Douglas D. Thomas
Associate Professor, College of Pharmacy - Medicinal Chemistry and Pharmacognosy
Director of Graduate Studies, College of Pharmacy - Medicinal Chemistry and Pharmacognosy
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About
Teaching and Supervision
Doctoral Restch in Med Chem (MDCH 599), 8/23/2021 – 12/3/2021
Research Presentation (PSCI 502), 8/23/2021 – 12/3/2021
Doctoral Restch in Med Chem (MDCH 599), 1/11/2021 – 4/30/2021
Biomedicinal Chemistry (PHAR 423), 1/11/2021 – 4/30/2021
Biomedicinal Chemistry (PHAR 423), 1/11/2021 – 4/30/2021
Selected Publications
McGinity, CL, Palmieri, EM, Somasundaram, V, Bhattacharyya, DD, Ridnour, LA, Cheng, RYS, Ryan, AE, Glynn, SA, Thomas, DD, Miranda, KM, Anderson, SK, Lockett, SJ, McVicar, DW, Wink, DA. (2021). Nitric oxide modulates metabolic processes in the tumor immune microenvironment. International Journal of Molecular Sciences, 22, (13). doi:10.3390/ijms22137068.
Kuschman, HP, Palczewski, MB, Thomas, DD. (2021). Nitric oxide and hydrogen sulfide: Sibling rivalry in the family of epigenetic regulators. Free Radical Biology and Medicine, 170, 34-43. doi:10.1016/j.freeradbiomed.2021.01.010.
Palczewski, MB, Kuschman, HP, Bovee, R, Hickok, JR, Thomas, DD. (2021). Vorinostat exhibits anticancer effects in triple-negative breast cancer cells by preventing nitric oxide-driven histone deacetylation. Biological Chemistry, 402, (4), 501-512. doi:10.1515/hsz-2020-0323.
Palczewski, MB, Petraitis, H, Thomas, DD. (2019). Nitric oxide is an epigenetic regulator of histone post-translational modifications in cancer. Current Opinion in Physiology, 9, 94-99. doi:10.1016/j.cophys.2019.05.006.
Somasundaram, V, Basudhar, D, Bharadwaj, G, No, JH, Ridnour, LA, Cheng, RYS, Fujita, M, Thomas, DD, Anderson, SK, McVicar, DW, Wink, DA. (2019). Molecular mechanisms of nitric oxide in cancer progression, signal transduction, and metabolism. Antioxidants and Redox Signaling, 30, (8), 1124-1143. doi:10.1089/ars.2018.7527.
Thomas, Douglas D. (2018). Oxidative Stress. Encyclopedia of Biophysics. (pp. 1-7). doi:10.1007/978-3-642-35943-9_48-1.
Sahni, S, Hickok, JR, Thomas, DD. (2018). Nitric oxide reduces oxidative stress in cancer cells by forming dinitrosyliron complexes. Nitric Oxide – Biology and Chemistry, 76, 37-44. doi:10.1016/j.niox.2018.03.003.
Thomas, DD, Corey, C, Hickok, J, Wang, Y, Shiva, S. (2018). Differential mitochondrial dinitrosyliron complex formation by nitrite and nitric oxide. Redox Biology, 15, 277-283. doi:10.1016/j.redox.2017.12.007.
Bovee, Rhea, Pham, Vy, Fernandez, Jenna, Tretyakova, Natalia, Thomas, Douglas D. (2018). P-228 Nitric oxide is an epigenetic regulator of gene expression by directly controlling DNA methylation patterns. Free Radical Biology and Medicine, 120, s114. doi:10.1016/j.freeradbiomed.2018.04.375.
Professional Leadership
President, Nitric Oxide Society, 1/1/2018 - Present
Education
Degrees:
BS, Washington State University, United States, 1992
PhD, Louisiana State University, United States, 2000
Selected Presentations
Thomas, Douglas. (2021 November 16). Epigenetic regulation by Nitric oxide. 27th Annual Conference of the Society for Redox Biology & Medicine. Virtual.
Thomas, Douglas, Thomas, Douglas. (2021 March 16). Epigenetic regulation: the third pillar of nitric oxide signaling. 20th Biennial Meeting of Society for Free Radical Research International. Virtual.
Thomas, Douglas, Thomas, Douglas. (2020 November 18). Epigenetic regulation by Nitric oxide. Nitric Oxide: Physiology, Pharmacology, and Therapeutic Applications. Virtual.
Thomas, Douglas. (2020 January 16). Epigenetic regulation: the third pillar of nitric oxide signaling. Douglas D Thomas. Minneapolis.