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Photo of Brian T. Murphy

Brian T. Murphy


Professor, College of Pharmacy - Pharmaceutical Sciences

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Teaching and Supervision Heading link

PSCI Ph.D. Thesis Research (PSCI 599), 8/22/2022 – 12/2/2022
Doctoral Research in Pharmacog (PMPG 599), 8/22/2022 – 12/2/2022
PSCI Ph.D. Thesis Research (PSCI 599), 5/16/2022 – 7/21/2022
Special Proj Pharmacognosy (PSCI 523), 1/10/2022 – 4/29/2022
Science Writing (PSCI 504), 1/10/2022 – 3/4/2022
Adv Pharmacognosy (PSCI 522), 1/10/2022 – 4/29/2022
PSCI Ph.D. Thesis Research (PSCI 599), 1/10/2022 – 4/29/2022
Doctoral Research in Pharmacog (PMPG 599), 1/10/2022 – 4/29/2022
Science writing and storytelling (PSCI 504), 8/25/2021 – Present

Selected Grants

Partnering with Community Centers to Perform 'Environment-to-Bioassay' Antbiotic Discovery, Purdue University., 6/1/2022 - 5/31/2023, Obligated Amount: $8970; Anticipated Amount: $8970

Rethinking STEM education: A university-community partnership to engage marginalized students in Great Lakes conservation and antibiotic discovery, Purdue University., 2/1/2022 - 1/31/2023, Obligated Amount: $97008; Anticipated Amount: $97008

Establishing two new bacterial phyla to produce the next generation of biomedical drug leads,�, Chicago Biomedical Consortium., 10/1/2021 - 9/30/2023, Obligated Amount: $125000; Anticipated Amount: $125000

Identification of antimicrobial reagents against TB and ESKAPE pathogens from bacteria collected in Vietnam�., Vietnam Academy of Science & Technology (Inst of Marine Biochemistry)., 5/5/2021 - 4/30/2022, Obligated Amount: $39975; Anticipated Amount: $39975

Development of a bacterial host for natural product discovery and production, National Institutes of Health (National Institute of General Medical Sciences)., 9/20/2020 - 6/30/2024, Obligated Amount: $1163044; Anticipated Amount: $1532645

A new paradigm for the creation and mining of microbial libraries for drug discovery, National Institutes of Health (National Institute of General Medical Sciences)., 8/10/2018 - 7/31/2023, Obligated Amount: $2069671; Anticipated Amount: $2069671

Antiparasitic Disease Screening in collaboration with UCSD, University of California - San Diego., 10/1/2017 - 12/31/2019, Obligated Amount: $10000; Anticipated Amount: $10000

Exploration and Mapping of Sponge Populations in the Great Lakes, National Geographic Society., 8/1/2017 - 7/30/2018, Obligated Amount: $19650; Anticipated Amount: $19650

Enhancing basic and translational TB research in northern Vietnam, National Institutes of Health (Fogarty International Center)., 6/1/2017 - 2/28/2023, Obligated Amount: $1083818; Anticipated Amount: $1083818

Selected Publications

Corona-Avila, I, Lee, J, Hernandez, A, Krull, N, Augustinovic, M, Jones, D, Ndekwe, T, Murphy, BT. (2022). Isolation and Characterization of Antimicrobials from Icelandic Aquatic Bacteria. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36. doi:10.1096/fasebj.2022.36.S1.0R442.

Clark, CM, Nguyen, L, Pham, VC, Sanchez, LM, Murphy, BT. (2022). Automated Microbial Library Generation Using the Bioinformatics Platform IDBac. Molecules, 27, (7). doi:10.3390/molecules27072038.

Li, K, Diakite, D, Austin, J, Lee, JH, Lantvit, DD, Murphy, BT, Burdette, JE. (2022). The Flavonoid Baicalein Negatively Regulates Progesterone Target Genes in the Uterus in Vivo. Journal of Natural Products, 85, (1), 237-247. doi:10.1021/acs.jnatprod.1c01008.

Austin, JR, Li, K, Rivera Rodríguez, R, Lantvit, DD, Murphy, BT, Burdette, JE. (2021). Irilone, a Red Clover Isoflavone, Combined with Progesterone Enhances PR Signaling through the Estrogen and Glucocorticoid Receptors. Journal of Natural Products, 84, (12), 3090-3099. doi:10.1021/acs.jnatprod.1c00835.

Elfeki, M, Mantri, S, Clark, CM, Green, SJ, Ziemert, N, Murphy, BT. (2021). Evaluating the Distribution of Bacterial Natural Product Biosynthetic Genes across Lake Huron Sediment. ACS Chemical Biology, 16, (11), 2623-2631. doi:10.1021/acschembio.1c00653.

Lee, JH, Austin, JR, Burdette, JE, Murphy, BT. (2021). Secoiridoids from Dogwood (Cornus officinalis) Potentiate Progesterone Signaling. Journal of Natural Products, 84, (9), 2612-2616. doi:10.1021/acs.jnatprod.1c00516.

Austin, Julia R, Lee, Jeongho, Murphy, Brian T, Burdette, Joanna Elizabeth. (2021). Mechanism of Action of Irilone as a Potentiator of Progesterone Receptor Signaling. Journal of the Endocrine Society, 5, (Suppl 1), a812-a812. doi:10.1210/jendso/bvab048.1653.

Hernandez, A, Nguyen, LT, Dhakal, R, Murphy, BT. (2021). The need to innovate sample collection and library generation in microbial drug discovery: A focus on academia. Natural Product Reports, 38, (2), 292-300. doi:10.1039/d0np00029a.

Hoa, TTT, Van Nam, V, Huong, DTM, Dao, PT, Phuong, NN, Minh, LTH, Quyen, VT, Anh, NM, Murphy, BT, Ly, HTM, Van Cuong, P. (2020). Flavonoids and Alkaloids from Marine-Derived Actinomycete Streptomyces sp. C011. Vietnam Journal of Chemistry, 58, (5), 610-614. doi:10.1002/vjch.202000046.

Professional Leadership

Executive Committee, American Society of Pharmacognosy, 1/1/2021 - Present

Executive Committee, American Society of Pharmacognosy, 1/1/2021 - Present

Diversity & Inclusion Committee, American Society of Pharmacognosy, 1/1/2021 - Present

NIH NCCIH Training and Education Review Panel, 3/20/2020 - Present

Education

Degrees:
PhD, Virginia Polytechnic Institute, United States, 2007
MS, University of Massachusetts Dartmouth, United States, 2003
BS, University of Massachusetts Dartmouth, United States, 2002

Selected Presentations

Nair, Shreya, Lee, J, Ma, R, Nguyen, L, Franzblau, S, Murphy, BT. (2019 January 01). A custom, reusable 3D-printed bioassay plate for the discovery of antibiotics from microorganisms under multiple cultivation conditions. ASP. Madison, USA.
Cho, Sang Hyun, Lee, J, Ma, R, Nguyen, L, Franzblau, SG, Murphy, BT. (2019 January 01). A custom, reusable 3D-printed bioassay plate for the discovery of antibiotics from microorganisms under multiple cultivation conditions. ASP. Madison, USA.