Gauri S. Shetye
Research Assistant Professor, Pharmaceutical Sciences
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About
Teaching and Supervision
Selected Grants
Development of novel ClpC1 modulators targeting proteostasis for the treatment of M. tuberculosis, Global Alliance for TB Drug Development., 11/1/2024 - 11/9/2026, Obligated Amount: $208524; Anticipated Amount: $208524
Marine sponge depsipeptides to minimize antibiotic collateral damage, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 5/19/2023 - 4/30/2026, Obligated Amount: $439725; Anticipated Amount: $439725
Identification of antimicrobial reagents against TB and ESKAPE pathogens from bacteria collected in Vietnam�., Vietnam Academy of Science & Technology (Institute of Marine Biochemistry)., 5/5/2021 - 4/30/2025, Obligated Amount: $39975; Anticipated Amount: $39975
Enhancing basic and translational TB research in northern Vietnam, National Institutes of Health., 7/1/2017 - 6/30/2022, Obligated Amount: $52396; No Anticipated Amount Set
Selected Publications
Thompson, Andrew M, Cheung, Chen-Yi, McNeil, Matthew B, Campbell, Ashley C, Záhorszká, Monika, Korduláková, Jana, Stelitano, Giovanni, Recchia, Deborah, Pasca, Maria Rosalia, Wan, Baojie, Khan, Shahebraj, Nikolic, Dejan S, Shetye, Gauri S, Franzblau, Scott G, Denny, William A, Cook, Gregory M, Krause, Kurt L. (2026). Advancing the antituberculosis activity of nitropicolinic acids and amides. European Journal of Medicinal Chemistry, 302, (Pt 2), 118324. doi:10.1016/j.ejmech.2025.118324.
Ratia, Kiira, Jin, Shengnan, Abad-Zapatero, Celerino, Shetye, Gauri S, Demissie, Robel, Qader, Mallique, Beautrait, Alexandre, Nikolic, Dejan S, Wolf, Nina M, Rubin, Eric J, Krandor, Olga, Serbina, Natalya, Li, Guiying, Pauli, Guido F, Klein, Larry L, Cho, Sanghyun, Franzblau, Scott G, Fotouhi, Nader, Kaneko, Takushi, Lee, Hyun. (2025). Unique Interactions of Novel Rufomycin “Click Chemistry” Analogs with Mtb ClpC1 and Implications. Journal of Medicinal Chemistry, 68, (24), 26298-26310. doi:10.1021/acs.jmedchem.5c02416.
Wang, Mingqian, He, YongLe, Cohen, Siobhan A, Strohm, Amanda R, Shetye, Gauri, Franzblau, Scott G, Walker, Stephen G, Alley, MRK, Tonge, Peter J. (2025). Selectivity of the Time-Dependent M. tuberculosis LeuRS Inhibitor Ganfeborole Is Driven by Target Vulnerability. ACS Chemical Biology, 20, (12), 2955-2965. doi:10.1021/acschembio.5c00705.
Lee, Jung-Ho, Tan, Jin Yi, Ma, Rui, Nguyen, Linh, Kahn, Shahebraj, Qader, Mallique, Mpofu, Enock, Shetye, Gauri, Krull, Nyssa K, Augustinović, Mario, Omarsdottir, Sesselja, Edmonson, William, Rodriguez, Jonathon, Cho, Sanghyun, Franzblau, Scott G, Murphy, Brian T. (2025). Antibiotic discovery from a bacterial colony: isolation of new peptidic antibiotics using robotics, 3D printed bioassays, and MS-based bioinformatics. Phytochemistry Letters, 69, 103160. doi:10.1016/j.phytol.2025.103160.
Kauffman, John, Cuevas, Jake, Feiner, Janaya, Metzger, Margaret, Shetye, Gauri, Wan, Baojie, Qader, Mallique, Nguyen, Duc, Nugent, Angela, Hossain, Akil, Franzblau, Scott, Umesiri, Francis E. (2025). Discovery of ultra short β-peptoids with selective activity against drug-resistant Mycobacterium tuberculosis. European Journal of Medicinal Chemistry, 290, 117531. doi:10.1016/j.ejmech.2025.117531.
Kumar, Boddupalli Venkata Siva, Talamadla, Mahesh Kumar, Nandikolla, Adinarayana, Khetmalis, Yogesh Mahadu, Shetye, Gauri, Franzblau, Scott G, Murugesan, Sankaranarayanan, Sekhar, Kondapalli Venkata Gowri Chandra. (2025). Exploration of quinoxaline triazoles as antimycobacterial agents: design, synthesis and biological evaluation. Bioorganic & Medicinal Chemistry Letters, 121, 130177. doi:10.1016/j.bmcl.2025.130177.
Su, Chun, Tuan, Nguyen-Quang, Li, Wen-Hua, Cheng, Jin-Hua, Jin, Ying-Yu, Hong, Soon-Kwang, Lee, Hyun, Qader, Mallique, Klein, Larry, Shetye, Gauri, Pauli, Guido F, Flanzblau, Scott G, Cho, Sang-Hyun, Zhao, Xin-Qing, Suh, Joo-Won. (2025). Enhancing rufomycin production by CRISPR/Cas9-based genome editing and promoter engineering in Streptomyces sp. MJM3502. Synthetic and Systems Biotechnology, 10, (2), 421-432. doi:10.1016/j.synbio.2025.01.002.
Zhou, Bin, Shetye, Gauri, Klein, Larry L, Wolf, Nina M, Lee, Hyun, McAlpine, James B, Harris, Guy, Chen, Shao-Nong, Suh, Joo Won, Cho, Sang-Hyun, Franzblau, Scott G, Abad-Zapatero, Celerino, Pauli, Guido F. (2025). Structure-Based Analysis of Semisynthetic Anti-TB Rufomycin Analogues. Journal of Natural Products, 88, (4), 907-925. doi:10.1021/acs.jnatprod.4c01266.
Tan, Jin Yi, Augustinović, Mario, Omar, Ashraf M, Lourenzon, Vitor B, Krull, Nyssa, Lopez, Xochitl, Khin, Manead, Shetye, Gauri, Nguyen, Duc, Qader, Mallique, Nugent, Angela C, Mpofu, Enock, Williams, Camarria, Rodriguez, Jonathon, Burdette, Joanna E, Cho, Sanghyun, Franzblau, Scott G, Eustáquio, Alessandra S, Zhang, Qibin, Murphy, Brian T. (2024). Discovery of New Cyclic Lipodepsipeptide Orfamide N via Partnership with Middle School Students from the Boys and Girls Club. ACS Omega, 9, (44), 44749-44759. doi:10.1021/acsomega.4c07459.