Photo of Jose A. Villegas

Jose A. Villegas


Assistant Professor, Pharmaceutical Sciences

Email:

josev@uic.edu

Related Sites:

Teaching and Supervision Heading link

PSCI Ph.D. Thesis Research (PSCI 599), 8/26/2024 – 12/6/2024
Departmental Seminar (BPS 595), 8/26/2024 – 12/6/2024
Seminar in Med Chem (MDCH 595), 8/26/2024 – 12/6/2024
Colloquium Lecture Series (PSCI 425), 8/26/2024 – 12/6/2024
Colloquium Lecture Series (PSCI 425), 8/26/2024 – 12/6/2024
Fundamentals of Drug Action (PHAR 422), 8/26/2024 – 12/6/2024
Fundamentals of Drug Action (PHAR 422), 8/26/2024 – 12/6/2024
Undergrad Res Pharm Sci (PSCI 380), 8/26/2024 – 12/6/2024
Medicinal Chemistry (PSCI 530), 1/8/2024 – 4/26/2024

Selected Grants

Collaborative Research: Filamentous Peptide Nanomaterials through Molecular Design, National Science Foundation., 8/1/2024 - 7/31/2027, Obligated Amount: $300000; Anticipated Amount: $300000

Inducing Off-pathway Assembly of HIV Gag Polyprotein with Computationally Designed Peptides, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 8/1/2023 - 7/31/2028, Obligated Amount: $918253; Anticipated Amount: $2344594

Selected Publications

Hennessy, Madeline R, Creed, Simone M, Gutridge, Anna M, Rusali, Lisa E, Luo, Dan, Sepehri, Bakhtyar, Rhoda, Elizabeth S, Villegas, José A, van Rijn, Richard M, Riley, Andrew P. (2024). Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.4c00736.

Sepehri, Bakhtyar, Drew, Kevin, Villegas, José A. (2023). Come for the atmosphere, stay for the interactions: Deciphering small molecule partitioning into biomolecular condensates. Cell Chemical Biology, 30, (11), 1337-1339. doi:10.1016/j.chembiol.2023.10.015.

Vaid, Tasneem M, Demissie, Robel, Kwon, Youngjin, Tran, Thao, Moon, Hyung-Geun, Villegas, José A, Park, Gye Young, Johnson, Michael E, Lee, Hyun. (2023). Synergistic Inhibition Guided Fragment-Linking Strategy and Quantitative Structure–Property Relationship Modeling To Design Inhalable Therapeutics for Asthma Targeting CSF1R. ACS Omega, 8, (23), 20505-20512. doi:10.1021/acsomega.3c00803.

Ticiani, Elvis, Villegas, José A, Murga-Zamalloa, Carlos, Veiga-Lopez, Almudena. (2023). Binding sites in the epidermal growth factor receptor are responsible for bisphenol S effects on trophoblast cell invasion. Chemosphere, 318, 137960. doi:10.1016/j.chemosphere.2023.137960.

Villegas, José A, Vaid, Tasneem M, Johnson, Michael E, Moore, Terry W. (2023). Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, 21, 1885-1892. doi:10.1016/j.csbj.2023.02.049.

Villegas, José A, Heidenreich, Meta, Levy, Emmanuel D. (2022). Molecular and environmental determinants of biomolecular condensate formation. Nature Chemical Biology, 18, (12), 1319-1329. doi:10.1038/s41589-022-01175-4.

Villegas, José A, Levy, Emmanuel D. (2022). A unified statistical potential reveals that amino acid stickiness governs nonspecific recruitment of client proteins into condensates. Protein Science, 31, (7), e4361. doi:10.1002/pro.4361.

Naidu, Sharadha Dayalan, Suzuki, Takafumi, Dikovskaya, Dina, Knatko, Elena V, Higgins, Maureen, Sato, Miu, Novak, Miroslav, Villegas, José A, Moore, Terry W, Yamamoto, Masayuki, Dinkova-Kostova, Albena T. (2022). The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2. iScience, 25, (1), 103703. doi:10.1016/j.isci.2021.103703.

Garcia‐Seisdedos, Hector, Villegas, José A, Levy, Emmanuel D. (2019). Infinite Assembly of Folded Proteins in Evolution, Disease, and Engineering. Angewandte Chemie International Edition, 58, (17), 5514-5531. doi:10.1002/anie.201806092.

Education

Degrees:
B.S., University of California, Santa Barbara, United States, 2003
M.A., Brooklyn College, United States, 2011
Ph.D., University of Pennsylvania, United States, 2017

Postgraduate Training:
Postdoctoral Fellow, Weizmann Institute of Science, Israel, 2020
Bridge to the Faculty Postdoctoral Research Associate, University of Illinois at Chicago, United States, 2022