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Photo of Stephanie A. Flowers

Stephanie A. Flowers


Assistant Professor, College of Pharmacy- Pharmacy Practice

Contact

Office Phone:

(312) 996-1925 (work)

Related Sites:

About Heading link

Overview:
My current research interest involves studying how medication interacts with microbial communities, and how that affects clinical outcomes. Research from my lab and others have shown that atypical antipsychotic administration results in changes in gut microbial communities that associates with deleterious outcomes in users including metabolic abnormalities. As antipsychotics and other neurotropic medications are known to have antimicrobial activity, we are also working to understand the contribution of antipsychotics medication to antibiotic resistance generation. There is a critical need to expand antimicrobial surveillance techniques beyond pathogens isolated from hospitals to include potential resistance mechanisms spread from commensal microorganisms in the human gut. Additionally, resistance surveillance may need to extend beyond the use of antimicrobial agents to include ‘host-directed’, or non-antimicrobial agents, that show activity against gut.

Teaching and Supervision Heading link

Undergrad Resrch Pharm Pract (PMPR 380), 1/10/2022 – 4/29/2022
College of Pharmacy Colloquium Lecture Series (BPS 425), 8/24/2021 – Present
Pharm Genomics Bioinformatics (PMMP/MDCH 412), 8/24/2021 – 12/3/2021
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021
Undergrad Resrch Pharm Pract (PMPR 380), 8/23/2021 – 12/3/2021
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021

Selected Grants

Antipsychotic Associated Acquisition of Antimicrobial Resistance Mechanisms in Gut Microbiota, Hans W. Vahlteich Research Award., 2/28/2022 - 2/28/2023, Obligated Amount: $50000; No Anticipated Amount Set

Pilot Grant, Michigan Institute for Clinical and Health Research., 6/1/2016 - 5/31/2017, Obligated Amount: $50000; No Anticipated Amount Set

Pilot Grant, Michigan Institute for Clinical and Health Research., 6/1/2016 - 5/31/2017, Obligated Amount: $50000; No Anticipated Amount Set

Community Volunteer Committee Grant, University of Michigan Depression Center., 9/1/2015 - 9/1/2016, Obligated Amount: $3800; No Anticipated Amount Set

Community Volunteer Committee Grant, University of Michigan Depression Center., 9/1/2015 - 9/1/2016, Obligated Amount: $3800; No Anticipated Amount Set

American Society for Microbiology Student Travel Grant, 11th ASM Conference on Candida and Candidiasis., 2012 - Present, No Obligated Amount Set; No Anticipated Amount Set

Small Grant, Le Bonheur Children’s Medical Center Foundation., 8/1/2011 - 8/1/2012, Obligated Amount: $5000; No Anticipated Amount Set

Small Grant, Le Bonheur Children’s Medical Center Foundation., 8/1/2011 - 8/1/2012, Obligated Amount: $5000; No Anticipated Amount Set

Antifungal Research Grant, Society of Infectious Disease Pharmacists/Astellas., 9/1/2009 - 8/1/2010, Obligated Amount: $20000; No Anticipated Amount Set

Selected Publications

Kyono, Yasuhiro, Ellezian, Lori, Hu, YueYue, Eliadis, Kanella, Moy, Junlone, Hirsch, Elizabeth B, Federle, Michael J, Flowers, Stephanie A. (2022). The Atypical Antipsychotic Quetiapine Promotes Multiple Antibiotic Resistance in Escherichia coli. Journal of Bacteriology, 204, (5), e00102-e00122. doi:10.1128/jb.00102-22.

Bulman, Zackery P, Tan, Xing, Chu, Ting-Yu, Huang, Yanqin, Rana, Amisha P, Singh, Nidhi, Flowers, Stephanie A, Kyono, Yasuhiro, Kreiswirth, Barry N, Chen, Liang. (2022). Ceftazidime-avibactam based combinations against carbapenemase producing Klebsiella pneumoniae harboring hypervirulence plasmids. Computational and Structural Biotechnology Journal, 20, 3946-3954. doi:10.1016/j.csbj.2022.07.017.

Vemu, Bhaskar, Tocmo, Restituo, Nauman, Mirielle C, Flowers, Stephanie A, Veenstra, Jacob P, Johnson, Jeremy J. (2021). Pharmacokinetic characterization of carnosol from rosemary (Salvia Rosmarinus) in male C57BL/6 mice and inhibition profile in human cytochrome P450 enzymes. Toxicology and Applied Pharmacology, 431, 115729. doi:10.1016/j.taap.2021.115729.

Flowers, Stephanie A, Bhat, Shubha, Lee, James C. (2020). Potential Implications of Gut Microbiota in Drug Pharmacokinetics and Bioavailability. Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy, 40, (7), 704-712. doi:10.1002/phar.2428.

Hamidovic, Ajna, Van Hedger, Kathryne, Choi, So Hee, Flowers, Stephanie, Wardle, Margaret, Childs, Emma. (2020). Quantitative meta-analysis of heart rate variability finds reduced parasympathetic cardiac tone in women compared to men during laboratory-based social stress. Neuroscience & Biobehavioral Reviews, 114, 194-200. doi:10.1016/j.neubiorev.2020.04.005.

Flowers, Stephanie, Bhat, Shubha, Lee, James C. (2020). Gut microbiome and stool-based testing. Ambulatory Care Self-Assessment Program, 2020 Book 3. (pp. 125-146). American College of Clinical Pharmacy.

Flowers, Stephanie A, Ward, Kristen M, Clark, Crystal T. (2019). The Gut Microbiome in Bipolar Disorder and Pharmacotherapy Management. Neuropsychobiology, 79, (1), 43-49. doi:10.1159/000504496.

Nishimoto, Andrew T, Wiederhold, Nathan P, Flowers, Stephanie A, Zhang, Qing, Kelly, Steven L, Morschhäuser, Joachim, Yates, Christopher M, Hoekstra, William J, Schotzinger, Robert J, Garvey, Edward P, Rogers, P David. (2019). In Vitro Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of Candida albicans.. Antimicrobial Agents and Chemotherapy, 63, (6). doi:10.1128/aac.00341-19.

Warrilow, Andrew G, Nishimoto, Andrew T, Parker, Josie E, Price, Claire L, Flowers, Stephanie A, Kelly, Diane E, Rogers, P David, Kelly, Steven L. (2019). The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions. Antimicrobial Agents and Chemotherapy, 63, (5), e02586-e02518. doi:10.1128/aac.02586-18.

Professional Leadership

ACCP Clinical Research Challenge, 5/20/2021 - Present

ACCP: On Demand Letter of Intent (LOI) Review Service, 5/16/2020 - 5/17/2022

ACCP Clinical Research Challenge, 5/5/2020 - Present

American College of Clinical Pharmacy: Committee (Credentials: Membership), 5/16/2019 - Present

Curriculum Vitae Review Service (ACCP), 1/13/2018 - Present

Education

Degrees:
PhD, University of Tennessee Health Science Center, Tennesee, 2013
PharmD, University of Southern California, United States, 2007
BS, University of California at Davis, United States, 2001
Minor BA, University of California at Davis, United States, 2001

Selected Presentations

Flowers, Stephanie. (2021 October 21). Implications of the gut microbiome for systemic drug therapy: Current understanding and future directions for translation into clinical practice.. American College of Clinical Pharmacy Virtual Annual Meeting.