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Photo of Jose A. Villegas

Jose A. Villegas

Assistant Professor, Pharmaceutical Sciences


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Teaching and Supervision Heading link

PSCI Ph.D. Thesis Research (PSCI 599), 1/8/2024 – 4/26/2024
Seminar in Pharmacognosy (PMPG 595), 1/8/2024 – 4/26/2024
Seminar in Med Chem (MDCH 595), 1/8/2024 – 4/26/2024
Departmental Seminar (BPS 595), 1/8/2024 – 4/26/2024
Medicinal Chemistry (PSCI 530), 1/8/2024 – 4/26/2024
Special Proj Pharm Sci (PSCI 390), 1/8/2024 – 4/26/2024
Undergrad Res Pharm Sci (PSCI 380), 1/8/2024 – 4/26/2024
Seminar in Med Chem (MDCH 595), 8/21/2023 – 12/1/2023
Departmental Seminar (BPS 595), 8/21/2023 – 12/1/2023

Selected Grants

Collaborative Research: Filamentous Peptide Nanomaterials through Molecular Design, National Science Foundation., 8/1/2024 - 7/31/2027, Obligated Amount: $300000; Anticipated Amount: $300000

Inducing Off-pathway Assembly of HIV Gag Polyprotein with Computationally Designed Peptides, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 8/1/2023 - 7/31/2028, Obligated Amount: $442806; Anticipated Amount: $2344594

Selected Publications

Sepehri, Bakhtyar, Drew, Kevin, Villegas, José A. (2023). Come for the atmosphere, stay for the interactions: Deciphering small molecule partitioning into biomolecular condensates. Cell Chemical Biology, 30, (11), 1337-1339. doi:10.1016/j.chembiol.2023.10.015.

Vaid, Tasneem M, Demissie, Robel, Kwon, Youngjin, Tran, Thao, Moon, Hyung-Geun, Villegas, José A, Park, Gye Young, Johnson, Michael E, Lee, Hyun. (2023). Synergistic Inhibition Guided Fragment-Linking Strategy and Quantitative Structure–Property Relationship Modeling To Design Inhalable Therapeutics for Asthma Targeting CSF1R. ACS Omega, 8, (23), 20505-20512. doi:10.1021/acsomega.3c00803.

Ticiani, Elvis, Villegas, José A, Murga-Zamalloa, Carlos, Veiga-Lopez, Almudena. (2023). Binding sites in the epidermal growth factor receptor are responsible for bisphenol S effects on trophoblast cell invasion. Chemosphere, 318, 137960. doi:10.1016/j.chemosphere.2023.137960.

Villegas, José A, Vaid, Tasneem M, Johnson, Michael E, Moore, Terry W. (2023). Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, 21, 1885-1892. doi:10.1016/j.csbj.2023.02.049.

Villegas, José A, Heidenreich, Meta, Levy, Emmanuel D. (2022). Molecular and environmental determinants of biomolecular condensate formation. Nature Chemical Biology, 18, (12), 1319-1329. doi:10.1038/s41589-022-01175-4.

Villegas, José A, Levy, Emmanuel D. (2022). A unified statistical potential reveals that amino acid stickiness governs nonspecific recruitment of client proteins into condensates. Protein Science, 31, (7), e4361. doi:10.1002/pro.4361.

Naidu, Sharadha Dayalan, Suzuki, Takafumi, Dikovskaya, Dina, Knatko, Elena V, Higgins, Maureen, Sato, Miu, Novak, Miroslav, Villegas, José A, Moore, Terry W, Yamamoto, Masayuki, Dinkova-Kostova, Albena T. (2022). The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2. iScience, 25, (1), 103703. doi:10.1016/j.isci.2021.103703.

Garcia‐Seisdedos, Hector, Villegas, José A, Levy, Emmanuel D. (2019). Infinite Assembly of Folded Proteins in Evolution, Disease, and Engineering. Angewandte Chemie International Edition, 58, (17), 5514-5531. doi:10.1002/anie.201806092.

Pulsipher, Katherine W, Bulos, Joshua A, Villegas, José A, Saven, Jeffery G, Dmochowski, Ivan J. (2018). A protein–protein host–guest complex: Thermostable ferritin encapsulating positively supercharged green fluorescent protein. Protein Science, 27, (10), 1755-1766. doi:10.1002/pro.3483.


B.S., University of California, Santa Barbara, United States, 2003
M.A., Brooklyn College, United States, 2011
Ph.D., University of Pennsylvania, United States, 2017

Postgraduate Training:
Postdoctoral Fellow, Weizmann Institute of Science, Israel, 2020
Bridge to the Faculty Postdoctoral Research Associate, University of Illinois at Chicago, United States, 2022