Joanna E. Burdette
Professor, College of Pharmacy - Pharmaceutical Sciences
Associate Dean for Research, College of Pharmacy - Pharmaceutical Sciences
Co-Lead Cancer Biology Program, UI Cancer Center
Co-Lead K12 IRACDA Postdoctoral Training, University of Illinois Chicago
Contact
Address:
900 S. Ashland Ave Room 3202, Chicago, IL
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About Heading link
Overview:
I am currently the Edward and Josephine Mika Professor in the Department of Pharmaceutical Sciences and Associate Dean for Research and Graduate Education in the College of Pharmacy at UIC. I am co-director of the NIH K12 IRACDA postdoc training grant. I serve as the co-lead for the Cancer Biology Program in the UI Cancer Center. My lab helped to validate that the major cell type giving rise to high grade serous cancer is the fallopian tube and we have also developed murine fallopian tube (or oviductal) cancer models that we use to study key pathways in tumor initiation and metastasis. I collaborate to study natural products as therapeutic leads in ovarian cancer models. I am strongly committed to training and received certification in the National Research Mentoring Network mentoring curriculum and its facilitation.
Research Interests:
ovarian cancer
reproductive biology of the fallopian tube
natural products drug discovery
progesterone biology
Teaching and Supervision Heading link
Doctoral Research in Pharmacog (PMPG 599), 1/9/2023 – 4/28/2023
PSCI Ph.D. Thesis Research (PSCI 599), 1/9/2023 – 4/28/2023
Doctoral Research in Pharmacog (PMPG 599), 8/22/2022 – 12/2/2022
PSCI Ph.D. Thesis Research (PSCI 599), 8/22/2022 – 12/2/2022
Research Presentation (PSCI 502), 8/22/2022 – 12/2/2022
Special Proj Pharm Sci (PSCI 390), 1/10/2022 – 4/29/2022
PSCI Ph.D. Thesis Research (PSCI 599), 1/10/2022 – 4/29/2022
Doctoral Restch in Med Chem (MDCH 599), 1/10/2022 – 4/29/2022
Doctoral Research in Pharmacog (PMPG 599), 1/10/2022 – 4/29/2022
Selected Grants
Tiny proteins in vaginal lavage for early detection of high grade serous ovarian cancer, Foundation for Women's Cancer., 4/1/2023 - 3/31/2024, Obligated Amount: $50000; Anticipated Amount: $50000
Development of a small-molecule Beclin1-ATG14L protein-protein interaction inhibitor for cancer therapy, American Cancer Society., 7/1/2022 - 6/30/2026, Obligated Amount: $198000; Anticipated Amount: $792000
Ovarian and Fallopian Tube Crosstalk via Extracellular Vesicles Promotes the Origin of Ovarian Cancer and the Precancerous Landscape, University of Kansas., 7/1/2022 - 6/30/2024, Obligated Amount: $50000; Anticipated Amount: $50000
Chicago Center for Health and Environment (CACHET), University of Chicago., 6/15/2022 - 3/31/2024, Obligated Amount: $1732094; Anticipated Amount: $1732094
Selected Publications
Maldonado, Amanda C, Haughan, Monica A, Khin, Manead, Ekiert, Julia, Zhang, Ziwei, Lantvit, Daniel, Subeh, Zeinab Y Al, Pierre, Herma C, Salkovski, Maryna, Hirschhorn, Tal, Gao, Yu, Pearce, Cedric J, Stockwell, Brent R, Aldrich, Leslie N, Oberlies, Nicholas H, Burdette, Joanna E. (2023). Probing the Cytotoxic Signaling Induced by Eupenifeldin in Ovarian Cancer Models. Journal of Natural Products. doi:10.1021/acs.jnatprod.3c00186.
Ren, Yulin, Kaweesa, Elizabeth N, Tian, Lei, Wu, Sijin, Sydara, Kongmany, Xayvue, Mouachanh, Moore, Curtis E, Soejarto, Djaja D, Cheng, Xiaolin, Yu, Jianhua, Burdette, Joanna E, Kinghorn, A Douglas. (2023). The Cytotoxic Cardiac Glycoside (−)-Cryptanoside A from the Stems of Cryptolepis dubia and Its Molecular Targets. Journal of Natural Products, 86, (6), 1411-1419. doi:10.1021/acs.jnatprod.3c00094.
Kaweesa, Elizabeth N, Bazioli, Jaqueline M, Pierre, Herma C, Lantvit, Daniel D, Kulp, Samuel K, Hill, Kasey L, Phelps, Mitch A, Coss, Christopher C, Fuchs, James R, Pearce, Cedric J, Oberlies, Nicholas H, Burdette, Joanna E. (2023). Exploration of Verticillins in High-Grade Serous Ovarian Cancer and Evaluation of Multiple Formulations in Preclinical In Vitro and In Vivo Models. Molecular Pharmaceutics, 20, (6), 3049-3059. doi:10.1021/acs.molpharmaceut.3c00069.
Luu, Gordon T, Ge, Chang, Tang, Yisha, Li, Kailiang, Cologna, Stephanie M, Godwin, Andrew K, Burdette, Joanna E, Su, Judith, Sanchez, Laura M. (2023). An integrated approach to protein discovery and detection from complex biofluids. Molecular & Cellular Proteomics, 100590. doi:10.1016/j.mcpro.2023.100590.
Subeh, Zeinab Y Al, Flores-Bocanegra, Laura, Raja, Huzefa A, Burdette, Joanna E, Pearce, Cedric J, Oberlies, Nicholas H. (2023). Embellicines C‑E: Macrocyclic Alkaloids with a Cyclopenta[b]fluorene Ring System from the Fungus Sarocladium sp.. Journal of Natural Products, 86, (3), 596-603. doi:10.1021/acs.jnatprod.2c01048.
Colby, Aaron H, Kirsch, Jack, Patwa, Amit N, Liu, Rong, Hollister, Beth, McCulloch, William, Burdette, Joanna E, Pearce, Cedric J, Oberliels, Nicholas H, Colson, Yolonda L, Liu, Kebin, Grinstaff, Mark W. (2023). Radiolabeled Biodistribution of Expansile Nanoparticles: Intraperitoneal Administration Results in Tumor Specific Accumulation. ACS Nano, 17, (3), 2212-2221. doi:10.1021/acsnano.2c08451.
Salvi, Amrita, Hardy, Laura R, Heath, Kimberly N, Watry, Samantha, Pergande, Melissa R, Cologna, Stephanie M, Burdette, Joanna E. (2023). PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome. Neoplasia, 36, 100866. doi:10.1016/j.neo.2022.100866.
Bergsten, Tova M, Levy, Sarah, Lusk, Hannah, Sanchez, Laura, Burdette, Joanna E. (2023). Abstract B006: Investigating the role of soluble metabolites in primary high grade serous ovarian cancer. Cancer Research, 83, (2_Supplement_2), b006-b006. doi:10.1158/1538-7445.metastasis22-b006.
Salvi, Amrita, Hardy, Laura R, Heath, Kimberly N, Watry, Samantha, Pergande, Melissa R, Cologna, Stephanie M, Burdette, Joanna E. (2023). Abstract B030: PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome. Cancer Research, 83, (2_Supplement_2), b030-b030. doi:10.1158/1538-7445.metastasis22-b030.