Photo of Dr. Sang Hyun  Cho

Sang Hyun Cho

Research Associate Professor, Institute for Tuberculosis Research
Research Associate Professor of Medicinal Chemistry, Pharmaceutical Sciences
Associate Director, Institute for Tuberculosis Research


Building & Room:



833 S. Wood Street, Chicago, IL, 60612

Office Phone:

(312) 355-4521

Selected Publications

  • Tiwari RA, Miller P, Cho SG, Franzblau SJ, Miller M. Syntheses and Antituberculosis Activity of 1,3-Benzothiazinone Sulfoxide and Sulfone Derived from BTZ043.. ACS medicinal chemistry letters. 2015;6(2):128-33. doi:10.1021/ml5003458.
  • Gao WY, Kim JR, Anderson J, Akopian TY, Hong SW, Jin YA, Kandror OY, Kim JG, Lee IH, Lee SM, Mulugeta SL, Sunoqrot SF, Wang YW, Yang SG, Yoon T, Goldberg A, Pauli G, Suh J, Franzblau S, Cho S. The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo.. Antimicrobial agents and chemotherapy. 2015;59(2):880-9. doi:10.1128/AAC.04054-14.
  • Upton AM, Cho S, Yang TJ, Kim Y, Wang YG, Lu Y, Wang B, Xu J, Mdluli K, Ma Z, Franzblau S. In vitro and in vivo activities of the nitroimidazole TBA-354 against Mycobacterium tuberculosis.. Antimicrobial agents and chemotherapy. 2015;59(1):136-44. doi:10.1128/AAC.03823-14.
  • Gao WY, Kim J, Chen S, Cho SU, Choi JY, Jaki BC, Jin YE, Lankin DY, Lee JG, Lee SG, Napolitano JW, Franzblau SF, Suh J, Pauli G. Discovery and characterization of the tuberculosis drug lead ecumicin.. Organic letters. 2014;16(23):6044-7. doi:10.1021/ol5026603.
  • Moraski GC, Oliver AG, Markley LD, Cho S, Franzblau SG, Miller MJ. Scaffold-switching: an exploration of 5,6-fused bicyclic heteroaromatics systems to afford antituberculosis activity akin to the imidazo[1,2-a]pyridine-3-carboxylates.. Bioorganic & medicinal chemistry letters. 2014;24(15):3493-8. doi:10.1016/j.bmcl.2014.05.062.
  • Tiwari R, Möllmann UG, Cho SA, Franzblau SJ, Miller P, Miller M. Design and Syntheses of Anti-Tuberculosis Agents Inspired by BTZ043 Using a Scaffold Simplification Strategy.. ACS medicinal chemistry letters. 2014;5(5):587-91. doi:10.1021/ml500039g.
  • Pieroni M, Wan B, Cho SG, Franzblau S, Costantino G. Design, synthesis and investigation on the structure-activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents.. European journal of medicinal chemistry. 2014;72:26-34. doi:10.1016/j.ejmech.2013.11.007.
  • Cai GG, Napolitano JU, Wang YW, Jaki BH, Suh JA, Yang SG, Lee IF, Franzblau S, Pauli G, Cho S. Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain.. Journal of natural products. 2013;76(11):2009-18. doi:10.1021/np400145u.
  • Hwang CH, Jaki BU, Klein L, Lankin DC, Napolitano JG, Fryling NA, Franzblau SG, Cho S, Stamets PE, Wang YF, Pauli G. Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.. Journal of natural products. 2013;76(10):1916-22. doi:10.1021/np400497f.
  • Grant SS, Kawate TP, Nag PR, Silvis MA, Stanley S, Kazyanskaya EG, Nietupski RT, Golas A, Cho S, Franzblau S, Hung D. Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model.. ACS chemical biology. 2013;8(10):2224-34. doi:10.1021/cb4004817.
  • Pavan FR, Poelhsitz GV, da Cunha LV, Barbosa MI, Leite SR, Batista AA, Cho S, Franzblau SG, de Camargo MS, Resende FA, Varanda EA, Leite CQ. In vitro and in vivo activities of ruthenium(II) phosphine/diimine/picolinate complexes (SCAR) against Mycobacterium tuberculosis.. PloS one. 2013;8(5):e64242. doi:10.1371/journal.pone.0064242.
  • Hwang JM, Oh TM, Kaneko TG, Upton A, Franzblau S, Ma Z, Cho S, Kim P. Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents.. Journal of natural products. 2013;76(3):354-67. doi:10.1021/np3007167.
  • Franzblau SG, DeGroote MA, Cho S, Andries KM, Nuermberger EJ, Orme I, Mdluli K, Angulo-Barturen I, Dick T, Dartois V, Lenaerts A. Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis.. Tuberculosis (Edinburgh, Scotland). 2012;92(6):453-88. doi:10.1016/
