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Photo of Karin C. Nitiss

Karin C. Nitiss


Research Assistant Professor, College of Medicine, Rockford - Biomedical Sciences
Research Assistant Professor, College of Pharmacy, Rockford - Biopharmaceutical Sciences

Related Sites:

Selected Grants

DNA Topoisomerase Misfunctioning in Neurological Disease, National Institutes of Health (National Institute of Neurological Disorders and Stroke)., 1/1/2021 - 11/30/2022, Obligated Amount: $159900; Anticipated Amount: $159900

Selected Publications

Boot, Arnoud, Liu, Mo, Stantial, Nicole, Shah, Viraj, Yu, Willie, Nitiss, Karin C, Nitiss, John L, Jinks-Robertson, Sue, Rozen, Steven G. (2022). Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers. Proceedings of the National Academy of Sciences of the United States of America, 119, (4), e2114024119. doi:10.1073/pnas.2114024119.

Nitiss, John L, Kiianitsa, Kostantin, Sun, Yilun, Nitiss, Karin C, Maizels, Nancy. (2021). Topoisomerase Assays. Current Protocols, 1, (10), e250. doi:10.1002/cpz1.250.

Sun, Yilun, Miller Jenkins, Lisa M, Su, Yijun P, Nitiss, Karin C, Nitiss, John L, Pommier, Yves. (2020). A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation. Science Advances, 6, (46), eaba6290. doi:10.1126/sciadv.aba6290.

Stantial, Nicole, Rogojina, Anna, Gilbertson, Matthew, Sun, Yilun, Miles, Hannah, Shaltz, Samantha, Berger, James, Nitiss, Karin C, Jinks-Robertson, Sue, Nitiss, John L. (2020). Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast. Proceedings of the National Academy of Sciences of the United States of America, 117, (43), 26876-26884. doi:10.1073/pnas.2008721117.

Nitiss, Karin C, Nitiss, John L, Hanakahi, Leslyn A. (2019). DNA Damage by an essential enzyme: A delicate balance act on the tightrope. DNA Repair, 82, 102639. doi:10.1016/j.dnarep.2019.102639.

Anand, Jay, Sun, Yilun, Zhao, Yang, Nitiss, Karin C, Nitiss, John L. (2017). Detection of Topoisomerase Covalent Complexes in Eukaryotic Cells. , 1703, 283-299. doi:10.1007/978-1-4939-7459-7_20.

Li, Jing, Summerlin, Matthew, Nitiss, Karin C, Nitiss, John L, Hanakahi, Leslyn A. (2017). TDP1 is required for efficient non-homologous end joining in human cells. DNA Repair, 60, 40-49. doi:10.1016/j.dnarep.2017.10.003.

Pan, Y, Ke, H, Yan, Z, Geng, Y, Asner, N, Palani, S, Munirathinam, G, Dasari, S, Nitiss, KC, Bliss, S, Patel, P, Shen, H, Reardon, CA, Getz, GS, Chen, A, Zheng, G. (2016). The western-type diet induces anti-HMGB1 autoimmunity in Apoe(-/-) mice. Atherosclerosis, 251, 31-38. doi:10.1016/j.atherosclerosis.2016.05.027.

Heo, Jinho, Li, Jing, Summerlin, Matthew, Hays, Annette, Katyal, Sachin, McKinnon, Peter J, Nitiss, Karin C, Nitiss, John L, Hanakahi, Leslyn A. (2015). TDP1 promotes assembly of non-homologous end joining protein complexes on DNA. DNA Repair, 30, 28-37. doi:10.1016/j.dnarep.2015.03.003.

Education

Degrees:
PhD, University of Southern California, United States, 1997
Bachelors of Science, University of California, United States, 1986