Brian T. Murphy
Professor, College of Pharmacy - Pharmaceutical Sciences
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Teaching and Supervision Heading link
PSCI Ph.D. Thesis Research (PSCI 599), 1/9/2023 – 4/28/2023
Doctoral Research in Pharmacog (PMPG 599), 1/9/2023 – 4/28/2023
Science Writing (PSCI 504), 1/9/2023 – 3/3/2023
Undergrad Res Pharm Sci (PSCI 380), 1/9/2023 – 4/28/2023
PSCI Ph.D. Thesis Research (PSCI 599), 8/22/2022 – 12/2/2022
Doctoral Research in Pharmacog (PMPG 599), 8/22/2022 – 12/2/2022
PSCI Ph.D. Thesis Research (PSCI 599), 5/16/2022 – 7/21/2022
Doctoral Research in Pharmacog (PMPG 599), 1/10/2022 – 4/29/2022
Adv Pharmacognosy (PSCI 522), 1/10/2022 – 4/29/2022
Selected Grants
Discovery of a pigment produced by Streptococcus pyogenes, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 3/1/2023 - 2/28/2025, Obligated Amount: $193496; Anticipated Amount: $423776
Partnering with Community Centers to Perform 'Environment-to-Bioassay' Antbiotic Discovery, Purdue University., 6/1/2022 - 5/31/2023, Obligated Amount: $8970; Anticipated Amount: $8970
Illinois-Indiana Sea Grant 2022-2023 Omnibus (Parent Record), Purdue University., 2/1/2022 - 1/31/2024, Obligated Amount: $97008; Anticipated Amount: $97008
Establishing two new bacterial phyla to produce the next generation of biomedical drug leads,�, Chicago Biomedical Consortium., 10/1/2021 - 9/30/2023, Obligated Amount: $125000; Anticipated Amount: $125000
Identification of antimicrobial reagents against TB and ESKAPE pathogens from bacteria collected in Vietnam�., Vietnam Academy of Science & Technology (Inst of Marine Biochemistry)., 5/5/2021 - 4/30/2023, Obligated Amount: $39975; Anticipated Amount: $39975
Development of a bacterial host for natural product discovery and production, National Institutes of Health (National Institute of General Medical Sciences)., 9/20/2020 - 6/30/2024, Obligated Amount: $1163044; Anticipated Amount: $1532645
A new paradigm for the creation and mining of microbial libraries for drug discovery, National Institutes of Health (National Institute of General Medical Sciences)., 8/10/2018 - 7/31/2023, Obligated Amount: $2069671; Anticipated Amount: $2069671
Antiparasitic Disease Screening in collaboration with UCSD, University of California - San Diego., 10/1/2017 - 12/31/2019, Obligated Amount: $10000; Anticipated Amount: $10000
Exploration and Mapping of Sponge Populations in the Great Lakes, National Geographic Society., 8/1/2017 - 7/30/2018, Obligated Amount: $19650; Anticipated Amount: $19650
Selected Publications
Corona-Avila, I, Lee, J, Hernandez, A, Krull, N, Augustinovic, M, Jones, D, Ndekwe, T, Murphy, BT. (2022). Isolation and Characterization of Antimicrobials from Icelandic Aquatic Bacteria. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36. doi:10.1096/fasebj.2022.36.S1.0R442.
Clark, CM, Nguyen, L, Pham, VC, Sanchez, LM, Murphy, BT. (2022). Automated Microbial Library Generation Using the Bioinformatics Platform IDBac. Molecules, 27, (7). doi:10.3390/molecules27072038.
Li, K, Diakite, D, Austin, J, Lee, JH, Lantvit, DD, Murphy, BT, Burdette, JE. (2022). The Flavonoid Baicalein Negatively Regulates Progesterone Target Genes in the Uterus in Vivo. Journal of Natural Products, 85, (1), 237-247. doi:10.1021/acs.jnatprod.1c01008.
Austin, JR, Li, K, Rivera Rodríguez, R, Lantvit, DD, Murphy, BT, Burdette, JE. (2021). Irilone, a Red Clover Isoflavone, Combined with Progesterone Enhances PR Signaling through the Estrogen and Glucocorticoid Receptors. Journal of Natural Products, 84, (12), 3090-3099. doi:10.1021/acs.jnatprod.1c00835.
Elfeki, M, Mantri, S, Clark, CM, Green, SJ, Ziemert, N, Murphy, BT. (2021). Evaluating the Distribution of Bacterial Natural Product Biosynthetic Genes across Lake Huron Sediment. ACS Chemical Biology, 16, (11), 2623-2631. doi:10.1021/acschembio.1c00653.
Lee, JH, Austin, JR, Burdette, JE, Murphy, BT. (2021). Secoiridoids from Dogwood (Cornus officinalis) Potentiate Progesterone Signaling. Journal of Natural Products, 84, (9), 2612-2616. doi:10.1021/acs.jnatprod.1c00516.
Austin, Julia R, Lee, Jeongho, Murphy, Brian T, Burdette, Joanna Elizabeth. (2021). Mechanism of Action of Irilone as a Potentiator of Progesterone Receptor Signaling. Journal of the Endocrine Society, 5, (Suppl 1), a812-a812. doi:10.1210/jendso/bvab048.1653.
Hernandez, A, Nguyen, LT, Dhakal, R, Murphy, BT. (2021). The need to innovate sample collection and library generation in microbial drug discovery: A focus on academia. Natural Product Reports, 38, (2), 292-300. doi:10.1039/d0np00029a.
Hoa, TTT, Van Nam, V, Huong, DTM, Dao, PT, Phuong, NN, Minh, LTH, Quyen, VT, Anh, NM, Murphy, BT, Ly, HTM, Van Cuong, P. (2020). Flavonoids and Alkaloids from Marine-Derived Actinomycete Streptomyces sp. C011. Vietnam Journal of Chemistry, 58, (5), 610-614. doi:10.1002/vjch.202000046.
Professional Leadership
Executive Committee, American Society of Pharmacognosy, 1/1/2021 - Present
Executive Committee, American Society of Pharmacognosy, 1/1/2021 - Present
Diversity & Inclusion Committee, American Society of Pharmacognosy, 1/1/2021 - Present
NIH NCCIH Training and Education Review Panel, 3/20/2020 - Present
Education
Degrees:
PhD, Virginia Polytechnic Institute, United States, 2007
MS, University of Massachusetts Dartmouth, United States, 2003
BS, University of Massachusetts Dartmouth, United States, 2002
Selected Presentations
Nair, Shreya, Lee, J, Ma, R, Nguyen, L, Franzblau, S, Murphy, BT. (2019 January 01). A custom, reusable 3D-printed bioassay plate for the discovery of antibiotics from microorganisms under multiple cultivation conditions. ASP. Madison, USA.
Cho, Sang Hyun, Lee, J, Ma, R, Nguyen, L, Franzblau, SG, Murphy, BT. (2019 January 01). A custom, reusable 3D-printed bioassay plate for the discovery of antibiotics from microorganisms under multiple cultivation conditions. ASP. Madison, USA.