Joanna E. Burdette
Professor, College of Pharmacy - Pharmaceutical Sciences
Associate Dean for Research, College of Pharmacy - Pharmaceutical Sciences
Co-Lead Tumor Biology Program, UI Cancer Center
Co-Lead K12 IRACDA Postdoctoral Training, University of Illinois Chicago
Contact
Address:
900 S. Ashland Ave Room 3202, Chicago, IL
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About Heading link
Overview:
I am currently the Edward and Josephine Mika Professor and also the Associate Dean for Research and Graduate Education in the College of Pharmacy at UIC. I am also the co-director of the NIH K12 IRACDA postdoc training grant. I also serve as the co-lead for the Tumor Biology Program in the UI Cancer Center. My lab has helped to validate that the major cell type giving rise to high grade serous cancer is the fallopian tube and we have also developed murine fallopian tube (or oviductal) cancer models that we use to study key pathways in tumor initiation and metastasis. I collaborate to study natural products as therapeutic leads in ovarian cancer models. I am strongly committed to training and received certification in the National Research Mentoring Network mentoring curriculum and its facilitation.
Research Interests:
ovarian cancer
reproductive biology of the fallopian tube
natural products drug discovery
progesterone biology
Teaching and Supervision Heading link
Doctoral Research in Pharmacog (PMPG 599), 1/9/2023 – 4/28/2023
PSCI Ph.D. Thesis Research (PSCI 599), 1/9/2023 – 4/28/2023
Doctoral Research in Pharmacog (PMPG 599), 8/22/2022 – 12/2/2022
PSCI Ph.D. Thesis Research (PSCI 599), 8/22/2022 – 12/2/2022
Research Presentation (PSCI 502), 8/22/2022 – 12/2/2022
Special Proj Pharm Sci (PSCI 390), 1/10/2022 – 4/29/2022
PSCI Ph.D. Thesis Research (PSCI 599), 1/10/2022 – 4/29/2022
Doctoral Restch in Med Chem (MDCH 599), 1/10/2022 – 4/29/2022
Doctoral Research in Pharmacog (PMPG 599), 1/10/2022 – 4/29/2022
Selected Grants
Development of a small-molecule Beclin1-ATG14L protein-protein interaction inhibitor for cancer therapy, American Cancer Society., 7/1/2022 - 6/30/2026, Obligated Amount: $198000; Anticipated Amount: $792000
Chicago Center for Health and Environment (CACHET), University of Chicago., 6/15/2022 - 3/31/2023, Obligated Amount: $876040; Anticipated Amount: $876040
Selected Publications
Colby, AH, Kirsch, J, Patwa, AN, Liu, R, Hollister, B, McCulloch, W, Burdette, JE, Pearce, CJ, Oberliels, NH, Colson, YL, Liu, K, Grinstaff, MW. (2023). Radiolabeled Biodistribution of Expansile Nanoparticles: Intraperitoneal Administration Results in Tumor Specific Accumulation. ACS Nano, 17, (3), 2212-2221. doi:10.1021/acsnano.2c08451.
Salvi, A, Hardy, LR, Heath, KN, Watry, S, Pergande, MR, Cologna, SM, Burdette, JE. (2023). PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome. Neoplasia (United States), 36. doi:10.1016/j.neo.2022.100866.
Bergsten, Tova M, Levy, Sarah, Lusk, Hannah, Sanchez, Laura, Burdette, Joanna E. (2023). Abstract B006: Investigating the role of soluble metabolites in primary high grade serous ovarian cancer. Cancer Research, 83, (2_Supplement_2), b006-b006. doi:10.1158/1538-7445.metastasis22-b006.
Salvi, Amrita, Hardy, Laura R, Heath, Kimberly N, Watry, Samantha, Pergande, Melissa R, Cologna, Stephanie M, Burdette, Joanna E. (2023). Abstract B030: PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome. Cancer Research, 83, (2_Supplement_2), b030-b030. doi:10.1158/1538-7445.metastasis22-b030.
Bergsten, TM, Levy, SE, Zink, KE, Lusk, HJ, Pergande, MR, Cologna, SM, Burdette, JE, Sanchez, LM. (2022). Fallopian tube secreted protein affects ovarian metabolites in high grade serous ovarian cancer. Frontiers in Cell and Developmental Biology, 10. doi:10.3389/fcell.2022.1042734.
El-Elimat, T, Al-Qiam, R, Burdette, JE, Al Sharie, AH, Al-Gharaibeh, M, Oberlies, NH. (2022). Homoisoflavonoids from the bulbs of Bellevalia longipes and an assessment of their potential cytotoxic activity. Phytochemistry, 203. doi:10.1016/j.phytochem.2022.113343.
Russo, A, Zizhao, Y, Heyrman, GM, Cain, BP, Lopez Carrero, A, Isenberg, BC, Dean, MJ, Coppeta, J, Burdette, JE. (2022). Versican secreted by the ovary links ovulation and migration in fallopian tube derived serous cancer. Cancer Letters, 543. doi:10.1016/j.canlet.2022.215779.
Al Subeh, ZY, Li, T, Ustoyev, A, Obike, JC, West, PM, Khin, M, Burdette, JE, Pearce, CJ, Oberlies, NH, Croatt, MP. (2022). Semisynthesis of Hypothemycin Analogues Targeting the C8-C9 Diol. Journal of Natural Products, 85, (8), 2018-2025. doi:10.1021/acs.jnatprod.2c00434.
Lusk, HJ, Levy, SE, Bergsten, TM, Burdette, JE, Sanchez, LM. (2022). Home-Built Spinning Apparatus for Drying Agarose-Based Imaging Mass Spectrometry Samples. Journal of the American Society for Mass Spectrometry, 33, (7), 1325-1328. doi:10.1021/jasms.2c00044.
Selected Presentations
Davis, Lydia, Bisson, Jonathan, Maldonado, Amanda, Burdette, Joanna, Orjala, Jimmy. (2020 August 10). nvestigation of Environmental Regulators of Metabolite Expression from Freshwater Cyanobacteria using Targeted and Untargeted Metabolomic Platforms. Chicago Mass Spec Day.
Davis, Lydia, Sullivan, Peter, Bisson, Jonathan, Kurina, Steven, Burdette, Joanna, Orjala, Jimmy. (2020 May 14). Mapping the Chemical Diversity of a Freshwater Cyanobacterial Library for Enhanced Drug Discovery using Informatic Tools. American Society for Mass Spectrometr.
Davis, Lydia, Maldonado, Amanda, Khin, Manead, Burdette, Joanna, Orjala, Jimmy. (2020 April 24). Discovery of Cytotoxic Isothiazole-containing Alkaloids with FOXO3a Activity from the Cyanobacterium Nostoc sp. UIC 10771. MIKIW Annual Meeting.
Davis, Lydia, Bisson, Jonathan, Sullivan, Peter, Kurina, Steven, Burdette, Joanna, Orjala, Jimmy. (2020 March 03). Discovery of novel chemicals from freshwater cyanobacteria using molecular networking. Pittcon, Annual Meeting.