Douglas D. Thomas
Associate Professor, College of Pharmacy - Medicinal Chemistry and Pharmacognosy
Director of Graduate Studies, College of Pharmacy - Medicinal Chemistry and Pharmacognosy
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Teaching and Supervision Heading link
Research Presentation (PSCI 502), 8/26/2024 – 12/6/2024
Integrated Physiology (PHAR 410), 8/26/2024 – 12/6/2024
Integrated Physiology (PHAR 410), 8/26/2024 – 12/6/2024
Integrated Physiology (PHAR 410), 8/26/2024 – 12/6/2024
Integrated Physiology (PHAR 410), 8/26/2024 – 12/6/2024
Research Presentation (PSCI 502), 8/21/2023 – 12/1/2023
Doctoral Restch in Med Chem (MDCH 599), 1/9/2023 – 4/28/2023
Biomedicinal Chemistry (PHAR 423), 1/9/2023 – 4/28/2023
Biomedicinal Chemistry (PHAR 423), 1/9/2023 – 4/28/2023
Selected Grants
Nitric oxide inhibits Iron(II)2-Oxogluterate dependent demethylases to regulate DNA and mRNA methylation, National Institutes of Health (National Institute of General Medical Sciences)., 8/1/2024 - 7/31/2026, Obligated Amount: $457972; Anticipated Amount: $900716
2021 Vahlteich Bridge funding, Vahlteich., 11/1/2022 - 10/31/2022, Obligated Amount: $25000; Anticipated Amount: $25000
Selected Publications
Thomas, Douglas. (2023). Nitric oxide inhibits FTO demethylase activity to regulate N6-methyladenosine mRNA methylation. Free Radical Biology and Medicine, 208, s143. doi:10.1016/j.freeradbiomed.2023.10.325.
Kuschman, Hannah Petraitis, Palczewski, Marianne B, Hoffman, Brian, Menhart, Mary, Wang, Xiaowei, Glynn, Sharon, Islam, Abul BMMK, Benevolenskaya, Elizaveta V, Thomas, Douglas D. (2023). Nitric oxide inhibits FTO demethylase activity to regulate N 6-methyladenosine mRNA methylation. Redox Biology, 67, 102928. doi:10.1016/j.redox.2023.102928.
Miranda, Katrina M, Ridnour, Lisa A, Cheng, Robert YS, Wink, David A, Thomas, Douglas D. (2023). The Chemical Biology of NO that Regulates Oncogenic Signaling and Metabolism: NOS2 and Its Role in Inflammatory Disease. Critical Reviews™ in Oncogenesis, 28, (1), 27-45. doi:10.1615/critrevoncog.2023047302.
Thomas, Douglas D, Shiva, Sruti. (2022). Methods to the madness – Fundamental techniques in NO research. Nitric Oxide, 122, 45-46. doi:10.1016/j.niox.2022.03.003.
Kuschman, Hannah Petraitis, Palczewski, Marianne B, Thomas, Douglas D. (2021). Nitric oxide and hydrogen sulfide: Sibling rivalry in the family of epigenetic regulators. Free Radical Biology and Medicine, 170, 34-43. doi:10.1016/j.freeradbiomed.2021.01.010.
Palczewski, Marianne B, Kuschman, Hannah Petraitis, Bovee, Rhea, Hickok, Jason R, Thomas, Douglas D. (2021). Vorinostat exhibits anticancer effects in triple-negative breast cancer cells by preventing nitric oxide-driven histone deacetylation. Biological Chemistry, 402, (4), 501-512. doi:10.1515/hsz-2020-0323.
Palczewski, Marianne B, Petraitis, Hannah, Thomas, Douglas D. (2019). Nitric oxide is an epigenetic regulator of histone post-translational modifications in cancer. Current Opinion in Physiology, 9, 94-99. doi:10.1016/j.cophys.2019.05.006.
Somasundaram, Veena, Basudhar, Debashree, Bharadwaj, Gaurav, No, Jae Hong, Ridnour, Lisa A, Cheng, Robert YS, Fujita, Mayumi, Thomas, Douglas D, Anderson, Stephen K, McVicar, Daniel W, Wink, David A. (2019). Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism. Antioxidants & Redox Signaling, 30, (8), 1124-1143. doi:10.1089/ars.2018.7527.
Sahni, Sumit, Hickok, Jason R, Thomas, Douglas D. (2018). Nitric oxide reduces oxidative stress in cancer cells by forming dinitrosyliron complexes. Nitric Oxide, 76, 37-44. doi:10.1016/j.niox.2018.03.003.
Professional Leadership
Council Member, Society for Redox Biology and Medicine, 11/1/2022 - 11/1/2026
President, Nitric Oxide Society, 1/1/2018 - Present
Education
Degrees:
BS, Washington State University, United States, 1992
PhD, Louisiana State University, United States, 2000
Selected Presentations
Thomas, Douglas. (2022 October 31). Nitric oxide is an epigenetic regulator in cancer. The 12th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide. Sendai Japan.
Thomas, Douglas. (2022 October 02). Nitric oxide is a regulator of the cellular methylome. REDOX inflammation and Signaling. Schoodic Institute at Acadia National Park, MN.
Douglas, Thomas. (2022 June 09). Epigenetic regulation: the third pillar of nitric oxide signaling. 2021 Great Lakes Regional Meeting. Virtual.
Thomas, Douglas. (2021 November 16). Epigenetic regulation by Nitric oxide. 27th Annual Conference of the Society for Redox Biology & Medicine. Virtual.
Douglas, Thomas. (2022 November 15). Nitric oxide is an epigenetic regulator. Gasotransmitter symposium honoring Marilyn Jorns. Virtual.