A custom, reusable 3D-printed bioassay plate for the discovery of antibiotics from microorganisms under multiple cultivation conditions. ASP. Madison, USA.
Cho, Sang Hyun, Lee, J, Ma, R, Nguyen, L, Franzblau, SG, Murphy, BT. (2019 January 01). A custom, reusable 3D-printed bioassay plate for the discovery of antibiotics from microorganisms under multiple cultivation conditions. ASP. Madison, USA.