Karin C. Nitiss
Research Assistant Professor, College of Medicine, Rockford - Biomedical Sciences
Research Assistant Professor, College of Pharmacy, Rockford - Biopharmaceutical Sciences
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Selected Grants
DNA Topoisomerase Misfunctioning in Neurological Disease, National Institutes of Health (National Institute of Neurological Disorders and Stroke)., 1/1/2021 - 11/30/2023, Obligated Amount: $159900; Anticipated Amount: $159900
Selected Publications
Sun, Y, Soans, E, Mishina, M, Petricci, E, Pommier, Y, Nitiss, KC, Nitiss, JL. (2022). Requirements for MRN endonuclease processing of topoisomerase II-mediated DNA damage in mammalian cells. Frontiers in Molecular Biosciences, 9. doi:10.3389/fmolb.2022.1007064.
Boot, A, Liu, M, Stantial, N, Shah, V, Yu, W, Nitiss, KC, Nitiss, JL, Jinks-Robertson, S, Rozen, SG. (2022). Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers. Proceedings of the National Academy of Sciences of the United States of America, 119, (4). doi:10.1073/pnas.2114024119.
Nitiss, JL, Kiianitsa, K, Sun, Y, Nitiss, KC, Maizels, N. (2021). Topoisomerase Assays. Current Protocols, 1, (10). doi:10.1002/cpz1.250.
Sun, Y, Jenkins, LMM, Su, YP, Nitiss, KC, Nitiss, JL, Pommier, Y. (2020). A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation. Science Advances, 6, (46). doi:10.1126/sciadv.aba6290.
Stantial, N, Rogojina, A, Gilbertson, M, Sun, Y, Miles, H, Shaltz, S, Berger, J, Nitiss, KC, Jinks-Robertson, S, Nitiss, JL. (2020). Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast. Proceedings of the National Academy of Sciences of the United States of America, 117, (43), 26876-26884. doi:10.1073/pnas.2008721117.
Nitiss, KC, Nitiss, JL, Hanakahi, LA. (2019). DNA Damage by an essential enzyme: A delicate balance act on the tightrope. DNA Repair, 82. doi:10.1016/j.dnarep.2019.102639.
Anand, J, Sun, Y, Zhao, Y, Nitiss, KC, Nitiss, JL. (2018). Detection of topoisomerase covalent complexes in eukaryotic cells. , 1703, 283-299. doi:10.1007/978-1-4939-7459-7_20.
Li, J, Summerlin, M, Nitiss, KC, Nitiss, JL, Hanakahi, LA. (2017). TDP1 is required for efficient non-homologous end joining in human cells. DNA Repair, 60, 40-49. doi:10.1016/j.dnarep.2017.10.003.
Pan, Y, Ke, H, Yan, Z, Geng, Y, Asner, N, Palani, S, Munirathinam, G, Dasari, S, Nitiss, KC, Bliss, S, Patel, P, Shen, H, Reardon, CA, Getz, GS, Chen, A, Zheng, G. (2016). The western-type diet induces anti-HMGB1 autoimmunity in Apoe(-/-) mice. Atherosclerosis, 251, 31-38. doi:10.1016/j.atherosclerosis.2016.05.027.
Education
Degrees:
PhD, University of Southern California, United States, 1997
Bachelors of Science, University of California, United States, 1986