Guido F. Pauli
Norman R. Farnsworth Chair of Pharmacognosy, University of Illinois College of Pharmacy
Distinguished Professor, University of Illinois at Chicago
Director, Pharmacognosy Institute, University of Illinois at Chicago
Associate Director, Institute for Tuberculosis Research, University of Illinois College of Pharmacy
Professor, College of Pharmacy - Pharmaceutical Sciences
Contact
Address:
833 S. Wood St, Chicago, IL
Office Phone:
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About
Overview:
Mission: Gain understanding of the small molecules that enable and guide life on Earth.
Appproach: Trans-disciplinary integration and innovation of natural products chemistry and pharmaceutical analysis in drug discovery, dietary supplements, and traditional medicine research
Research Interests:
Metabolites from natural sources across the phylogenetic tree have always played an important role in pharmacy, physiology, biochemistry, pharmacology, drug discovery and medicine. Their separation, chemical analysis, and pharmacological/biological evaluation are core elements of modern pharmacognosy, representing a highly interdisciplinary field of research.
Gaining a more holistic insight into the overwhelming complexity of the total pool of metabolites produced by any single organism (metabolome) requires the development of innovative (bio)-analytical methodology. To this end, contributions from our laboratory involve the advancement of loss-free and high-resolution countercurrent separation and parition chromatography (CCS/CCC/CPC), and pioneering developments in quantitative NMR (qNMR) for natural product analysis. We also develop other innovative spectroscopic (NMR, LC/GC-MS) as well as computational methods.
Solving analytical puzzles continues to be a challenge for those metabolites that today are classified as ‘small molecules’ or designated as ‘secondary metabolites’. These organic compound open the door to an incredibly large and very important part of nature’s chemical space. The design of innovative separation technology and spectroscopic methods for structural analysis and determination of purity and residual complexity, combined with qualitative and quantitative analysis of bioactive principles and their in-depth biological evaluation, are important aspects of secondary metabolome research. Such bio-analytical contributions can advance interdisciplinary research projects and create new insights of biomedical relevance, which can impact current practice and future paradigms of contemporary healthcare research.
UIC Webpage: https://gfp.people.uic.edu/index.html
LinkedIn: https://www.linkedin.com/in/guidopauli-chicago/
Teaching Statement:
Mission: train pharmacists in natural products, drug discovery, and pharmaceutical quality control, and educate the next generation of pharmacognosists
Teaching and Supervision
Undergrad Res Exp Pharm Sci (PSCI 300), 1/13/2025 – 5/2/2025
Undergrad Res Exp Pharm Sci (PSCI 300), 8/26/2024 – 12/6/2024
Doctoral Research in Pharmacog (PMPG 599), 6/10/2024 – 8/2/2024
Doctoral Research in Pharmacog (PMPG 599), 1/8/2024 – 4/26/2024
Undergrad Res Exp Pharm Sci (PSCI 300), 1/8/2024 – 4/26/2024
Doctoral Research in Pharmacog (PMPG 599), 8/21/2023 – 12/1/2023
Undergrad Res Exp Pharm Sci (PSCI 300), 8/21/2023 – 12/1/2023
Doctoral Research in Pharmacog (PMPG 599), 6/12/2023 – 8/4/2023
Doctoral Research in Pharmacog (PMPG 599), 1/9/2023 – 4/28/2023
Selected Grants
Interoperable Ethnomedical Agents Library, California Community Foundation., 10/16/2024 - 10/15/2026, Obligated Amount: $228952.62; Anticipated Amount: $228952.62
Research Training in Natural Product Complementary and Integrative Health, National Institutes of Health (National Center for Complementary and Integrative Health)., 8/1/2024 - 7/31/2029, Obligated Amount: $253764; Anticipated Amount: $1217204
Aristotelia Alkaloids as Probes for the Nicotinic Acetylcholine Receptors, National Institutes of Health (National Center for Complementary and Integrative Health)., 5/16/2024 - 5/15/2026, Obligated Amount: $48974; Anticipated Amount: $95388
Dentin Biomodification or Optimization of Bioadhesive Dental Restorations, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 6/24/2023 - 4/30/2026, Obligated Amount: $840402.48; Anticipated Amount: $840402.48
Residual Complexity (RC) of Antiviral Isoquercitrin (IQC), Institut de Recherches Cliniques de Montreal., 4/11/2023 - 12/31/2024, Obligated Amount: $125000; Anticipated Amount: $125000
Modularity in Oligomeric Phenol Chemistry for Biomodulation of Dental Structures, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 2/1/2023 - 1/31/2026, Obligated Amount: $445213; Anticipated Amount: $445213
Helium Recycling for UIC Nuclear Magnetic Resonance, National Institutes of Health (Office of the Director)., 8/1/2022 - 7/31/2023, Obligated Amount: $350895; Anticipated Amount: $350895
Pharmacopoeial NMR and qNMR Method Development, US Pharmacopeial Convention., 5/1/2022 - 4/30/2023, Obligated Amount: $100000; Anticipated Amount: $100000
Dentin Biomodification for Optimization of Bioadhesive Dental Restorations, Marquette University., 5/1/2020 - 5/15/2023, Obligated Amount: $627339; Anticipated Amount: $627339
Selected Publications
Su, Chun, Tuan, Nguyen-Quang, Li, Wen-Hua, Cheng, Jin-Hua, Jin, Ying-Yu, Hong, Soon-Kwang, Lee, Hyun, Qader, Mallique, Klein, Larry, Shetye, Gauri, Pauli, Guido F, Flanzblau, Scott G, Cho, Sang-Hyun, Zhao, Xin-Qing, Suh, Joo-Won. (2025). Enhancing rufomycin production by CRISPR/Cas9-based genome editing and promoter engineering in Streptomyces sp. MJM3502. Synthetic and Systems Biotechnology, 10, (2), 421-432. doi:10.1016/j.synbio.2025.01.002.
