Gauri S. Shetye
Research Assistant Professor, Pharmaceutical Sciences
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About
Teaching and Supervision
Selected Grants
Development of novel ClpC1 modulators targeting proteostasis for the treatment of M. tuberculosis, Global Alliance for TB Drug Development., 11/1/2024 - 11/9/2025, Obligated Amount: $208524; Anticipated Amount: $208524
Marine sponge depsipeptides to minimize antibiotic collateral damage, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 5/19/2023 - 4/30/2026, Obligated Amount: $439725; Anticipated Amount: $439725
Identification of antimicrobial reagents against TB and ESKAPE pathogens from bacteria collected in Vietnam�., Vietnam Academy of Science & Technology (Inst of Marine Biochemistry)., 5/5/2021 - 4/30/2023, Obligated Amount: $39975; Anticipated Amount: $39975
Enhancing basic and translational TB research in northern Vietnam, National Institutes of Health., 7/1/2017 - 6/30/2022, Obligated Amount: $52396; No Anticipated Amount Set
Selected Publications
Kauffman, John, Cuevas, Jake, Feiner, Janaya, Metzger, Margaret, Shetye, Gauri, Wan, Baojie, Qader, Mallique, Nguyen, Duc, Nugent, Angela, Hossain, Akil, Franzblau, Scott, Umesiri, Francis E. (2025). Discovery of ultra short β-peptoids with selective activity against drug-resistant Mycobacterium tuberculosis. European Journal of Medicinal Chemistry, 290, 117531. doi:10.1016/j.ejmech.2025.117531.
Kumar, Boddupalli Venkata Siva, Talamadla, Mahesh Kumar, Nandikolla, Adinarayana, Khetmalis, Yogesh Mahadu, Shetye, Gauri, Franzblau, Scott G, Murugesan, Sankaranarayanan, Sekhar, Kondapalli Venkata Gowri Chandra. (2025). Exploration of quinoxaline triazoles as antimycobacterial agents: design, synthesis and biological evaluation. Bioorganic & Medicinal Chemistry Letters, 121, 130177. doi:10.1016/j.bmcl.2025.130177.
Su, Chun, Tuan, Nguyen-Quang, Li, Wen-Hua, Cheng, Jin-Hua, Jin, Ying-Yu, Hong, Soon-Kwang, Lee, Hyun, Qader, Mallique, Klein, Larry, Shetye, Gauri, Pauli, Guido F, Flanzblau, Scott G, Cho, Sang-Hyun, Zhao, Xin-Qing, Suh, Joo-Won. (2025). Enhancing rufomycin production by CRISPR/Cas9-based genome editing and promoter engineering in Streptomyces sp. MJM3502. Synthetic and Systems Biotechnology, 10, (2), 421-432. doi:10.1016/j.synbio.2025.01.002.
Zhou, Bin, Shetye, Gauri, Klein, Larry L, Wolf, Nina M, Lee, Hyun, McAlpine, James B, Harris, Guy, Chen, Shao-Nong, Suh, Joo Won, Cho, Sang-Hyun, Franzblau, Scott G, Abad-Zapatero, Celerino, Pauli, Guido F. (2025). Structure-Based Analysis of Semisynthetic Anti-TB Rufomycin Analogues. Journal of Natural Products. doi:10.1021/acs.jnatprod.4c01266.
Tan, Jin Yi, Augustinović, Mario, Omar, Ashraf M, Lourenzon, Vitor B, Krull, Nyssa, Lopez, Xochitl, Khin, Manead, Shetye, Gauri, Nguyen, Duc, Qader, Mallique, Nugent, Angela C, Mpofu, Enock, Williams, Camarria, Rodriguez, Jonathon, Burdette, Joanna E, Cho, Sanghyun, Franzblau, Scott G, Eustáquio, Alessandra S, Zhang, Qibin, Murphy, Brian T. (2024). Discovery of New Cyclic Lipodepsipeptide Orfamide N via Partnership with Middle School Students from the Boys and Girls Club. ACS Omega, 9, (44), 44749-44759. doi:10.1021/acsomega.4c07459.
Kumar, Boddupalli Venkata Siva, Khetmalis, Yogesh Mahadu, Chaitanya, Kosana Sai, Chandu, Ala, Shetye, Gauri, Ma, Rui, Murugesan, Sankaranarayanan, Franzblau, Scott G, Sekhar, Kondapalli Venkata Gowri Chandra. (2024). Design, synthesis and biological evaluation of novel pyrido-[2,3-d]-pyrimidin-2-amine analogues as antimycobacterial agents. Journal of Molecular Structure, 1303, 137600. doi:10.1016/j.molstruc.2024.137600.
Wang, Weihong, Lee, JunI, Roh, Eun, Shetye, Gauri, Cao, Jin, McAlpine, James, Pauli, Guido, Franzblau, Scott, Vu, Thi Hanh Nguyen, Quach, Ngoc Tung, Oh, Eunseok, Park, Kyu-Hyung, Park, Chanyoon, Cho, Youbin, Jang, Hyeseon, Han, SongJoo, Kim, Hiyoung, Cho, Sanghyun, Phi, Quyet-Tien, Kang, Heonjoong. (2024). Cavomycins A–C, Linear Oligomer Depsipeptides from an Annelid-Associated Streptomyces cavourensis. Journal of Natural Products, 87, (4), 976-983. doi:10.1021/acs.jnatprod.3c01275.
Gurgul, Aleksandra, Wu, Zhenlong, Han, Kyu-Yeon, Shetye, Gauri, Sydara, Kongmany, Souliya, Onevilay, Johnson, Jeremy J, Che, Chun-Tao. (2023). Polyoxygenated cyclohexene derivatives and other constituents of Uvaria rufa stem. Phytochemistry, 216, 113884. doi:10.1016/j.phytochem.2023.113884.
Gurgul, Aleksandra, Nauman, Mirielle C, Wu, Zhenlong, Shetye, Gauri, Ma, Rui, Youn, Isoo, Souliya, Onevilay, Bisson, Jonathan, Johnson, Jeremy J, Che, Chun-Tao. (2023). Chemical constituents of the stem of Marsypopetalum modestum and their bioactivities. Natural Product Research, 37, (21), 3623-3630. doi:10.1080/14786419.2022.2097229.