  • Silveira GP, Ferreira MC, Fernandes L, Moraski GG, Cho SM, Hwang C, Franzblau S, Sá M. Allylic thiocyanates as a new class of antitubercular agents.. Bioorganic & medicinal chemistry letters. 2012;22(20):6486-9. doi:10.1016/j.bmcl.2012.08.048.
  • Moraski GC, Markley LD, Chang M, Cho SG, Franzblau SH, Hwang CJ, Boshoff H, Miller M. Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds.. Bioorganic & medicinal chemistry. 2012;20(7):2214-20. doi:10.1016/j.bmc.2012.02.025.
  • Moraski GC, Markley LD, Hipskind PA, Boshoff H, Cho SG, Franzblau SJ, Miller M. Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity.. ACS medicinal chemistry letters. 2011;2(6):466-470. doi:10.1021/ml200036r.
  • Pieroni M, Lilienkampf A, Wang YG, Wan BP, Cho S, Franzblau S, Kozikowski A. NOC chemistry for tuberculosis-further investigations on the structure-activity relationships of antitubercular isoxazole-3-carboxylic acid ester derivatives.. ChemMedChem. 2010;5(10):1667-72. doi:10.1002/cmdc.201000169.
  • Hurdle JG, Lee RB, Budha NR, Carson EI, Qi JS, Scherman M, Cho SR, McNeil MJ, Lenaerts AG, Franzblau SE, Meibohm B, Lee R. A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents.. The Journal of antimicrobial chemotherapy. 2008;62(5):1037-45. doi:10.1093/jac/dkn307.
  • Vicente EA, Villar RJ, Burguete AG, Solano B, Pérez-Silanes SC, Aldana I, Maddry J, Lenaerts A, Franzblau S, Cho S, Monge A, Goldman R. Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis.. Antimicrobial agents and chemotherapy. 2008;52(9):3321-6. doi:10.1128/AAC.00379-08.
  • Villar RA, Vicente EJ, Solano BG, Pérez-Silanes S, Aldana IC, Maddry J, Lenaerts A, Franzblau S, Cho S, Monge A, Goldman R. In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide.. The Journal of antimicrobial chemotherapy. 2008;62(3):547-54. doi:10.1093/jac/dkn214.
  • Ly LH, Barhoumi R, Cho SG, Franzblau SN, McMurray D. Vaccination with Bacille-Calmette Guérin promotes mycobacterial control in guinea pig macrophages infected in vivo.. The Journal of infectious diseases. 2008;198(5):768-71. doi:10.1086/590436.
  • Deng S, Wang YR, Inui T, Chen SG, Farnsworth NF, Cho S, Franzblau S, Pauli G. Anti-TB polyynes from the roots of Angelica sinensis.. Phytotherapy research : PTR. 2008;22(7):878-82. doi:10.1002/ptr.2303.
  • Zhou YB, Beeler A, Cho SG, Wang YK, Franzblau S, Snyder J. Library synthesis using 5,6,7,8-tetrahydro-1,6-naphthyridines as scaffolds.. Journal of combinatorial chemistry. 2008;10(4):534-40. doi:10.1021/cc800038r.
  • Cho S, Warit S, Wan BH, Hwang CF, Pauli GG, Franzblau S. Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.. Antimicrobial agents and chemotherapy. 2007;51(4):1380-5. doi:10.1128/AAC.00055-06.
  • Bate AB, Kalin JH, Fooksman EM, Amorose EL, Price CM, Williams HM, Rodig MJ, Mitchell MO, Cho S, Wang YG, Franzblau S. Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives.. Bioorganic & medicinal chemistry letters. 2007;17(5):1346-8. doi:10.1016/j.bmcl.2006.11.091.
  • Case RJ, Franzblau SG, Wang Y, Cho SD, Soejarto DF, Pauli G. Ethnopharmacological evaluation of the informant consensus model on anti-tuberculosis claims among the Manus.. Journal of ethnopharmacology. 2006;106(1):82-9. doi:10.1016/j.jep.2005.12.005.
  • Jaki BU, Franzblau SG, Cho S, Pauli GF. Development of an extraction method for mycobacterial metabolome analysis.. Journal of pharmaceutical and biomedical analysis. 2006;41(1):196-200. doi:10.1016/j.jpba.2005.10.022.
  • Pauli GF, Case RJ, Inui T, Wang YH, Cho SG, Fischer N, Franzblau S. New perspectives on natural products in TB drug research.. Life sciences. 2005;78(5):485-94. doi:10.1016/j.lfs.2005.09.004.
  • Education

  • PhD, Mycobacteriology, Konkuk Univ, Seoul, Korea
  • Professional Memberships

  • American Society of Microbiology