Bim‐Junior, Odair, Jing, Shuxi, McAlpine, James B, Chen, Shao‐Nong, Pauli, Guido F, Bedran‐Russo, Ana K. (2025). Regulatory Potency of Oligomeric Proanthocyanidins (PACs) on Extrafibrillar and Intrafibrillar Collagen Mineralization. Journal of Applied Polymer Science, 142, (14). doi:10.1002/app.56694.
Botros, Lucy, Liu, Yang, Corbett, Charlotte, Sørensen, Dan, Szabo, Christina, Bzhelyansky, Anton, Niemitz, Matthias, Korhonen, Petrus, Pauli, Guido F, Giraudeau, Patrick, Ray, G Joseph. (2025). Connecting the Practice of Modern Qualitative and Quantitative NMR Analysis with Its Theoretical Foundation. Journal of Natural Products, 88, (3), 877-888. doi:10.1021/acs.jnatprod.4c01013.
Zhou, Bin, Shetye, Gauri, Klein, Larry L, Wolf, Nina M, Lee, Hyun, McAlpine, James B, Harris, Guy, Chen, Shao-Nong, Suh, Joo Won, Cho, Sang-Hyun, Franzblau, Scott G, Abad-Zapatero, Celerino, Pauli, Guido F. (2025). Structure-Based Analysis of Semisynthetic Anti-TB Rufomycin Analogues. Journal of Natural Products. doi:10.1021/acs.jnatprod.4c01266.
Jing, Shu-Xi, Neves, José Guilherme, Liberato, Walleska, Ferreira, Daneel, Bedran-Russo, Ana K, McAlpine, James B, Chen, Shao-Nong, Pauli, Guido F. (2025). Preparation, Modification, Quantitation, and Dentin Biomodification Activity of Selectively Enriched Proanthocyanidins. Journal of Natural Products, 88, (1), 152-161. doi:10.1021/acs.jnatprod.4c01213.
Liberato, W, Neves, JG, Junior, OB, Jing, S, Chen, S, Pauli, G, Bedran-Russo, A. (2025). 109 Hydric Organization in Dentin Matrix Modified by Proanthocyanidins. Dental Materials, 41, e50. doi:10.1016/j.dental.2025.01.122.
Neves, JG, Liberato, W, Jing, S, Chen, S-N, Pauli, G, Bedran-Russo, AK. (2025). 136 Effect of leaching Proanthocyanidin DESIGNERs over Dental Pulp Stem Cells. Dental Materials, 41, e63. doi:10.1016/j.dental.2025.01.149.
Neves, JG, Liberato, W, Reis-Havlat, M, Jing, S, Chen, S, Pauli, G, Bedran-Russo, A. (2025). 14 Proanthocyanidin DESIGNERs enhance the viscoelasticity properties of dentin-resin interface. Dental Materials, 41, e12. doi:10.1016/j.dental.2025.01.028.
Zagal, Daniel, Graham, James G, Bisson, Jonathan, Green, Stefan J, Pauli, Guido F. (2024). Medicinal Plant Microbiomes: Factors Affecting Bacterial and Fungal Community Composition. Planta Medica, 90, (15), 1130-1142. doi:10.1055/a-2420-0270.
Professional Leadership
NCI Research Interest Group on Ayurveda and Integrative Oncology, National Institutes of Health (NIH), National Cancer Institute, 3/2021 - Present
Non-Botanical Dietary Supplements Expert Commitee, United States Pharmacopoiea, 8/2020 - 7/2025
Modernization of Analytical Methods (MAM) Joint Subcommittee, United States Pharmacopoeia, 8/2020 - 7/2025
General Chapter on Nuclear Magnetic Resonance Expert Panel, United States Pharmacopeial Convention, 8/2020 - Present
Council of Experts, 8/1/2020 - 8/31/2024
PDQ Cancer Complementary and Alternative Medicine Editorial Board, National Institutes of Health, 2012 - Present
Notable Honors
2022, Norman R. Farnworth Excellence in Botanical Research Award, American Botaincal Council (ABC)
2019, Distinguished Professor, University of Illinois at Chicago, University of Illinois at Chicago
2018, Varro E. Tyler Award, American Society of Pharmacognosy
2014, University Scholar, University of Illinois at Chicago
Education
Degrees:
Dr. rer. nat., Heinrich Heine University Düsseldorf, Germany, 1993