Photo of Professor Jeremy J. Johnson

Jeremy J. Johnson


Associate Professor, Pharmacy Practice

Contact

Address:

833 South Wood Street, Chicago, IL, 60612

Office Phone:

(312) 996-4368

Office Phone TTY:

(312) 996-0379

About

Our research group is focused on evaluating promising phytochemicals or semi-synthetic derivatives for cancer, inflammatory bowel disease, colitis and inflammation from pre-clinical research to early phase human clinical trials. Ongoing projects are evaluating phytochemicals from Mediterranean herbs including rosemary, the south east Asian Mangosteen fruit and the human pharmacokinetics of phytochemicals including. We are especially interested in understanding the pharmacological properties and pharmacokinetic properties of pure phytochemicals or phytochemicals in standardized extracts.

Selected Publications

  • Petiwala SM, Li G, Ramaiya A, Kumar A, Gill RK, Saksena S, Johnson JJ. Pharmacokinetic characterization of mangosteen (Garcinia mangostana) fruit extract standardized to α-mangostin in C57BL/6 mice.. Nutrition research (New York, N.Y.). 2014;34(4):336-45. doi:10.1016/j.nutres.2014.03.002.
  • Petiwala SM, Berhe S, Li G, Puthenveetil AG, Rahman O, Nonn L, Johnson JJ. Rosemary (Rosmarinus officinalis) extract modulates CHOP/GADD153 to promote androgen receptor degradation and decreases xenograft tumor growth.. PloS one. 2014;9(3):e89772. doi:10.1371/journal.pone.0089772.
  • Li G, Thomas S, Johnson JJ. Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer.. Frontiers in pharmacology. 2013;4:80. doi:10.3389/fphar.2013.00080.
  • Petiwala SM, Puthenveetil AG, Johnson JJ. Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer.. Frontiers in pharmacology. 2013;4:29. doi:10.3389/fphar.2013.00029.
  • Li G, Petiwala SM, Pierce DR, Nonn L, Johnson JJ. Selective modulation of endoplasmic reticulum stress markers in prostate cancer cells by a standardized mangosteen fruit extract.. PloS one. 2013;8(12):e81572. doi:10.1371/journal.pone.0081572.
  • Ramaiya A, Li G, Petiwala SM, Johnson JJ. Single dose oral pharmacokinetic profile of α-mangostin in mice.. Current drug targets. 2012;13(14):1698-704.
  • Johnson JJ, Petiwala SM, Syed DN, Rasmussen JT, Adhami VM, Siddiqui IA, Kohl AM, Mukhtar H. α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth.. Carcinogenesis. 2012;33(2):413-9. doi:10.1093/carcin/bgr291.
  • Johnson JJ, Nihal M, Siddiqui IA, Scarlett CO, Bailey HH, Mukhtar H, Ahmad N. Enhancing the bioavailability of resveratrol by combining it with piperine.. Molecular nutrition & food research. 2011;55(8):1169-76. doi:10.1002/mnfr.201100117.
  • Johnson JJ. Carnosol: a promising anti-cancer and anti-inflammatory agent.. Cancer letters. 2011;305(1):1-7. doi:10.1016/j.canlet.2011.02.005.
  • Syed DN, Afaq F, Maddodi N, Johnson JJ, Sarfaraz S, Ahmad A, Setaluri V, Mukhtar H. Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased Mitf levels.. The Journal of investigative dermatology. 2011;131(6):1291-9. doi:10.1038/jid.2011.6.
  • Johnson JJ, Syed DN, Suh Y, Heren CR, Saleem M, Siddiqui IA, Mukhtar H. Disruption of androgen and estrogen receptor activity in prostate cancer by a novel dietary diterpene carnosol: implications for chemoprevention.. Cancer prevention research (Philadelphia, Pa.). 2010;3(9):1112-23. doi:10.1158/1940-6207.CAPR-10-0168.
  • Johnson JJ, Bailey HH, Mukhtar H. Green tea polyphenols for prostate cancer chemoprevention: a translational perspective.. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010;17(1):3-13. doi:10.1016/j.phymed.2009.09.011.
  • Saleem M, Murtaza I, Tarapore RS, Suh Y, Adhami VM, Johnson JJ, Siddiqui IA, Khan N, Asim M, Hafeez BB, Shekhani MT, Li B, Mukhtar H. Lupeol inhibits proliferation of human prostate cancer cells by targeting beta-catenin signaling.. Carcinogenesis. 2009;30(5):808-17. doi:10.1093/carcin/bgp044.
  • Suh Y, Afaq F, Johnson JJ, Mukhtar H. A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways.. Carcinogenesis. 2009;30(2):300-7. doi:10.1093/carcin/bgn269.
  • Johnson JJ, Syed DN, Heren CR, Suh Y, Adhami VM, Mukhtar H. Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 5′-AMP-activated protein kinase (AMPK) pathway.. Pharmaceutical research. 2008;25(9):2125-34. doi:10.1007/s11095-008-9552-0.
  • Pomplun M, Johnson JJ, Johnston S, Kolesar JM. Stability of a heparin-free 50% ethanol lock solution for central venous catheters.. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2007;13(1):33-7. doi:10.1177/1078155207077598.
  • Saleem M, Kweon MH, Johnson JJ, Adhami VM, Elcheva I, Khan N, Bin Hafeez B, Bhat KM, Sarfaraz S, Reagan-Shaw S, Spiegelman VS, Setaluri V, Mukhtar H. S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9.. Proceedings of the National Academy of Sciences of the United States of America. 2006;103(40):14825-30. doi:10.1073/pnas.0606747103.
  • Education

  • , Clinical and Translational Science, NIH, Fellowship
  • PhD, Cancer Chemoprevention / Translational Research, University of Wisconsin - Comparative and Biomedical Sciences, WI
  • PharmD, Pharmacy, University of Wisconsin School of Pharmacy, WI
  • BS, Biology, University of Wisconsin-Stevens Point, WI
  • Licensures and Certifications

  • State of Illinois (Active), Registered Pharmacist (R.Ph.), 2011
  • APHA, Pharmacy-Based Immunization Delivery, 2009
  • State of Wisconsin (Active), Registered Pharmacist (R.Ph.), 2007
  • Professional Memberships

  • ASPET (American Society of Pharmacology and Experimental Therapeutics)
  • PSNA (Phytochemical Society of North America)
  • AACR (American Association of Cancer Research)