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Photo of Leslyn Hanakahi

Leslyn Hanakahi


Associate Professor, College of Pharmacy - Pharmaceutical Sciences

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Teaching and Supervision Heading link

Undergrad Res Pharm Sci (PSCI 380), 1/10/2022 – 4/29/2022
Drugs in Society (PHAR 201), 1/10/2022 – 4/29/2022
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021
Colloquium Lecture Series (PSCI 425), 8/23/2021 – 12/3/2021
Colloquium Lecture Series (PSCI 425), 8/23/2021 – 12/3/2021

Selected Grants

3/3: The Chicago Cancer Health Equity Collaborative (ChicagoCHEC), National Institutes of Health (National Cancer Institute)., 9/22/2020 - 8/31/2025, Obligated Amount: $2805763; Anticipated Amount: $6834852

Leveraging DNA Repair to Enhance Chrispr Genome Editing, Chicago Biomedical Consortium., 3/1/2019 - 11/30/2022, Obligated Amount: $150000; Anticipated Amount: $150000

Regulation of Non-Homologous End Joining Through End Processing, National Institutes of Health (National Cancer Institute)., 7/1/2014 - 12/31/2017, Obligated Amount: $360967; Anticipated Amount: $360967

Tech transfer Seed Grant Award, Bloomberg School of Public Health, Johns Hopkins University., 10/1/2004 - Present, Obligated Amount: $25000; No Anticipated Amount Set

MOLECULAR MECHANISMS OF NHEJ IN MAMMALIAN CELLS, National Institute of General Medical Sciences., 7/1/2004 - 3/31/2010, Obligated Amount: $1169513; No Anticipated Amount Set

Faculty Research Initiatives Fund., 7/1/2004 - 6/30/2007, No Obligated Amount Set; No Anticipated Amount Set

Faculty Innovation Fund, Bloomberg School of Public Health, Johns Hopkins University., 5/1/2004 - 4/30/2005, Obligated Amount: $30000; No Anticipated Amount Set

Maryland Cigarette Restitution Fund Grant., 1/1/2004 - 12/31/2004, Obligated Amount: $125000; No Anticipated Amount Set

Rita Allen Foundation Scholar’s Award., 10/1/2003 - 8/30/2006, No Obligated Amount Set; No Anticipated Amount Set

Selected Publications

Flor, Amy, Wolfgeher, Donald, Li, Jing, Hanakahi, Leslyn A, Kron, Stephen J. (2020). Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons. Cell Chemical Biology, 28, (6), 776-787.e8. doi:10.1016/j.chembiol.2020.11.011.

Gavande, Navnath S, VanderVere-Carozza, Pamela S, Pawelczak, Katherine S, Mendoza-Munoz, Pamela, Vernon, Tyler L, Hanakahi, Leslyn A, Summerlin, Matthew, Dynlacht, Joseph R, Farmer, Annabelle H, Sears, Catherine R, Nasrallah, Nawar Al, Garrett, Joy, Turchi, John J. (2020). Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku–DNA interaction. Nucleic Acids Research, 48, (20), 11536-11550. doi:10.1093/nar/gkaa934.

Nitiss, Karin C, Nitiss, John L, Hanakahi, Leslyn A. (2019). DNA Damage by an essential enzyme: A delicate balance act on the tightrope. DNA Repair, 82, 102639. doi:10.1016/j.dnarep.2019.102639.

Clarke, Ryan, Heler, Robert, MacDougall, Matthew S, Yeo, Nan Cher, Chavez, Alejandro, Regan, Maureen, Hanakahi, Leslyn, Church, George M, Marraffini, Luciano A, Merrill, Bradley J. (2018). Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks. Molecular Cell, 71, (1), 42-55.e8. doi:10.1016/j.molcel.2018.06.005.

Li, Jing, Summerlin, Matthew, Nitiss, Karin C, Nitiss, John L, Hanakahi, Leslyn A. (2017). TDP1 is required for efficient non-homologous end joining in human cells. DNA Repair, 60, 40-49. doi:10.1016/j.dnarep.2017.10.003.

Jiao, Chensong, Summerlin, Matthew, Bruzik, Karol S, Hanakahi, Leslyn. (2015). Synthesis of Biotinylated Inositol Hexakisphosphate To Study DNA Double-Strand Break Repair and Affinity Capture of IP6‑Binding Proteins. Biochemistry, 54, (41), 6312-6322. doi:10.1021/acs.biochem.5b00642.

Heo, Jinho, Li, Jing, Summerlin, Matthew, Hays, Annette, Katyal, Sachin, McKinnon, Peter J, Nitiss, Karin C, Nitiss, John L, Hanakahi, Leslyn A. (2015). TDP1 promotes assembly of non-homologous end joining protein complexes on DNA. DNA Repair, 30, 28-37. doi:10.1016/j.dnarep.2015.03.003.

Slavoff, Sarah A, Heo, Jinho, Budnik, Bogdan A, Hanakahi, Leslyn A, Saghatelian, Alan. (2014). A Human Short Open Reading Frame (sORF)-encoded Polypeptide That Stimulates DNA End Joining*. Journal of Biological Chemistry, 289, (16), 10950-10957. doi:10.1074/jbc.c113.533968.

Gilson, Timra, Greer, Amy E, Vindigni, Alessandro, Ketner, Gary, Hanakahi, Leslyn A. (2012). The α2 helix in the DNA ligase IV BRCT-1 domain is required for targeted degradation of ligase IV during adenovirus infection. Virology, 428, (2), 128-135. doi:10.1016/j.virol.2012.03.006.

Notable Honors

2019, University of Illinois at Chicago Teaching Recognition Program Award,

2018, ABRCMS Judge Travel Award,

Education

Degrees:
B.S., University of Hawaii at Manoa, United States, 1990
Ph.D., Yale University, United States, 1996

Postgraduate Training:
Post-doctoral training, Yale University, United States, 1998
Post-doctoral training, Clare Hall Laboratories, United Kingdom, 2003