Leslyn Hanakahi
Associate Professor, College of Pharmacy - Pharmaceutical Sciences
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PSCI Ph.D. Thesis Research (PSCI 599), 8/26/2024 – 12/6/2024
PDAT 4: Immunology/Respiratory (PHAR 504), 8/26/2024 – 12/6/2024
PDAT 4: Immunology/Respiratory (PHAR 504), 8/26/2024 – 12/6/2024
PDAT 4: Immunology/Respiratory (PHAR 504), 8/26/2024 – 12/6/2024
PDAT 4: Immunology/Respiratory (PHAR 504), 8/26/2024 – 12/6/2024
PDAT 4: Immunology/Respiratory (PHAR 504), 8/26/2024 – 12/6/2024
Special Proj Pharm Sci (PSCI 390), 8/26/2024 – 12/6/2024
Undergrad Res Pharm Sci (PSCI 380), 8/26/2024 – 12/6/2024
Pharmaceutical Care in the US (PHAR 201), 8/26/2024 – 12/6/2024
Selected Grants
3/3: The Chicago Cancer Health Equity Collaborative (ChicagoCHEC), National Institutes of Health (National Cancer Institute)., 9/22/2020 - 8/31/2025, Obligated Amount: $6715338; Anticipated Amount: $6834852
Leveraging DNA Repair to Enhance Chrispr Genome Editing, Chicago Biomedical Consortium., 3/1/2019 - 11/30/2022, Obligated Amount: $150000; Anticipated Amount: $150000
Regulation of Non-Homologous End Joining Through End Processing, National Institutes of Health (National Cancer Institute)., 7/1/2014 - 12/31/2017, Obligated Amount: $360967; Anticipated Amount: $360967
Tech transfer Seed Grant Award, Bloomberg School of Public Health, Johns Hopkins University., 10/1/2004 - Present, Obligated Amount: $25000; No Anticipated Amount Set
MOLECULAR MECHANISMS OF NHEJ IN MAMMALIAN CELLS, National Institute of General Medical Sciences., 7/1/2004 - 3/31/2010, Obligated Amount: $1169513; No Anticipated Amount Set
Faculty Research Initiatives Fund., 7/1/2004 - 6/30/2007, No Obligated Amount Set; No Anticipated Amount Set
Faculty Innovation Fund, Bloomberg School of Public Health, Johns Hopkins University., 5/1/2004 - 4/30/2005, Obligated Amount: $30000; No Anticipated Amount Set
Maryland Cigarette Restitution Fund Grant., 1/1/2004 - 12/31/2004, Obligated Amount: $125000; No Anticipated Amount Set
Rita Allen Foundation Scholar’s Award., 10/1/2003 - 8/30/2006, No Obligated Amount Set; No Anticipated Amount Set
Selected Publications
Hayes, Catherine M, Bharti, Aditya, Hanakahi, Les A. (2022). Examining the Interaction Between Cas9 and Ku, and its Implications for Gene Editing. The FASEB Journal, 36, (S1). doi:10.1096/fasebj.2022.36.s1.r2092.
Flor, Amy, Wolfgeher, Donald, Li, Jing, Hanakahi, Leslyn A, Kron, Stephen J. (2021). Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons. Cell Chemical Biology, 28, (6), 776-787.e8. doi:10.1016/j.chembiol.2020.11.011.
Gavande, Navnath S, VanderVere-Carozza, Pamela S, Pawelczak, Katherine S, Mendoza-Munoz, Pamela, Vernon, Tyler L, Hanakahi, Leslyn A, Summerlin, Matthew, Dynlacht, Joseph R, Farmer, Annabelle H, Sears, Catherine R, Al Nasrallah, Nawar, Garrett, Joy, Turchi, John J. (2020). Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku–DNA interaction. Nucleic Acids Research, 48, (20), gkaa934-. doi:10.1093/nar/gkaa934.
Nitiss, Karin C, Nitiss, John L, Hanakahi, Leslyn A. (2019). DNA Damage by an essential enzyme: A delicate balance act on the tightrope. DNA Repair, 82, 102639. doi:10.1016/j.dnarep.2019.102639.
Clarke, Ryan, Heler, Robert, MacDougall, Matthew S, Yeo, Nan Cher, Chavez, Alejandro, Regan, Maureen, Hanakahi, Leslyn, Church, George M, Marraffini, Luciano A, Merrill, Bradley J. (2018). Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks. Molecular Cell, 71, (1), 42-55.e8. doi:10.1016/j.molcel.2018.06.005.
Li, Jing, Summerlin, Matthew, Nitiss, Karin C, Nitiss, John L, Hanakahi, Leslyn A. (2017). TDP1 is required for efficient non-homologous end joining in human cells. DNA Repair, 60, 40-49. doi:10.1016/j.dnarep.2017.10.003.
Jiao, Chensong, Summerlin, Matthew, Bruzik, Karol S, Hanakahi, Leslyn. (2015). Synthesis of Biotinylated Inositol Hexakisphosphate To Study DNA Double-Strand Break Repair and Affinity Capture of IP6‑Binding Proteins. Biochemistry, 54, (41), 6312-6322. doi:10.1021/acs.biochem.5b00642.
Heo, Jinho, Li, Jing, Summerlin, Matthew, Hays, Annette, Katyal, Sachin, McKinnon, Peter J, Nitiss, Karin C, Nitiss, John L, Hanakahi, Leslyn A. (2015). TDP1 promotes assembly of non-homologous end joining protein complexes on DNA. DNA Repair, 30, 28-37. doi:10.1016/j.dnarep.2015.03.003.
Slavoff, Sarah A, Heo, Jinho, Budnik, Bogdan A, Hanakahi, Leslyn A, Saghatelian, Alan. (2014). A Human Short Open Reading Frame (sORF)-encoded Polypeptide That Stimulates DNA End Joining*. Journal of Biological Chemistry, 289, (16), 10950-10957. doi:10.1074/jbc.c113.533968.
Notable Honors
2019, University of Illinois at Chicago Teaching Recognition Program Award,
2018, ABRCMS Judge Travel Award,
Education
Degrees:
B.S., University of Hawaii at Manoa, United States, 1990
Ph.D., Yale University, United States, 1996
Postgraduate Training:
Post-doctoral training, Yale University, United States, 1998
Post-doctoral training, Clare Hall Laboratories, United Kingdom, 2003