Karin C. Nitiss
Research Assistant Professor, College of Medicine, Rockford - Biomedical Sciences
Research Assistant Professor, College of Pharmacy, Rockford - Biopharmaceutical Sciences
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About Heading link
Teaching and Supervision Heading link
Principles and Techniques of Molecular Biology (MBT 505), 8/22/2022 – 12/9/2022
Recombinant DNA Technology (MBT 530), 1/10/2022 – 5/6/2022
Selected Grants
DNA Topoisomerase Misfunctioning in Neurological Disease, National Institutes of Health (National Institute of Neurological Disorders and Stroke)., 1/1/2021 - 11/30/2023, Obligated Amount: $159900; Anticipated Amount: $159900
Selected Publications
Evoli, Stefania, Kariyawasam, Nilusha L, Nitiss, Karin C, Nitiss, John L, Wereszczynski, Jeff. (2024). Modeling allosteric mechanisms of eukaryotic type II topoisomerases. Biophysical Journal, 123, (12), 1620-1634. doi:10.1016/j.bpj.2024.05.004.
Bandak, Afif F, Blower, Tim R, Nitiss, Karin C, Shah, Viraj, Nitiss, John L, Berger, James M. (2024). Using energy to go downhill—a genoprotective role for ATPase activity in DNA topoisomerase II. Nucleic Acids Research, 52, (3), 1313-1324. doi:10.1093/nar/gkad1157.
D’Alessandro, Giuseppina, Morales-Juarez, David A, Richards, Sean L, Nitiss, Karin C, Serrano-Benitez, Almudena, Wang, Juanjuan, Thomas, John C, Gupta, Vipul, Voigt, Andrea, Belotserkovskaya, Rimma, Goh, Chen Gang, Bowden, Anne Ramsay, Galanty, Yaron, Beli, Petra, Nitiss, John L, Zagnoli-Vieira, Guido, Jackson, Stephen P. (2023). RAD54L2 counters TOP2-DNA adducts to promote genome stability. Science Advances, 9, (49), eadl2108. doi:10.1126/sciadv.adl2108.
Bandak, Afif F, Blower, Tim R, Nitiss, Karin C, Gupta, Raveena, Lau, Albert Y, Guha, Ria, Nitiss, John L, Berger, James M. (2023). Naturally mutagenic sequence diversity in a human type II topoisomerase. Proceedings of the National Academy of Sciences of the United States of America, 120, (28), e2302064120. doi:10.1073/pnas.2302064120.
Boot, Arnoud, Liu, Mo, Stantial, Nicole, Shah, Viraj, Yu, Willie, Nitiss, Karin C, Nitiss, John L, Jinks-Robertson, Sue, Rozen, Steven G. (2022). Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers. Proceedings of the National Academy of Sciences of the United States of America, 119, (4), e2114024119. doi:10.1073/pnas.2114024119.
Nitiss, John L, Kiianitsa, Kostantin, Sun, Yilun, Nitiss, Karin C, Maizels, Nancy. (2021). Topoisomerase Assays. Current Protocols, 1, (10), e250. doi:10.1002/cpz1.250.
Sun, Yilun, Miller Jenkins, Lisa M, Su, Yijun P, Nitiss, Karin C, Nitiss, John L, Pommier, Yves. (2020). A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation. Science Advances, 6, (46), eaba6290. doi:10.1126/sciadv.aba6290.
Stantial, Nicole, Rogojina, Anna, Gilbertson, Matthew, Sun, Yilun, Miles, Hannah, Shaltz, Samantha, Berger, James, Nitiss, Karin C, Jinks-Robertson, Sue, Nitiss, John L. (2020). Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast. Proceedings of the National Academy of Sciences of the United States of America, 117, (43), 26876-26884. doi:10.1073/pnas.2008721117.
Nitiss, Karin C, Nitiss, John L, Hanakahi, Leslyn A. (2019). DNA Damage by an essential enzyme: A delicate balance act on the tightrope. DNA Repair, 82, 102639. doi:10.1016/j.dnarep.2019.102639.
Education
Degrees:
PhD, University of Southern California, United States, 1997
Bachelors of Science, University of California, United States, 1986