Photo of Leslyn Hanakahi

Leslyn Hanakahi


Associate Professor, College of Pharmacy - Pharmaceutical Sciences

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Teaching and Supervision

Undergrad Res Pharm Sci (PSCI 380), 8/23/2021 – 12/3/2021
Colloquium Lecture Series (PSCI 425), 8/23/2021 – 12/3/2021
Colloquium Lecture Series (PSCI 425), 8/23/2021 – 12/3/2021
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021
PDAT 4: Immunology/Respiratory (PHAR 504), 8/23/2021 – 12/3/2021
Undergrad Res Exp Biopharm Sci (BPS 300), 1/11/2021 – 4/30/2021

Selected Grants

3/3: The Chicago Cancer Health Equity Collaborative (ChicagoCHEC), National Institutes of Health (National Cancer Institute)., 9/22/2020 - 8/31/2025, Obligated Amount: $2805763; Anticipated Amount: $6834852

Leveraging DNA Repair to Enhance Chrispr Genome Editing, Chicago Biomedical Consortium., 3/1/2019 - 2/28/2022, Obligated Amount: $150000; Anticipated Amount: $150000

Regulation of Non-Homologous End Joining Through End Processing, National Institutes of Health (National Cancer Institute)., 7/1/2014 - 12/31/2017, Obligated Amount: $360967; Anticipated Amount: $360967

Tech transfer Seed Grant Award, Bloomberg School of Public Health, Johns Hopkins University., 10/1/2004 - Present, Obligated Amount: $25000; No Anticipated Amount Set

MOLECULAR MECHANISMS OF NHEJ IN MAMMALIAN CELLS, National Institute of General Medical Sciences., 7/1/2004 - 3/31/2010, Obligated Amount: $1169513; No Anticipated Amount Set

Faculty Research Initiatives Fund., 7/1/2004 - 6/30/2007, No Obligated Amount Set; No Anticipated Amount Set

Faculty Innovation Fund, Bloomberg School of Public Health, Johns Hopkins University., 5/1/2004 - 4/30/2005, Obligated Amount: $30000; No Anticipated Amount Set

Maryland Cigarette Restitution Fund Grant., 1/1/2004 - 12/31/2004, Obligated Amount: $125000; No Anticipated Amount Set

Rita Allen Foundation Scholar’s Award., 10/1/2003 - 8/30/2006, No Obligated Amount Set; No Anticipated Amount Set

Selected Publications

Flor, A, Wolfgeher, D, Li, J, Hanakahi, LA, Kron, SJ. (2021). Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons. Cell Chemical Biology, 28, (6), 776-787.e8. doi:10.1016/j.chembiol.2020.11.011.

Gavande, NS, Vandervere-Carozza, PS, Pawelczak, KS, Mendoza-Munoz, P, Vernon, TL, Hanakahi, LA, Summerlin, M, Dynlacht, JR, Farmer, AH, Sears, CR, Nasrallah, NA, Garrett, J, Turchi, JJ. (2020). Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku-DNA interaction. Nucleic Acids Research, 48, (20), 11536-11550. doi:10.1093/nar/gkaa934.

Nitiss, KC, Nitiss, JL, Hanakahi, LA. (2019). DNA Damage by an essential enzyme: A delicate balance act on the tightrope. DNA Repair, 82. doi:10.1016/j.dnarep.2019.102639.

Clarke, R, Heler, R, MacDougall, MS, Yeo, NC, Chavez, A, Regan, M, Hanakahi, L, Church, GM, Marraffini, LA, Merrill, BJ. (2018). Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks. Molecular Cell, 71, (1), 42-55.e8. doi:10.1016/j.molcel.2018.06.005.

Li, J, Summerlin, M, Nitiss, KC, Nitiss, JL, Hanakahi, LA. (2017). TDP1 is required for efficient non-homologous end joining in human cells. DNA Repair, 60, 40-49. doi:10.1016/j.dnarep.2017.10.003.

Jiao, C, Summerlin, M, Bruzik, KS, Hanakahi, L. (2015). Synthesis of Biotinylated Inositol Hexakisphosphate to Study DNA Double-Strand Break Repair and Affinity Capture of IP6-Binding Proteins. Biochemistry, 54, (41), 6312-6322. doi:10.1021/acs.biochem.5b00642.

Heo, J, Li, J, Summerlin, M, Hays, A, Katyal, S, McKinnon, PJ, Nitiss, KC, Nitiss, JL, Hanakahi, LA. (2015). TDP1 promotes assembly of non-homologous end joining protein complexes on DNA. DNA Repair, 30, 28-37. doi:10.1016/j.dnarep.2015.03.003.

Slavoff, SA, Heo, J, Budnik, BA, Hanakahi, LA, Saghatelian, A. (2014). A human short open reading frame (sORF)-Encoded polypeptide that stimulates DNA end joining. Journal of Biological Chemistry, 289, (16), 10950-10957. doi:10.1074/jbc.C113.533968.

Gilson, T, Greer, AE, Vindigni, A, Ketner, G, Hanakahi, LA. (2012). The α2 helix in the DNA ligase IV BRCT-1 domain is required for targeted degradation of ligase IV during adenovirus infection. Virology, 428, (2), 128-135. doi:10.1016/j.virol.2012.03.006.

Notable Honors

2019, University of Illinois at Chicago Teaching Recognition Program Award,

2018, ABRCMS Judge Travel Award,

Education

Degrees:
B.S., University of Hawaii at Manoa, United States, 1990
Ph.D., Yale University, United States, 1996

Postgraduate Training:
Post-doctoral training, Yale University, United States, 1998
Post-doctoral training, Clare Hall Laboratories, United Kingdom, 2003